JP2017525350A5 - - Google Patents
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- JP2017525350A5 JP2017525350A5 JP2017504739A JP2017504739A JP2017525350A5 JP 2017525350 A5 JP2017525350 A5 JP 2017525350A5 JP 2017504739 A JP2017504739 A JP 2017504739A JP 2017504739 A JP2017504739 A JP 2017504739A JP 2017525350 A5 JP2017525350 A5 JP 2017525350A5
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- JP
- Japan
- Prior art keywords
- mir
- hsa
- mirna
- regulated
- stage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002679 microRNA Substances 0.000 claims 27
- 108700011259 MicroRNAs Proteins 0.000 claims 25
- 230000001105 regulatory effect Effects 0.000 claims 18
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 12
- 206010017758 gastric cancer Diseases 0.000 claims 12
- -1 hsa-miR-1280 Proteins 0.000 claims 12
- 201000011549 stomach cancer Diseases 0.000 claims 12
- 108091065168 Homo sapiens miR-29c stem-loop Proteins 0.000 claims 6
- 108091069045 Homo sapiens miR-15b stem-loop Proteins 0.000 claims 5
- 108091070400 Homo sapiens miR-27a stem-loop Proteins 0.000 claims 5
- 108091068845 Homo sapiens miR-29b-2 stem-loop Proteins 0.000 claims 5
- 108091070377 Homo sapiens miR-93 stem-loop Proteins 0.000 claims 5
- 108091008051 MIR27A Proteins 0.000 claims 5
- 108091069085 Homo sapiens miR-126 stem-loop Proteins 0.000 claims 4
- 108091069017 Homo sapiens miR-140 stem-loop Proteins 0.000 claims 4
- 108091061631 Homo sapiens miR-629 stem-loop Proteins 0.000 claims 4
- 230000002222 downregulating effect Effects 0.000 claims 4
- 108091065165 Homo sapiens miR-106b stem-loop Proteins 0.000 claims 3
- 108091068928 Homo sapiens miR-107 stem-loop Proteins 0.000 claims 3
- 108091068993 Homo sapiens miR-142 stem-loop Proteins 0.000 claims 3
- 108091067654 Homo sapiens miR-148a stem-loop Proteins 0.000 claims 3
- 108091031921 Homo sapiens miR-18b stem-loop Proteins 0.000 claims 3
- 108091067982 Homo sapiens miR-197 stem-loop Proteins 0.000 claims 3
- 108091070517 Homo sapiens miR-19a stem-loop Proteins 0.000 claims 3
- 108091068837 Homo sapiens miR-29b-1 stem-loop Proteins 0.000 claims 3
- 108091066993 Homo sapiens miR-339 stem-loop Proteins 0.000 claims 3
- 108091032108 Homo sapiens miR-424 stem-loop Proteins 0.000 claims 3
- 108091035183 Homo sapiens miR-4306 stem-loop Proteins 0.000 claims 3
- 108091063772 Homo sapiens miR-589 stem-loop Proteins 0.000 claims 3
- 108091061594 Homo sapiens miR-590 stem-loop Proteins 0.000 claims 3
- 108091061783 Homo sapiens miR-598 stem-loop Proteins 0.000 claims 3
- 108091065457 Homo sapiens miR-99b stem-loop Proteins 0.000 claims 3
- 108091068840 Homo sapiens miR-101-1 stem-loop Proteins 0.000 claims 2
- 108091065458 Homo sapiens miR-101-2 stem-loop Proteins 0.000 claims 2
