JP2017536343A5 - - Google Patents

Info

Publication number

JP2017536343A5

JP2017536343A5 JP2017518929A JP2017518929A JP2017536343A5 JP 2017536343 A5 JP2017536343 A5 JP 2017536343A5 JP 2017518929 A JP2017518929 A JP 2017518929A JP 2017518929 A JP2017518929 A JP 2017518929A JP 2017536343 A5 JP2017536343 A5 JP 2017536343A5

Authority

JP

Japan

Prior art keywords

amino

carboxy

butanoyl

ethoxy

glp

Prior art date

2015-10-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 196
• 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 129
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 118
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 84
• 102100037963 Importin-7 Human genes 0.000 claims 75
• 101710125784 Importin-7 Proteins 0.000 claims 75
• 150000001408 amides Chemical group 0.000 claims 50
• 239000000126 substance Substances 0.000 claims 42
• -1 17-carboxyheptadecanoylamino Chemical group 0.000 claims 36
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 20
• 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 11
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 8
• 125000001424 substituent group Chemical group 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 150000001413 amino acids Chemical group 0.000 claims 4
• 125000004432 carbon atom Chemical group C* 0.000 claims 4
• 150000002148 esters Chemical class 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 101100335894 Caenorhabditis elegans gly-8 gene Proteins 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 claims 1
• 208000002705 Glucose Intolerance Diseases 0.000 claims 1
• 101000788682 Homo sapiens GATA-type zinc finger protein 1 Proteins 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 238000007792 addition Methods 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 201000009104 prediabetes syndrome Diseases 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 0 *C(CCc1cnc[n]1)=O Chemical compound *C(CCc1cnc[n]1)=O 0.000 description 1