JP2017522025A5 - - Google Patents
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- JP2017522025A5 JP2017522025A5 JP2017502212A JP2017502212A JP2017522025A5 JP 2017522025 A5 JP2017522025 A5 JP 2017522025A5 JP 2017502212 A JP2017502212 A JP 2017502212A JP 2017502212 A JP2017502212 A JP 2017502212A JP 2017522025 A5 JP2017522025 A5 JP 2017522025A5
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- oncolytic virus
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- 244000309459 oncolytic virus Species 0.000 claims 27
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 8
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 8
- 102000006601 Thymidine Kinase Human genes 0.000 claims 5
- 108020004440 Thymidine kinase Proteins 0.000 claims 5
- 241000700618 Vaccinia virus Species 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 3
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 3
- 102000000505 Ribonucleotide Reductases Human genes 0.000 claims 3
- 108010041388 Ribonucleotide Reductases Proteins 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 108091000036 uracil phosphoribosyltransferase Proteins 0.000 claims 3
- 241000711404 Avian avulavirus 1 Species 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 2
- 101000807008 Homo sapiens Uracil phosphoribosyltransferase homolog Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 101100502554 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) FCY1 gene Proteins 0.000 claims 2
- 241000837158 Senecavirus A Species 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 102100037717 Uracil phosphoribosyltransferase homolog Human genes 0.000 claims 2
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 230000000415 inactivating effect Effects 0.000 claims 2
- 230000002601 intratumoral effect Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101100043727 Caenorhabditis elegans syx-2 gene Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 101100535673 Drosophila melanogaster Syn gene Proteins 0.000 claims 1
- 101150067602 F4L gene Proteins 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 101150046249 Havcr2 gene Proteins 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 101150060895 I4L gene Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 102100037357 Thymidylate kinase Human genes 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 108700005077 Viral Genes Proteins 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 108010000742 dTMP kinase Proteins 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 102000048776 human CD274 Human genes 0.000 claims 1
- 102000046157 human CSF2 Human genes 0.000 claims 1
- 102000043321 human CTLA4 Human genes 0.000 claims 1
- 102000048362 human PDCD1 Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229950010773 pidilizumab Drugs 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229950007217 tremelimumab Drugs 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14306153 | 2014-07-16 | ||
| EP14306153.9 | 2014-07-16 | ||
| PCT/EP2015/066263 WO2016008976A1 (en) | 2014-07-16 | 2015-07-16 | Oncolytic virus for expression of immune checkpoint modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020163305A Division JP7077377B2 (ja) | 2014-07-16 | 2020-09-29 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522025A JP2017522025A (ja) | 2017-08-10 |
| JP2017522025A5 true JP2017522025A5 (enExample) | 2018-08-16 |
| JP6895374B2 JP6895374B2 (ja) | 2021-06-30 |
Family
ID=51220528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502212A Active JP6895374B2 (ja) | 2014-07-16 | 2015-07-16 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
| JP2020163305A Active JP7077377B2 (ja) | 2014-07-16 | 2020-09-29 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020163305A Active JP7077377B2 (ja) | 2014-07-16 | 2020-09-29 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10555981B2 (enExample) |
| EP (2) | EP3169341B1 (enExample) |
| JP (2) | JP6895374B2 (enExample) |
| CN (2) | CN120555373A (enExample) |
| AU (2) | AU2015289125B2 (enExample) |
| CA (2) | CA3190510A1 (enExample) |
| DK (2) | DK3169341T3 (enExample) |
| ES (2) | ES2743873T3 (enExample) |
| HU (1) | HUE045108T2 (enExample) |
| IL (1) | IL250058A0 (enExample) |
| PL (1) | PL3169341T3 (enExample) |
| PT (1) | PT3169341T (enExample) |
| RU (1) | RU2696312C2 (enExample) |
| WO (1) | WO2016008976A1 (enExample) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2890714A2 (en) * | 2012-08-30 | 2015-07-08 | Amgen Inc. | A method for treating melanoma using a herpes simplex virus and an immune checkpoint inhibitor |
| MX370449B (es) | 2013-12-12 | 2019-12-13 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de unión al antígeno de este y uso médico de este. |
| CA3190510A1 (en) * | 2014-07-16 | 2016-01-21 | Transgene Sa | Oncolytic virus for expression of immune checkpoint modulators |
| KR102504758B1 (ko) * | 2014-07-16 | 2023-02-28 | 트랜스진 | 종양 세포 붕괴성 바이러스와 면역 체크포인트 조절제의 배합물 |
| RU2716821C2 (ru) | 2014-10-24 | 2020-03-17 | Калиди Биотерапьютикс, Инк. | Комбинированный иммунотерапевтический подход к лечению рака |
| CN115300622A (zh) | 2015-02-25 | 2022-11-08 | 纪念斯隆-凯特琳癌症中心 | 使用灭活的修饰的痘苗病毒安卡拉作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂组合 |
| PT3283508T (pt) | 2015-04-17 | 2021-06-21 | Alpine Immune Sciences Inc | Proteínas imuno modulatórias com afinidades afináveis |
| CN107847534B (zh) | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| EP3736290A1 (en) | 2015-05-29 | 2020-11-11 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
| JP2018527895A (ja) | 2015-06-29 | 2018-09-27 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 抗−ａｐｏｂｅｃ３抗体並びにその製造及び使用方法 |
| WO2017004165A1 (en) * | 2015-06-29 | 2017-01-05 | Regents Of The University Of Minnesota | Apobec3b mutagenesis and immunotherapy |
| US10513558B2 (en) | 2015-07-13 | 2019-12-24 | Cytomx Therapeutics, Inc. | Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof |
| CN115212301A (zh) | 2015-08-11 | 2022-10-21 | 卡利迪生物治疗有限公司 | 用以癌症治疗的天花疫苗 |
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| WO2017106332A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3393468B1 (en) | 2015-12-22 | 2022-09-14 | X4 Pharmaceuticals, Inc. | Methods for treating immunodeficiency disease |
| EP3400290B1 (en) | 2016-01-08 | 2023-04-05 | Replimune Limited | Oncolytic virus strain |
| CN108883132A (zh) * | 2016-01-22 | 2018-11-23 | X4 制药有限公司 | 用于治疗癌症的方法 |
| AR107469A1 (es) | 2016-01-27 | 2018-05-02 | Oncorus Inc | Vectores virales oncolíticos y sus usos |
| SG11201807022XA (en) | 2016-02-25 | 2018-09-27 | Memorial Sloan Kettering Cancer Center | Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors |
| WO2017147553A2 (en) | 2016-02-25 | 2017-08-31 | Memorial Sloan-Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy |
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| KR102824067B1 (ko) | 2016-04-15 | 2025-06-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
| WO2017201281A1 (en) | 2016-05-18 | 2017-11-23 | Mayo Foundation For Medical Education And Research | Targeting pd-l1 on tumor cells |
| EP3808748A1 (en) | 2016-06-21 | 2021-04-21 | X4 Pharmaceuticals, Inc. | Substituted piperidines as cxcr4-inhibitors |
| JP7084624B2 (ja) | 2016-06-21 | 2022-06-15 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
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| EP3494219A1 (en) * | 2016-08-03 | 2019-06-12 | Aalborg Universitet | ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS |
| TW201825674A (zh) * | 2016-09-09 | 2018-07-16 | 美商艾斯合顧問有限公司 | 表現雙特異性接合分子的溶瘤病毒 |
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