- 108091069102 Homo sapiens miR-136 stem-loop Proteins 0.000 claims 2
- 108091069089 Homo sapiens miR-146a stem-loop Proteins 0.000 claims 2
- 108091067618 Homo sapiens miR-181a-2 stem-loop Proteins 0.000 claims 2
- 108091067605 Homo sapiens miR-183 stem-loop Proteins 0.000 claims 2
- 108091032024 Homo sapiens miR-20b stem-loop Proteins 0.000 claims 2
- 108091067572 Homo sapiens miR-221 stem-loop Proteins 0.000 claims 2
- 108091056662 Homo sapiens miR-23c stem-loop Proteins 0.000 claims 2
- 108091070372 Homo sapiens miR-26a-1 stem-loop Proteins 0.000 claims 2
- 108091065428 Homo sapiens miR-26a-2 stem-loop Proteins 0.000 claims 2
- 108091070398 Homo sapiens miR-29a stem-loop Proteins 0.000 claims 2
- 108091070365 Homo sapiens miR-30a stem-loop Proteins 0.000 claims 2
- 108091060457 Homo sapiens miR-320b-1 stem-loop Proteins 0.000 claims 2
- 108091062096 Homo sapiens miR-320b-2 stem-loop Proteins 0.000 claims 2
- 108091067013 Homo sapiens miR-337 stem-loop Proteins 0.000 claims 2
- 108091032103 Homo sapiens miR-425 stem-loop Proteins 0.000 claims 2
- 108091032793 Homo sapiens miR-450a-1 stem-loop Proteins 0.000 claims 2
- 108091064510 Homo sapiens miR-450a-2 stem-loop Proteins 0.000 claims 2
- 108091064507 Homo sapiens miR-500a stem-loop Proteins 0.000 claims 2
- 108091064508 Homo sapiens miR-501 stem-loop Proteins 0.000 claims 2
- 108091061685 Homo sapiens miR-550a-1 stem-loop Proteins 0.000 claims 2
- 108091061593 Homo sapiens miR-550a-2 stem-loop Proteins 0.000 claims 2
- 108091061779 Homo sapiens miR-616 stem-loop Proteins 0.000 claims 2
- 108091045790 miR-106b stem-loop Proteins 0.000 claims 2
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 2
- 108091044046 miR-17-1 stem-loop Proteins 0.000 claims 2
- 108091065423 miR-17-3 stem-loop Proteins 0.000 claims 2
- 108091086421 miR-223 stem-loop Proteins 0.000 claims 2
- 108091037240 miR-423 stem-loop Proteins 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 108091068855 Homo sapiens miR-103a-1 stem-loop Proteins 0.000 claims 1
- 108091068838 Homo sapiens miR-103a-2 stem-loop Proteins 0.000 claims 1
- 108091067628 Homo sapiens miR-10a stem-loop Proteins 0.000 claims 1
- 108091067631 Homo sapiens miR-10b stem-loop Proteins 0.000 claims 1
- 108091069016 Homo sapiens miR-122 stem-loop Proteins 0.000 claims 1
- 108091044796 Homo sapiens miR-1290 stem-loop Proteins 0.000 claims 1
- 108091069022 Homo sapiens miR-130a stem-loop Proteins 0.000 claims 1
- 108091069094 Homo sapiens miR-134 stem-loop Proteins 0.000 claims 1
- 108091067617 Homo sapiens miR-139 stem-loop Proteins 0.000 claims 1
- 108091068991 Homo sapiens miR-141 stem-loop Proteins 0.000 claims 1
- 108091069088 Homo sapiens miR-150 stem-loop Proteins 0.000 claims 1
- 108091068955 Homo sapiens miR-154 stem-loop Proteins 0.000 claims 1
