JP2017519740A - ドラプロイン‐ドライソロイインペプチド誘導体 - Google Patents

ドラプロイン‐ドライソロイインペプチド誘導体 Download PDF

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Publication number
JP2017519740A
JP2017519740A JP2016569825A JP2016569825A JP2017519740A JP 2017519740 A JP2017519740 A JP 2017519740A JP 2016569825 A JP2016569825 A JP 2016569825A JP 2016569825 A JP2016569825 A JP 2016569825A JP 2017519740 A JP2017519740 A JP 2017519740A
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methoxy
methyl
methylbutanamide
amino
pyrrolidin
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JP2017519740A5 (https=
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ブライアン アラン メンデルソーン
ブライアン アラン メンデルソーン
ジュリエン デュガル‐テリア
ジュリエン デュガル‐テリア
スチュアート ダニエル バーンシェア
スチュアート ダニエル バーンシェア
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アジェンシス，インコーポレイテッド
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Publication of JP2017519740A publication Critical patent/JP2017519740A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016569825A 2014-05-28 2015-05-27 ドラプロイン‐ドライソロイインペプチド誘導体 Pending JP2017519740A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462004084P 2014-05-28 2014-05-28
US62/004,084 2014-05-28
PCT/US2015/032704 WO2015183978A1 (en) 2014-05-28 2015-05-27 Derivatives of dolaproine-dolaisoleuine peptides

Related Child Applications (1)

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JP2020081698A Division JP6995160B2 (ja) 2014-05-28 2020-05-07 ドラプロイン‐ドライソロイインペプチド誘導体

Publications (2)

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JP2017519740A true JP2017519740A (ja) 2017-07-20
JP2017519740A5 JP2017519740A5 (https=) 2018-07-05

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JP2016569825A Pending JP2017519740A (ja) 2014-05-28 2015-05-27 ドラプロイン‐ドライソロイインペプチド誘導体
JP2020081698A Active JP6995160B2 (ja) 2014-05-28 2020-05-07 ドラプロイン‐ドライソロイインペプチド誘導体
JP2021202579A Active JP7292366B2 (ja) 2014-05-28 2021-12-14 ドラプロイン‐ドライソロイインペプチド誘導体

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JP2020081698A Active JP6995160B2 (ja) 2014-05-28 2020-05-07 ドラプロイン‐ドライソロイインペプチド誘導体
JP2021202579A Active JP7292366B2 (ja) 2014-05-28 2021-12-14 ドラプロイン‐ドライソロイインペプチド誘導体

Country Status (9)

Country Link
US (3) US20170190735A1 (https=)
EP (1) EP3149024B9 (https=)
JP (3) JP2017519740A (https=)
KR (1) KR102413079B1 (https=)
CN (2) CN121949442A (https=)
ES (1) ES2883023T3 (https=)
RU (1) RU2747989C2 (https=)
SG (1) SG11201609739UA (https=)
WO (1) WO2015183978A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015183978A1 (en) * 2014-05-28 2015-12-03 Agensys, Inc. Derivatives of dolaproine-dolaisoleuine peptides
WO2017058808A1 (en) * 2015-10-02 2017-04-06 Sirenas Llc Anti-cancer compounds and conjugates thereof
EP4321522A1 (en) * 2022-08-12 2024-02-14 Seagen Inc. Cytotoxic compounds and conjugates thereof
CN120917016A (zh) * 2023-05-06 2025-11-07 荣昌生物制药(烟台)股份有限公司 一种奥瑞他汀衍生物中间体的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003054A1 (fr) * 1991-08-09 1993-02-18 Teikoku Hormone Mfg. Co., Ltd. Nouveau derive de tetrapeptide
WO1995009864A1 (en) * 1993-10-01 1995-04-13 Teikoku Hormone Mfg. Co., Ltd. Novel peptide derivative
JP2004531544A (ja) * 2001-04-30 2004-10-14 シアトル ジェネティクス，インコーポレーテッド ペンタペプチド化合物及びそれに関する使用
JP2014512375A (ja) * 2011-04-21 2014-05-22 シアトル ジェネティックス， インコーポレイテッド 新規な結合剤−薬物複合体（ａｄｃ）およびそれらの使用

