JP6777626B2 - セリネクソールの多形体 - Google Patents

セリネクソールの多形体 Download PDF

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JP6777626B2
JP6777626B2 JP2017508087A JP2017508087A JP6777626B2 JP 6777626 B2 JP6777626 B2 JP 6777626B2 JP 2017508087 A JP2017508087 A JP 2017508087A JP 2017508087 A JP2017508087 A JP 2017508087A JP 6777626 B2 JP6777626 B2 JP 6777626B2
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structural formula
single crystal
compound
crystal form
cancer
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JP2017527549A (ja
JP2017527549A5 (enExample
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クリントン オースタッド，ブライアン
クリントン オースタッド，ブライアン
ロー，デービッド，ジー．
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カリオファーム セラピューティクス，インコーポレイテッド
カリオファーム セラピューティクス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2017508087A 2014-08-15 2015-08-14 セリネクソールの多形体 Active JP6777626B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462038069P 2014-08-15 2014-08-15
US62/038,069 2014-08-15
PCT/US2015/045395 WO2016025904A1 (en) 2014-08-15 2015-08-14 Polymorphs of selinexor

Related Child Applications (1)

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JP2020093874A Division JP7218323B2 (ja) 2014-08-15 2020-05-29 セリネクソールの多形体

Publications (3)

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JP2017527549A JP2017527549A (ja) 2017-09-21
JP2017527549A5 JP2017527549A5 (enExample) 2018-09-27
JP6777626B2 true JP6777626B2 (ja) 2020-10-28

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JP2017508087A Active JP6777626B2 (ja) 2014-08-15 2015-08-14 セリネクソールの多形体
JP2020093874A Active JP7218323B2 (ja) 2014-08-15 2020-05-29 セリネクソールの多形体
JP2023009361A Active JP7558310B2 (ja) 2014-08-15 2023-01-25 セリネクソールの多形体

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JP2023009361A Active JP7558310B2 (ja) 2014-08-15 2023-01-25 セリネクソールの多形体

Country Status (18)

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US (7) US10519139B2 (enExample)
EP (2) EP4112615A1 (enExample)
JP (3) JP6777626B2 (enExample)
KR (1) KR102608259B1 (enExample)
CN (3) CN111481553B (enExample)
AU (4) AU2015301484B2 (enExample)
CA (1) CA2957266A1 (enExample)
CO (1) CO2017001884A2 (enExample)
DK (1) DK3180331T3 (enExample)
EA (1) EA201790384A1 (enExample)
ES (1) ES2926377T3 (enExample)
IL (1) IL250328B (enExample)
MA (1) MA40254B1 (enExample)
MX (2) MX388170B (enExample)
SG (2) SG11201700789SA (enExample)
UA (1) UA123535C2 (enExample)
WO (1) WO2016025904A1 (enExample)
ZA (1) ZA201700880B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020143144A (ja) * 2014-08-15 2020-09-10 カリオファーム セラピューティクス，インコーポレイテッド セリネクソールの多形体

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US10202366B2 (en) 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
KR102322794B1 (ko) 2013-06-21 2021-11-05 카리오팜 쎄라퓨틱스, 인코포레이티드 핵수송 조절인자 및 이의 용도
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EP3962898A1 (en) 2019-05-01 2022-03-09 Karyopharm Therapeutics, Inc. Process for preparing xpo1 inhibitors and intermediates for use in the preparation of xp01 inhibitors
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CN112679477B (zh) * 2020-12-17 2021-10-26 佛山奕安赛医药科技有限公司 塞利尼索及其中间体的制备方法
AU2022276509A1 (en) 2021-05-20 2023-12-07 Karyopharm Therapeutics Inc. Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
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CN116675677B (zh) * 2023-08-02 2023-09-26 中国林业科学研究院林产化学工业研究所 一种c8漆酚衍生物及其制备方法和应用

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2020143144A (ja) * 2014-08-15 2020-09-10 カリオファーム セラピューティクス，インコーポレイテッド セリネクソールの多形体
JP7218323B2 (ja) 2014-08-15 2023-02-06 カリオファーム セラピューティクス，インコーポレイテッド セリネクソールの多形体

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CN107072992B (zh) 2020-03-10
JP2020143144A (ja) 2020-09-10
NZ728850A (en) 2024-03-22
US20240208943A1 (en) 2024-06-27
AU2020203246A1 (en) 2020-06-04
AU2015301484B2 (en) 2020-02-20
ZA201700880B (en) 2020-01-29
AU2024202835B2 (en) 2026-07-09
WO2016025904A1 (en) 2016-02-18
AU2021286266B2 (en) 2024-02-01
EP3180331A1 (en) 2017-06-21
CA2957266A1 (en) 2016-02-18
US11807629B2 (en) 2023-11-07
CN111484483B (zh) 2023-05-26
JP7218323B2 (ja) 2023-02-06
US11078190B2 (en) 2021-08-03
CN107072992A (zh) 2017-08-18
US12371420B2 (en) 2025-07-29
AU2021286266A1 (en) 2022-01-06
US20220135545A1 (en) 2022-05-05
US20230242516A1 (en) 2023-08-03
KR20170043561A (ko) 2017-04-21
JP7558310B2 (ja) 2024-09-30
MA40254A (fr) 2021-05-19
US20260152489A1 (en) 2026-06-04
EP3180331B1 (en) 2022-06-08
JP2017527549A (ja) 2017-09-21
KR102608259B1 (ko) 2023-11-29
US20200283419A1 (en) 2020-09-10
SG11201700789SA (en) 2017-02-27
AU2015301484A1 (en) 2017-03-02
MX2021014128A (es) 2022-01-04
CN111481553B (zh) 2023-09-01
SG10201808624VA (en) 2018-11-29
EA201790384A1 (ru) 2017-08-31
US10519139B2 (en) 2019-12-31
IL250328A0 (en) 2017-03-30
MA40254B1 (fr) 2022-09-30
DK3180331T3 (da) 2022-09-12
EP4112615A1 (en) 2023-01-04
CN111484483A (zh) 2020-08-04
MX388170B (es) 2025-03-19
IL250328B (en) 2022-05-01
UA123535C2 (uk) 2021-04-21
US11753401B2 (en) 2023-09-12
US20230242517A1 (en) 2023-08-03
CN111481553A (zh) 2020-08-04
ES2926377T3 (es) 2022-10-25
US20180215733A1 (en) 2018-08-02
US11746102B2 (en) 2023-09-05
JP2023052622A (ja) 2023-04-11
AU2020203246B2 (en) 2021-09-16
AU2024202835A1 (en) 2024-05-23
CO2017001884A2 (es) 2017-07-19
MX2017002013A (es) 2017-05-12

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