JP2017532954A5 - - Google Patents
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- Publication number
- JP2017532954A5 JP2017532954A5 JP2017512937A JP2017512937A JP2017532954A5 JP 2017532954 A5 JP2017532954 A5 JP 2017532954A5 JP 2017512937 A JP2017512937 A JP 2017512937A JP 2017512937 A JP2017512937 A JP 2017512937A JP 2017532954 A5 JP2017532954 A5 JP 2017532954A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- brn3a
- neurofilament
- composition
- thy1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 23
- 101150008375 Pou4f1 gene Proteins 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- 102000008763 Neurofilament Proteins Human genes 0.000 claims 9
- 108010088373 Neurofilament Proteins Proteins 0.000 claims 9
- 210000005044 neurofilament Anatomy 0.000 claims 9
- 101150052863 THY1 gene Proteins 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 101000701154 Homo sapiens Transcription factor ATOH7 Proteins 0.000 claims 7
- 102100029372 Transcription factor ATOH7 Human genes 0.000 claims 7
- 101150073614 POU4F2 gene Proteins 0.000 claims 6
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims 5
- 101150070110 Isl1 gene Proteins 0.000 claims 5
- 239000002243 precursor Substances 0.000 claims 5
- 230000002055 immunohistochemical effect Effects 0.000 claims 4
- 208000003098 Ganglion Cysts Diseases 0.000 claims 3
- 208000005400 Synovial Cyst Diseases 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000006143 cell culture medium Substances 0.000 claims 2
- 230000003833 cell viability Effects 0.000 claims 2
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 2
- 101100295848 Drosophila melanogaster Optix gene Proteins 0.000 claims 1
- 101150040658 LHX2 gene Proteins 0.000 claims 1
- 102000008730 Nestin Human genes 0.000 claims 1
- 108010088225 Nestin Proteins 0.000 claims 1
- 101150092239 OTX2 gene Proteins 0.000 claims 1
- 102000007354 PAX6 Transcription Factor Human genes 0.000 claims 1
- 101150081664 PAX6 gene Proteins 0.000 claims 1
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 1
- 108700010572 Sine oculis homeobox homolog 3 Proteins 0.000 claims 1
- 101150111019 Tbx3 gene Proteins 0.000 claims 1
- 210000000411 amacrine cell Anatomy 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 238000012744 immunostaining Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000005055 nestin Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 108091008695 photoreceptors Proteins 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462046165P | 2014-09-05 | 2014-09-05 | |
| US62/046,165 | 2014-09-05 | ||
| PCT/US2015/048741 WO2016037159A1 (en) | 2014-09-05 | 2015-09-05 | Retinal ganglion cells and progenitors thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020124010A Division JP7263293B2 (ja) | 2014-09-05 | 2020-07-20 | 網膜神経節細胞およびその前駆体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532954A JP2017532954A (ja) | 2017-11-09 |
| JP2017532954A5 true JP2017532954A5 (https=) | 2018-09-27 |
| JP6778181B2 JP6778181B2 (ja) | 2020-10-28 |
Family
ID=55440432
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512937A Active JP6778181B2 (ja) | 2014-09-05 | 2015-09-05 | 網膜神経節細胞およびその前駆体 |
| JP2020124010A Active JP7263293B2 (ja) | 2014-09-05 | 2020-07-20 | 網膜神経節細胞およびその前駆体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020124010A Active JP7263293B2 (ja) | 2014-09-05 | 2020-07-20 | 網膜神経節細胞およびその前駆体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170274019A1 (https=) |
| EP (2) | EP3189135B1 (https=) |
| JP (2) | JP6778181B2 (https=) |
| KR (1) | KR20170077117A (https=) |
| CN (1) | CN107148276A (https=) |
| AU (2) | AU2015311702A1 (https=) |
| CA (1) | CA2960211A1 (https=) |
| ES (1) | ES2883600T3 (https=) |
