JP2017527549A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017527549A5 JP2017527549A5 JP2017508087A JP2017508087A JP2017527549A5 JP 2017527549 A5 JP2017527549 A5 JP 2017527549A5 JP 2017508087 A JP2017508087 A JP 2017508087A JP 2017508087 A JP2017508087 A JP 2017508087A JP 2017527549 A5 JP2017527549 A5 JP 2017527549A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- single crystal
- crystal form
- ray powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 37
- 239000013078 crystal Substances 0.000 claims 35
- 239000000203 mixture Substances 0.000 claims 33
- 239000007787 solid Substances 0.000 claims 21
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 20
- 238000000634 powder X-ray diffraction Methods 0.000 claims 20
- 239000002002 slurry Substances 0.000 claims 18
- WEVYAHXRMPXWCK-UHFFFAOYSA-N methyl cyanide Natural products CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 10
- 230000015572 biosynthetic process Effects 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 239000002904 solvent Substances 0.000 claims 7
- 238000001816 cooling Methods 0.000 claims 6
- 239000011541 reaction mixture Substances 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 230000001939 inductive effect Effects 0.000 claims 5
- PAQZWJGSJMLPMG-UHFFFAOYSA-N 2,4,6-tripropyl-1,3,5,2$l^{5},4$l^{5},6$l^{5}-trioxatriphosphinane 2,4,6-trioxide Chemical compound CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1 PAQZWJGSJMLPMG-UHFFFAOYSA-N 0.000 claims 2
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 125000005270 trialkylamine group Chemical group 0.000 claims 2
- 101100004408 Arabidopsis thaliana BIG gene Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101100485279 Drosophila melanogaster emb gene Proteins 0.000 claims 1
- 102100029095 Exportin-1 Human genes 0.000 claims 1
- 101100485284 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CRM1 gene Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 101150094313 XPO1 gene Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 150000007960 acetonitrile Chemical class 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 108700002148 exportin 1 Proteins 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 238000001757 thermogravimetry curve Methods 0.000 claims 1
- 230000008467 tissue growth Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 0 CCN=C(C*)C(C1)N1C(*)C(C)C Chemical compound CCN=C(C*)C(C1)N1C(*)C(C)C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038069P | 2014-08-15 | 2014-08-15 | |
| US62/038,069 | 2014-08-15 | ||
| PCT/US2015/045395 WO2016025904A1 (en) | 2014-08-15 | 2015-08-14 | Polymorphs of selinexor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093874A Division JP7218323B2 (ja) | 2014-08-15 | 2020-05-29 | セリネクソールの多形体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527549A JP2017527549A (ja) | 2017-09-21 |
| JP2017527549A5 true JP2017527549A5 (https=) | 2018-09-27 |
| JP6777626B2 JP6777626B2 (ja) | 2020-10-28 |
Family
ID=53969460
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508087A Active JP6777626B2 (ja) | 2014-08-15 | 2015-08-14 | セリネクソールの多形体 |
| JP2020093874A Active JP7218323B2 (ja) | 2014-08-15 | 2020-05-29 | セリネクソールの多形体 |
| JP2023009361A Active JP7558310B2 (ja) | 2014-08-15 | 2023-01-25 | セリネクソールの多形体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093874A Active JP7218323B2 (ja) | 2014-08-15 | 2020-05-29 | セリネクソールの多形体 |
| JP2023009361A Active JP7558310B2 (ja) | 2014-08-15 | 2023-01-25 | セリネクソールの多形体 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US10519139B2 (https=) |
