JP2017527549A5 - - Google Patents
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- JP2017527549A5 JP2017527549A5 JP2017508087A JP2017508087A JP2017527549A5 JP 2017527549 A5 JP2017527549 A5 JP 2017527549A5 JP 2017508087 A JP2017508087 A JP 2017508087A JP 2017508087 A JP2017508087 A JP 2017508087A JP 2017527549 A5 JP2017527549 A5 JP 2017527549A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- single crystal
- crystal form
- ray powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 37
- 239000013078 crystal Substances 0.000 claims 35
- 239000000203 mixture Substances 0.000 claims 33
- 239000007787 solid Substances 0.000 claims 21
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 20
- 238000000634 powder X-ray diffraction Methods 0.000 claims 20
- 239000002002 slurry Substances 0.000 claims 18
- WEVYAHXRMPXWCK-UHFFFAOYSA-N methyl cyanide Natural products CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 10
- 230000015572 biosynthetic process Effects 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 239000002904 solvent Substances 0.000 claims 7
- 238000001816 cooling Methods 0.000 claims 6
- 239000011541 reaction mixture Substances 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 230000001939 inductive effect Effects 0.000 claims 5
- PAQZWJGSJMLPMG-UHFFFAOYSA-N 2,4,6-tripropyl-1,3,5,2$l^{5},4$l^{5},6$l^{5}-trioxatriphosphinane 2,4,6-trioxide Chemical compound CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1 PAQZWJGSJMLPMG-UHFFFAOYSA-N 0.000 claims 2
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 125000005270 trialkylamine group Chemical group 0.000 claims 2
- 101100004408 Arabidopsis thaliana BIG gene Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101100485279 Drosophila melanogaster emb gene Proteins 0.000 claims 1
- 102100029095 Exportin-1 Human genes 0.000 claims 1
- 101100485284 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CRM1 gene Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 101150094313 XPO1 gene Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 150000007960 acetonitrile Chemical class 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 108700002148 exportin 1 Proteins 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 238000001757 thermogravimetry curve Methods 0.000 claims 1
- 230000008467 tissue growth Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 0 CCN=C(C*)C(C1)N1C(*)C(C)C Chemical compound CCN=C(C*)C(C1)N1C(*)C(C)C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038069P | 2014-08-15 | 2014-08-15 | |
| US62/038,069 | 2014-08-15 | ||
| PCT/US2015/045395 WO2016025904A1 (en) | 2014-08-15 | 2015-08-14 | Polymorphs of selinexor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093874A Division JP7218323B2 (ja) | 2014-08-15 | 2020-05-29 | セリネクソールの多形体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527549A JP2017527549A (ja) | 2017-09-21 |
| JP2017527549A5 true JP2017527549A5 (enExample) | 2018-09-27 |
| JP6777626B2 JP6777626B2 (ja) | 2020-10-28 |
Family
ID=53969460
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508087A Active JP6777626B2 (ja) | 2014-08-15 | 2015-08-14 | セリネクソールの多形体 |
| JP2020093874A Active JP7218323B2 (ja) | 2014-08-15 | 2020-05-29 | セリネクソールの多形体 |
| JP2023009361A Active JP7558310B2 (ja) | 2014-08-15 | 2023-01-25 | セリネクソールの多形体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093874A Active JP7218323B2 (ja) | 2014-08-15 | 2020-05-29 | セリネクソールの多形体 |
| JP2023009361A Active JP7558310B2 (ja) | 2014-08-15 | 2023-01-25 | セリネクソールの多形体 |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US10519139B2 (enExample) |
| EP (2) | EP4112615A1 (enExample) |
| JP (3) | JP6777626B2 (enExample) |
| KR (1) | KR102608259B1 (enExample) |
| CN (3) | CN111481553B (enExample) |
| AU (4) | AU2015301484B2 (enExample) |
| CA (1) | CA2957266A1 (enExample) |
| CO (1) | CO2017001884A2 (enExample) |
| DK (1) | DK3180331T3 (enExample) |
| EA (1) | EA201790384A1 (enExample) |
| ES (1) | ES2926377T3 (enExample) |
| IL (1) | IL250328B (enExample) |
| MA (1) | MA40254B1 (enExample) |
| MX (2) | MX388170B (enExample) |
| SG (2) | SG11201700789SA (enExample) |
| UA (1) | UA123535C2 (enExample) |
| WO (1) | WO2016025904A1 (enExample) |
| ZA (1) | ZA201700880B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR087342A1 (es) | 2011-07-29 | 2014-03-19 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear que contienen hidrazida y sus usos |