| IL (3) | IL250924B (https=) |
| PL (1) | PL3189135T3 (https=) |
| PT (1) | PT3189135T (https=) |
| SG (3) | SG11201701709YA (https=) |
| WO (1) | WO2016037159A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL287381B2 (en) * | 2011-11-14 | 2024-04-01 | Astellas Inst For Regenerative Medicine | Pharmaceutical preparations of human rpe cells and uses thereof |
| SG10201907918VA (en) | 2015-03-23 | 2019-10-30 | Astellas Inst For Regenerative Medicine | Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors |
| CN108697641A (zh) | 2015-08-18 | 2018-10-23 | 安斯泰来再生医药协会 | 临床制剂 |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2019078781A1 (en) | 2017-10-17 | 2019-04-25 | National University Of Singapore | SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS |
| US12213996B2 (en) | 2018-02-02 | 2025-02-04 | University Of Maryland, Baltimore | Methods of treating optic nerve diseases using neural progenitor cell growth factors |
| US11621058B2 (en) | 2018-02-08 | 2023-04-04 | Ohio State Innovation Foundation | Synthetic IHC-stained digital sides generated using artificial neural networks |
| PT4234024T (pt) * | 2018-06-20 | 2026-01-21 | Biolamina Ab | Métodos e composições para produzir células do epitélio do pigmento da retina |
| KR102196069B1 (ko) | 2019-04-17 | 2020-12-29 | 경북대학교 산학협력단 | 망막신경절세포의 분리방법 및 그에 의해 분리된 세포의 용도 |
| CN112251408B (zh) * | 2020-09-14 | 2022-04-12 | 郑州大学 | 视网膜神经节细胞的制备方法 |
| CN114917367A (zh) * | 2021-06-02 | 2022-08-19 | 中国科学院动物研究所 | Lhx2在促进中枢系统神经元的损伤修复再生中的应用 |
| CN115404219B (zh) * | 2022-09-09 | 2023-10-27 | 中国医学科学院医学生物学研究所 | 一种树鼩视网膜神经节细胞的分离培养方法 |
| CN117821382A (zh) * | 2023-12-29 | 2024-04-05 | 广州赛莱拉干细胞科技股份有限公司 | 一种毛囊干细胞无血清培养基和培养方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009029173A1 (en) * | 2007-08-23 | 2009-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptogenesis |
| KR101718375B1 (ko) * | 2007-12-04 | 2017-03-22 | 프로테오바이오엑티브스 피티와이 엘티디 | 전구 세포의 보호 및 그의 분화 조절 |
| EP2470645B1 (en) * | 2009-08-24 | 2019-06-26 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| EP2486126B1 (en) * | 2009-10-06 | 2017-12-06 | SNU R & DB Foundation | Method for differentiation into retinal cells from stem cells |
| KR101712556B1 (ko) | 2014-08-27 | 2017-03-08 | 서울대학교산학협력단 | 줄기세포를 망막신경절세포로 분화시키는 방법 |
-
2015
- 2015-09-05 EP EP15838263.0A patent/EP3189135B1/en active Active
- 2015-09-05 JP JP2017512937A patent/JP6778181B2/ja active Active
- 2015-09-05 KR KR1020177008900A patent/KR20170077117A/ko not_active Ceased
- 2015-09-05 SG SG11201701709YA patent/SG11201701709YA/en unknown
- 2015-09-05 US US15/508,533 patent/US20170274019A1/en active Pending
- 2015-09-05 PT PT158382630T patent/PT3189135T/pt unknown
- 2015-09-05 AU AU2015311702A patent/AU2015311702A1/en not_active Abandoned
- 2015-09-05 SG SG10201901559SA patent/SG10201901559SA/en unknown
- 2015-09-05 PL PL15838263T patent/PL3189135T3/pl unknown
- 2015-09-05 CN CN201580056489.7A patent/CN107148276A/zh active Pending
- 2015-09-05 ES ES15838263T patent/ES2883600T3/es active Active
- 2015-09-05 WO PCT/US2015/048741 patent/WO2016037159A1/en not_active Ceased
- 2015-09-05 EP EP21168050.9A patent/EP3922717A1/en not_active Withdrawn
- 2015-09-05 SG SG10201912296RA patent/SG10201912296RA/en unknown
- 2015-09-05 CA CA2960211A patent/CA2960211A1/en not_active Abandoned
-
2017
- 2017-03-05 IL IL250924A patent/IL250924B/en active IP Right Grant
-
2020
- 2020-07-20 JP JP2020124010A patent/JP7263293B2/ja active Active
- 2020-10-04 IL IL277780A patent/IL277780B/en unknown
-
2021
- 2021-08-01 IL IL285258A patent/IL285258A/en unknown
- 2021-09-28 AU AU2021240145A patent/AU2021240145A1/en not_active Abandoned
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