JP2017527559A5 - - Google Patents
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- Publication number
- JP2017527559A5 JP2017527559A5 JP2017511927A JP2017511927A JP2017527559A5 JP 2017527559 A5 JP2017527559 A5 JP 2017527559A5 JP 2017511927 A JP2017511927 A JP 2017511927A JP 2017511927 A JP2017511927 A JP 2017511927A JP 2017527559 A5 JP2017527559 A5 JP 2017527559A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- isoindol
- pyridin
- imaging agent
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043644P | 2014-08-29 | 2014-08-29 | |
| US62/043,644 | 2014-08-29 | ||
| PCT/US2015/047396 WO2016033436A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020016705A Division JP6843282B2 (ja) | 2014-08-29 | 2020-02-04 | ハンチントンタンパク質のイメージング用プローブ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017527559A JP2017527559A (ja) | 2017-09-21 |
| JP2017527559A5 true JP2017527559A5 (https=) | 2018-10-04 |
Family
ID=55400644
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511927A Ceased JP2017527559A (ja) | 2014-08-29 | 2015-08-28 | ハンチントンタンパク質のイメージング用プローブ |
| JP2020016705A Active JP6843282B2 (ja) | 2014-08-29 | 2020-02-04 | ハンチントンタンパク質のイメージング用プローブ |
| JP2021026146A Active JP7042940B2 (ja) | 2014-08-29 | 2021-02-22 | ハンチントンタンパク質のイメージング用プローブ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020016705A Active JP6843282B2 (ja) | 2014-08-29 | 2020-02-04 | ハンチントンタンパク質のイメージング用プローブ |
| JP2021026146A Active JP7042940B2 (ja) | 2014-08-29 | 2021-02-22 | ハンチントンタンパク質のイメージング用プローブ |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11071793B2 (https=) |
| EP (1) | EP3186241B1 (https=) |
| JP (3) | JP2017527559A (https=) |
| KR (1) | KR102410760B1 (https=) |
| CN (2) | CN107074817B (https=) |
| AU (1) | AU2015308765B2 (https=) |
| BR (1) | BR112017004136B1 (https=) |
| CA (1) | CA2959531C (https=) |
| DK (1) | DK3186241T3 (https=) |
| EA (1) | EA037275B1 (https=) |
| ES (1) | ES2841746T3 (https=) |
| HR (1) | HRP20202032T1 (https=) |
| HU (1) | HUE052892T2 (https=) |
| IL (1) | IL250805B (https=) |
| MX (2) | MX383202B (https=) |
| PL (1) | PL3186241T3 (https=) |
| PT (1) | PT3186241T (https=) |
| SG (1) | SG11201701578YA (https=) |
| SI (1) | SI3186241T1 (https=) |
| WO (1) | WO2016033436A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE056957T2 (hu) | 2014-08-29 | 2022-04-28 | Chdi Foundation Inc | Próbák huntingtin fehérjét megjelenítõ képalkotásra |
| AU2015308709B2 (en) | 2014-08-29 | 2020-01-02 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| DK3197277T3 (da) | 2014-08-29 | 2022-01-31 | Chdi Foundation Inc | Prober til billeddannelse af huntingtin-protein |
| EP3186241B1 (en) | 2014-08-29 | 2020-10-07 | CHDI Foundation, Inc. | Probes for imaging huntington protein |
| PT3340796T (pt) | 2015-08-28 | 2021-07-28 | Chdi Foundation Inc | Sondas para imagens da proteína huntingtina |
| WO2018049324A1 (en) | 2016-09-12 | 2018-03-15 | Numerate, Inc. | Monocyclic compounds useful as gpr120 modulators |
| EP3509588B1 (en) * | 2016-09-12 | 2023-06-07 | Integral Health,Inc. | Bicyclic compounds useful as gpr120 modulators |
| JP7619952B2 (ja) | 2019-02-25 | 2025-01-22 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | 変異型ハンチンチンタンパク質を標的とするための化合物及びその使用 |
| JP7720847B2 (ja) * | 2019-12-18 | 2025-08-08 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | ハンチンチンタンパク質をイメージングするための化合物及びプローブ |
| WO2021252775A1 (en) * | 2020-06-11 | 2021-12-16 | Chdi Foundation, Inc. | Heterocyclic compounds and imaging agents for imaging huntingtin protein |
