NL2013317B1 - Amphiphilic block copolymers for delivery of active agents. - Google Patents

Amphiphilic block copolymers for delivery of active agents. Download PDF

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Publication number
NL2013317B1
NL2013317B1 NL2013317A NL2013317A NL2013317B1 NL 2013317 B1 NL2013317 B1 NL 2013317B1 NL 2013317 A NL2013317 A NL 2013317A NL 2013317 A NL2013317 A NL 2013317A NL 2013317 B1 NL2013317 B1 NL 2013317B1
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NL
Netherlands
Prior art keywords
hydrophobic
micelles
block
copolymer
controlled release
Prior art date
Application number
NL2013317A
Other languages
English (en)
Inventor
Everhardus Hennink Wilhelmus
Shi Yang
Franciscus Van Nostrum Cornelus
Original Assignee
Univ Utrecht Holding Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utrecht Holding Bv filed Critical Univ Utrecht Holding Bv
Priority to NL2013317A priority Critical patent/NL2013317B1/en
Priority to CN201580053545.1A priority patent/CN107106693B/zh
Priority to AU2015302410A priority patent/AU2015302410B2/en
Priority to US15/503,204 priority patent/US11007148B2/en
Priority to CA2957900A priority patent/CA2957900C/en
Priority to JP2017508049A priority patent/JP6837962B2/ja
Priority to EP15767355.9A priority patent/EP3191534B1/en
Priority to PCT/NL2015/050574 priority patent/WO2016024861A1/en
Application granted granted Critical
Publication of NL2013317B1 publication Critical patent/NL2013317B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL2013317A 2014-08-11 2014-08-11 Amphiphilic block copolymers for delivery of active agents. NL2013317B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NL2013317A NL2013317B1 (en) 2014-08-11 2014-08-11 Amphiphilic block copolymers for delivery of active agents.
CN201580053545.1A CN107106693B (zh) 2014-08-11 2015-08-11 用于活性剂递送的两亲性嵌段共聚物
AU2015302410A AU2015302410B2 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents
US15/503,204 US11007148B2 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents
CA2957900A CA2957900C (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents
JP2017508049A JP6837962B2 (ja) 2014-08-11 2015-08-11 活性薬剤の送達のための両親媒性ブロックコポリマー
EP15767355.9A EP3191534B1 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents
PCT/NL2015/050574 WO2016024861A1 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2013317A NL2013317B1 (en) 2014-08-11 2014-08-11 Amphiphilic block copolymers for delivery of active agents.

Publications (1)

Publication Number Publication Date
NL2013317B1 true NL2013317B1 (en) 2016-09-21

Family

ID=51660570

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2013317A NL2013317B1 (en) 2014-08-11 2014-08-11 Amphiphilic block copolymers for delivery of active agents.

Country Status (8)

Country Link
US (1) US11007148B2 (enExample)
EP (1) EP3191534B1 (enExample)
JP (1) JP6837962B2 (enExample)
CN (1) CN107106693B (enExample)
AU (1) AU2015302410B2 (enExample)
CA (1) CA2957900C (enExample)
NL (1) NL2013317B1 (enExample)
WO (1) WO2016024861A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022008527A1 (en) 2020-07-06 2022-01-13 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Polymeric micelles comprising glucuronide-prodrugs
US20240374792A1 (en) 2021-09-15 2024-11-14 Gelmedix, Inc. Gelma polymer compositions and uses thereof
WO2023044389A1 (en) 2021-09-15 2023-03-23 Gelmedix, Inc. Gelma polymer compositions comprising corticosteroids

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100247654A1 (en) * 2009-03-25 2010-09-30 National Tsing Hua University Stable micelles formed with diblock copolymers of critical micelle concentration copolymer and temperature-sensitive copolymer
ES2391187A1 (es) * 2011-04-26 2012-11-22 Consejo Superior De Investigaciones Científicas (Csic) Compuestos poliméricos bioactivos nanoestructurados derivados de fármacos antiinflamatorios no esteroideos (aine) e imidazol.

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
GB0131112D0 (en) * 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
WO2009094053A1 (en) * 2008-01-25 2009-07-30 E. I. Du Pont De Nemours And Company Ink jet inks having improved corrosion resistance for use in ink jet print heads comprising nickel or nickel alloys
WO2010053597A2 (en) * 2008-11-06 2010-05-14 University Of Washington/////////////////////-+ Micelles of hydrophilically shielded membrane-destabilizing copolymers
JP5679253B2 (ja) * 2009-05-26 2015-03-04 国立大学法人東京工業大学 自立性高分子薄膜
US8470891B2 (en) 2009-12-23 2013-06-25 International Business Machines Corporation Biodegradable block polymers for drug delivery, and methods related thereto
JP5864837B2 (ja) * 2010-03-24 2016-02-17 セイコーエプソン株式会社 光重合性ポリマーミセルを含む記録液、及び記録液に用いる光重合性ポリマーミセルの製造方法
ES1075003Y (es) * 2011-06-16 2011-10-10 Antimo Juan Manuel Cuartero Recuperador de calor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100247654A1 (en) * 2009-03-25 2010-09-30 National Tsing Hua University Stable micelles formed with diblock copolymers of critical micelle concentration copolymer and temperature-sensitive copolymer
ES2391187A1 (es) * 2011-04-26 2012-11-22 Consejo Superior De Investigaciones Científicas (Csic) Compuestos poliméricos bioactivos nanoestructurados derivados de fármacos antiinflamatorios no esteroideos (aine) e imidazol.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
YANG SHI ET AL: "[Pi]-[Pi] Stacking Increases the Stability and Loading Capacity of Thermosensitive Polymeric Micelles for Chemotherapeutic Drugs", BIOMACROMOLECULES, vol. 14, no. 6, 10 June 2013 (2013-06-10), pages 1826 - 1837, XP055180653, ISSN: 1525-7797, DOI: 10.1021/bm400234c *
YI-TING CHIANG ET AL: "Polymer-Liposome Complexes with a Functional Hydrogen-Bond Cross-Linker for Preventing Protein Adsorption and Improving Tumor Accumulation", CHEMISTRY OF MATERIALS, vol. 25, no. 21, 12 November 2013 (2013-11-12), pages 4364 - 4372, XP055180824, ISSN: 0897-4756, DOI: 10.1021/cm402614k *

Also Published As

Publication number Publication date
JP2017524791A (ja) 2017-08-31
CN107106693B (zh) 2021-08-24
JP6837962B2 (ja) 2021-03-03
WO2016024861A1 (en) 2016-02-18
EP3191534B1 (en) 2025-10-01
EP3191534A1 (en) 2017-07-19
CA2957900C (en) 2023-06-13
EP3191534C0 (en) 2025-10-01
AU2015302410B2 (en) 2019-01-17
US20170231908A1 (en) 2017-08-17
AU2015302410A1 (en) 2017-03-09
CA2957900A1 (en) 2016-02-18
CN107106693A (zh) 2017-08-29
US11007148B2 (en) 2021-05-18

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