JP2017521090A5 - - Google Patents
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- Publication number
- JP2017521090A5 JP2017521090A5 JP2017512466A JP2017512466A JP2017521090A5 JP 2017521090 A5 JP2017521090 A5 JP 2017521090A5 JP 2017512466 A JP2017512466 A JP 2017512466A JP 2017512466 A JP2017512466 A JP 2017512466A JP 2017521090 A5 JP2017521090 A5 JP 2017521090A5
- Authority
- JP
- Japan
- Prior art keywords
- polyplex
- cancer
- cooh
- target moiety
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920000642 polymer Polymers 0.000 claims 26
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 17
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 17
- 102000001301 EGF receptor Human genes 0.000 claims 15
- 108060006698 EGF receptor Proteins 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 15
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 10
- 125000002947 alkylene group Chemical group 0.000 claims 9
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 9
- SOAPXKSPJAZNGO-WDSKDSINSA-N (2s)-2-[[(1s)-1,3-dicarboxypropyl]carbamoylamino]pentanedioic acid Chemical group OC(=O)CC[C@@H](C(O)=O)NC(=O)N[C@H](C(O)=O)CCC(O)=O SOAPXKSPJAZNGO-WDSKDSINSA-N 0.000 claims 8
- 239000002202 Polyethylene glycol Substances 0.000 claims 7
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 238000004581 coalescence Methods 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 4
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 claims 1
- 241000257303 Hymenoptera Species 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 101000851196 Mus musculus Pro-epidermal growth factor Proteins 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000005218 alkyleneheteroaryl group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 229940022353 herceptin Drugs 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 0 CC(CC(N(CCCO)**N)=*)=C Chemical compound CC(CC(N(CCCO)**N)=*)=C 0.000 description 3
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020139643A JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2023211790A JP2024028995A (ja) | 2014-05-14 | 2023-12-15 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993110P | 2014-05-14 | 2014-05-14 | |
| US61/993,110 | 2014-05-14 | ||
| PCT/IL2015/050514 WO2015173824A1 (en) | 2014-05-14 | 2015-05-14 | Improved polyethyleneimine polyethyleneglycol vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139643A Division JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521090A JP2017521090A (ja) | 2017-08-03 |
| JP2017521090A5 true JP2017521090A5 (show.php) | 2018-06-21 |
| JP6753843B2 JP6753843B2 (ja) | 2020-09-16 |
Family
ID=54479412
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512466A Active JP6753843B2 (ja) | 2014-05-14 | 2015-05-14 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2020139643A Active JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2023211790A Pending JP2024028995A (ja) | 2014-05-14 | 2023-12-15 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139643A Active JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2023211790A Pending JP2024028995A (ja) | 2014-05-14 | 2023-12-15 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10278991B2 (show.php) |
| EP (1) | EP3142673A4 (show.php) |
| JP (3) | JP6753843B2 (show.php) |
| KR (2) | KR102589295B1 (show.php) |
| CN (3) | CN116966311A (show.php) |
| AU (2) | AU2015260725B2 (show.php) |
| CA (1) | CA2949017A1 (show.php) |
| IL (2) | IL287206B2 (show.php) |
| MA (1) | MA39970A (show.php) |
| MX (2) | MX377654B (show.php) |
