|
DE69133557D1
(de)
*
|
1990-08-29 |
2007-03-15 |
Pharming Intellectual Pty Bv |
Homologe rekombination in säugetier-zellen
|
|
US5830729A
(en)
|
1996-04-18 |
1998-11-03 |
Institut Pasteur |
I Sce I-induced gene replacement and gene conversion in embryonic stem cells
|
|
AU8587598A
(en)
|
1997-07-26 |
1999-02-16 |
Wisconsin Alumni Research Foundation |
Trans-species nuclear transfer
|
|
US6372956B1
(en)
|
1998-12-31 |
2002-04-16 |
The J. David Gladstone Institutes |
Transgenic rats and rat cell lines expressing human CD4 and a human chemokine receptor
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US20030104526A1
(en)
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
HK1049515B
(en)
|
1999-12-06 |
2006-01-13 |
Sangamo Biosciences Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
US20050144655A1
(en)
|
2000-10-31 |
2005-06-30 |
Economides Aris N. |
Methods of modifying eukaryotic cells
|
|
US7105348B2
(en)
*
|
2000-10-31 |
2006-09-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
AU2884102A
(en)
|
2000-12-07 |
2002-06-18 |
Sangamo Biosciences Inc |
Regulation of angiogenesis with zinc finger proteins
|
|
AU2002225187A1
(en)
|
2001-01-22 |
2002-07-30 |
Sangamo Biosciences, Inc. |
Zinc finger polypeptides and their use
|
|
CA2435394C
(en)
|
2001-01-22 |
2018-01-09 |
Sangamo Biosciences, Inc. |
Modified zinc finger binding proteins
|
|
AUPR451401A0
(en)
|
2001-04-20 |
2001-05-24 |
Monash University |
A method of nuclear transfer
|
|
AU2003251286B2
(en)
|
2002-01-23 |
2007-08-16 |
The University Of Utah Research Foundation |
Targeted chromosomal mutagenesis using zinc finger nucleases
|
|
AU2003215869B2
(en)
|
2002-03-15 |
2008-04-24 |
Cellectis |
Hybrid and single chain meganucleases and use thereof
|
|
US20030232410A1
(en)
|
2002-03-21 |
2003-12-18 |
Monika Liljedahl |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
|
US7612250B2
(en)
|
2002-07-29 |
2009-11-03 |
Trustees Of Tufts College |
Nuclear transfer embryo formation method
|
|
JP2006502748A
(ja)
|
2002-09-05 |
2006-01-26 |
カリフォルニア インスティテュート オブ テクノロジー |
遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法
|
|
AU2003290518A1
(en)
|
2002-09-06 |
2004-04-23 |
Fred Hutchinson Cancer Research Center |
Methods and compositions concerning designed highly-specific nucleic acid binding proteins
|
|
US20030175968A1
(en)
|
2002-10-30 |
2003-09-18 |
Golic Kent G. |
Gene targeting method
|
|
JP2006517101A
(ja)
|
2003-01-13 |
2006-07-20 |
エス. ラオ、マヘンドラ |
治療用産物を送達するための、増殖性の幹細胞および前駆細胞における候補分子の持続的発現
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
EP1591521A1
(en)
|
2004-04-30 |
2005-11-02 |
Cellectis |
I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof
|
|
EP2292274A1
(en)
|
2004-09-16 |
2011-03-09 |
Sangamo BioSciences, Inc. |
Compositions and methods for protein production
|
|
WO2006044962A1
(en)
|
2004-10-19 |
2006-04-27 |
Regeneron Pharmaceuticals, Inc. |
Method for generating an animal homozygous for a genetic modification
|
|
FR2879622B1
(fr)
|
2004-12-17 |
2008-02-01 |
Agronomique Inst Nat Rech |
Procede in vitro de production d'ovocytes ou d'oeufs presentant une modification genomique ciblee
|
|
WO2006097784A1
(en)
|
2005-03-15 |
2006-09-21 |
Cellectis |
I-crei meganuclease variants with modified specificity, method of preparation and uses thereof
|
|
AU2006224248B2
(en)
|
2005-03-15 |
2011-01-06 |
Cellectis |
I-Crei meganuclease variants with modified specificity, method of preparation and uses thereof
|
|
GB0615327D0
(en)
|
2006-03-30 |
2006-09-13 |
Univ Edinburgh |
