JP6837962B2 - 活性薬剤の送達のための両親媒性ブロックコポリマー - Google Patents

活性薬剤の送達のための両親媒性ブロックコポリマー Download PDF

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JP6837962B2
JP6837962B2 JP2017508049A JP2017508049A JP6837962B2 JP 6837962 B2 JP6837962 B2 JP 6837962B2 JP 2017508049 A JP2017508049 A JP 2017508049A JP 2017508049 A JP2017508049 A JP 2017508049A JP 6837962 B2 JP6837962 B2 JP 6837962B2
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block
hydrophobic
micelles
controlled release
ptx
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JP2017524791A (ja
JP2017524791A5 (enExample
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エヴァハーダス ヘニンク，ウィルヘルマス
エヴァハーダス ヘニンク，ウィルヘルマス
シー，ヤン
ノストラム，コーネラス フランシスカス ヴァン
ノストラム，コーネラス フランシスカス ヴァン
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RWTH Aachen University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Graft Or Block Polymers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017508049A 2014-08-11 2015-08-11 活性薬剤の送達のための両親媒性ブロックコポリマー Active JP6837962B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2013317 2014-08-11
NL2013317A NL2013317B1 (en) 2014-08-11 2014-08-11 Amphiphilic block copolymers for delivery of active agents.
PCT/NL2015/050574 WO2016024861A1 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents

Publications (3)

Publication Number Publication Date
JP2017524791A JP2017524791A (ja) 2017-08-31
JP2017524791A5 JP2017524791A5 (enExample) 2020-01-09
JP6837962B2 true JP6837962B2 (ja) 2021-03-03

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JP2017508049A Active JP6837962B2 (ja) 2014-08-11 2015-08-11 活性薬剤の送達のための両親媒性ブロックコポリマー

Country Status (8)

Country Link
US (1) US11007148B2 (enExample)
EP (1) EP3191534B1 (enExample)
JP (1) JP6837962B2 (enExample)
CN (1) CN107106693B (enExample)
AU (1) AU2015302410B2 (enExample)
CA (1) CA2957900C (enExample)
NL (1) NL2013317B1 (enExample)
WO (1) WO2016024861A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4175966A1 (en) 2020-07-06 2023-05-10 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Polymeric micelles comprising glucuronide-prodrugs
WO2023044389A1 (en) 2021-09-15 2023-03-23 Gelmedix, Inc. Gelma polymer compositions comprising corticosteroids
IL311339A (en) 2021-09-15 2024-05-01 Gelmedix Inc Gelma polymer compositions and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
GB0131112D0 (en) 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
JP2011515504A (ja) 2008-01-25 2011-05-19 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー ニッケルまたはニッケル合金を含むインクジェットプリントヘッドに用いる改善された耐食性を有するインクジェットインク
US20110281934A1 (en) * 2008-11-06 2011-11-17 Phaserx, Inc. Micelles of hydrophilically shielded membrane-destabilizing copolymers
US8299178B2 (en) * 2009-03-25 2012-10-30 National Tsing Hua University Stable micelles formed with diblock copolymers of critical micelle concentration copolymer and temperature-sensitive copolymer
JP5679253B2 (ja) * 2009-05-26 2015-03-04 国立大学法人東京工業大学 自立性高分子薄膜
US8470891B2 (en) 2009-12-23 2013-06-25 International Business Machines Corporation Biodegradable block polymers for drug delivery, and methods related thereto
JP5864837B2 (ja) * 2010-03-24 2016-02-17 セイコーエプソン株式会社 光重合性ポリマーミセルを含む記録液、及び記録液に用いる光重合性ポリマーミセルの製造方法
ES2391187B1 (es) * 2011-04-26 2013-10-18 Consejo Superior De Investigaciones Científicas (Csic) Compuestos poliméricos bioactivos nanoestructurados derivados de fármacos antiinflamatorios no esteroideos (aine) e imidazol.
ES1075003Y (es) * 2011-06-16 2011-10-10 Antimo Juan Manuel Cuartero Recuperador de calor

Also Published As

Publication number Publication date
US11007148B2 (en) 2021-05-18
JP2017524791A (ja) 2017-08-31
CA2957900A1 (en) 2016-02-18
WO2016024861A1 (en) 2016-02-18
AU2015302410B2 (en) 2019-01-17
NL2013317B1 (en) 2016-09-21
CN107106693A (zh) 2017-08-29
US20170231908A1 (en) 2017-08-17
EP3191534A1 (en) 2017-07-19
EP3191534C0 (en) 2025-10-01
CA2957900C (en) 2023-06-13
EP3191534B1 (en) 2025-10-01
AU2015302410A1 (en) 2017-03-09
CN107106693B (zh) 2021-08-24

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