| NZ (1) | NZ727092A (show.php) |
| PH (1) | PH12016502258B1 (show.php) |
| RU (1) | RU2771104C2 (show.php) |
| SG (2) | SG10201911695SA (show.php) |
| WO (1) | WO2015173824A1 (show.php) |
| ZA (1) | ZA201608042B (show.php) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015260725B2 (en) | 2014-05-14 | 2021-02-25 | Targimmune Therapeutics Ag | Improved polyethyleneimine polyethyleneglycol vectors |
| CN112294757B (zh) | 2015-11-17 | 2024-02-13 | 亮点医疗有限责任公司 | 包含含有双链聚核糖核苷酸与聚亚烷基亚胺的复合物的粒子的医药组合物 |
| AR107823A1 (es) | 2016-03-07 | 2018-06-06 | Hanmi Pharm Ind Co Ltd | Derivados de polietilenglicol y uso de los mismos |
| JP7096249B2 (ja) * | 2016-09-04 | 2022-07-05 | ターグイミューン セラピューティクス アーゲー | ｄｓＲＮＡを標的化するためのキメラタンパク質 |
| EP3448363B1 (en) | 2017-05-17 | 2022-05-11 | Highlight Therapeutics, S.L. | Novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine |
| IL273195B2 (en) * | 2017-09-27 | 2024-04-01 | Targimmune Therapeutics Ag | Castration-resistant prostate cancer |
| JP2021516056A (ja) * | 2018-03-08 | 2021-07-01 | ターグイミューン セラピューティクス アーゲー | 二本鎖ｒｎａ結合ドメインを含む組換えタンパク質 |
| CN109893657B (zh) * | 2019-02-28 | 2022-04-29 | 中国人民解放军军事科学院军事医学研究院 | 基因递送载体、药物复合物、抗肺纤维化药物及应用 |
| CA3131535A1 (en) | 2019-04-03 | 2020-10-08 | Targimmune Therapeutics Ag | Immunotherapy for the treatment of cancer |
| WO2020263782A1 (en) * | 2019-06-24 | 2020-12-30 | North Carolina State University | Methods and compositions for modifying nucleic acids and for killing cells |
| WO2021001023A1 (en) * | 2019-07-02 | 2021-01-07 | Biontech Rna Pharmaceuticals Gmbh | Rna formulations suitable for therapy |
| KR20230084476A (ko) * | 2020-10-08 | 2023-06-13 | 타르그이뮨 테라퓨틱스 아게 | 암의 치료를 위한 면역요법 |
| WO2023079142A2 (en) | 2021-11-05 | 2023-05-11 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| US20240091348A1 (en) * | 2022-09-20 | 2024-03-21 | Highlight Therapeutics, S.L. | Novel compositions based on polyinosinic-polycytidylic acid |
| AU2023376546A1 (en) * | 2022-11-07 | 2025-05-15 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| CN120456930A (zh) | 2022-11-07 | 2025-08-08 | 塔尔格免疫治疗有限公司 | 包含聚乙烯亚胺和聚乙二醇的靶向偶联物与核酸的聚合物复合物 |
| JP2025537203A (ja) | 2022-11-07 | 2025-11-14 | ターグイミューン セラピューティクス アクチエンゲゼルシャフト | ポリエチレンイミンおよびポリエチレングリコールを含むｐｓｍａ標的化線状コンジュゲートならびにそれを含むポリプレックス |
| WO2025238236A1 (en) | 2024-05-16 | 2025-11-20 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol |
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| CN104341488A (zh) | 2013-08-02 | 2015-02-11 | 复旦大学 | c(LyP-1)多肽及其构建的纳米递药系统和应用 |
| US20160312218A1 (en) | 2013-11-04 | 2016-10-27 | Northeastern University | System for co-delivery of polynucleotides and drugs into protease-expressing cells |
| WO2015070080A2 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Nucleic acid nanostructures for in vivo agent delivery |
| TWI693937B (zh) | 2014-03-14 | 2020-05-21 | 美商輝瑞大藥廠 | 包含治療劑之治療性奈米顆粒及其製造及使用方法 |
| WO2015144736A1 (en) | 2014-03-24 | 2015-10-01 | Riboxx Gmbh | Double-stranded rna conjugates and their use |
| CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
| AU2015260725B2 (en) * | 2014-05-14 | 2021-02-25 | Targimmune Therapeutics Ag | Improved polyethyleneimine polyethyleneglycol vectors |
| US20180016352A1 (en) | 2015-02-05 | 2018-01-18 | The University Of Queensland | Targeting constructs for delivery of payloads |
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| CN112294757B (zh) | 2015-11-17 | 2024-02-13 | 亮点医疗有限责任公司 | 包含含有双链聚核糖核苷酸与聚亚烷基亚胺的复合物的粒子的医药组合物 |
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