JP2017524127A5 - - Google Patents
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- Publication number
- JP2017524127A5 JP2017524127A5 JP2017502806A JP2017502806A JP2017524127A5 JP 2017524127 A5 JP2017524127 A5 JP 2017524127A5 JP 2017502806 A JP2017502806 A JP 2017502806A JP 2017502806 A JP2017502806 A JP 2017502806A JP 2017524127 A5 JP2017524127 A5 JP 2017524127A5
- Authority
- JP
- Japan
- Prior art keywords
- aflibercept
- treatment
- level
- interleukin
- colorectal cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004890 Interleukin-8 Human genes 0.000 claims description 37
- 108090001007 Interleukin-8 Proteins 0.000 claims description 37
- 229940096397 interleukin-8 Drugs 0.000 claims description 37
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims description 37
- 108010081667 aflibercept Proteins 0.000 claims description 31
- 206010009944 Colon cancer Diseases 0.000 claims description 22
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 19
- 229960002833 aflibercept Drugs 0.000 claims description 15
- 229960002760 ziv-aflibercept Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 239000000090 biomarker Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 5
- 238000003556 assay Methods 0.000 claims 2
- 230000004071 biological effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 229960002949 fluorouracil Drugs 0.000 description 3
- 229960000397 bevacizumab Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940036061 zaltrap Drugs 0.000 description 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
- 206010052358 Colorectal cancer metastatic Diseases 0.000 description 1
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
- 235000008191 folinic acid Nutrition 0.000 description 1
- 239000011672 folinic acid Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
- 229960001691 leucovorin Drugs 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14306172 | 2014-07-18 | ||
| EP14306172.9 | 2014-07-18 | ||
| PCT/EP2015/066262 WO2016008975A1 (en) | 2014-07-18 | 2015-07-16 | Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524127A JP2017524127A (ja) | 2017-08-24 |
| JP2017524127A5 true JP2017524127A5 (OSRAM) | 2020-02-13 |
| JP6685276B2 JP6685276B2 (ja) | 2020-04-22 |
Family
ID=51220534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502806A Active JP6685276B2 (ja) | 2014-07-18 | 2015-07-16 | 癌に罹患していることが疑われる患者のアフリベルセプトを用いた処置の結果を予測するための方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10501523B2 (OSRAM) |
| EP (1) | EP3170005B1 (OSRAM) |
| JP (1) | JP6685276B2 (OSRAM) |
| KR (1) | KR102486321B1 (OSRAM) |
| CN (1) | CN107076750B (OSRAM) |
| AU (1) | AU2015289124B2 (OSRAM) |
| CY (1) | CY1122233T1 (OSRAM) |
| DK (1) | DK3170005T3 (OSRAM) |
| EA (1) | EA035674B1 (OSRAM) |
| ES (1) | ES2732925T3 (OSRAM) |
| HR (1) | HRP20191145T1 (OSRAM) |
| HU (1) | HUE043951T2 (OSRAM) |
| IL (1) | IL250110B (OSRAM) |
| LT (1) | LT3170005T (OSRAM) |
| MA (1) | MA40354A (OSRAM) |
| MX (1) | MX375557B (OSRAM) |
| PL (1) | PL3170005T3 (OSRAM) |
| PT (1) | PT3170005T (OSRAM) |
| RS (1) | RS58957B1 (OSRAM) |
| SG (1) | SG11201700284UA (OSRAM) |
| SI (1) | SI3170005T1 (OSRAM) |
| TR (1) | TR201909951T4 (OSRAM) |
| TW (1) | TWI705247B (OSRAM) |
| WO (1) | WO2016008975A1 (OSRAM) |
| ZA (1) | ZA201700371B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| JP6685276B2 (ja) | 2014-07-18 | 2020-04-22 | サノフイＳａｎｏｆｉ | 癌に罹患していることが疑われる患者のアフリベルセプトを用いた処置の結果を予測するための方法 |
| NZ744185A (en) | 2015-12-30 | 2025-09-26 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
| CN108496084B (zh) * | 2016-01-25 | 2021-11-05 | 赛诺菲 | 通过测量血浆生物标记的水平预测疑似患有癌症的患者使用阿柏西普的治疗的结果的方法 |
| CN107602702A (zh) * | 2017-09-22 | 2018-01-19 | 生标（上海）医疗器械科技有限公司 | 一种同时靶向人p185和血管内皮生长因子的抗体及其应用 |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| PT4364724T (pt) | 2018-05-10 | 2025-12-16 | Regeneron Pharma | Formulações contendo uma proteína de fusão do recetor do vegf de concentração elevada |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| KR102720956B1 (ko) * | 2020-12-15 | 2024-10-24 | 삼천당제약주식회사 | 안과용 제형을 포함하는 시린지 |
| WO2023153535A1 (ko) * | 2022-02-09 | 2023-08-17 | 삼천당제약주식회사 | 안과용 제형을 포함하는 시린지 |
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| ES2653646T3 (es) * | 2010-07-14 | 2018-02-08 | Vision Tech Bio Pty Ltd | Diagnóstico para cáncer colorrectal |
| WO2012123227A1 (en) | 2011-02-23 | 2012-09-20 | Sanofi | Single nucleotide polymorphisms in the promoter of vegfa gene and their use as predictive markers for anti-vegf treatments |
| TWI671315B (zh) * | 2011-03-28 | 2019-09-11 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| JO3283B1 (ar) * | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| ES2841809T3 (es) * | 2011-06-03 | 2021-07-09 | Eisai R&D Man Co Ltd | Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
| EP2844270A4 (en) * | 2012-03-15 | 2016-01-27 | Univ New York State Res Found | COMBINATION THERAPIES WITH INHIBITORS OF THE EXTRACELLULAR DOMAIN OF E-CADHERINE |
| JP6019790B2 (ja) | 2012-06-19 | 2016-11-02 | 富士電機株式会社 | 接合方法及び接合部材 |
| AR091967A1 (es) | 2012-08-02 | 2015-03-11 | Sanofi Sa | Articulo de fabricacion que comprende aflibercept o 2iv-aflibercept |
| JP6685276B2 (ja) | 2014-07-18 | 2020-04-22 | サノフイＳａｎｏｆｉ | 癌に罹患していることが疑われる患者のアフリベルセプトを用いた処置の結果を予測するための方法 |
| CN108496084B (zh) | 2016-01-25 | 2021-11-05 | 赛诺菲 | 通过测量血浆生物标记的水平预测疑似患有癌症的患者使用阿柏西普的治疗的结果的方法 |
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