- 108091070507 Homo sapiens miR-15a stem-loop Proteins 0.000 claims 1
- 108091070491 Homo sapiens miR-16-1 stem-loop Proteins 0.000 claims 1
- 108091068927 Homo sapiens miR-16-2 stem-loop Proteins 0.000 claims 1
- 108091067469 Homo sapiens miR-181a-1 stem-loop Proteins 0.000 claims 1
- 108091068956 Homo sapiens miR-186 stem-loop Proteins 0.000 claims 1
- 108091070490 Homo sapiens miR-18a stem-loop Proteins 0.000 claims 1
- 108091068998 Homo sapiens miR-191 stem-loop Proteins 0.000 claims 1
- 108091092301 Homo sapiens miR-193b stem-loop Proteins 0.000 claims 1
- 108091068960 Homo sapiens miR-195 stem-loop Proteins 0.000 claims 1
- 108091069457 Homo sapiens miR-200b stem-loop Proteins 0.000 claims 1
- 108091070493 Homo sapiens miR-21 stem-loop Proteins 0.000 claims 1
- 108091070494 Homo sapiens miR-22 stem-loop Proteins 0.000 claims 1
- 108091070492 Homo sapiens miR-23a stem-loop Proteins 0.000 claims 1
- 108091070371 Homo sapiens miR-25 stem-loop Proteins 0.000 claims 1
- 108091069021 Homo sapiens miR-30b stem-loop Proteins 0.000 claims 1
- 108091067650 Homo sapiens miR-30d stem-loop Proteins 0.000 claims 1
- 108091060471 Homo sapiens miR-320c-1 stem-loop Proteins 0.000 claims 1
- 108091078079 Homo sapiens miR-320c-2 stem-loop Proteins 0.000 claims 1
- 108091072689 Homo sapiens miR-320e stem-loop Proteins 0.000 claims 1
- 108091067005 Homo sapiens miR-328 stem-loop Proteins 0.000 claims 1
- 108091067010 Homo sapiens miR-338 stem-loop Proteins 0.000 claims 1
- 108091067259 Homo sapiens miR-362 stem-loop Proteins 0.000 claims 1
- 108091067286 Homo sapiens miR-363 stem-loop Proteins 0.000 claims 1
- 108091086479 Homo sapiens miR-374b stem-loop Proteins 0.000 claims 1
- 108091067245 Homo sapiens miR-378a stem-loop Proteins 0.000 claims 1
- 108091032537 Homo sapiens miR-409 stem-loop Proteins 0.000 claims 1
- 108091062137 Homo sapiens miR-454 stem-loop Proteins 0.000 claims 1
- 108091053854 Homo sapiens miR-484 stem-loop Proteins 0.000 claims 1
- 108091053855 Homo sapiens miR-485 stem-loop Proteins 0.000 claims 1
- 108091092297 Homo sapiens miR-495 stem-loop Proteins 0.000 claims 1
- 108091092303 Homo sapiens miR-497 stem-loop Proteins 0.000 claims 1
- 108091063565 Homo sapiens miR-532 stem-loop Proteins 0.000 claims 1
- 108091063718 Homo sapiens miR-579 stem-loop Proteins 0.000 claims 1
- 108091061621 Homo sapiens miR-627 stem-loop Proteins 0.000 claims 1
- 108091061622 Homo sapiens miR-628 stem-loop Proteins 0.000 claims 1
- 108091061608 Homo sapiens miR-650 stem-loop Proteins 0.000 claims 1
- 108091060463 Homo sapiens miR-671 stem-loop Proteins 0.000 claims 1
- 108091086652 Homo sapiens miR-885 stem-loop Proteins 0.000 claims 1
- 108091069003 Homo sapiens miR-9-1 stem-loop Proteins 0.000 claims 1
- 108091068996 Homo sapiens miR-9-2 stem-loop Proteins 0.000 claims 1
