JP2017537611A5 - - Google Patents
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- JP2017537611A5 JP2017537611A5 JP2017522083A JP2017522083A JP2017537611A5 JP 2017537611 A5 JP2017537611 A5 JP 2017537611A5 JP 2017522083 A JP2017522083 A JP 2017522083A JP 2017522083 A JP2017522083 A JP 2017522083A JP 2017537611 A5 JP2017537611 A5 JP 2017537611A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- dna binding
- atr
- operably linked
- binding domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000004568 DNA-binding Effects 0.000 claims description 131
- 108091033319 polynucleotide Proteins 0.000 claims description 61
- 102000040430 polynucleotide Human genes 0.000 claims description 61
- 239000002157 polynucleotide Substances 0.000 claims description 61
- 238000013518 transcription Methods 0.000 claims description 46
- 230000035897 transcription Effects 0.000 claims description 46
- 102100024811 DNA (cytosine-5)-methyltransferase 3-like Human genes 0.000 claims description 36
- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 claims description 36
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims description 36
- 101000909250 Homo sapiens DNA (cytosine-5)-methyltransferase 3-like Proteins 0.000 claims description 36
- 108010009540 DNA (Cytosine-5-)-Methyltransferase 1 Proteins 0.000 claims description 33
- 102100036279 DNA (cytosine-5)-methyltransferase 1 Human genes 0.000 claims description 33
- 102100024810 DNA (cytosine-5)-methyltransferase 3B Human genes 0.000 claims description 33
- 101710123222 DNA (cytosine-5)-methyltransferase 3B Proteins 0.000 claims description 33
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 102100023696 Histone-lysine N-methyltransferase SETDB1 Human genes 0.000 claims description 28
- 101000684609 Homo sapiens Histone-lysine N-methyltransferase SETDB1 Proteins 0.000 claims description 28
- 238000002560 therapeutic procedure Methods 0.000 claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 239000012636 effector Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 108091006107 transcriptional repressors Proteins 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 108091033409 CRISPR Proteins 0.000 claims description 9
- 238000010354 CRISPR gene editing Methods 0.000 claims description 9
- 230000027455 binding Effects 0.000 claims description 8
- 102100025169 Max-binding protein MNT Human genes 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- 101150061166 tetR gene Proteins 0.000 claims description 6
- 239000011701 zinc Substances 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- 238000001415 gene therapy Methods 0.000 claims description 5
- 239000013598 vector Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 230000030279 gene silencing Effects 0.000 claims description 3
- 230000010474 transient expression Effects 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000001890 transfection Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 19
- 108020004414 DNA Proteins 0.000 description 5
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010361 transduction Methods 0.000 description 2
- 230000026683 transduction Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021213691A JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1418965.8 | 2014-10-24 | ||
| GBGB1418965.8A GB201418965D0 (cg-RX-API-DMAC7.html) | 2014-10-24 | 2014-10-24 | |
| PCT/IB2015/058202 WO2016063264A1 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213691A Division JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537611A JP2017537611A (ja) | 2017-12-21 |
| JP2017537611A5 true JP2017537611A5 (cg-RX-API-DMAC7.html) | 2018-12-06 |
| JP7002936B2 JP7002936B2 (ja) | 2022-02-04 |
Family
ID=52103358
