JP2017526652A5 - - Google Patents
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- JP2017526652A5 JP2017526652A5 JP2017503957A JP2017503957A JP2017526652A5 JP 2017526652 A5 JP2017526652 A5 JP 2017526652A5 JP 2017503957 A JP2017503957 A JP 2017503957A JP 2017503957 A JP2017503957 A JP 2017503957A JP 2017526652 A5 JP2017526652 A5 JP 2017526652A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- contacting
- composition
- cit
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028679P | 2014-07-24 | 2014-07-24 | |
| US62/028,679 | 2014-07-24 | ||
| PCT/US2015/040931 WO2016014360A1 (en) | 2014-07-24 | 2015-07-17 | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199681A Division JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526652A JP2017526652A (ja) | 2017-09-14 |
| JP2017526652A5 true JP2017526652A5 (enExample) | 2018-08-30 |
| JP6956630B2 JP6956630B2 (ja) | 2021-11-02 |
Family
ID=55163580
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503957A Active JP6956630B2 (ja) | 2014-07-24 | 2015-07-17 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2020199681A Active JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2023010054A Pending JP2023052645A (ja) | 2014-07-24 | 2023-01-26 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199681A Active JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2023010054A Pending JP2023052645A (ja) | 2014-07-24 | 2023-01-26 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11370838B2 (enExample) |
| EP (1) | EP3172219A4 (enExample) |
| JP (3) | JP6956630B2 (enExample) |
| KR (1) | KR102463267B1 (enExample) |
| CN (1) | CN106536540A (enExample) |
| AR (1) | AR101304A1 (enExample) |
| AU (2) | AU2015294389B2 (enExample) |
| BR (1) | BR112017001403A2 (enExample) |
| CA (1) | CA2955007C (enExample) |
| IL (1) | IL250148B2 (enExample) |
| MX (2) | MX2017001022A (enExample) |
| MY (1) | MY198629A (enExample) |
| RU (2) | RU2021106673A (enExample) |
| SG (2) | SG10202102467RA (enExample) |
| WO (1) | WO2016014360A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102463267B1 (ko) * | 2014-07-24 | 2022-11-03 | 제넨테크, 인크. | 적어도 하나의 트리설파이드 결합을 함유하는 단백질에서 티올 모이어티에 제제의 접합 방법 |
| RU2759602C2 (ru) * | 2017-02-08 | 2021-11-16 | Пфайзер Инк. | Процесс крупномасштабного производства кэпированных и некэпированных цистеинов антител и их применение для конъюгации терапевтических белков |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| JP2665353B2 (ja) * | 1988-09-10 | 1997-10-22 | 住商ファーマインターナショナル株式会社 | 双特異性抗体の製造法 |
| JPH0278699A (ja) | 1988-09-12 | 1990-03-19 | Green Cross Corp:The | ベンゾイルウレア系化合物・アルブミン複合体 |
| JPH02218700A (ja) * | 1989-02-17 | 1990-08-31 | Nippon Kayaku Co Ltd | 双特異性抗体及びそれを用いる養子免疫療法 |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| ZA955789B (en) | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| JPH11124395A (ja) | 1997-10-16 | 1999-05-11 | Seiwa Kasei Kk | システイン導入ペプチドおよびその製造方法 |
| SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
| CA2374050A1 (en) | 1999-05-20 | 2000-11-30 | Scios Inc. | Vascular endothelial growth factor dimers |
| WO2002062827A2 (en) | 2000-10-31 | 2002-08-15 | The Regents Of The University Of Colorado, A Body Corporate | Improved protein disaggregation and refolding using high pressure |
| ES2544527T3 (es) | 2002-07-31 | 2015-09-01 | Seattle Genetics, Inc. | Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa |
| US20040048315A1 (en) | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| DK1594542T3 (da) * | 2003-02-20 | 2010-10-11 | Seattle Genetics Inc | Anti-CD70 antistof-lægemiddelkonjugater og deres anvendelse ved behandling af cancer |
| WO2005047337A1 (en) | 2003-11-13 | 2005-05-26 | Hanmi Pharmaceutical Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
| CA2558399C (en) * | 2004-03-02 | 2015-05-19 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
