JP2017523983A5 - - Google Patents
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- Publication number
- JP2017523983A5 JP2017523983A5 JP2017505869A JP2017505869A JP2017523983A5 JP 2017523983 A5 JP2017523983 A5 JP 2017523983A5 JP 2017505869 A JP2017505869 A JP 2017505869A JP 2017505869 A JP2017505869 A JP 2017505869A JP 2017523983 A5 JP2017523983 A5 JP 2017523983A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- gel
- nanoparticles
- polymer
- lutein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 76
- 229920000642 polymer Polymers 0.000 claims description 69
- 239000002105 nanoparticle Substances 0.000 claims description 49
- 239000000499 gel Substances 0.000 claims description 37
- 235000012680 lutein Nutrition 0.000 claims description 32
- 239000001656 lutein Substances 0.000 claims description 32
- 229960005375 lutein Drugs 0.000 claims description 32
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 32
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 32
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 32
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 32
- 239000000227 bioadhesive Substances 0.000 claims description 29
- 210000001519 tissue Anatomy 0.000 claims description 29
- 102000004169 proteins and genes Human genes 0.000 claims description 28
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 239000003963 antioxidant agent Substances 0.000 claims description 23
- 235000006708 antioxidants Nutrition 0.000 claims description 23
- 239000000017 hydrogel Substances 0.000 claims description 18
- 235000021466 carotenoid Nutrition 0.000 claims description 15
- 150000001747 carotenoids Chemical class 0.000 claims description 15
- 230000003078 antioxidant effect Effects 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 241000124008 Mammalia Species 0.000 claims description 12
- 210000004087 cornea Anatomy 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 208000002177 Cataract Diseases 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 208000002780 macular degeneration Diseases 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 8
- 229920001059 synthetic polymer Polymers 0.000 claims description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 6
- 229920002494 Zein Polymers 0.000 claims description 5
- 230000015556 catabolic process Effects 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 5
- 238000006731 degradation reaction Methods 0.000 claims description 5
- 239000005019 zein Substances 0.000 claims description 5
- 229940093612 zein Drugs 0.000 claims description 5
- 210000000795 conjunctiva Anatomy 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 3
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 3
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 3
- 235000013734 beta-carotene Nutrition 0.000 claims description 3
- 239000011648 beta-carotene Substances 0.000 claims description 3
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 3
- 229960002747 betacarotene Drugs 0.000 claims description 3
- 235000012661 lycopene Nutrition 0.000 claims description 3
- 239000001751 lycopene Substances 0.000 claims description 3
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 3
- 229960004999 lycopene Drugs 0.000 claims description 3
- 210000004877 mucosa Anatomy 0.000 claims description 3
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 3
- 235000020944 retinol Nutrition 0.000 claims description 3
- 239000011607 retinol Substances 0.000 claims description 3
- 229960003471 retinol Drugs 0.000 claims description 3
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 3
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229960000502 poloxamer Drugs 0.000 claims description 2
- 229920001983 poloxamer Polymers 0.000 claims description 2
- 210000001525 retina Anatomy 0.000 claims description 2
- 238000000034 method Methods 0.000 description 10
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035683P | 2014-08-11 | 2014-08-11 | |
| US62/035,683 | 2014-08-11 | ||
| US201562172455P | 2015-06-08 | 2015-06-08 | |
| US62/172,455 | 2015-06-08 | ||
| PCT/US2015/044483 WO2016025394A2 (en) | 2014-08-11 | 2015-08-10 | Delivery of bioactive, nanoencapsulated antioxidants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523983A JP2017523983A (ja) | 2017-08-24 |
| JP2017523983A5 true JP2017523983A5 (enExample) | 2018-09-20 |
| JP6668327B2 JP6668327B2 (ja) | 2020-03-18 |
Family
ID=55304745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505869A Active JP6668327B2 (ja) | 2014-08-11 | 2015-08-10 | 生理活性で、ナノカプセル化された抗酸化物質の送達 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10292943B2 (enExample) |