Culture medium containing kinase inhibitors and uses thereof
|
|
JP5514539B2
(ja)
|
2006-03-31 |
2014-06-04 |
メダレックス・リミテッド・ライアビリティ・カンパニー |
ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物
|
|
CN101117633B
(zh)
|
2006-08-03 |
2011-07-20 |
上海交通大学附属儿童医院 |
一种细胞核移植方法
|
|
ES2586210T3
(es)
|
2006-12-14 |
2016-10-13 |
Sangamo Biosciences, Inc. |
Proteínas de dedo de zinc no canónicas optimizadas
|
|
US7771967B2
(en)
|
2006-12-22 |
2010-08-10 |
The J. David Gladstone Institutes |
Nucleic acid encoding apolipoprotein E-I3
|
|
CA2684378C
(en)
|
2007-04-26 |
2016-11-29 |
Sangamo Biosciences, Inc. |
Targeted integration into the ppp1r12c locus
|
|
CA2688834C
(en)
|
2007-06-01 |
2020-01-07 |
Ronald Buelow |
Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies
|
|
GB0803109D0
(en)
*
|
2008-02-20 |
2008-03-26 |
Gene Bridges Gmbh |
Method of nucleic acid recombination
|
|
AU2009322964B2
(en)
|
2008-12-04 |
2014-10-09 |
Sangamo Therapeutics, Inc. |
Genome editing in rats using zinc-finger nucleases
|
|
US20110239315A1
(en)
|
2009-01-12 |
2011-09-29 |
Ulla Bonas |
Modular dna-binding domains and methods of use
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
WO2010107493A2
(en)
|
2009-03-20 |
2010-09-23 |
Sangamo Biosciences, Inc. |
Modification of cxcr4 using engineered zinc finger proteins
|
|
US8772008B2
(en)
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
|
WO2011017293A2
(en)
|
2009-08-03 |
2011-02-10 |
The General Hospital Corporation |
Engineering of zinc finger arrays by context-dependent assembly
|
|
EP2493288B1
(en)
|
2009-10-28 |
2015-02-18 |
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Homologous recombination in the oocyte
|
|
PT2494047T
(pt)
|
2009-10-29 |
2017-02-08 |
Regeneron Pharma |
Alelos multifuncionais
|
|
US20120315670A1
(en)
|
2009-11-02 |
2012-12-13 |
Gen9, Inc. |
Compositions and Methods for the Regulation of Multiple Genes of Interest in a Cell
|
|
JP5807862B2
(ja)
|
2009-12-01 |
2015-11-10 |
国立研究開発法人国立がん研究センター |
ラット胚性幹細胞を用いたキメララットの作製法
|
|
NO2510096T3
(enExample)
|
2009-12-10 |
2015-03-21 |
|
|
|
AU2010335107B2
(en)
|
2009-12-21 |
2014-07-03 |
Keygene N.V. |
Improved techniques for transfecting protoplasts
|
|
JP2013518602A
(ja)
|
2010-02-09 |
2013-05-23 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
部分的に一本鎖のドナー分子による標的化ゲノム改変
|
|
GB201009732D0
(en)
*
|
2010-06-10 |
2010-07-21 |
Gene Bridges Gmbh |
Direct cloning
|
|
CN104711218B
(zh)
|
2010-06-11 |
2018-09-25 |
瑞泽恩制药公司 |
由xy es细胞制备能育的xy雌性动物
|
|
CA3157027A1
(en)
|
2010-07-21 |
2012-01-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of a t-cell receptor gene
|
|
BR112013001685B1
(pt)
|
2010-07-23 |
2021-10-13 |
Sigma-Aldrich Co. Llc |
Método para editar pelo menos uma sequência cromossômica endógena em uma célula pela inserção de uma sequência na sequência cromossômica
|
|
WO2012018726A1
(en)
|
2010-08-02 |
2012-02-09 |
Cellectis Sa |
Method for increasing double-strand break-induced gene targeting
|
|
WO2012129198A1
(en)
|
2011-03-23 |
2012-09-27 |
Transposagen Biopharmaceuticals, Inc. |
Genetically modified rat models for obesity and diabetes
|
|
HUE053444T2
(hu)
|
2011-10-28 |
2021-06-28 |
Regeneron Pharma |
Genetikailag módosított T-sejt receptoros egerek
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
RU2645475C2
(ru)
|
2012-04-25 |
2018-02-21 |
Регенерон Фармасьютикалз, Инк. |
Опосредованное нуклеазой нацеливание с большими нацеливающими векторами
|
|
JP6559063B2
(ja)
|
2012-05-07 |
2019-08-14 |
サンガモ セラピューティクス, インコーポレイテッド |
導入遺伝子のヌクレアーゼ媒介標的化組み込みのための方法および組成物
|
|
LT3401400T
(lt)
|