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522083A Active JP7002936B2 (ja) | 2014-10-24 | 2015-10-23 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2021213691A Active JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A Pending JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213691A Active JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| JP2025005873A Pending JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12152240B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3209783B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP7002936B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN116789846A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2015334469B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2965591A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3209783T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2906263T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201418965D0 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE057846T2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3209783T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3209783T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016063264A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013163628A2 (en) | 2012-04-27 | 2013-10-31 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| GB201418965D0 (cg-RX-API-DMAC7.html) * | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| EP3215623A4 (en) * | 2014-11-06 | 2018-09-26 | President and Fellows of Harvard College | Cells lacking b2m surface expression and methods for allogeneic administration of such cells |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| BR112017020750A2 (pt) * | 2015-03-27 | 2018-06-26 | Harvard College | células t modificadas e métodos de produção e utilização das mesmas |
| US11674144B2 (en) * | 2015-04-16 | 2023-06-13 | California Institute Of Technology | Fractional regulation of transcription |
| CA2988854A1 (en) | 2015-05-08 | 2016-11-17 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| EP4644567A2 (en) | 2015-11-30 | 2025-11-05 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| CN108699557B (zh) | 2015-12-04 | 2025-08-15 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| EP3463484A4 (en) * | 2016-05-27 | 2019-10-30 | The Regents of the University of California | METHOD AND COMPOSITIONS FOR TARGETING RNA POLYMERASES AND NON-CODING RNA BIOGENESIS AT SPECIFIC LOCI |
| US20190100732A1 (en) * | 2016-06-02 | 2019-04-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Assay for the removal of methyl-cytosine residues from dna |
| WO2018017754A1 (en) | 2016-07-19 | 2018-01-25 | Duke University | Therapeutic applications of cpf1-based genome editing |
| US11434476B2 (en) | 2016-08-19 | 2022-09-06 | Whitehead Institute For Biomedical Research | Methods of editing DNA methylation |
| CN109890962A (zh) | 2016-09-07 | 2019-06-14 | 旗舰创业股份有限公司 | 用于调节基因表达的方法和组合物 |
| EP3551218A4 (en) * | 2016-12-12 | 2020-12-09 | Whitehead Institute for Biomedical Research | REGULATION OF TRANSCRIPTION THANKS TO CTCF LOOP ANCHORS |
| US11873496B2 (en) | 2017-01-09 | 2024-01-16 | Whitehead Institute For Biomedical Research | Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops |
| WO2018160908A1 (en) * | 2017-03-03 | 2018-09-07 | Flagship Pioneering, Inc. | Methods and systems for modifying dna |
| CN110832075A (zh) | 2017-03-22 | 2020-02-21 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
| CN110914289B (zh) | 2017-05-12 | 2024-05-14 | 克里斯珀医疗股份公司 | 用于工程化细胞的材料和方法及其在免疫肿瘤学中的用途 |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| US11072782B2 (en) | 2017-07-24 | 2021-07-27 | Albert-Ludwigs-Universitaet Freiburg | Construct for epigenetic modification and its use in the silencing of genes |
| CN107759673B (zh) * | 2017-09-27 | 2021-06-04 | 复旦大学 | 可对hbv的dna进行表观甲基化修饰的蛋白分子及其应用 |
| US11629342B2 (en) | 2017-10-17 | 2023-04-18 | President And Fellows Of Harvard College | Cas9-based transcription modulation systems |
| EP3781705A4 (en) * | 2018-04-19 | 2022-01-26 | The Regents of the University of California | COMPOSITIONS AND METHODS OF GENE EDIT |
| PE20210666A1 (es) | 2018-05-11 | 2021-03-31 | Crispr Therapeutics Ag | Metodos y composiciones para tratar el cancer |
| JP2022511345A (ja) * | 2018-09-21 | 2022-01-31 | カファ セラピューティクス リミテッド | ＣＲＩＳＰＲ／Ｃａｓシステムに基づいた細胞の遺伝子編集の方法 |
| GB201817821D0 (en) * | 2018-10-31 | 2018-12-19 | Ospedale San Raffaele Srl | TCR and peptides |
| US12428639B2 (en) | 2019-03-05 | 2025-09-30 | Ramot At Tel-Aviv University Ltd. | Plant DNA methyltransferases and uses thereof |
| SG11202111443SA (en) | 2019-04-23 | 2021-11-29 | Sangamo Therapeutics Inc | Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof |
| EA202192975A1 (ru) | 2019-04-30 | 2022-02-01 | Криспр Терапьютикс Аг | Аллогенная клеточная терапия b-клеточных злокачественных новообразований с применением генетически сконструированных т-клеток, нацеливающихся на cd19 |
| JP2022548399A (ja) | 2019-09-23 | 2022-11-18 | オメガ セラピューティクス， インコーポレイテッド | 肝細胞核因子４－アルファ（ＨＮＦ４α）遺伝子発現をモジュレートするための組成物および方法 |
| BR112022009152A2 (pt) * | 2019-11-13 | 2022-07-26 | Crispr Therapeutics Ag | Processo de fabricação para preparar células t expressando receptores de antígenos quiméricos |
| MX2022005817A (es) * | 2019-11-13 | 2022-06-08 | Crispr Therapeutics Ag | Metodos de fabricacion de linfocitos t-car. |
| US20230399640A1 (en) * | 2020-09-24 | 2023-12-14 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for inhibiting gene expression |
| EP4267743A4 (en) * | 2020-12-22 | 2024-12-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic editing |
| US20240139319A1 (en) * | 2021-02-01 | 2024-05-02 | Epsilen Bio S.R.L | Gene silencing |
| AU2022220842A1 (en) * | 2021-02-15 | 2023-09-21 | Consiglio Nazionale Delle Ricerche | Epigenetic silencing for treatment of cancer |
| CN115247175B (zh) * | 2021-11-25 | 2025-10-17 | 南京启真基因工程有限公司 | 构建setdb1基因突变的表观遗传失调模型猪核移植供体细胞的基因编辑系统及其应用 |
| JP2025507990A (ja) * | 2022-03-04 | 2025-03-21 | エピジェニック・セラピューティクス・インコーポレイテッド | ゲノム編集の組成物及び方法 |
| EP4543908A1 (en) * | 2022-06-23 | 2025-04-30 | nChroma Bio, Inc. | Compositions and methods for epigenetic editing |
| EP4544058A1 (en) * | 2022-06-23 | 2025-04-30 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of ciita expression |
| JP2025524455A (ja) * | 2022-06-23 | 2025-07-30 | エヌクロマ・バイオ，インコーポレーテッド | Ｔｒａｃ発現のエピジェネティック調節のための組成物及び方法 |
| CA3260474A1 (en) * | 2022-06-23 | 2023-12-28 | Chroma Medicine, Inc. | COMPOSITIONS AND METHODS OF EPIGENETIC REGULATION OF B2M EXPRESSION |
| KR20250044484A (ko) | 2022-06-24 | 2025-03-31 | 튠 쎄라퓨틱스, 인코포레이티드 | 표적 유전자 억제를 통해 저밀도 지단백질을 감소시키기 위한 조성물, 시스템, 및 방법 |
| CN120435557A (zh) | 2022-08-19 | 2025-08-05 | 图恩疗法股份有限公司 | 通过靶向基因阻遏调节乙型肝炎病毒的组合物、系统和方法 |
| WO2024064910A1 (en) * | 2022-09-23 | 2024-03-28 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024081879A1 (en) * | 2022-10-14 | 2024-04-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of cd247 expression |
| EP4665855A1 (en) | 2023-02-17 | 2025-12-24 | Whitehead Institute for Biomedical Research | Compositions and methods for making epigenetic modifications |
| WO2024220857A1 (en) * | 2023-04-20 | 2024-10-24 | Chroma Medicine, Inc. | Fusion proteins for epigenetic regulation |
| AU2024270764A1 (en) | 2023-05-15 | 2025-12-04 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024238700A1 (en) * | 2023-05-15 | 2024-11-21 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| IT202300011790A1 (it) | 2023-06-08 | 2024-12-08 | Fond Telethon Ets | Protocolli di manipolazione genica in cellule immunitarie |
| CN119464241A (zh) * | 2023-08-09 | 2025-02-18 | 厦门大学 | 瓜氨酸化setdb1多肽及其在诊断类风湿性关节炎中的应用 |
| WO2025160155A1 (en) | 2024-01-22 | 2025-07-31 | The Broad Institute, Inc. | Epigenetic targeting of prion diseases |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723315A (en) | 1996-08-23 | 1998-03-03 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US6118001A (en) | 1996-08-07 | 2000-09-12 | Darwin Discovery, Ltd. | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| US20020188103A1 (en) | 1998-10-09 | 2002-12-12 | Timothy H. Bestor | Chimeric dna-binding/dna methyltransferase nucleic acid and polypeptide and uses thereof |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| AU2001253914B2 (en) * | 2000-04-28 | 2006-06-08 | Sangamo Therapeutics, Inc. | Targeted modification of chromatin structure |
| US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| WO2003072788A1 (en) | 2002-02-21 | 2003-09-04 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for reversibly controlling expression of target genes in cells |
| US7407776B2 (en) | 2003-09-19 | 2008-08-05 | Sangamo Biosciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| US20070192880A1 (en) | 2003-10-03 | 2007-08-16 | University Of Rochester | Horming response element binding transregulators |
| CA2562193A1 (en) | 2004-04-08 | 2005-10-27 | Sangamo Biosciences, Inc. | Treatment of neuropathic pain with zinc finger proteins |
| GB0526449D0 (en) | 2005-12-23 | 2006-02-08 | Medical Res Council | Polypeptide targeting |