| EP (2) | EP4112615A1 (https=) |
| JP (3) | JP6777626B2 (https=) |
| KR (1) | KR102608259B1 (https=) |
| CN (3) | CN111484483B (https=) |
| AU (4) | AU2015301484B2 (https=) |
| CA (1) | CA2957266A1 (https=) |
| CO (1) | CO2017001884A2 (https=) |
| DK (1) | DK3180331T3 (https=) |
| EA (1) | EA201790384A1 (https=) |
| ES (1) | ES2926377T3 (https=) |
| IL (1) | IL250328B (https=) |
| MA (1) | MA40254B1 (https=) |
| MX (2) | MX388170B (https=) |
| SG (2) | SG11201700789SA (https=) |
| UA (1) | UA123535C2 (https=) |
| WO (1) | WO2016025904A1 (https=) |
| ZA (1) | ZA201700880B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201800171T1 (it) | 2011-07-29 | 2018-07-17 | Karyopharm Therapeutics Inc | Modulatori di trasporto nucleare contenenti idrazide e loro usi |
| CA2872190C (en) | 2012-05-09 | 2024-06-25 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| DK3492455T3 (da) | 2013-06-21 | 2023-08-14 | Karyopharm Therapeutics Inc | 1,2,4-triazoler som nukleare transportmodulatorer og anvendelse til behandling af specifikke former for cancer |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2017117535A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2017118940A1 (en) | 2016-01-08 | 2017-07-13 | Dr. Reddy's Laboratories Limited | Solid forms of selinexor and process for their preparation |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| WO2018129227A1 (en) | 2017-01-05 | 2018-07-12 | Watson Laboratories Inc. | Novel crystalline forms of selinexor and process for their preparation |
| CN106831731B (zh) * | 2017-01-17 | 2019-11-08 | 广州市闻皓生物科技有限公司 | 一种Selinexor原料药的合成方法 |
| WO2019232724A1 (en) | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Compounds as nuclear transport modulators and uses thereof |
| WO2020072008A1 (en) * | 2018-10-04 | 2020-04-09 | Deva Holding Anonim Sirketi | Novel solid dispersions of selinexor |
| CA3130107A1 (en) * | 2019-03-20 | 2020-09-24 | Johnson Matthey Public Limited Company | Co-crystal forms of selinexor |
| KR20220004142A (ko) | 2019-05-01 | 2022-01-11 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | Xp01 억제제 및 xp01 억제제의 제조에 사용하기 위한 중간체의 제조 방법 |
| US20220218725A1 (en) * | 2019-05-16 | 2022-07-14 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP3808742A1 (en) | 2019-10-16 | 2021-04-21 | Sandoz AG | Polymorph of selinexor |
| WO2022087218A1 (en) | 2020-10-21 | 2022-04-28 | Karyopharm Therapeutics Inc. | Crystalline form of selinexor |
| CN112679477B (zh) * | 2020-12-17 | 2021-10-26 | 佛山奕安赛医药科技有限公司 | 塞利尼索及其中间体的制备方法 |
| WO2023122014A1 (en) * | 2021-12-20 | 2023-06-29 | Raytheon Technologies Corporation | Particle enhancement of ceramic matrix composites, method of manufacture thereof and articles comprising the same |
| CN116675677B (zh) * | 2023-08-02 | 2023-09-26 | 中国林业科学研究院林产化学工业研究所 | 一种c8漆酚衍生物及其制备方法和应用 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1017398A (en) | 1911-01-16 | 1912-02-13 | John E Folsom | Telegraph-key. |
| CS229934B2 (en) | 1981-07-07 | 1984-07-16 | Pfizer | Production method subst.indolylacryte acid derivative |
| KR840000529A (ko) | 1981-07-07 | 1984-02-25 | 콘스탄틴 루이스 클레멘트 | 인돌 유도체의 제조방법 |
| US4778796A (en) | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| JP3111321B2 (ja) | 1990-02-23 | 2000-11-20 | 武田薬品工業株式会社 | 縮合チアゾール化合物 |
| IL97249A (en) | 1990-02-23 | 1995-01-24 | Takeda Chemical Industries Ltd | Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or |
| US5541213A (en) | 1993-06-24 | 1996-07-30 | Eisai Co., Ltd. | Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility |
| US5468353A (en) | 1994-05-05 | 1995-11-21 | Minnesota Mining And Manufacturing Company | Mist suppressant for solvent extraction metal electrowinning |
| AU4368996A (en) | 1994-11-23 | 1996-06-17 | Neurogen Corporation | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands |
| US20030018025A1 (en) | 1995-06-07 | 2003-01-23 | Neurogen Corporation, Corporation Of The State Of Delaware | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands |
| EP0858457A1 (de) | 1995-10-20 | 1998-08-19 | Dr. Karl Thomae GmbH | 5-gliedrige heterocyclen, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung |
| CA2250002C (en) | 1996-04-04 | 2008-03-25 | Shionogi & Co., Ltd. | Cephem compounds and drugs containing the compounds |
| EP0913392B1 (en) | 1996-04-25 | 2003-07-02 | Nissan Chemical Industries, Limited | Ethylene derivatives and pest controlling agents |
| JP4054992B2 (ja) | 1996-04-25 | 2008-03-05 | 日産化学工業株式会社 | エチレン誘導体および有害生物防除剤 |
| DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| US5994398A (en) | 1996-12-11 | 1999-11-30 | Elan Pharmaceuticals, Inc. | Arylsulfonamides as phospholipase A2 inhibitors |
| JP4416198B2 (ja) | 1997-12-19 | 2010-02-17 | 武田薬品工業株式会社 | アニリド誘導体、その製造法および用途 |
| WO1999050264A1 (en) | 1998-03-30 | 1999-10-07 | Kyowa Hakko Kogyo Co., Ltd. | Quinazoline derivatives |
| US6743585B2 (en) | 1999-09-16 | 2004-06-01 | Agilent Technologies, Inc. | Methods for preparing conjugates |
| AR029803A1 (es) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
| EP1335898B1 (en) | 2000-09-29 | 2005-11-23 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
| EP1429765A2 (en) | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| AU2003287965A1 (en) | 2002-10-24 | 2004-05-13 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
| DE10250743A1 (de) | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| JP4145230B2 (ja) | 2002-11-01 | 2008-09-03 | 武田薬品工業株式会社 | 神経障害の予防・治療剤 |
| NZ540381A (en) | 2002-11-01 | 2007-11-30 | Takeda Pharmaceutical | 5-membered aromatic heterocycle derivatives as prophylactic and therapeutic agents for treating neuropathy |
| ATE552253T1 (de) | 2002-11-08 | 2012-04-15 | Novartis Int Pharm Ltd | 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren |
| EP1599447A1 (en) | 2003-02-28 | 2005-11-30 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
| MY149038A (en) | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
| MX2007001634A (es) | 2004-08-11 | 2007-04-23 | Kyorin Seiyaku Kk | Nuevo derivado de acido amino benzoico ciclico. |
| WO2006019020A1 (ja) | 2004-08-16 | 2006-02-23 | Sankyo Company, Limited | 置換されたウレア化合物 |
| EP1849465A4 (en) | 2005-02-18 | 2008-12-24 | Takeda Pharmaceutical | AGENS TO CONTROL THE FUNCTION OF THE GPR34 RECEPTOR |
| US8637559B2 (en) * | 2005-11-15 | 2014-01-28 | Otsuka Pharmaceutical Co., Ltd. | Oxazole compound and pharmaceutical composition |
| JP2007210929A (ja) | 2006-02-09 | 2007-08-23 | Sankyo Co Ltd | ウレア化合物を含有する医薬 |
| AR059955A1 (es) | 2006-03-09 | 2008-05-14 | Eisai R&D Man Co Ltd | Compuestos policiclicos no peptidicos, medicamentos que los contienen, y usos para prevenir o tratar enfermedades causadas por la produccion de beta amiloide |
| KR101495611B1 (ko) | 2006-04-07 | 2015-02-25 | 메틸진 인코포레이티드 | 히스톤 데아세틸라아제의 억제제 |
| CN101466687B (zh) | 2006-04-18 | 2012-04-11 | 日本化学医药株式会社 | 过氧化物酶体增殖剂激活受体δ的激活剂 |
| KR101130380B1 (ko) | 2006-06-13 | 2012-04-23 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 헤테로시클릭 비뉴클레오시드 화합물, 그의 제조방법, 약학적 조성물 및 항바이러스성 약제로서의 용도 |
