JP2017520530A5 - - Google Patents
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- Publication number
- JP2017520530A5 JP2017520530A5 JP2016568820A JP2016568820A JP2017520530A5 JP 2017520530 A5 JP2017520530 A5 JP 2017520530A5 JP 2016568820 A JP2016568820 A JP 2016568820A JP 2016568820 A JP2016568820 A JP 2016568820A JP 2017520530 A5 JP2017520530 A5 JP 2017520530A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- independently
- ring
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 64
- 125000001188 haloalkyl group Chemical group 0.000 claims 38
- 229910052736 halogen Inorganic materials 0.000 claims 38
- 150000002367 halogens Chemical class 0.000 claims 37
- 125000003282 alkyl amino group Chemical group 0.000 claims 35
- 125000004663 dialkyl amino group Chemical group 0.000 claims 34
- -1 cyano, hydroxy Chemical group 0.000 claims 33
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 33
- 125000000623 heterocyclic group Chemical group 0.000 claims 32
- 125000003342 alkenyl group Chemical group 0.000 claims 26
- 125000000304 alkynyl group Chemical group 0.000 claims 26
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 26
- 125000001072 heteroaryl group Chemical group 0.000 claims 25
- 125000001424 substituent group Chemical group 0.000 claims 25
- 125000004103 aminoalkyl group Chemical group 0.000 claims 24
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000005110 aryl thio group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000000262 haloalkenyl group Chemical group 0.000 claims 16
- 125000004995 haloalkylthio group Chemical group 0.000 claims 16
- 125000000232 haloalkynyl group Chemical group 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 15
- 125000004414 alkyl thio group Chemical group 0.000 claims 15
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 15
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 15
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 15
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 15
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 15
- 125000004104 aryloxy group Chemical group 0.000 claims 15
- 125000002837 carbocyclic group Chemical group 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- 125000004438 haloalkoxy group Chemical group 0.000 claims 15
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims 15
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 15
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 15
- 125000005367 heteroarylalkylthio group Chemical group 0.000 claims 15
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 15
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 claims 15
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 15
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 11
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 11
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 11
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 11
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 11
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 11
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 10
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 10
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 10
- 125000005368 heteroarylthio group Chemical group 0.000 claims 10
- 125000005087 alkynylcarbonyl group Chemical group 0.000 claims 9
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 9
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 claims 6
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 6
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 4
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000002393 azetidinyl group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000006413 ring segment Chemical group 0.000 claims 4
- 206010061217 Infestation Diseases 0.000 claims 3
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000004617 chromonyl group Chemical group O1C(=CC(C2=CC=CC=C12)=O)* 0.000 claims 3
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 claims 3
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 3
- 125000004611 dihydroisoindolyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 3
- 125000004609 dihydroquinazolinyl group Chemical group N1(CN=CC2=CC=CC=C12)* 0.000 claims 3
- 125000004612 furopyridinyl group Chemical group O1C(=CC2=C1C=CC=N2)* 0.000 claims 3
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 3
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000006085 pyrrolopyridyl group Chemical group 0.000 claims 3
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 3
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 claims 3
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 3
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 3
- 125000003627 8 membered carbocyclic group Chemical group 0.000 claims 2
- 125000003566 oxetanyl group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000026803 Animal Parasitic disease Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 244000000054 animal parasite Species 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000008282 halocarbons Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000000590 parasiticidal effect Effects 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462000256P | 2014-05-19 | 2014-05-19 | |
| US62/000,256 | 2014-05-19 | ||
| PCT/US2015/031599 WO2015179414A1 (en) | 2014-05-19 | 2015-05-19 | Anthelmintic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520530A JP2017520530A (ja) | 2017-07-27 |
| JP2017520530A5 true JP2017520530A5 (cg-RX-API-DMAC7.html) | 2018-06-28 |
| JP6616786B2 JP6616786B2 (ja) | 2019-12-04 |
Family
ID=54554638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568820A Expired - Fee Related JP6616786B2 (ja) | 2014-05-19 | 2015-05-19 | 駆虫性化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10045979B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3145925B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6616786B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106536518B (cg-RX-API-DMAC7.html) |
| AR (1) | AR100530A1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015264336B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2949511A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2842592T3 (cg-RX-API-DMAC7.html) |
| MX (2) | MX361606B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ726874A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015179414A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| KR20130056244A (ko) | 2010-04-22 | 2013-05-29 | 버텍스 파마슈티칼스 인코포레이티드 | 시클로알킬카르복스아미도-인돌 화합물의 제조 방법 |
| ES2885181T3 (es) | 2014-04-15 | 2021-12-13 | Vertex Pharma | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
| ES2842592T3 (es) * | 2014-05-19 | 2021-07-14 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelmínticos |
| WO2016118638A1 (en) | 2015-01-20 | 2016-07-28 | Merial Inc. | Anthelmintic compounds, compositions and method of using thereof |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| CA3112443A1 (en) | 2018-09-12 | 2020-03-19 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| US11517568B2 (en) | 2018-09-12 | 2022-12-06 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| FI3853234T3 (fi) | 2018-09-18 | 2025-07-28 | Nikang Therapeutics Inc | Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä |
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| CR20230325A (es) | 2020-12-30 | 2023-12-11 | Tyra Biosciences Inc | Compuestos de indazol como inhibidores de cinasas |
| BR112023015210A2 (pt) | 2021-01-29 | 2023-11-07 | Cedilla Therapeutics Inc | Inibidores de cdk2 e métodos de uso dos mesmos |
| CN117561058A (zh) | 2021-06-26 | 2024-02-13 | 塞迪拉治疗股份有限公司 | Cdk2抑制剂及其使用方法 |
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-
2015
- 2015-05-19 ES ES15726481T patent/ES2842592T3/es active Active
- 2015-05-19 AU AU2015264336A patent/AU2015264336B2/en not_active Ceased
- 2015-05-19 WO PCT/US2015/031599 patent/WO2015179414A1/en not_active Ceased
- 2015-05-19 NZ NZ726874A patent/NZ726874A/en not_active IP Right Cessation
- 2015-05-19 EP EP15726481.3A patent/EP3145925B1/en not_active Not-in-force
- 2015-05-19 CA CA2949511A patent/CA2949511A1/en not_active Abandoned
- 2015-05-19 JP JP2016568820A patent/JP6616786B2/ja not_active Expired - Fee Related
- 2015-05-19 CN CN201580034873.7A patent/CN106536518B/zh not_active Expired - Fee Related
- 2015-05-19 US US15/311,848 patent/US10045979B2/en active Active
- 2015-05-19 MX MX2016015090A patent/MX361606B/es active IP Right Grant
- 2015-05-19 MX MX2018015206A patent/MX375153B/es unknown
- 2015-05-19 AR ARP150101560A patent/AR100530A1/es active IP Right Grant
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2018
- 2018-08-03 US US16/054,101 patent/US10463661B2/en active Active
- 2018-11-30 AU AU2018271390A patent/AU2018271390B2/en not_active Ceased
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