JP2015522281A5 - - Google Patents
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- Publication number
- JP2015522281A5 JP2015522281A5 JP2015520349A JP2015520349A JP2015522281A5 JP 2015522281 A5 JP2015522281 A5 JP 2015522281A5 JP 2015520349 A JP2015520349 A JP 2015520349A JP 2015520349 A JP2015520349 A JP 2015520349A JP 2015522281 A5 JP2015522281 A5 JP 2015522281A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition
- reprogrammed
- lineage
- pancreatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 13
- 230000008672 reprogramming Effects 0.000 claims 5
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 101100239628 Danio rerio myca gene Proteins 0.000 claims 1
- 102100028098 Homeobox protein Nkx-6.1 Human genes 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 1
- 101150039798 MYC gene Proteins 0.000 claims 1
- 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 claims 1
- 108050000588 Neurogenic differentiation factor 1 Proteins 0.000 claims 1
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 1
- 101100459258 Xenopus laevis myc-a gene Proteins 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000004039 endoderm cell Anatomy 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000003716 mesoderm Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000004923 pancreatic tissue Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664259P | 2012-06-26 | 2012-06-26 | |
| US61/664,259 | 2012-06-26 | ||
| PCT/US2013/047243 WO2014004341A1 (en) | 2012-06-26 | 2013-06-24 | Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149816A Division JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522281A JP2015522281A (ja) | 2015-08-06 |
| JP2015522281A5 true JP2015522281A5 (https=) | 2016-08-04 |
| JP6386453B2 JP6386453B2 (ja) | 2018-09-05 |
Family
ID=48746139
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520349A Active JP6386453B2 (ja) | 2012-06-26 | 2013-06-24 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
| JP2018149816A Active JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149816A Active JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9968639B2 (https=) |
| EP (2) | EP2864473B1 (https=) |
| JP (2) | JP6386453B2 (https=) |
| KR (2) | KR102174581B1 (https=) |
| CN (2) | CN113265370A (https=) |
| AU (2) | AU2013280698B2 (https=) |
| BR (1) | BR112014031676A2 (https=) |
| CA (1) | CA2876677C (https=) |
| DK (1) | DK2864473T3 (https=) |
| EA (2) | EA201992135A1 (https=) |
| ES (1) | ES2745704T3 (https=) |
| IL (2) | IL236346B (https=) |
| IN (1) | IN2015DN00281A (https=) |
| PT (1) | PT2864473T (https=) |
| SG (1) | SG11201408717XA (https=) |
| WO (1) | WO2014004341A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106467918B (zh) * | 2015-08-18 | 2020-07-31 | 中国科学技术大学先进技术研究院 | 一种基于人皮肤细胞的胰岛素分泌细胞的诱导方法及应用 |
| CN105434471A (zh) * | 2015-11-26 | 2016-03-30 | 深圳爱生再生医学科技有限公司 | 治疗糖尿病的干细胞制剂及其制备方法 |
| EP3749752A1 (en) * | 2018-02-09 | 2020-12-16 | Seraxis, Inc. | Pancreatic cells for treating diabetes and methods of generating the same |
| KR20210077698A (ko) * | 2018-10-15 | 2021-06-25 | 사이니티 가부시키가이샤 | 저분자 화합물에 의한 내배엽 조직 또는 기관 유래 세포로부터의 줄기/전구 세포의 제작 방법 |
| WO2021117840A1 (ja) * | 2019-12-11 | 2021-06-17 | 国立大学法人 東京大学 | Ｍｙｃｌの一過性発現による増殖可能な膵島前駆細胞様細胞の誘導とインスリン陽性細胞への分化誘導 |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| US20230330264A1 (en) | 2022-04-15 | 2023-10-19 | Smartcella Solutions Ab | COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS |
| JP2026505821A (ja) | 2023-02-03 | 2026-02-18 | セラクシス，インコーポレーテッド | 治療細胞およびそれらに関連する方法 |
| WO2025029826A1 (en) | 2023-07-31 | 2025-02-06 | Seraxis, Inc. | Modified therapeutics cells and methods relating to the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861313A (en) * | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
| AU2376200A (en) | 1999-01-07 | 2000-07-24 | Incyte Pharmaceuticals, Inc. | Insulin-synthesis genes |
| US6815203B1 (en) * | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