| EP (1) | EP3179988A4 (enExample) |
| JP (1) | JP6668327B2 (enExample) |
| KR (1) | KR102218883B1 (enExample) |
| AP (1) | AP2017009684A0 (enExample) |
| AU (1) | AU2015301945B2 (enExample) |
| BR (1) | BR112017002580A2 (enExample) |
| CA (1) | CA2992879C (enExample) |
| EA (1) | EA035620B1 (enExample) |
| MX (1) | MX388028B (enExample) |
| WO (1) | WO2016025394A2 (enExample) |
| ZA (1) | ZA201700987B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017002580A2 (pt) * | 2014-08-11 | 2018-03-27 | Univ Louisiana State | administração de antioxidantes bioativos nanoencapsulados |
| WO2019148140A2 (en) * | 2018-01-26 | 2019-08-01 | Wu Joseph C | Implantable biomaterials that enhance stem cell survival and function |
| EP3982939A1 (en) * | 2019-06-14 | 2022-04-20 | Folium Biosciences Europe B.V. | Method for micro-encapsulation of natural ingredients by means of contacting with supercritical gas |
| JP2023526040A (ja) * | 2020-05-11 | 2023-06-20 | オプ２ライシス | 血栓性または出血性疾患の治療に使用するための徐放性プラスミノーゲン活性化因子製剤 |
| US11253481B1 (en) | 2021-07-12 | 2022-02-22 | King Abdulaziz University | Self-nanoemulsifying 3D-printed tablet composition and method of use thereof |
| US11298321B1 (en) | 2021-07-12 | 2022-04-12 | King Abdulaziz University | Methods for treating metabolic disorder |
| KR102824097B1 (ko) | 2022-12-07 | 2025-06-24 | 주식회사 엘지생활건강 | 바이오틴이 담지된 나노파티클 및 이의 제조 방법, 및 이의 용도 |
| WO2025106389A1 (en) * | 2023-11-13 | 2025-05-22 | Universitatea De Medicină Şi Farmacie Iluiu Haţieganu | New forms of lutein and their uses |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0386960A3 (en) | 1989-03-07 | 1991-10-23 | American Cyanamid Company | Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings |
| US6573299B1 (en) * | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
| US6703039B2 (en) | 2000-12-06 | 2004-03-09 | Bausch & Lomb Incorporated | Reversible gelling system for ocular drug delivery |
| DE10141018A1 (de) * | 2001-08-22 | 2003-03-13 | Eth Zuerich Eidgenoessische Te | Verwendung von negativ geladenen Phospholipiden, sowie Zusammensetzungen umfassend Phospholipide zur Behandlung des Auges |
| US20040009212A1 (en) * | 2002-01-30 | 2004-01-15 | Pharma Power Biotec Co. Ltd. | Mucoadhesive thermoresponsive medicament-carrier composition |
| JP4448441B2 (ja) | 2002-06-05 | 2010-04-07 | ユニヴァーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド | 眼科用医薬のデリバリーシステム |
| RU2008119234A (ru) | 2005-10-16 | 2009-11-27 | Ликорд Лтд. (Il) | Композиции для лечения глазных заболеваний |
| US9707185B2 (en) * | 2007-05-07 | 2017-07-18 | Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College | Water-soluble nanoparticles containing water-insoluble compounds |
| AU2011278186B2 (en) | 2010-07-16 | 2015-02-05 | Centro Nacional De Tecnologia Y Seguridad Alimentaria, Laboratorio Del Ebro | Nanoparticles for the encapsulation of compounds, the obtaining and uses thereof |
| ES2524580T3 (es) | 2010-09-03 | 2014-12-10 | Santen Sas | Una emulsión de tipo agua en aceite para tratar una enfermedad de los ojos |
| EP2678007A4 (en) * | 2011-02-25 | 2015-08-12 | Univ South Dakota | PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION |
| US20120231072A1 (en) * | 2011-03-11 | 2012-09-13 | Chemisches Institut Schaefer Ag | Thermo-responsive hydrogel compositions |
| CN103845278B (zh) | 2012-11-30 | 2016-06-22 | 沈阳药科大学 | 一种叶黄素眼用纳米乳-温度敏感型原位凝胶及其制备方法 |
| BR112017002580A2 (pt) * | 2014-08-11 | 2018-03-27 | Univ Louisiana State | administração de antioxidantes bioativos nanoencapsulados |
-
2015
- 2015-08-10 BR BR112017002580A patent/BR112017002580A2/pt not_active Application Discontinuation
- 2015-08-10 AP AP2017009684A patent/AP2017009684A0/en unknown
- 2015-08-10 AU AU2015301945A patent/AU2015301945B2/en active Active
- 2015-08-10 EP EP15831551.5A patent/EP3179988A4/en active Pending
- 2015-08-10 EA EA201790361A patent/EA035620B1/ru unknown
- 2015-08-10 MX MX2017001903A patent/MX388028B/es unknown
- 2015-08-10 CA CA2992879A patent/CA2992879C/en active Active
- 2015-08-10 WO PCT/US2015/044483 patent/WO2016025394A2/en not_active Ceased
- 2015-08-10 US US15/502,415 patent/US10292943B2/en active Active
- 2015-08-10 KR KR1020177003119A patent/KR102218883B1/ko active Active
- 2015-08-10 JP JP2017505869A patent/JP6668327B2/ja active Active
-
2017
- 2017-02-03 ZA ZA2017/00987A patent/ZA201700987B/en unknown
-
2019
- 2019-04-30 US US16/399,388 patent/US10952974B2/en active Active
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