| KR100756055B1 (ko) | 2006-01-27 | 2007-09-07 | 연세대학교 산학협력단 | 신생혈관 생성을 조절하는 재조합 아데노바이러스 |
| GB0607063D0 (en) | 2006-04-07 | 2006-05-17 | Cellcentric Ltd | Compositions and methods for epigenetic modification of nucleic acid sequences in vivo |
| GB0700374D0 (en) * | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| US20120207744A1 (en) * | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| EP2727600B1 (en) | 2009-07-28 | 2019-03-27 | Sangamo Therapeutics, Inc. | Zinc finger fusion proteins for repressing a huntington gene |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| GB201121924D0 (en) * | 2011-12-20 | 2012-02-01 | Fahy Gurteen Labs Ltd | Detection of breast cancer |
| EP2820127B1 (en) | 2012-02-28 | 2018-09-26 | Sigma Aldrich Co. LLC | Targeted histone acetylation |
| JP6490426B2 (ja) | 2012-02-29 | 2019-03-27 | サンガモ セラピューティクス， インコーポレイテッド | ハンチントン病を治療するための方法および組成物 |
| IN2014DN06898A (cg-RX-API-DMAC7.html) * | 2012-03-14 | 2015-05-15 | Salk Inst For Biological Studi | |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| GB2537000C (en) | 2012-05-25 | 2019-10-09 | Univ California | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| EP4556564A3 (en) | 2012-10-23 | 2025-09-03 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| CA2891347C (en) | 2012-12-06 | 2018-02-27 | Sigma-Aldrich Co. Llc | Crispr-based genome modification and regulation |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| KR20150105635A (ko) | 2012-12-12 | 2015-09-17 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| US20140186919A1 (en) | 2012-12-12 | 2014-07-03 | Feng Zhang | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| PL2771468T3 (pl) | 2012-12-12 | 2015-07-31 | Broad Inst Inc | Inżynieria systemów, metod i zoptymalizowanych kompozycji kierujących dla manipulacji sekwencjami |
| US9970024B2 (en) | 2012-12-17 | 2018-05-15 | President And Fellows Of Harvard College | RNA-guided human genome engineering |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| KR102874079B1 (ko) | 2013-03-15 | 2025-10-22 | 더 제너럴 하스피탈 코포레이션 | Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용 |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| EP4435110A3 (en) | 2013-06-05 | 2025-01-01 | Duke University | Rna-guided gene editing and gene regulation |
| JP6718813B2 (ja) | 2013-07-10 | 2020-07-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Ｒｎａ誘導性遺伝子制御および編集のための直交性ｃａｓ９タンパク質 |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150191744A1 (en) | 2013-12-17 | 2015-07-09 | University Of Massachusetts | Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling |
| JP2017514513A (ja) | 2014-03-20 | 2017-06-08 | ユニベルシテ ラバル | フラタキシンレベルを増加させるためのｃｒｉｓｐｒ系の方法及び生成物、ならびにそれらの使用 |
| US11254933B2 (en) | 2014-07-14 | 2022-02-22 | The Regents Of The University Of California | CRISPR/Cas transcriptional modulation |
| EP3169702A4 (en) | 2014-07-14 | 2018-04-18 | The Regents of The University of California | A protein tagging system for in vivo single molecule imaging and control of gene transcription |
| WO2016054106A1 (en) | 2014-09-29 | 2016-04-07 | The Regents Of The University Of California | SCAFFOLD RNAs |
| CA2964234A1 (en) | 2014-10-10 | 2016-04-14 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules in vitro and in vivo |
| GB201418965D0 (cg-RX-API-DMAC7.html) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| SI3250691T1 (sl) | 2015-01-28 | 2023-10-30 | Caribou Biosciences, Inc. | Hibridni dna/rna-polinukleotidi crispr in postopki za uporabo |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| WO2017015637A1 (en) | 2015-07-22 | 2017-01-26 | Duke University | High-throughput screening of regulatory element function with epigenome editing technologies |
| EP3347026A4 (en) | 2015-09-09 | 2019-05-08 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | GENEMANIPULATION OF MACROPHAGES FOR IMMUNOTHERAPY |
| EP3147363B1 (en) | 2015-09-26 | 2019-10-16 | B.R.A.I.N. Ag | Activation of taste receptor genes in mammalian cells using crispr-cas-9 |
| US10612044B2 (en) | 2015-11-25 | 2020-04-07 | National University Corporation Gunma University | DNA methylation editing kit and DNA methylation editing method |
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