- 108091069001 Homo sapiens miR-9-3 stem-loop Proteins 0.000 claims 1
- 108091068854 Homo sapiens miR-99a stem-loop Proteins 0.000 claims 1
- 108091008060 MIR10A Proteins 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000003828 downregulation Effects 0.000 claims 1
- 108091049679 miR-20a stem-loop Proteins 0.000 claims 1
- 108091030817 miR-20a-1 stem-loop Proteins 0.000 claims 1
- 108091086627 miR-20a-2 stem-loop Proteins 0.000 claims 1
- 108091069790 miR-20a-3 stem-loop Proteins 0.000 claims 1
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020081954A JP7614735B2 (ja) | 2014-08-07 | 2020-05-07 | 胃がん診断用のマイクロｒｎａバイオマーカー |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201404742W | 2014-08-07 | ||
| SG10201404742W | 2014-08-07 | ||
| PCT/SG2015/050256 WO2016022076A1 (en) | 2014-08-07 | 2015-08-11 | Microrna biomarker for the diagnosis of gastric cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081954A Division JP7614735B2 (ja) | 2014-08-07 | 2020-05-07 | 胃がん診断用のマイクロｒｎａバイオマーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525350A JP2017525350A (ja) | 2017-09-07 |
| JP2017525350A5 true JP2017525350A5 (OSRAM) | 2017-10-19 |
| JP6702935B2 JP6702935B2 (ja) | 2020-06-03 |
Family
ID=55264222
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504739A Active JP6702935B2 (ja) | 2014-08-07 | 2015-08-11 | 胃がん診断用のマイクロｒｎａバイオマーカー |
| JP2020081954A Active JP7614735B2 (ja) | 2014-08-07 | 2020-05-07 | 胃がん診断用のマイクロｒｎａバイオマーカー |
| JP2022144766A Active JP7635186B2 (ja) | 2014-08-07 | 2022-09-12 | 胃がん診断用のマイクロｒｎａバイオマーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081954A Active JP7614735B2 (ja) | 2014-08-07 | 2020-05-07 | 胃がん診断用のマイクロｒｎａバイオマーカー |
| JP2022144766A Active JP7635186B2 (ja) | 2014-08-07 | 2022-09-12 | 胃がん診断用のマイクロｒｎａバイオマーカー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10767230B2 (OSRAM) |
| EP (3) | EP4137586A1 (OSRAM) |
| JP (3) | JP6702935B2 (OSRAM) |
| KR (2) | KR102604163B1 (OSRAM) |
| CN (1) | CN107109470B (OSRAM) |
| SG (2) | SG10202011339RA (OSRAM) |
| WO (1) | WO2016022076A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016022076A1 (en) * | 2014-08-07 | 2016-02-11 | Agency For Science, Technology And Research | Microrna biomarker for the diagnosis of gastric cancer |
| US20180119222A1 (en) * | 2015-05-08 | 2018-05-03 | Agency For Science, Technology And Research | Method for diagnosis and prognosis of chronic heart failure |
| CN106636334B (zh) * | 2016-10-09 | 2020-07-03 | 山东大学 | microRNA标志物组及其在制备检测胃癌淋巴结转移试剂盒中的应用 |
| JP6280997B1 (ja) * | 2016-10-31 | 2018-02-14 | 株式会社Preferred Networks | 疾患の罹患判定装置、疾患の罹患判定方法、疾患の特徴抽出装置及び疾患の特徴抽出方法 |
| CN106755377B (zh) * | 2016-12-12 | 2021-05-25 | 浙江省中医院 | 一种胃癌血清学检测鉴定试剂盒及方法 |