| CN117412960A (zh) * | 2021-04-08 | 2024-01-16 | Chdi基金会股份有限公司 | 用于对亨廷顿蛋白成像的异吲哚啉酮化合物和显像剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726197A (en) * | 1992-11-02 | 1998-03-10 | Syntex (U.S.A.) Inc. | Isoindolinyl derivatives |
| DE60012742T2 (de) * | 1999-06-10 | 2005-01-13 | Warner-Lambert Co. Llc | Inhibition von amyloid protein aggregation und bilderzeugung von amyloidniederschlägen mit isoindolderivate |
| KR101011657B1 (ko) * | 2002-03-01 | 2011-01-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 항우울제 |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
| US20100267712A1 (en) * | 2007-09-27 | 2010-10-21 | The United States of America, as represented by the Secretary, Department of Health and | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| JP5632612B2 (ja) * | 2007-12-05 | 2014-11-26 | あすか製薬株式会社 | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| WO2010104324A2 (ko) * | 2009-03-10 | 2010-09-16 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도 |
| KR102090944B1 (ko) * | 2012-04-25 | 2020-03-19 | 라퀄리아 파마 인코포레이티드 | Ttx-s 차단제로서의 피롤로피리디논 유도체 |
| EP3055301B1 (en) * | 2013-10-07 | 2019-11-20 | Kadmon Corporation, LLC | (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases |
| AU2015308709B2 (en) | 2014-08-29 | 2020-01-02 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| DK3197277T3 (da) | 2014-08-29 | 2022-01-31 | Chdi Foundation Inc | Prober til billeddannelse af huntingtin-protein |
| EP3186241B1 (en) | 2014-08-29 | 2020-10-07 | CHDI Foundation, Inc. | Probes for imaging huntington protein |
| HUE056957T2 (hu) | 2014-08-29 | 2022-04-28 | Chdi Foundation Inc | Próbák huntingtin fehérjét megjelenítõ képalkotásra |
| PT3340796T (pt) | 2015-08-28 | 2021-07-28 | Chdi Foundation Inc | Sondas para imagens da proteína huntingtina |
-
2015
- 2015-08-28 EP EP15836970.2A patent/EP3186241B1/en active Active
- 2015-08-28 BR BR112017004136-7A patent/BR112017004136B1/pt active IP Right Grant
- 2015-08-28 HU HUE15836970A patent/HUE052892T2/hu unknown
- 2015-08-28 ES ES15836970T patent/ES2841746T3/es active Active
- 2015-08-28 PT PT158369702T patent/PT3186241T/pt unknown
- 2015-08-28 EA EA201790432A patent/EA037275B1/ru unknown
- 2015-08-28 SG SG11201701578YA patent/SG11201701578YA/en unknown
- 2015-08-28 HR HRP20202032TT patent/HRP20202032T1/hr unknown
- 2015-08-28 WO PCT/US2015/047396 patent/WO2016033436A1/en not_active Ceased
- 2015-08-28 KR KR1020177008418A patent/KR102410760B1/ko active Active
- 2015-08-28 US US15/507,214 patent/US11071793B2/en active Active
- 2015-08-28 MX MX2017002704A patent/MX383202B/es unknown
- 2015-08-28 DK DK15836970.2T patent/DK3186241T3/da active
- 2015-08-28 JP JP2017511927A patent/JP2017527559A/ja not_active Ceased
- 2015-08-28 AU AU2015308765A patent/AU2015308765B2/en active Active
- 2015-08-28 SI SI201531461T patent/SI3186241T1/sl unknown
- 2015-08-28 CN CN201580058254.1A patent/CN107074817B/zh active Active
- 2015-08-28 PL PL15836970T patent/PL3186241T3/pl unknown
- 2015-08-28 CA CA2959531A patent/CA2959531C/en active Active
- 2015-08-28 CN CN202311625463.2A patent/CN118005611A/zh active Pending
-
2017
- 2017-02-27 IL IL250805A patent/IL250805B/en active IP Right Grant
- 2017-02-28 MX MX2021005891A patent/MX2021005891A/es unknown
-
2020
- 2020-02-04 JP JP2020016705A patent/JP6843282B2/ja active Active
-
2021
- 2021-02-22 JP JP2021026146A patent/JP7042940B2/ja active Active
- 2021-06-21 US US17/353,611 patent/US12036291B2/en active Active
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