CN107106693B - 用于活性剂递送的两亲性嵌段共聚物 - Google Patents

用于活性剂递送的两亲性嵌段共聚物 Download PDF

Info

Publication number
CN107106693B
CN107106693B CN201580053545.1A CN201580053545A CN107106693B CN 107106693 B CN107106693 B CN 107106693B CN 201580053545 A CN201580053545 A CN 201580053545A CN 107106693 B CN107106693 B CN 107106693B
Authority
CN
China
Prior art keywords
hydrophobic
block
controlled release
micelles
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580053545.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN107106693A (zh
Inventor
W·E·海宁克
石洋
C·F·范诺斯特朗姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aachen University Of Technology
Original Assignee
Aachen University Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aachen University Of Technology filed Critical Aachen University Of Technology
Publication of CN107106693A publication Critical patent/CN107106693A/zh
Application granted granted Critical
Publication of CN107106693B publication Critical patent/CN107106693B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580053545.1A 2014-08-11 2015-08-11 用于活性剂递送的两亲性嵌段共聚物 Active CN107106693B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2013317A NL2013317B1 (en) 2014-08-11 2014-08-11 Amphiphilic block copolymers for delivery of active agents.
NL2013317 2014-08-11
PCT/NL2015/050574 WO2016024861A1 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents

Publications (2)

Publication Number Publication Date
CN107106693A CN107106693A (zh) 2017-08-29
CN107106693B true CN107106693B (zh) 2021-08-24

Family

ID=51660570

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580053545.1A Active CN107106693B (zh) 2014-08-11 2015-08-11 用于活性剂递送的两亲性嵌段共聚物

Country Status (8)

Country Link
US (1) US11007148B2 (enExample)
EP (1) EP3191534B1 (enExample)
JP (1) JP6837962B2 (enExample)
CN (1) CN107106693B (enExample)
AU (1) AU2015302410B2 (enExample)
CA (1) CA2957900C (enExample)
NL (1) NL2013317B1 (enExample)
WO (1) WO2016024861A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022008527A1 (en) 2020-07-06 2022-01-13 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Polymeric micelles comprising glucuronide-prodrugs
US20240374792A1 (en) 2021-09-15 2024-11-14 Gelmedix, Inc. Gelma polymer compositions and uses thereof
WO2023044389A1 (en) 2021-09-15 2023-03-23 Gelmedix, Inc. Gelma polymer compositions comprising corticosteroids

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
GB0131112D0 (en) * 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
WO2009094053A1 (en) * 2008-01-25 2009-07-30 E. I. Du Pont De Nemours And Company Ink jet inks having improved corrosion resistance for use in ink jet print heads comprising nickel or nickel alloys
WO2010053597A2 (en) * 2008-11-06 2010-05-14 University Of Washington/////////////////////-+ Micelles of hydrophilically shielded membrane-destabilizing copolymers
US8299178B2 (en) * 2009-03-25 2012-10-30 National Tsing Hua University Stable micelles formed with diblock copolymers of critical micelle concentration copolymer and temperature-sensitive copolymer
JP5679253B2 (ja) * 2009-05-26 2015-03-04 国立大学法人東京工業大学 自立性高分子薄膜
US8470891B2 (en) 2009-12-23 2013-06-25 International Business Machines Corporation Biodegradable block polymers for drug delivery, and methods related thereto
JP5864837B2 (ja) * 2010-03-24 2016-02-17 セイコーエプソン株式会社 光重合性ポリマーミセルを含む記録液、及び記録液に用いる光重合性ポリマーミセルの製造方法
ES2391187B1 (es) * 2011-04-26 2013-10-18 Consejo Superior De Investigaciones Científicas (Csic) Compuestos poliméricos bioactivos nanoestructurados derivados de fármacos antiinflamatorios no esteroideos (aine) e imidazol.
ES1075003Y (es) * 2011-06-16 2011-10-10 Antimo Juan Manuel Cuartero Recuperador de calor

Also Published As

Publication number Publication date
JP2017524791A (ja) 2017-08-31
JP6837962B2 (ja) 2021-03-03
WO2016024861A1 (en) 2016-02-18
EP3191534B1 (en) 2025-10-01
EP3191534A1 (en) 2017-07-19
CA2957900C (en) 2023-06-13
EP3191534C0 (en) 2025-10-01
AU2015302410B2 (en) 2019-01-17
US20170231908A1 (en) 2017-08-17
NL2013317B1 (en) 2016-09-21
AU2015302410A1 (en) 2017-03-09
CA2957900A1 (en) 2016-02-18
CN107106693A (zh) 2017-08-29
US11007148B2 (en) 2021-05-18

Similar Documents

Publication Publication Date Title
Van Der Poll et al. Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer
AU2016269511B2 (en) Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging
Fan et al. Recent progress of crosslinking strategies for polymeric micelles with enhanced drug delivery in cancer therapy
EP2723388B1 (en) Controlled release system
CN108542885B (zh) 抗肿瘤药物及其制备方法
Liu et al. A novel galactose-PEG-conjugated biodegradable copolymer is an efficient gene delivery vector for immunotherapy of hepatocellular carcinoma
CN103655517B (zh) 一种胶质瘤归巢肽介导的靶向纳米递药系统及其制备方法
CN109381705B (zh) 具有不对称膜结构的可逆交联生物可降解聚合物囊泡及其制备方法
Jagur‐Grodzinski Polymers for targeted and/or sustained drug delivery
CN107106693B (zh) 用于活性剂递送的两亲性嵌段共聚物
CN109762099B (zh) 一种聚合物-抗肿瘤药物偶联物及其制备方法和用途
Nakka et al. Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma
CN108126210B (zh) 一种单靶向还原响应囊泡纳米药物在制备脑肿瘤治疗药物中的应用
CN106029059A (zh) 用于药品递送的自组装刷状嵌段共聚物-纳米颗粒
CN111529486A (zh) 一种基于pH/MMP响应的“可解离”纳米胶束的制备方法及应用
CN107998081B (zh) 囊泡纳米药物在制备脑肿瘤治疗药物中的应用
CN102648221A (zh) 含α-生育酚接枝侧链的丙烯酸和/或甲基丙烯酸类聚合物
CN114099705B (zh) 一种基于肼屈嗪改善肿瘤微环境的纳米药物及其制备和应用
CN114177137B (zh) 一种基于免疫激活的胍基化纳米药物及其制备和应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant