JP2015522281A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015522281A5 JP2015522281A5 JP2015520349A JP2015520349A JP2015522281A5 JP 2015522281 A5 JP2015522281 A5 JP 2015522281A5 JP 2015520349 A JP2015520349 A JP 2015520349A JP 2015520349 A JP2015520349 A JP 2015520349A JP 2015522281 A5 JP2015522281 A5 JP 2015522281A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition
- reprogrammed
- lineage
- pancreatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 13
- 230000008672 reprogramming Effects 0.000 claims 5
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 101100239628 Danio rerio myca gene Proteins 0.000 claims 1
- 102100028098 Homeobox protein Nkx-6.1 Human genes 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 1
- 101150039798 MYC gene Proteins 0.000 claims 1
- 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 claims 1
- 108050000588 Neurogenic differentiation factor 1 Proteins 0.000 claims 1
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 1
- 101100459258 Xenopus laevis myc-a gene Proteins 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000004039 endoderm cell Anatomy 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000003716 mesoderm Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000004923 pancreatic tissue Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664259P | 2012-06-26 | 2012-06-26 | |
| US61/664,259 | 2012-06-26 | ||
| PCT/US2013/047243 WO2014004341A1 (en) | 2012-06-26 | 2013-06-24 | Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149816A Division JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522281A JP2015522281A (ja) | 2015-08-06 |
| JP2015522281A5 true JP2015522281A5 (https=) | 2016-08-04 |
| JP6386453B2 JP6386453B2 (ja) | 2018-09-05 |
Family
ID=48746139
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520349A Active JP6386453B2 (ja) | 2012-06-26 | 2013-06-24 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
| JP2018149816A Active JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149816A Active JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9968639B2 (https=) |
| EP (2) | EP3611255A1 (https=) |
| JP (2) | JP6386453B2 (https=) |
| KR (2) | KR102058259B1 (https=) |
| CN (2) | CN104640979B (https=) |
| AU (2) | AU2013280698B2 (https=) |
| BR (1) | BR112014031676A2 (https=) |
| CA (1) | CA2876677C (https=) |
| DK (1) | DK2864473T3 (https=) |
| EA (2) | EA033954B1 (https=) |
| ES (1) | ES2745704T3 (https=) |
| IL (2) | IL236346B (https=) |
| IN (1) | IN2015DN00281A (https=) |
| PT (1) | PT2864473T (https=) |
| SG (1) | SG11201408717XA (https=) |
| WO (1) | WO2014004341A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106467918B (zh) * | 2015-08-18 | 2020-07-31 | 中国科学技术大学先进技术研究院 | 一种基于人皮肤细胞的胰岛素分泌细胞的诱导方法及应用 |
| CN105434471A (zh) * | 2015-11-26 | 2016-03-30 | 深圳爱生再生医学科技有限公司 | 治疗糖尿病的干细胞制剂及其制备方法 |
| KR102788426B1 (ko) * | 2018-02-09 | 2025-04-01 | 세라시스, 인코포레이티드 | 당뇨병을 치료하기 위한 췌장 세포 및 이를 생성하는 방법 |
| ES3062949T3 (en) * | 2018-10-15 | 2026-04-14 | Evia Life Sciences Inc | Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ |
| CA3164215A1 (en) * | 2019-12-11 | 2021-06-17 | The University Of Tokyo | Induction of proliferous pancreatic islet precursor cell-like cells by transient expression of mycl and induction of differentiation into insulin-positive cells |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| JP2025512066A (ja) | 2022-04-15 | 2025-04-16 | スマートセラ ソリューションズ エービー | エキソソームを介したｍＲＮＡ剤の送達のための組成物及び方法 |
| KR20250163871A (ko) | 2023-02-03 | 2025-11-21 | 세라시스, 인코포레이티드 | 치료 세포 및 이와 관련된 방법 |
| WO2025029826A1 (en) | 2023-07-31 | 2025-02-06 | Seraxis, Inc. | Modified therapeutics cells and methods relating to the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861313A (en) * | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
| CA2357677A1 (en) | 1999-01-07 | 2000-07-13 | Incyte Pharmaceuticals, Inc. | Insulin-synthesis genes |
| US6815203B1 (en) | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| CA2392615A1 (en) | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| US6436704B1 (en) * | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| JP2005537803A (ja) | 2002-09-06 | 2005-12-15 | アムサイト インコーポレーティッド | Ｃｄ５６陽性ヒト成体膵臓内分泌前駆細胞 |
| DK1636348T3 (da) | 2003-06-20 | 2009-11-23 | Vrije Universiteit Brussel Vub | Fremgangsmåde til generering af beta-öceller ud fra eksokrine pankreatiske celler |
| CA2581424A1 (en) * | 2004-03-09 | 2005-09-22 | Gang Xu | Methods for generating insulin-producing cells |
| US20060029987A1 (en) | 2004-08-06 | 2006-02-09 | Applera Corporation | Diagnosis of pancreatic cancer by using pancreatic targets |
| US7807459B2 (en) | 2005-09-27 | 2010-10-05 | Reneuron, Inc. | EphA4-positive human adult pancreatic endocrine progenitor cells |
| EP2054079A4 (en) * | 2006-07-19 | 2009-12-23 | Univ Florida | COMPOSITIONS FOR CELL REPROGRAMMING AND USES THEREOF |
| WO2008112278A2 (en) | 2007-03-12 | 2008-09-18 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for modulating insulin secretion and glucose metabolism |
| EP2205724B1 (en) * | 2007-11-09 | 2016-04-27 | RNL Bio Co., Ltd. | Method for isolating and culturing adult stem cells derived from human amniotic epithelium |
| WO2009128533A1 (ja) * | 2008-04-18 | 2009-10-22 | 国立大学法人名古屋大学 | 間葉系幹細胞およびその生産方法 |
| US20110158961A1 (en) | 2008-05-09 | 2011-06-30 | The University Court Of The University Of Glasgow | Materials and methods relating to cell based therapies |
| WO2010022395A2 (en) * | 2008-08-22 | 2010-02-25 | President And Fellows Of Harvard College | Methods of reprogramming cells |
| EP2641911A3 (en) * | 2008-12-23 | 2014-01-01 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification |
| WO2011032025A2 (en) * | 2009-09-10 | 2011-03-17 | The Salk Institute For Biological Studies | Adipose-derived induced pluripotent stem cells |
| RU2587634C2 (ru) | 2010-05-12 | 2016-06-20 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| WO2012025914A1 (en) * | 2010-08-22 | 2012-03-01 | Ramot At Tel-Aviv University Ltd. | Induced pluripotent stem cells derived from human pancreatic beta cells |
| CN103154237B (zh) * | 2010-08-31 | 2016-03-16 | 詹森生物科技公司 | 多能干细胞的分化 |
| CN103210082A (zh) * | 2010-09-15 | 2013-07-17 | 雷蒙特亚特特拉维夫大学有限公司 | 扩增胰岛β细胞和使其再分化的方法 |
| US20120135015A1 (en) * | 2010-09-28 | 2012-05-31 | Baylor Research Institute | Induction of Pancreatic Stem Cells by Transient Overexpression of Reprogramming Factors and PDX1 Selection |
-
2013
- 2013-06-24 SG SG11201408717XA patent/SG11201408717XA/en unknown
- 2013-06-24 KR KR1020157000845A patent/KR102058259B1/ko active Active
- 2013-06-24 CA CA2876677A patent/CA2876677C/en active Active
- 2013-06-24 ES ES13733516T patent/ES2745704T3/es active Active
- 2013-06-24 PT PT13733516T patent/PT2864473T/pt unknown
- 2013-06-24 EP EP19185702.8A patent/EP3611255A1/en active Pending
- 2013-06-24 US US13/925,248 patent/US9968639B2/en active Active
- 2013-06-24 EP EP13733516.2A patent/EP2864473B1/en active Active
- 2013-06-24 AU AU2013280698A patent/AU2013280698B2/en active Active
- 2013-06-24 JP JP2015520349A patent/JP6386453B2/ja active Active
- 2013-06-24 KR KR1020197036838A patent/KR102174581B1/ko active Active
- 2013-06-24 CN CN201380033028.9A patent/CN104640979B/zh active Active
- 2013-06-24 DK DK13733516.2T patent/DK2864473T3/da active
- 2013-06-24 EA EA201590088A patent/EA033954B1/ru not_active IP Right Cessation
- 2013-06-24 CN CN202110419726.9A patent/CN113265370A/zh active Pending
- 2013-06-24 EA EA201992135A patent/EA201992135A1/ru unknown
- 2013-06-24 WO PCT/US2013/047243 patent/WO2014004341A1/en not_active Ceased
- 2013-06-24 BR BR112014031676A patent/BR112014031676A2/pt not_active Application Discontinuation
-
2014
- 2014-12-18 IL IL236346A patent/IL236346B/en active IP Right Grant
-
2015
- 2015-01-13 IN IN281DEN2015 patent/IN2015DN00281A/en unknown
- 2015-04-22 US US14/693,245 patent/US9474772B2/en active Active
-
2018
- 2018-08-09 JP JP2018149816A patent/JP6856586B2/ja active Active
-
2019
- 2019-03-26 AU AU2019202085A patent/AU2019202085A1/en not_active Abandoned
- 2019-05-28 IL IL266965A patent/IL266965B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015522281A5 (https=) | ||
| JP6954877B2 (ja) | 小分子を用いた多能性幹細胞からの膵臓内胚葉の作製 | |
| JP7005528B2 (ja) | 消化管由来上皮細胞を内胚葉幹細胞／前駆細胞に初期化するための低分子化合物の組み合わせ、初期化方法および適用 | |
| JP6312591B2 (ja) | 多能性幹細胞からの胚体内胚葉の効率的な誘導 | |
| EP3039122A1 (en) | Generation of endocrine progenitor cells from human pluripotent stem cells using small molecules | |
| JP6502323B2 (ja) | 多能性幹細胞培養用培地 | |
| KR102790025B1 (ko) | 다분화능성 줄기세포 분화 촉진제 | |
| JP2011518562A5 (https=) | ||
| JP2017532047A5 (https=) | ||
| CN103380212A (zh) | 用于单细胞分选与增强ipsc重新编程的细胞培养平台 | |
| JP6304818B2 (ja) | 皮膚由来多能性前駆細胞の作製方法 | |
| CN105385651B (zh) | 诱导性多能干细胞定向诱导分化为肝细胞的方法及肝细胞 | |
| Rao et al. | Highly efficient derivation of skeletal myotubes from human embryonic stem cells | |
| CN101974488B (zh) | 一种永生化的猪胰腺干细胞系及其构建与分化方法 | |
| JP2019511228A (ja) | 多能性幹細胞の中腸内胚葉細胞への分化 | |
| JP2012143229A5 (https=) | ||
| WO2014168157A1 (ja) | 肝幹前駆様細胞の培養方法及びその培養物 | |
| TWI438275B (zh) | 促進幹細胞分化為胰島素製造細胞的方法 | |
| CN110392735A (zh) | 胰腺祖细胞的维持和扩增 | |
| Konagaya et al. | Reproducible preparation of spheroids of pancreatic hormone positive cells from human iPS cells: An in vitro study | |
| WO2014179198A8 (en) | Methods for producing insulin-secreting beta cells from human pluripotent stem cells | |
| KR20170006949A (ko) | 줄기 세포의 신경 전구 세포로의 분화용 조성물 및 이를 이용한 방법 | |
| WO2014129628A1 (ja) | 多能性幹細胞から膵ランゲルハンス島を製造する方法 | |
| CN106367380B (zh) | 可在体外制备肝芽的细胞共培养方法和肝芽 | |
| CA3093074A1 (en) | Method for generating multiple cellular products from single pluripotent cell source |