JP2017536343A - 安定したｇｌｐ−１ベースのｇｌｐ−１／グルカゴン受容体コアゴニスト - Google Patents

安定したｇｌｐ−１ベースのｇｌｐ−１／グルカゴン受容体コアゴニスト Download PDF

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Publication number
JP2017536343A
JP2017536343A JP2017518929A JP2017518929A JP2017536343A JP 2017536343 A JP2017536343 A JP 2017536343A JP 2017518929 A JP2017518929 A JP 2017518929A JP 2017518929 A JP2017518929 A JP 2017518929A JP 2017536343 A JP2017536343 A JP 2017536343A
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JP
Japan
Prior art keywords
amino
glp
carboxy
butanoyl
ethoxy
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JP2017518929A
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English (en)
Japanese (ja)
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JP2017536343A5 (enExample
Inventor
ステフェン・リーツ−ルンゲ
ウルリヒ・ゼンスフース
トーマス・クルーセ
ヤーネ・スペツラー
ヘニング・トゥーヤスン
クリスティアン・ヴェンゼル・トーヌー
イェスパー・エフ・ラウ
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Novo Nordisk AS
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Novo Nordisk AS
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Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of JP2017536343A publication Critical patent/JP2017536343A/ja
Publication of JP2017536343A5 publication Critical patent/JP2017536343A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2017518929A 2014-10-10 2015-10-09 安定したｇｌｐ−１ベースのｇｌｐ−１／グルカゴン受容体コアゴニスト Withdrawn JP2017536343A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14188421 2014-10-10
EP14188421.3 2014-10-10
PCT/EP2015/073372 WO2016055610A1 (en) 2014-10-10 2015-10-09 Stable glp-1 based glp-1/glucagon receptor co-agonists

Publications (2)

Publication Number Publication Date
JP2017536343A true JP2017536343A (ja) 2017-12-07
JP2017536343A5 JP2017536343A5 (enExample) 2018-11-08

Family

ID=51663097

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017518929A Withdrawn JP2017536343A (ja) 2014-10-10 2015-10-09 安定したｇｌｐ−１ベースのｇｌｐ−１／グルカゴン受容体コアゴニスト

Country Status (7)

Country Link
US (1) US9988430B2 (enExample)
EP (1) EP3204408B1 (enExample)
JP (1) JP2017536343A (enExample)
CN (1) CN107108713A (enExample)
ES (1) ES2805326T3 (enExample)
TW (1) TW201629095A (enExample)
WO (1) WO2016055610A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
PT2934568T (pt) 2012-12-21 2018-01-04 Sanofi Sa Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
KR102608220B1 (ko) 2016-05-06 2023-11-29 아이오니스 파마수티컬즈, 인코포레이티드 Glp-1 수용체 리간드 모이어티 컨쥬게이트된 올리고뉴클레오티드 및 이의 용도
JP6601578B2 (ja) * 2017-07-13 2019-11-06 不二製油グループ本社株式会社 ペプチド
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
WO2023044290A1 (en) 2021-09-15 2023-03-23 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
CN115536739B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004528014A (ja) * 2000-12-07 2004-09-16 イーライ・リリー・アンド・カンパニー Ｇｌｐ−１融合タンパク質
US20090209469A1 (en) * 2006-08-04 2009-08-20 Dennis Kim Use of Exendins and GLP-1 Receptor Agonists for Altering Lipoprotein Particle Size and Subclass Composition
JP2010538042A (ja) * 2007-09-05 2010-12-09 ノボ・ノルデイスク・エー／エス グルカゴン様ペプチド−１誘導体及びそれらの医薬用途
JP2010538048A (ja) * 2007-09-05 2010-12-09 ノボ・ノルデイスク・エー／エス Ａ−ｂ−ｃ−ｄ−で誘導体化されたペプチドとその治療用途
WO2013041678A1 (en) * 2011-09-23 2013-03-28 Novo Nordisk A/S Novel glucagon analogues
JP2013517307A (ja) * 2010-01-20 2013-05-16 ジーランド ファーマ アクティーゼルスカブ 心臓病の処置
JP2013523618A (ja) * 2010-03-26 2013-06-17 ノヴォ ノルディスク アー／エス 新規のグルカゴン類似体
JP2013530969A (ja) * 2010-06-24 2013-08-01 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102075337A (zh) 2009-11-20 2011-05-25 腾讯科技（深圳）有限公司 一种即时通信消息显示方法和相关装置
US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
CA2832811A1 (en) 2011-04-12 2012-10-18 Novo Nordisk A/S Double-acylated glp-1 derivatives
BR112016016321A2 (pt) 2014-02-18 2017-10-03 Novo Nordisk As Derivados de análogos de glucagon estáveis, seus usos, e composição farmacêutica

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004528014A (ja) * 2000-12-07 2004-09-16 イーライ・リリー・アンド・カンパニー Ｇｌｐ−１融合タンパク質
US20090209469A1 (en) * 2006-08-04 2009-08-20 Dennis Kim Use of Exendins and GLP-1 Receptor Agonists for Altering Lipoprotein Particle Size and Subclass Composition
JP2010538042A (ja) * 2007-09-05 2010-12-09 ノボ・ノルデイスク・エー／エス グルカゴン様ペプチド−１誘導体及びそれらの医薬用途
JP2010538048A (ja) * 2007-09-05 2010-12-09 ノボ・ノルデイスク・エー／エス Ａ−ｂ−ｃ−ｄ−で誘導体化されたペプチドとその治療用途
JP2013517307A (ja) * 2010-01-20 2013-05-16 ジーランド ファーマ アクティーゼルスカブ 心臓病の処置
JP2013523618A (ja) * 2010-03-26 2013-06-17 ノヴォ ノルディスク アー／エス 新規のグルカゴン類似体
JP2013530969A (ja) * 2010-06-24 2013-08-01 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
WO2013041678A1 (en) * 2011-09-23 2013-03-28 Novo Nordisk A/S Novel glucagon analogues

Also Published As

Publication number Publication date
ES2805326T3 (es) 2021-02-11
WO2016055610A1 (en) 2016-04-14
EP3204408A1 (en) 2017-08-16
TW201629095A (zh) 2016-08-16
EP3204408B1 (en) 2020-05-06
CN107108713A (zh) 2017-08-29
US20160102129A1 (en) 2016-04-14
US9988430B2 (en) 2018-06-05

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