| US20010046489A1 (en) | 1999-12-06 | 2001-11-29 | Habener Joel E. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| AU2003268534A1 (en) | 2002-09-06 | 2004-03-29 | Amcyte Inc. | Cd56 positive human adult pancreatic endocrine progenitor cells |
| CA2527626A1 (en) | 2003-06-20 | 2004-12-29 | Vrije Universiteit Brussel | Method of generating islet beta-cells from exocrine pancreatic cells |
| CA2581424A1 (en) * | 2004-03-09 | 2005-09-22 | Gang Xu | Methods for generating insulin-producing cells |
| US20060029987A1 (en) | 2004-08-06 | 2006-02-09 | Applera Corporation | Diagnosis of pancreatic cancer by using pancreatic targets |
| US7807459B2 (en) | 2005-09-27 | 2010-10-05 | Reneuron, Inc. | EphA4-positive human adult pancreatic endocrine progenitor cells |
| US20100137202A1 (en) * | 2006-07-19 | 2010-06-03 | University Of Florida Research Foundation | Compositions for reprogramming a cell and uses therefor |
| WO2008112278A2 (en) | 2007-03-12 | 2008-09-18 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for modulating insulin secretion and glucose metabolism |
| CA2692634C (en) | 2007-11-09 | 2014-05-27 | Rnl Bio Co., Ltd | Method for isolating and culturing adult stem cells derived from human amniotic epithelium |
| WO2009128533A1 (ja) | 2008-04-18 | 2009-10-22 | 国立大学法人名古屋大学 | 間葉系幹細胞およびその生産方法 |
| CN102083964B (zh) * | 2008-05-09 | 2013-06-12 | 格拉斯哥大学大学行政评议会 | 与基于细胞的疗法相关的材料和方法 |
| WO2010022395A2 (en) * | 2008-08-22 | 2010-02-25 | President And Fellows Of Harvard College | Methods of reprogramming cells |
| JP2012513218A (ja) * | 2008-12-23 | 2012-06-14 | ヴィヴォスクリプト，インコーポレイテッド | 遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| WO2011032025A2 (en) * | 2009-09-10 | 2011-03-17 | The Salk Institute For Biological Studies | Adipose-derived induced pluripotent stem cells |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| SG187830A1 (en) * | 2010-08-22 | 2013-03-28 | Univ Ramot | Induced pluripotent stem cells derived from human pancreatic beta cells |
| EP2611907B1 (en) * | 2010-08-31 | 2016-05-04 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| CN103210082A (zh) * | 2010-09-15 | 2013-07-17 | 雷蒙特亚特特拉维夫大学有限公司 | 扩增胰岛β细胞和使其再分化的方法 |
| WO2012044486A1 (en) * | 2010-09-28 | 2012-04-05 | Baylor Research Institute | Induction of pancreatic stem cells by transient overexpression of reprogramming factors and pdxi selection |
-
2013
- 2013-06-24 EP EP13733516.2A patent/EP2864473B1/en active Active
- 2013-06-24 JP JP2015520349A patent/JP6386453B2/ja active Active
- 2013-06-24 EP EP19185702.8A patent/EP3611255A1/en active Pending
- 2013-06-24 KR KR1020197036838A patent/KR102174581B1/ko active Active
- 2013-06-24 KR KR1020157000845A patent/KR102058259B1/ko active Active
- 2013-06-24 ES ES13733516T patent/ES2745704T3/es active Active
- 2013-06-24 CA CA2876677A patent/CA2876677C/en active Active
- 2013-06-24 EA EA201992135A patent/EA201992135A1/ru unknown
- 2013-06-24 EA EA201590088A patent/EA033954B1/ru not_active IP Right Cessation
- 2013-06-24 PT PT13733516T patent/PT2864473T/pt unknown
- 2013-06-24 AU AU2013280698A patent/AU2013280698B2/en active Active
- 2013-06-24 WO PCT/US2013/047243 patent/WO2014004341A1/en not_active Ceased
- 2013-06-24 DK DK13733516.2T patent/DK2864473T3/da active
- 2013-06-24 US US13/925,248 patent/US9968639B2/en active Active
- 2013-06-24 CN CN202110419726.9A patent/CN113265370A/zh active Pending
- 2013-06-24 SG SG11201408717XA patent/SG11201408717XA/en unknown
- 2013-06-24 BR BR112014031676A patent/BR112014031676A2/pt not_active Application Discontinuation
- 2013-06-24 CN CN201380033028.9A patent/CN104640979B/zh active Active
-
2014
- 2014-12-18 IL IL236346A patent/IL236346B/en active IP Right Grant
-
2015
- 2015-01-13 IN IN281DEN2015 patent/IN2015DN00281A/en unknown
- 2015-04-22 US US14/693,245 patent/US9474772B2/en active Active
-
2018
- 2018-08-09 JP JP2018149816A patent/JP6856586B2/ja active Active
-
2019
- 2019-03-26 AU AU2019202085A patent/AU2019202085A1/en not_active Abandoned
- 2019-05-28 IL IL266965A patent/IL266965B/en unknown
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