2012-05-25 |
2019-06-10 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui
|
|
PL4397760T3
(pl)
|
2012-10-23 |
2026-03-30 |
Toolgen Incorporated |
Kompozycja do rozszczepiania docelowego dna zawierająca prowadzące rna specyficzne dla docelowego dna i kwas nukleinowy kodujący białko cas lub białko cas oraz jej zastosowanie
|
|
EP3135765A1
(en)
|
2012-12-06 |
2017-03-01 |
Sigma-Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
IL239317B
(en)
|
2012-12-12 |
2022-07-01 |
Broad Inst Inc |
Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
SG11201504676VA
(en)
*
|
2012-12-14 |
2015-07-30 |
Omt Inc |
Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
|
|
SG10201912991WA
(en)
|
2012-12-17 |
2020-03-30 |
Harvard College |
Rna-guided human genome engineering
|
|
WO2014104878A1
(en)
|
2012-12-27 |
2014-07-03 |
Keygene N.V. |
Method for removing genetic linkage in a plant
|
|
US20140235933A1
(en)
|
2013-02-20 |
2014-08-21 |
Regeneron Pharmaceuticals, Inc. |
Genetic modification of rats
|
|
JP2016507244A
(ja)
|
2013-02-27 |
2016-03-10 |
ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum MuenchenDeutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) |
Cas9ヌクレアーゼによる卵母細胞における遺伝子編集
|
|
US10612043B2
(en)
|
2013-03-09 |
2020-04-07 |
Agilent Technologies, Inc. |
Methods of in vivo engineering of large sequences using multiple CRISPR/cas selections of recombineering events
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
EP2975942B1
(en)
|
2013-03-21 |
2018-08-08 |
Sangamo Therapeutics, Inc. |
Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
|
|
DK2986729T3
(en)
|
2013-04-16 |
2018-10-29 |
Regeneron Pharma |
TARGETED MODIFICATION OF ROOT THROUGH
|
|
ES2844174T3
(es)
|
2013-09-18 |
2021-07-21 |
Kymab Ltd |
Métodos, células y organismos
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
WO2015088643A1
(en)
|
2013-12-11 |
2015-06-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
|
AU2014368982B2
(en)
|
2013-12-19 |
2021-03-25 |
Amyris, Inc. |
Methods for genomic integration
|
|
US20170076039A1
(en)
|
2014-04-24 |
2017-03-16 |
Institute For Basic Science |
A Method of Selecting a Nuclease Target Sequence for Gene Knockout Based on Microhomology
|
|
GB201407852D0
(en)
|
2014-05-02 |
2014-06-18 |
Iontas Ltd |
Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
|
|
RU2704283C9
(ru)
|
2014-06-06 |
2020-02-07 |
Регенерон Фармасьютикалз, Инк. |
Способы и композиции для модификации целевого локуса
|
|
PT3161128T
(pt)
|
2014-06-26 |
2018-11-21 |
Regeneron Pharma |
Métodos e composições para modificações genéticas alvejadas e métodos de utilização
|
|
KR20170083534A
(ko)
*
|
2014-09-19 |
2017-07-18 |
리제너론 파마슈티칼스 인코포레이티드 |
키메라 항원 수용체
|
|
WO2016061073A1
(en)
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
|
SG11201702309RA
(en)
|
2014-10-15 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for generating or maintaining pluripotent cells
|
|
WO2016080399A1
(ja)
|
2014-11-20 |
2016-05-26 |
国立大学法人京都大学 |
哺乳動物の標的ゲノム領域にdnaをノックインする方法及び細胞
|
|
CA2968440A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
WO2016089866A1
(en)
|
2014-12-01 |
2016-06-09 |
President And Fellows Of Harvard College |
Rna-guided systems for in vivo gene editing
|
|
BR112017013104A2
(en)
|
2014-12-19 |
2018-05-15 |
Regeneron Pharmaceuticals, Inc. |
methods for modifying a target genomic locus in a cell, for enhancing homologous recombination at a target genomic locus in a cell, and for producing an f0 generation from a nonhuman animal.
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|