| MXPA06014065A (es) * | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
| ATE463503T1 (de) * | 2004-12-29 | 2010-04-15 | Novo Nordisk Healthcare Ag | Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden |
| WO2007140371A2 (en) * | 2006-05-30 | 2007-12-06 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| US20080220448A1 (en) | 2006-09-01 | 2008-09-11 | Blincko Stuart J | Antigenic protein conjugates and process for preparing same |
| JP5394246B2 (ja) | 2007-03-30 | 2014-01-22 | ジェネンテック， インコーポレイテッド | 抗体及びイムノコンジュゲートとこれらの使用方法 |
| TW200902554A (en) * | 2007-05-08 | 2009-01-16 | Genentech Inc | Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates |
| ES2528922T3 (es) | 2007-07-16 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso |
| ATE543835T1 (de) | 2007-07-16 | 2012-02-15 | Genentech Inc | Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren |
| MX2010008310A (es) * | 2008-01-31 | 2010-12-21 | Georgia Pacific Chemicals Llc | Composicion oxidada y maleatada modificada. |
| PT2247620T (pt) | 2008-01-31 | 2016-08-23 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| EP2483289B2 (en) * | 2009-10-02 | 2025-03-26 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| EP2542576B1 (en) * | 2010-03-02 | 2016-04-20 | Seattle Genetics, Inc. | Methods for screening antibodies |
| WO2012059873A2 (en) * | 2010-11-05 | 2012-05-10 | Covx Technologies Ireland, Ltd. | Anti-diabetic compounds |
| US9562252B2 (en) * | 2011-05-13 | 2017-02-07 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
| DK2771364T3 (da) * | 2011-10-27 | 2019-08-19 | Genmab As | Fremstilling af heterodimere proteiner |
| EP3539982B1 (en) * | 2011-12-23 | 2025-02-19 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| BR112014027166A2 (pt) * | 2012-05-01 | 2017-06-27 | Genentech Inc | anticorpo, ácido nucleico, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, método de tratamento, método de inibir proliferação e métodos de detecção. |
| SG11201407600UA (en) * | 2012-06-19 | 2014-12-30 | Polytherics Ltd | Novel process for preparation of antibody conjugates and novel antibody conjugates |
| KR102463267B1 (ko) | 2014-07-24 | 2022-11-03 | 제넨테크, 인크. | 적어도 하나의 트리설파이드 결합을 함유하는 단백질에서 티올 모이어티에 제제의 접합 방법 |
-
2015
- 2015-07-17 KR KR1020177003843A patent/KR102463267B1/ko active Active
- 2015-07-17 SG SG10202102467RA patent/SG10202102467RA/en unknown
- 2015-07-17 CN CN201580041071.9A patent/CN106536540A/zh active Pending
- 2015-07-17 MX MX2017001022A patent/MX2017001022A/es unknown
- 2015-07-17 CA CA2955007A patent/CA2955007C/en active Active
- 2015-07-17 RU RU2021106673A patent/RU2021106673A/ru unknown
- 2015-07-17 JP JP2017503957A patent/JP6956630B2/ja active Active
- 2015-07-17 BR BR112017001403A patent/BR112017001403A2/pt not_active Application Discontinuation
- 2015-07-17 WO PCT/US2015/040931 patent/WO2016014360A1/en not_active Ceased
- 2015-07-17 RU RU2017105428A patent/RU2744978C2/ru active
- 2015-07-17 EP EP15824358.4A patent/EP3172219A4/en active Pending
- 2015-07-17 SG SG11201700365TA patent/SG11201700365TA/en unknown
- 2015-07-17 AU AU2015294389A patent/AU2015294389B2/en not_active Expired - Fee Related
- 2015-07-17 MY MYPI2017000109A patent/MY198629A/en unknown
- 2015-07-24 AR ARP150102358A patent/AR101304A1/es not_active Application Discontinuation
-
2017
- 2017-01-16 IL IL250148A patent/IL250148B2/en unknown
- 2017-01-20 MX MX2022012589A patent/MX2022012589A/es unknown
- 2017-01-24 US US15/414,330 patent/US11370838B2/en active Active
-
2020
- 2020-12-01 JP JP2020199681A patent/JP7219256B2/ja active Active
-
2021
- 2021-07-27 AU AU2021209196A patent/AU2021209196B2/en not_active Ceased
-
2022
- 2022-05-24 US US17/752,631 patent/US20220372141A1/en not_active Abandoned
-
2023
- 2023-01-26 JP JP2023010054A patent/JP2023052645A/ja active Pending
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