JP2017524791A5 - - Google Patents
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- Publication number
- JP2017524791A5 JP2017524791A5 JP2017508049A JP2017508049A JP2017524791A5 JP 2017524791 A5 JP2017524791 A5 JP 2017524791A5 JP 2017508049 A JP2017508049 A JP 2017508049A JP 2017508049 A JP2017508049 A JP 2017508049A JP 2017524791 A5 JP2017524791 A5 JP 2017524791A5
- Authority
- JP
- Japan
- Prior art keywords
- controlled release
- hydrophobic
- release system
- copolymer
- block
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002209 hydrophobic effect Effects 0.000 claims description 13
- 229920001577 copolymer Polymers 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 6
- 239000000693 micelle Substances 0.000 claims description 6
- 229930012538 Paclitaxel Natural products 0.000 claims description 4
- 229960001592 paclitaxel Drugs 0.000 claims description 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims 8
- 238000013270 controlled release Methods 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229920001400 block copolymer Polymers 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- -1 hydroxyalkyl methacrylamide Chemical compound 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims 1
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 claims 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 1
- YSFGBPCBPNVLOK-UHFFFAOYSA-N 6-hydroxy-2-methylhex-2-enamide Chemical compound NC(=O)C(C)=CCCCO YSFGBPCBPNVLOK-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- DWJXYEABWRJFSP-XOBRGWDASA-N DAPT Chemical compound N([C@@H](C)C(=O)N[C@H](C(=O)OC(C)(C)C)C=1C=CC=CC=1)C(=O)CC1=CC(F)=CC(F)=C1 DWJXYEABWRJFSP-XOBRGWDASA-N 0.000 claims 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 150000001241 acetals Chemical class 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 238000011977 dual antiplatelet therapy Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 claims 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
- 229960002411 imatinib Drugs 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 3
- RCHCPBMAHMWFCD-UHFFFAOYSA-N 2-hydroxypropanoic acid;n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)C(O)=O.CC(O)CNC(=O)C(C)=C RCHCPBMAHMWFCD-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 230000001687 destabilization Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2013317A NL2013317B1 (en) | 2014-08-11 | 2014-08-11 | Amphiphilic block copolymers for delivery of active agents. |
| NL2013317 | 2014-08-11 | ||
| PCT/NL2015/050574 WO2016024861A1 (en) | 2014-08-11 | 2015-08-11 | Amphiphilic block copolymers for delivery of active agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524791A JP2017524791A (ja) | 2017-08-31 |
| JP2017524791A5 true JP2017524791A5 (enExample) | 2020-01-09 |
| JP6837962B2 JP6837962B2 (ja) | 2021-03-03 |
Family
ID=51660570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508049A Active JP6837962B2 (ja) | 2014-08-11 | 2015-08-11 | 活性薬剤の送達のための両親媒性ブロックコポリマー |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11007148B2 (enExample) |
| EP (1) | EP3191534B1 (enExample) |
| JP (1) | JP6837962B2 (enExample) |
| CN (1) | CN107106693B (enExample) |
| AU (1) | AU2015302410B2 (enExample) |
| CA (1) | CA2957900C (enExample) |
| NL (1) | NL2013317B1 (enExample) |
| WO (1) | WO2016024861A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022008527A1 (en) | 2020-07-06 | 2022-01-13 | Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen | Polymeric micelles comprising glucuronide-prodrugs |
| US20240374792A1 (en) | 2021-09-15 | 2024-11-14 | Gelmedix, Inc. | Gelma polymer compositions and uses thereof |
| WO2023044389A1 (en) | 2021-09-15 | 2023-03-23 | Gelmedix, Inc. | Gelma polymer compositions comprising corticosteroids |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7425581B2 (en) * | 1999-07-30 | 2008-09-16 | Universiteit Utrecht | Temperature sensitive polymers |
| US7217770B2 (en) * | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
| US20050158271A1 (en) * | 2000-10-11 | 2005-07-21 | Lee Sang C. | Pharmaceutical applications of hydrotropic polymer micelles |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| GB0131112D0 (en) * | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
| WO2009094053A1 (en) * | 2008-01-25 | 2009-07-30 | E. I. Du Pont De Nemours And Company | Ink jet inks having improved corrosion resistance for use in ink jet print heads comprising nickel or nickel alloys |
| WO2010053597A2 (en) * | 2008-11-06 | 2010-05-14 | University Of Washington/////////////////////-+ | Micelles of hydrophilically shielded membrane-destabilizing copolymers |
| US8299178B2 (en) * | 2009-03-25 | 2012-10-30 | National Tsing Hua University | Stable micelles formed with diblock copolymers of critical micelle concentration copolymer and temperature-sensitive copolymer |
| JP5679253B2 (ja) * | 2009-05-26 | 2015-03-04 | 国立大学法人東京工業大学 | 自立性高分子薄膜 |
| US8470891B2 (en) | 2009-12-23 | 2013-06-25 | International Business Machines Corporation | Biodegradable block polymers for drug delivery, and methods related thereto |
| JP5864837B2 (ja) * | 2010-03-24 | 2016-02-17 | セイコーエプソン株式会社 | 光重合性ポリマーミセルを含む記録液、及び記録液に用いる光重合性ポリマーミセルの製造方法 |
| ES2391187B1 (es) * | 2011-04-26 | 2013-10-18 | Consejo Superior De Investigaciones Científicas (Csic) | Compuestos poliméricos bioactivos nanoestructurados derivados de fármacos antiinflamatorios no esteroideos (aine) e imidazol. |
| ES1075003Y (es) * | 2011-06-16 | 2011-10-10 | Antimo Juan Manuel Cuartero | Recuperador de calor |
-
2014
- 2014-08-11 NL NL2013317A patent/NL2013317B1/en not_active IP Right Cessation
-
2015
- 2015-08-11 AU AU2015302410A patent/AU2015302410B2/en active Active
- 2015-08-11 CN CN201580053545.1A patent/CN107106693B/zh active Active
- 2015-08-11 WO PCT/NL2015/050574 patent/WO2016024861A1/en not_active Ceased
- 2015-08-11 CA CA2957900A patent/CA2957900C/en active Active
- 2015-08-11 JP JP2017508049A patent/JP6837962B2/ja active Active
- 2015-08-11 EP EP15767355.9A patent/EP3191534B1/en active Active
- 2015-08-11 US US15/503,204 patent/US11007148B2/en active Active
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