| SMT202000347T1 (it) | 2012-05-09 | 2020-07-08 | Biogen Ma Inc | Modulatori di trasporto nucleare e loro usi |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| KR102322794B1 (ko) | 2013-06-21 | 2021-11-05 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | 핵수송 조절인자 및 이의 용도 |
| SG11201700789SA (en) * | 2014-08-15 | 2017-02-27 | Karyopharm Therapeutics Inc | Polymorphs of selinexor |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US11034675B2 (en) | 2016-01-08 | 2021-06-15 | Dr. Reddy's Laboratories Limited | Solid forms of Selinexor and process for their preparation |
| WO2018098472A1 (en) | 2016-11-28 | 2018-05-31 | Karyopharm Therapeutics Inc. | Crm1 inhibitors for treating epilepsy |
| EP3565813A1 (en) | 2017-01-05 | 2019-11-13 | Watson Laboratories, Inc. | Novel crystalline forms of selinexor and process for their preparation |
| CN106831731B (zh) * | 2017-01-17 | 2019-11-08 | 广州市闻皓生物科技有限公司 | 一种Selinexor原料药的合成方法 |
| WO2019232724A1 (en) | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Compounds as nuclear transport modulators and uses thereof |
| WO2020072008A1 (en) * | 2018-10-04 | 2020-04-09 | Deva Holding Anonim Sirketi | Novel solid dispersions of selinexor |
| BR112021016762A2 (pt) * | 2019-03-20 | 2021-10-19 | Johnson Matthey Public Limited Company | Cocristal de selinexor, composição farmacêutica, método de tratamento de doenças, e, processo para a preparação de cocristal de selinexor |
| EP3962898A1 (en) | 2019-05-01 | 2022-03-09 | Karyopharm Therapeutics, Inc. | Process for preparing xpo1 inhibitors and intermediates for use in the preparation of xp01 inhibitors |
| US20220218725A1 (en) * | 2019-05-16 | 2022-07-14 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP3808742A1 (en) | 2019-10-16 | 2021-04-21 | Sandoz AG | Polymorph of selinexor |
| WO2022087218A1 (en) | 2020-10-21 | 2022-04-28 | Karyopharm Therapeutics Inc. | Crystalline form of selinexor |
| CN112679477B (zh) * | 2020-12-17 | 2021-10-26 | 佛山奕安赛医药科技有限公司 | 塞利尼索及其中间体的制备方法 |
| AU2022276509A1 (en) | 2021-05-20 | 2023-12-07 | Karyopharm Therapeutics Inc. | Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms |
| WO2023122014A1 (en) * | 2021-12-20 | 2023-06-29 | Raytheon Technologies Corporation | Particle enhancement of ceramic matrix composites, method of manufacture thereof and articles comprising the same |
| CN116675677B (zh) * | 2023-08-02 | 2023-09-26 | 中国林业科学研究院林产化学工业研究所 | 一种c8漆酚衍生物及其制备方法和应用 |
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| US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US11034675B2 (en) * | 2016-01-08 | 2021-06-15 | Dr. Reddy's Laboratories Limited | Solid forms of Selinexor and process for their preparation |
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| WO2018098472A1 (en) | 2016-11-28 | 2018-05-31 | Karyopharm Therapeutics Inc. | Crm1 inhibitors for treating epilepsy |
| EP3565813A1 (en) * | 2017-01-05 | 2019-11-13 | Watson Laboratories, Inc. | Novel crystalline forms of selinexor and process for their preparation |
| CN106831731B (zh) | 2017-01-17 | 2019-11-08 | 广州市闻皓生物科技有限公司 | 一种Selinexor原料药的合成方法 |
| CA3131720A1 (en) | 2019-03-27 | 2020-10-01 | Andrea Califano | Biomarkers for selinexor |
| EP3808742A1 (en) | 2019-10-16 | 2021-04-21 | Sandoz AG | Polymorph of selinexor |
| ES3001533T3 (en) | 2019-12-06 | 2025-03-05 | Bae Systems Plc | Light source |
| WO2022087218A1 (en) | 2020-10-21 | 2022-04-28 | Karyopharm Therapeutics Inc. | Crystalline form of selinexor |
-
2015
- 2015-08-14 SG SG11201700789SA patent/SG11201700789SA/en unknown
- 2015-08-14 MX MX2017002013A patent/MX388170B/es unknown
- 2015-08-14 EP EP22176543.1A patent/EP4112615A1/en active Pending
- 2015-08-14 KR KR1020177006680A patent/KR102608259B1/ko active Active
- 2015-08-14 CN CN202010093239.3A patent/CN111481553B/zh active Active
- 2015-08-14 EA EA201790384A patent/EA201790384A1/ru unknown
- 2015-08-14 MA MA40254A patent/MA40254B1/fr unknown
- 2015-08-14 WO PCT/US2015/045395 patent/WO2016025904A1/en not_active Ceased
- 2015-08-14 CA CA2957266A patent/CA2957266A1/en active Pending
- 2015-08-14 CN CN201580056017.1A patent/CN107072992B/zh active Active
- 2015-08-14 EP EP15754099.8A patent/EP3180331B1/en active Active
- 2015-08-14 DK DK15754099.8T patent/DK3180331T3/da active
- 2015-08-14 CN CN202010093491.4A patent/CN111484483B/zh active Active
- 2015-08-14 JP JP2017508087A patent/JP6777626B2/ja active Active
- 2015-08-14 ES ES15754099T patent/ES2926377T3/es active Active
- 2015-08-14 UA UAA201702169A patent/UA123535C2/uk unknown
- 2015-08-14 AU AU2015301484A patent/AU2015301484B2/en active Active
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