| EP3601564A4 (en) * | 2017-03-23 | 2021-03-31 | Quadrant Biosciences Inc. | PROCESS FOR DIAGNOSING OR MONITORING CONDITIONS CHARACTERIZED BY ABNORMAL TEMPORAL VARIATIONS, PROCESS FOR NORMALIZING EPIGENETIC DATA TO COMPENSATE FOR TEMPORAL VARIATIONS |
| CL2017002289A1 (es) | 2017-09-08 | 2019-08-16 | Univ Pontificia Catolica Chile | Método no invasivo de diagnóstico temprano de cáncer gástrico, usando como biomarcador los niveles de metilación de la secuencia de adn del promotor del microrna -335-5p |
| CN107723366B (zh) * | 2017-09-11 | 2019-10-01 | 朱伟 | 一种与贲门癌辅助诊断相关的血清miRNA标志物及其应用 |
| CN107746880B (zh) * | 2017-11-01 | 2018-12-14 | 健生生物技术有限公司 | 一种基于RT-qPCR法检测胃癌的试剂盒及其制备方法和应用 |
| CN108611414A (zh) * | 2018-04-26 | 2018-10-02 | 北京工业大学 | 新的靶向肿瘤微环境与肺癌干细胞相互作用的miRNA的检测及应用 |
| CN108743617A (zh) * | 2018-05-03 | 2018-11-06 | 武汉科技大学 | miR-15a-5p在提高CAR-T细胞抗肿瘤能力中的应用 |
| US20210269884A1 (en) * | 2018-06-21 | 2021-09-02 | Public University Corporation Nagoya City University | Gastric cancer biomarker and use thereof |
| KR102089559B1 (ko) * | 2018-08-31 | 2020-03-16 | 차의과학대학교 산학협력단 | 난소의 fsh에 대한 반응성의 진단 또는 예측용 바이오마커 및 이의 용도 |
| TW202018727A (zh) | 2018-11-09 | 2020-05-16 | 財團法人工業技術研究院 | 整體式學習預測方法與系統 |
| JP7512285B2 (ja) * | 2018-12-19 | 2024-07-08 | エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ | マイクロｒｎａを用いた胃癌の診断方法 |
| WO2020132494A2 (en) * | 2018-12-21 | 2020-06-25 | Baylor Research Institute | Methods for prognosing, diagnosing, and treating gastric cancer |
| CN110066870B (zh) * | 2019-04-12 | 2021-12-14 | 江苏省人民医院（南京医科大学第一附属医院） | hsa-miR-382-5p在制备诊断视网膜变性疾病的试剂盒中的应用 |
| CN117683886A (zh) * | 2019-04-30 | 2024-03-12 | 觅瑞实验室私人有限公司 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
| KR102288359B1 (ko) * | 2019-12-06 | 2021-08-10 | 주식회사 레피겐엠디 | 면역력 감소에 의한 질병의 발병 위험 예측용 다중 유전자 마커 및 이를 이용한 질병의 발병 위험 예측 방법 |
| CN111471764B (zh) * | 2019-12-27 | 2023-09-15 | 陈锦飞 | 一种用于筛查或辅助诊断胃癌的生物标志物组合及其试剂盒和应用 |
| JP7511823B2 (ja) * | 2020-01-24 | 2024-07-08 | 株式会社The IT Lab | ｍｉＲＮＡの発現レベルをがんの確定診断の前のスクリーニングの指標として用いるがんの診断を補助する方法 |
| CN111471683B (zh) * | 2020-04-15 | 2021-09-07 | 湖南省科域生物医药科技有限公司 | miR-93-5p作为诊断和治疗胃癌标志物的应用 |
| KR102489708B1 (ko) * | 2020-09-14 | 2023-01-18 | 서울대학교산학협력단 | GDF11 유전자의 발현을 조절하는 PCBP2와 microRNA를 함유하는 조성물 |
| CN112226514B (zh) * | 2020-11-23 | 2021-08-03 | 苏州京脉生物科技有限公司 | 用于早期胃癌检测的标志物组合、试剂盒及其应用 |
| CN112941185B (zh) * | 2021-03-26 | 2023-06-23 | 杭州医学院 | miR-29a作为标志物在制备恶性间皮瘤检测试剂盒中的应用 |
| CN113151477B (zh) * | 2021-05-08 | 2022-04-15 | 武汉大学中南医院 | 用于检测肠癌的miRNA标记物及其应用 |
| CN113186285B (zh) * | 2021-05-10 | 2022-05-24 | 深圳市展行生物有限公司 | 一种辅助诊断胃癌的方法及其使用的miRNA组合 |
| CN113913516B (zh) * | 2021-05-26 | 2023-08-29 | 东莞市松山湖中心医院(东莞市石龙人民医院、东莞市第三人民医院、东莞市心血管病研究所) | hsa_circ_0006470作为靶点在制备miR-27b-3p的调节剂的应用 |
| JP7406059B1 (ja) | 2022-10-20 | 2023-12-27 | 防衛装備庁長官 | 急性ストレス評価用データの生成方法 |