| PL2054411T3 (pl) | 2006-07-27 | 2015-02-27 | Amorepacific Corp | Nowe związki, ich izomery lub ich farmaceutycznie dopuszczalne sole jako antagoniści receptora waniloidowego oraz zawierające je kompozycje farmaceutyczne |
| AU2007292155B2 (en) | 2006-09-05 | 2012-11-01 | Kyowa Kirin Co., Ltd. | Imidazole derivative |
| EP1942104A1 (en) | 2006-12-20 | 2008-07-09 | sanofi-aventis | Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals |
| EP1939180A1 (en) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase |
| US7795457B2 (en) | 2007-02-26 | 2010-09-14 | Kosan Biosciences Incorporated | Carbamate compounds |
| EP2003118A1 (de) | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Zimtsäurederivate als Modulatoren des EP2-Rezeptors |
| US8106083B2 (en) | 2008-08-08 | 2012-01-31 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| CN102480969A (zh) | 2009-07-09 | 2012-05-30 | 科锐医疗有限公司 | 伤口愈合和瘢痕调制方法 |
| US8518968B2 (en) | 2009-12-04 | 2013-08-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hydrazone and diacyl hydrazine compounds and methods of use |
| CN103002742B (zh) | 2010-03-05 | 2016-07-13 | 卡尔约药物治疗公司 | 核转运调节剂及其应用 |
| JP6106605B2 (ja) | 2011-01-17 | 2017-04-05 | カリオファーム セラピューティクス，インコーポレイテッド | オレフィン含有核輸送調節剤およびその使用 |
| US9428490B2 (en) | 2011-07-29 | 2016-08-30 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| SMT201800171T1 (it) | 2011-07-29 | 2018-07-17 | Karyopharm Therapeutics Inc | Modulatori di trasporto nucleare contenenti idrazide e loro usi |
| WO2013020024A2 (en) | 2011-08-03 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Maleimide compounds and methods of treatment |
| CA2872190C (en) | 2012-05-09 | 2024-06-25 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| US20160016916A1 (en) | 2013-03-15 | 2016-01-21 | Karyopharm Therapeutics Inc. | Exo Olefin-Containing Nuclear Transport Modulators and Uses Thereof |
| US10202366B2 (en) * | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| WO2014205393A1 (en) | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| DK3492455T3 (da) | 2013-06-21 | 2023-08-14 | Karyopharm Therapeutics Inc | 1,2,4-triazoler som nukleare transportmodulatorer og anvendelse til behandling af specifikke former for cancer |
| WO2015073908A1 (en) * | 2013-11-15 | 2015-05-21 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method for selecting cancer treatment regimen |
| US10969391B2 (en) | 2014-07-11 | 2021-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing hematological cancers |
| KR20170032244A (ko) * | 2014-07-26 | 2017-03-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Cdk 저해제로서 2-아미노-피리도[2,3-d]피리미딘-7(8h)-온 유도체 및 그 용도 |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| CN108348547B (zh) | 2015-08-28 | 2023-09-22 | 纽约市哥伦比亚大学信托人 | 用于匹配肿瘤学特征的系统和方法 |
| WO2017117535A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2017118940A1 (en) | 2016-01-08 | 2017-07-13 | Dr. Reddy's Laboratories Limited | Solid forms of selinexor and process for their preparation |
| JP6765198B2 (ja) | 2016-03-10 | 2020-10-07 | パナソニック株式会社 | 潜熱蓄熱材及びそれを用いる蓄熱システム |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| WO2018129227A1 (en) * | 2017-01-05 | 2018-07-12 | Watson Laboratories Inc. | Novel crystalline forms of selinexor and process for their preparation |
| CN106831731B (zh) | 2017-01-17 | 2019-11-08 | 广州市闻皓生物科技有限公司 | 一种Selinexor原料药的合成方法 |
| SG11202110589PA (en) | 2019-03-27 | 2021-10-28 | Karyopharm Therapeutics Inc | Biomarkers for selinexor |
