CN107108713A - 稳定的基于glp‑1的glp‑1/胰高血糖素受体共激动剂 - Google Patents
稳定的基于glp‑1的glp‑1/胰高血糖素受体共激动剂 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188421 | 2014-10-10 | ||
| EP14188421.3 | 2014-10-10 | ||
| PCT/EP2015/073372 WO2016055610A1 (en) | 2014-10-10 | 2015-10-09 | Stable glp-1 based glp-1/glucagon receptor co-agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107108713A true CN107108713A (zh) | 2017-08-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580055061.0A Withdrawn CN107108713A (zh) | 2014-10-10 | 2015-10-09 | 稳定的基于glp‑1的glp‑1/胰高血糖素受体共激动剂 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9988430B2 (enExample) |
| EP (1) | EP3204408B1 (enExample) |
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Families Citing this family (9)
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| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| PT2934568T (pt) | 2012-12-21 | 2018-01-04 | Sanofi Sa | Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| KR102608220B1 (ko) | 2016-05-06 | 2023-11-29 | 아이오니스 파마수티컬즈, 인코포레이티드 | Glp-1 수용체 리간드 모이어티 컨쥬게이트된 올리고뉴클레오티드 및 이의 용도 |
| JP6601578B2 (ja) * | 2017-07-13 | 2019-11-06 | 不二製油グループ本社株式会社 | ペプチド |
| CA3204051A1 (en) | 2021-01-20 | 2022-07-28 | Brian Lian | Compositions and methods for the treatment of metabolic and liver disorders |
| WO2023044290A1 (en) | 2021-09-15 | 2023-03-23 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| CN115536739B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法 |
Citations (4)
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| WO2008019143A2 (en) * | 2006-08-04 | 2008-02-14 | Amylin Pharmaceuticals, Inc | Use of exendins and glp-i receptor agonists for altering lipoprotein particle size and subclass composition |
| CN101868476A (zh) * | 2007-09-05 | 2010-10-20 | 诺沃-诺迪斯克有限公司 | 胰高血糖素样肽-1衍生物及其制药用途 |
| CN102918056A (zh) * | 2010-03-26 | 2013-02-06 | 诺沃—诺迪斯克有限公司 | 新的胰高血糖素类似物 |
| CN104093735A (zh) * | 2011-09-23 | 2014-10-08 | 诺沃—诺迪斯克有限公司 | 新的胰高血糖素类似物 |
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| DK1355942T3 (da) | 2000-12-07 | 2008-11-17 | Lilly Co Eli | GLP-1-fusionsproteiner |
| WO2009030771A1 (en) * | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| CN102075337A (zh) | 2009-11-20 | 2011-05-25 | 腾讯科技（深圳）有限公司 | 一种即时通信消息显示方法和相关装置 |
| US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| BR112012018104A2 (pt) | 2010-01-20 | 2017-10-17 | Zeland Pharma As | tratamento de doenças cardíacas |
| MA34383B1 (fr) * | 2010-06-24 | 2013-07-03 | Zealand Pharma As | Analogues de glucagon |
| CA2832811A1 (en) | 2011-04-12 | 2012-10-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| BR112016016321A2 (pt) | 2014-02-18 | 2017-10-03 | Novo Nordisk As | Derivados de análogos de glucagon estáveis, seus usos, e composição farmacêutica |
-
2015
- 2015-10-09 WO PCT/EP2015/073372 patent/WO2016055610A1/en not_active Ceased
- 2015-10-09 CN CN201580055061.0A patent/CN107108713A/zh not_active Withdrawn
- 2015-10-09 ES ES15778311T patent/ES2805326T3/es active Active
- 2015-10-09 JP JP2017518929A patent/JP2017536343A/ja not_active Withdrawn
- 2015-10-09 EP EP15778311.9A patent/EP3204408B1/en active Active
- 2015-10-09 US US14/879,428 patent/US9988430B2/en not_active Expired - Fee Related
- 2015-10-12 TW TW104133364A patent/TW201629095A/zh unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008019143A2 (en) * | 2006-08-04 | 2008-02-14 | Amylin Pharmaceuticals, Inc | Use of exendins and glp-i receptor agonists for altering lipoprotein particle size and subclass composition |
| CN101868476A (zh) * | 2007-09-05 | 2010-10-20 | 诺沃-诺迪斯克有限公司 | 胰高血糖素样肽-1衍生物及其制药用途 |
| CN102918056A (zh) * | 2010-03-26 | 2013-02-06 | 诺沃—诺迪斯克有限公司 | 新的胰高血糖素类似物 |
| CN104093735A (zh) * | 2011-09-23 | 2014-10-08 | 诺沃—诺迪斯克有限公司 | 新的胰高血糖素类似物 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2805326T3 (es) | 2021-02-11 |
| WO2016055610A1 (en) | 2016-04-14 |
| JP2017536343A (ja) | 2017-12-07 |
| EP3204408A1 (en) | 2017-08-16 |
| TW201629095A (zh) | 2016-08-16 |
| EP3204408B1 (en) | 2020-05-06 |
| US20160102129A1 (en) | 2016-04-14 |
| US9988430B2 (en) | 2018-06-05 |
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