KR102218883B1 - 생물활성, 나노입자포집된 항산화제의 전달 - Google Patents

생물활성, 나노입자포집된 항산화제의 전달 Download PDF

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KR102218883B1
KR102218883B1 KR1020177003119A KR20177003119A KR102218883B1 KR 102218883 B1 KR102218883 B1 KR 102218883B1 KR 1020177003119 A KR1020177003119 A KR 1020177003119A KR 20177003119 A KR20177003119 A KR 20177003119A KR 102218883 B1 KR102218883 B1 KR 102218883B1
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lutein
nanoparticles
composition
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KR20170097601A (ko
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크리스티나 엠. 사블리브
카롤스 이. 아스테테
에드 보도키
올리뷰 보스티라루
오비듀 치프리안 사모이라
엘레나 딘테
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보드 오브 슈퍼바이저스 오브 루이지애나 스테이트 유니버시티 앤드 애그리컬춰럴 앤드 메카니컬 컬리지 쓰루 더 엘에스유 에이쥐센터
이울이우 하티에가누 유니버시티 오브 메디신 앤드 파르마시
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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    • A61K9/5107—Excipients; Inactive ingredients
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    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
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    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

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  • Nanotechnology (AREA)
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  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020177003119A 2014-08-11 2015-08-10 생물활성, 나노입자포집된 항산화제의 전달 Active KR102218883B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462035683P 2014-08-11 2014-08-11
US62/035,683 2014-08-11
US201562172455P 2015-06-08 2015-06-08
US62/172,455 2015-06-08
PCT/US2015/044483 WO2016025394A2 (en) 2014-08-11 2015-08-10 Delivery of bioactive, nanoencapsulated antioxidants

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KR20170097601A KR20170097601A (ko) 2017-08-28
KR102218883B1 true KR102218883B1 (ko) 2021-02-23

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US (2) US10292943B2 (enExample)
EP (1) EP3179988A4 (enExample)
JP (1) JP6668327B2 (enExample)
KR (1) KR102218883B1 (enExample)
AP (1) AP2017009684A0 (enExample)
AU (1) AU2015301945B2 (enExample)
BR (1) BR112017002580A2 (enExample)
CA (1) CA2992879C (enExample)
EA (1) EA035620B1 (enExample)
MX (1) MX388028B (enExample)
WO (1) WO2016025394A2 (enExample)
ZA (1) ZA201700987B (enExample)

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EA035620B1 (ru) * 2014-08-11 2020-07-16 Борд Оф Сьюпервайзорз Оф Луизиана Стэйт Юниверсити Энд Эгрикалчурал Энд Мекэникал Колледж Способы и композиция для лечения или профилактики катаракты
WO2019148140A2 (en) * 2018-01-26 2019-08-01 Wu Joseph C Implantable biomaterials that enhance stem cell survival and function
US20220257521A1 (en) * 2019-06-14 2022-08-18 Folium Biosciences Europe B.V. Method for micro-encapsulation of natural ingredients by means of contacting with supercritical gas
JP2023526040A (ja) * 2020-05-11 2023-06-20 オプ２ライシス 血栓性または出血性疾患の治療に使用するための徐放性プラスミノーゲン活性化因子製剤
US11298321B1 (en) 2021-07-12 2022-04-12 King Abdulaziz University Methods for treating metabolic disorder
US11253481B1 (en) 2021-07-12 2022-02-22 King Abdulaziz University Self-nanoemulsifying 3D-printed tablet composition and method of use thereof
KR102824097B1 (ko) 2022-12-07 2025-06-24 주식회사 엘지생활건강 바이오틴이 담지된 나노파티클 및 이의 제조 방법, 및 이의 용도
WO2025106389A1 (en) * 2023-11-13 2025-05-22 Universitatea De Medicină Şi Farmacie Iluiu Haţieganu New forms of lutein and their uses

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CA2011423A1 (en) * 1989-03-07 1990-09-07 Peter M. Taylor Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
US6573299B1 (en) * 1999-09-20 2003-06-03 Advanced Medical Instruments Method and compositions for treatment of the aging eye
US6703039B2 (en) * 2000-12-06 2004-03-09 Bausch & Lomb Incorporated Reversible gelling system for ocular drug delivery
DE10141018A1 (de) * 2001-08-22 2003-03-13 Eth Zuerich Eidgenoessische Te Verwendung von negativ geladenen Phospholipiden, sowie Zusammensetzungen umfassend Phospholipide zur Behandlung des Auges
US20040009212A1 (en) * 2002-01-30 2004-01-15 Pharma Power Biotec Co. Ltd. Mucoadhesive thermoresponsive medicament-carrier composition
WO2003103549A1 (en) * 2002-06-05 2003-12-18 University Of Florida Ophthalmic drug delivery system
RU2008119234A (ru) 2005-10-16 2009-11-27 Ликорд Лтд. (Il) Композиции для лечения глазных заболеваний
WO2008137831A1 (en) * 2007-05-07 2008-11-13 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Water-soluble nanoparticles containing water-insoluble compounds
DK2594140T3 (da) * 2010-07-16 2019-06-03 Univ Navarra Nanopartikler til indkapsling af forbindelser, fremstilling og anvendelse deraf
MY157513A (en) * 2010-09-03 2016-06-15 Santen Sas A water-in-oil type emulsion for treating a disease of the eye
EP2678007A4 (en) * 2011-02-25 2015-08-12 Univ South Dakota PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION
US20120231072A1 (en) * 2011-03-11 2012-09-13 Chemisches Institut Schaefer Ag Thermo-responsive hydrogel compositions
CN103845278B (zh) * 2012-11-30 2016-06-22 沈阳药科大学 一种叶黄素眼用纳米乳-温度敏感型原位凝胶及其制备方法
EA035620B1 (ru) * 2014-08-11 2020-07-16 Борд Оф Сьюпервайзорз Оф Луизиана Стэйт Юниверсити Энд Эгрикалчурал Энд Мекэникал Колледж Способы и композиция для лечения или профилактики катаракты

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BR112017002580A2 (pt) 2018-03-27
US20170216221A1 (en) 2017-08-03
US20190254987A1 (en) 2019-08-22
ZA201700987B (en) 2019-05-29
US10952974B2 (en) 2021-03-23
JP2017523983A (ja) 2017-08-24
AP2017009684A0 (enExample) 2017-01-31
EA201790361A1 (ru) 2017-06-30
EP3179988A2 (en) 2017-06-21
CA2992879C (en) 2022-10-25
EA035620B1 (ru) 2020-07-16
US10292943B2 (en) 2019-05-21
WO2016025394A2 (en) 2016-02-18
AU2015301945A1 (en) 2017-03-09
WO2016025394A3 (en) 2016-05-19
MX2017001903A (es) 2017-09-26
CA2992879A1 (en) 2016-02-18
JP6668327B2 (ja) 2020-03-18
EP3179988A4 (en) 2018-11-14
MX388028B (es) 2025-03-19
KR20170097601A (ko) 2017-08-28
AU2015301945B2 (en) 2020-05-14

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