AU2015302410B2 - Amphiphilic block copolymers for delivery of active agents - Google Patents

Amphiphilic block copolymers for delivery of active agents Download PDF

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Publication number
AU2015302410B2
AU2015302410B2 AU2015302410A AU2015302410A AU2015302410B2 AU 2015302410 B2 AU2015302410 B2 AU 2015302410B2 AU 2015302410 A AU2015302410 A AU 2015302410A AU 2015302410 A AU2015302410 A AU 2015302410A AU 2015302410 B2 AU2015302410 B2 AU 2015302410B2
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AU
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Prior art keywords
micelles
hydrophobic
controlled release
release system
block
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AU2015302410A
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AU2015302410A1 (en
Inventor
Wilhelmus Everhardus Hennink
Yang Shi
Cornelus Franciscus Van Nostrum
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Rheinisch Westlische Technische Hochschuke RWTH
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Rheinisch Westlische Technische Hochschuke RWTH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2015302410A 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents Active AU2015302410B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2013317A NL2013317B1 (en) 2014-08-11 2014-08-11 Amphiphilic block copolymers for delivery of active agents.
NL2013317 2014-08-11
PCT/NL2015/050574 WO2016024861A1 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents

Publications (2)

Publication Number Publication Date
AU2015302410A1 AU2015302410A1 (en) 2017-03-09
AU2015302410B2 true AU2015302410B2 (en) 2019-01-17

Family

ID=51660570

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015302410A Active AU2015302410B2 (en) 2014-08-11 2015-08-11 Amphiphilic block copolymers for delivery of active agents

Country Status (8)

Country Link
US (1) US11007148B2 (enExample)
EP (1) EP3191534B1 (enExample)
JP (1) JP6837962B2 (enExample)
CN (1) CN107106693B (enExample)
AU (1) AU2015302410B2 (enExample)
CA (1) CA2957900C (enExample)
NL (1) NL2013317B1 (enExample)
WO (1) WO2016024861A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022008527A1 (en) 2020-07-06 2022-01-13 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Polymeric micelles comprising glucuronide-prodrugs
US20240374792A1 (en) 2021-09-15 2024-11-14 Gelmedix, Inc. Gelma polymer compositions and uses thereof
WO2023044389A1 (en) 2021-09-15 2023-03-23 Gelmedix, Inc. Gelma polymer compositions comprising corticosteroids

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
GB0131112D0 (en) * 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
WO2009094053A1 (en) * 2008-01-25 2009-07-30 E. I. Du Pont De Nemours And Company Ink jet inks having improved corrosion resistance for use in ink jet print heads comprising nickel or nickel alloys
WO2010053597A2 (en) * 2008-11-06 2010-05-14 University Of Washington/////////////////////-+ Micelles of hydrophilically shielded membrane-destabilizing copolymers
US8299178B2 (en) * 2009-03-25 2012-10-30 National Tsing Hua University Stable micelles formed with diblock copolymers of critical micelle concentration copolymer and temperature-sensitive copolymer
JP5679253B2 (ja) * 2009-05-26 2015-03-04 国立大学法人東京工業大学 自立性高分子薄膜
US8470891B2 (en) 2009-12-23 2013-06-25 International Business Machines Corporation Biodegradable block polymers for drug delivery, and methods related thereto
JP5864837B2 (ja) * 2010-03-24 2016-02-17 セイコーエプソン株式会社 光重合性ポリマーミセルを含む記録液、及び記録液に用いる光重合性ポリマーミセルの製造方法
ES2391187B1 (es) * 2011-04-26 2013-10-18 Consejo Superior De Investigaciones Científicas (Csic) Compuestos poliméricos bioactivos nanoestructurados derivados de fármacos antiinflamatorios no esteroideos (aine) e imidazol.
ES1075003Y (es) * 2011-06-16 2011-10-10 Antimo Juan Manuel Cuartero Recuperador de calor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YANG SHI ET AL, "[Pi]-[Pi] Stacking Increases the Stability and Loading Capacity of Thermosensitive Polymeric Micelles for Chemotherapeutic Drugs", BIOMACROMOLECULES, (2013-06-10), vol. 14, no. 6, pp. 1826 - 1837 *

Also Published As

Publication number Publication date
JP2017524791A (ja) 2017-08-31
CN107106693B (zh) 2021-08-24
JP6837962B2 (ja) 2021-03-03
WO2016024861A1 (en) 2016-02-18
EP3191534B1 (en) 2025-10-01
EP3191534A1 (en) 2017-07-19
CA2957900C (en) 2023-06-13
EP3191534C0 (en) 2025-10-01
US20170231908A1 (en) 2017-08-17
NL2013317B1 (en) 2016-09-21
AU2015302410A1 (en) 2017-03-09
CA2957900A1 (en) 2016-02-18
CN107106693A (zh) 2017-08-29
US11007148B2 (en) 2021-05-18

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