| WO2024229279A2 (en) * | 2023-05-02 | 2024-11-07 | Dana-Farber Cancer Institute, Inc. | Use of circulating microrna profiles for identification of brca1 or brca2 mutations |
| CN118547069B (zh) * | 2024-05-14 | 2025-08-22 | 北京热景生物技术股份有限公司 | 一种基于细胞外囊泡miRNA的胃癌诊断标志物及其应用 |
| CN119580829A (zh) * | 2024-11-25 | 2025-03-07 | 苏州大学 | 一种早期胃癌检测的标志物识别方法及诊断模型构建方法 |
| CN119351558A (zh) * | 2024-12-10 | 2025-01-24 | 西藏自治区人民政府驻成都办事处医院 | 一种检测胃癌的标志物、检测试剂盒及药物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2536423T3 (es) | 2006-01-05 | 2015-05-25 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico de cáncer de próstata |
| AU2013245505B2 (en) * | 2006-01-05 | 2016-06-23 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| US20110034538A1 (en) | 2008-02-28 | 2011-02-10 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer |
| WO2009147656A1 (en) * | 2008-06-01 | 2009-12-10 | Rosetta Genomics Ltd. | Compositions and methods for prognosis of gastric cancer |
| CN101988059B (zh) * | 2009-07-30 | 2014-04-02 | 江苏命码生物科技有限公司 | 胃癌检测标记物及其检测试剂盒和生物芯片 |
| WO2012010584A1 (en) * | 2010-07-20 | 2012-01-26 | Febit Holding Gmbh | Complex mirna sets as novel biomarkers for gastric cancer |
| US9939442B2 (en) * | 2011-09-08 | 2018-04-10 | The Regents Of The University Of California | Salivary biomarkers for gastric cancer detection |
| JP2013085542A (ja) | 2011-10-21 | 2013-05-13 | Sysmex Corp | 胃癌の検出方法、胃癌の血液マーカーおよびその使用 |
| GB201317887D0 (en) * | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product |
| CN103773761B (zh) * | 2014-01-14 | 2016-01-20 | 南京医科大学 | 检测胃癌的血清/血浆微小rna标志物及其应用 |
| CN103937888B (zh) | 2014-04-14 | 2016-08-17 | 上海交通大学 | 鉴别胃癌的血浆microRNA标志物的筛选与应用 |
| WO2016022076A1 (en) * | 2014-08-07 | 2016-02-11 | Agency For Science, Technology And Research | Microrna biomarker for the diagnosis of gastric cancer |
-
2015
- 2015-08-11 WO PCT/SG2015/050256 patent/WO2016022076A1/en not_active Ceased
- 2015-08-11 EP EP22187157.7A patent/EP4137586A1/en active Pending
- 2015-08-11 KR KR1020217009878A patent/KR102604163B1/ko active Active
- 2015-08-11 US US15/501,691 patent/US10767230B2/en active Active
- 2015-08-11 SG SG10202011339RA patent/SG10202011339RA/en unknown
- 2015-08-11 JP JP2017504739A patent/JP6702935B2/ja active Active
- 2015-08-11 CN CN201580054452.0A patent/CN107109470B/zh active Active
- 2015-08-11 SG SG11201700944RA patent/SG11201700944RA/en unknown
- 2015-08-11 KR KR1020177003456A patent/KR102237960B1/ko active Active
- 2015-08-11 EP EP19204522.7A patent/EP3744859B1/en active Active
- 2015-08-11 EP EP15828973.6A patent/EP3177739B1/en active Active
-
2020
- 2020-05-07 JP JP2020081954A patent/JP7614735B2/ja active Active
-
2022
- 2022-09-12 JP JP2022144766A patent/JP7635186B2/ja active Active
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