| EP3808742A1 (en) | 2019-10-16 | 2021-04-21 | Sandoz AG | Polymorph of selinexor |
| ES3001533T3 (en) | 2019-12-06 | 2025-03-05 | Bae Systems Plc | Light source |
| WO2022087218A1 (en) | 2020-10-21 | 2022-04-28 | Karyopharm Therapeutics Inc. | Crystalline form of selinexor |
-
2015
- 2015-08-14 CN CN202010093491.4A patent/CN111484483B/zh active Active
- 2015-08-14 EP EP22176543.1A patent/EP4112615A1/en active Pending
- 2015-08-14 WO PCT/US2015/045395 patent/WO2016025904A1/en not_active Ceased
- 2015-08-14 KR KR1020177006680A patent/KR102608259B1/ko active Active
- 2015-08-14 SG SG11201700789SA patent/SG11201700789SA/en unknown
- 2015-08-14 CA CA2957266A patent/CA2957266A1/en active Pending
- 2015-08-14 US US15/503,319 patent/US10519139B2/en active Active
- 2015-08-14 DK DK15754099.8T patent/DK3180331T3/da active
- 2015-08-14 CN CN202010093239.3A patent/CN111481553B/zh active Active
- 2015-08-14 SG SG10201808624VA patent/SG10201808624VA/en unknown
- 2015-08-14 EP EP15754099.8A patent/EP3180331B1/en active Active
- 2015-08-14 UA UAA201702169A patent/UA123535C2/uk unknown
- 2015-08-14 MX MX2017002013A patent/MX388170B/es unknown
- 2015-08-14 EA EA201790384A patent/EA201790384A1/ru unknown
- 2015-08-14 AU AU2015301484A patent/AU2015301484B2/en active Active
- 2015-08-14 ES ES15754099T patent/ES2926377T3/es active Active
- 2015-08-14 CN CN201580056017.1A patent/CN107072992B/zh active Active
- 2015-08-14 MA MA40254A patent/MA40254B1/fr unknown
- 2015-08-14 JP JP2017508087A patent/JP6777626B2/ja active Active
-
2017
- 2017-01-29 IL IL250328A patent/IL250328B/en unknown
- 2017-02-03 ZA ZA2017/00880A patent/ZA201700880B/en unknown
- 2017-02-14 MX MX2021014128A patent/MX2021014128A/es unknown
- 2017-02-24 CO CONC2017/0001884A patent/CO2017001884A2/es unknown
-
2019
- 2019-11-11 US US16/679,630 patent/US11078190B2/en active Active
-
2020
- 2020-05-19 AU AU2020203246A patent/AU2020203246B2/en active Active
- 2020-05-29 JP JP2020093874A patent/JP7218323B2/ja active Active
-
2021
- 2021-07-01 US US17/365,656 patent/US11807629B2/en active Active
- 2021-12-14 AU AU2021286266A patent/AU2021286266B2/en active Active
-
2023
- 2023-01-25 JP JP2023009361A patent/JP7558310B2/ja active Active
- 2023-04-05 US US18/131,273 patent/US11753401B2/en active Active
- 2023-04-07 US US18/132,241 patent/US11746102B2/en active Active
- 2023-07-26 US US18/226,570 patent/US12371420B2/en active Active
-
2024
- 2024-04-30 AU AU2024202835A patent/AU2024202835A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017527549A5 (https=) | ||
| JP2018528199A5 (https=) | ||
| ES2778274T3 (es) | Síntesis de productos intermedios para producir derivados de prostaciclina | |
| JP2017535550A5 (https=) | ||
| JP2018511634A5 (https=) | ||
| JP2017505329A5 (https=) | ||
| JP2020517611A5 (https=) | ||
| JP2014524442A5 (https=) | ||
| JP6483674B2 (ja) | ５−ブロモ−２−（α−ヒドロキシペンチル）安息香酸ナトリウム塩の複数の異なる結晶型及びそれらの調製方法 | |
| JP2019504103A5 (https=) | ||
| JP6678711B2 (ja) | マルトール第二鉄の結晶形態 | |
| CN101528762A (zh) | 5-氨基-3-(2′,3′-二-O-乙酰基-β-D-呋喃核糖基)-3H-噻唑并[4,5-D]嘧啶-2-酮的马来酸盐的结晶A和B形式 | |
| JP2015509973A5 (https=) | ||
| JP2016537346A5 (https=) | ||
| JP2019505533A5 (https=) | ||
| JP2016190843A5 (https=) | ||
| JP2013541592A5 (https=) | ||
| JP2018520147A5 (https=) | ||
| JP2019505532A5 (https=) | ||
| JP2016510768A5 (https=) | ||
| JP2014506602A5 (https=) | ||
| JP2006151999A5 (https=) | ||
| WO2011050638A1 (zh) | 一种比马前列素晶体及其制备方法和用途 | |
| TWI808069B (zh) | [(1S)-1-[(2S,4R,5R)-5-(5-胺基-2-酮基-噻唑并[4,5-d]嘧啶-3-基)-4-羥基-四氫呋喃-2-基]丙基]乙酸酯之新穎固態形式 | |
| JP2020502077A5 (https=) |