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US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US6569834B1 (en) 1992-12-03 2003-05-27 George R. Pettit Elucidation and synthesis of antineoplastic tetrapeptide w-aminoalkyl-amides
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
JPH06234790A (ja) * 1993-02-09 1994-08-23 Teikoku Hormone Mfg Co Ltd 新規テトラペプチドアミド誘導体
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5521284A (en) * 1994-08-01 1996-05-28 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide amides and esters
US5663149A (en) 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
US20030083263A1 (en) * 2001-04-30 2003-05-01 Svetlana Doronina Pentapeptide compounds and uses related thereto
US7008928B2 (en) * 2001-09-20 2006-03-07 Teikoku Hormone Mfg. Co., Ltd. Tetrapeptide derivative TZT-1027 crystal
EP1675465B1 (en) 2003-10-22 2010-03-03 The Johns Hopkins University Improved combination bacteriolytic therapy for the treatment of tumors
CA2572318A1 (en) * 2004-07-02 2006-01-12 Neutec Pharma Plc Treatment of cancer
US8288352B2 (en) * 2004-11-12 2012-10-16 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the N terminus
US7608592B2 (en) 2005-06-30 2009-10-27 Virobay, Inc. HCV inhibitors
CN101242816B (zh) * 2005-06-30 2012-10-31 维罗贝股份有限公司 Hcv抑制剂
ES2708763T3 (es) * 2005-07-07 2019-04-11 Seattle Genetics Inc Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
CN101932598B (zh) 2008-01-30 2016-12-21 皮里斯股份公司 具有对人c-met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法
DK2265283T3 (da) * 2008-03-18 2014-10-20 Seattle Genetics Inc Auristatin-lægemiddel-linker-konjugater
US9120854B2 (en) * 2008-04-11 2015-09-01 Seattle Genetics, Inc. Detection and treatment of pancreatic, ovarian and other cancers
RU2566693C2 (ru) * 2011-07-08 2015-10-27 Сименс Акциенгезелльшафт Система слоев с двухслойным металлическим слоем
US20130190248A1 (en) * 2011-07-26 2013-07-25 Agensys, Inc. Substituted peptide analogs
CN104185477B (zh) * 2011-11-17 2017-05-24 辉瑞公司 细胞毒性肽及其抗体‑药物缀合物
CN104640572B (zh) * 2012-05-15 2018-04-27 索伦托医疗有限公司 药物偶联物，偶联方法，及其用途
KR101763499B1 (ko) * 2012-11-07 2017-07-31 화이자 인코포레이티드 항-il-13 수용체 알파 2 항체 및 항체-약물 접합체
CA2890571A1 (en) 2012-11-07 2014-05-15 Kenneth G. Geles Anti-notch3 antibodies and antibody-drug conjugates
WO2015183978A1 (en) * 2014-05-28 2015-12-03 Agensys, Inc. Derivatives of dolaproine-dolaisoleuine peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003054A1 (fr) * 1991-08-09 1993-02-18 Teikoku Hormone Mfg. Co., Ltd. Nouveau derive de tetrapeptide
WO1995009864A1 (en) * 1993-10-01 1995-04-13 Teikoku Hormone Mfg. Co., Ltd. Novel peptide derivative
JP2004531544A (ja) * 2001-04-30 2004-10-14 シアトル ジェネティクス，インコーポレーテッド ペンタペプチド化合物及びそれに関する使用
JP2014512375A (ja) * 2011-04-21 2014-05-22 シアトル ジェネティックス， インコーポレイテッド 新規な結合剤−薬物複合体（ａｄｃ）およびそれらの使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIYAZAKI ET AL., CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 1995, Vol.43, No.10, JPN6019015654, pages 1706 - 1718, ISSN: 0004026095 *

Also Published As

Publication number Publication date
EP3149024A1 (en) 2017-04-05
EP3149024B1 (en) 2021-05-12
CN107041139A (zh) 2017-08-11
EP3149024A4 (en) 2018-06-06
CN121949442A (zh) 2026-05-01
ES2883023T3 (es) 2021-12-03
RU2016150426A3 (https=) 2018-12-20
WO2015183978A1 (en) 2015-12-03
SG11201609739UA (en) 2016-12-29
JP2022027896A (ja) 2022-02-14
US20200325170A1 (en) 2020-10-15
JP2020128405A (ja) 2020-08-27
JP6995160B2 (ja) 2022-01-14
KR20170005495A (ko) 2017-01-13
JP7292366B2 (ja) 2023-06-16
RU2747989C2 (ru) 2021-05-18
US20170190735A1 (en) 2017-07-06
RU2016150426A (ru) 2018-07-03
US11312748B2 (en) 2022-04-26
KR102413079B1 (ko) 2022-06-24
US20220204557A1 (en) 2022-06-30
US12612429B2 (en) 2026-04-28
EP3149024B9 (en) 2021-10-27

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