JP2017518372A5 - - Google Patents
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- JP2017518372A5 JP2017518372A5 JP2017515026A JP2017515026A JP2017518372A5 JP 2017518372 A5 JP2017518372 A5 JP 2017518372A5 JP 2017515026 A JP2017515026 A JP 2017515026A JP 2017515026 A JP2017515026 A JP 2017515026A JP 2017518372 A5 JP2017518372 A5 JP 2017518372A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- complementary sequence
- guide rna
- ebv genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 75
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 42
- 108020005004 Guide RNA Proteins 0.000 claims description 38
- 239000013598 vector Substances 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 17
- 241000700605 Viruses Species 0.000 claims description 16
- 230000003612 virological effect Effects 0.000 claims description 15
- 108091033409 CRISPR Proteins 0.000 claims description 14
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- 239000013612 plasmid Substances 0.000 claims description 12
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- 108020004707 nucleic acids Proteins 0.000 claims description 7
- 102000039446 nucleic acids Human genes 0.000 claims description 7
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 239000013603 viral vector Substances 0.000 claims description 6
- 230000010076 replication Effects 0.000 claims description 5
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- 241001430294 unidentified retrovirus Species 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims 38
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
- 206010015108 Epstein-Barr virus infection Diseases 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 1
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- 101710163270 Nuclease Proteins 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 11
- 229940124597 therapeutic agent Drugs 0.000 description 11
- 241000282414 Homo sapiens Species 0.000 description 5
- 238000010354 CRISPR gene editing Methods 0.000 description 4
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- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 1
- 241001302512 Banna virus Species 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 201000003075 Crimean-Congo hemorrhagic fever Diseases 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 241000190708 Guanarito mammarenavirus Species 0.000 description 1
- 241000893570 Hendra henipavirus Species 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 208000005331 Hepatitis D Diseases 0.000 description 1
- 241000724675 Hepatitis E virus Species 0.000 description 1
- 241000709721 Hepatovirus A Species 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 101100325746 Homo sapiens BAK1 gene Proteins 0.000 description 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
- 241001479210 Human astrovirus Species 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 241000046923 Human bocavirus Species 0.000 description 1
- 241000342334 Human metapneumovirus Species 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- 241000702617 Human parvovirus B19 Species 0.000 description 1
- 241000829111 Human polyomavirus 1 Species 0.000 description 1
- 241000701460 JC polyomavirus Species 0.000 description 1
- 241000712890 Junin mammarenavirus Species 0.000 description 1
- 241000712902 Lassa mammarenavirus Species 0.000 description 1
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- 241001115401 Marburgvirus Species 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
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- 108020005091 Replication Origin Proteins 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 241000315672 SARS coronavirus Species 0.000 description 1
- 241000192617 Sabia mammarenavirus Species 0.000 description 1
- 238000010459 TALEN Methods 0.000 description 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 241000710886 West Nile virus Species 0.000 description 1
- 241000710772 Yellow fever virus Species 0.000 description 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
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- 230000002950 deficient Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005395P | 2014-05-30 | 2014-05-30 | |
| US62/005,395 | 2014-05-30 | ||
| US201462029072P | 2014-07-25 | 2014-07-25 | |
| US62/029,072 | 2014-07-25 | ||
| PCT/US2015/033186 WO2015184262A1 (en) | 2014-05-30 | 2015-05-29 | Compositions and methods of delivering treatments for latent viral infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017518372A JP2017518372A (ja) | 2017-07-06 |
| JP2017518372A5 true JP2017518372A5 (cg-RX-API-DMAC7.html) | 2018-07-05 |
Family
ID=53366336
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515025A Pending JP2017518075A (ja) | 2014-05-30 | 2015-05-29 | 潜伏性ウイルス感染を処置するための組成物および方法 |
| JP2017515026A Pending JP2017518372A (ja) | 2014-05-30 | 2015-05-29 | 潜伏性ウイルス感染用の処置剤を送達するための組成物および方法 |
| JP2019205922A Pending JP2020043862A (ja) | 2014-05-30 | 2019-11-14 | 潜伏性ウイルス感染を処置するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515025A Pending JP2017518075A (ja) | 2014-05-30 | 2015-05-29 | 潜伏性ウイルス感染を処置するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019205922A Pending JP2020043862A (ja) | 2014-05-30 | 2019-11-14 | 潜伏性ウイルス感染を処置するための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US20160060655A1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP3149171A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2017518075A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170005494A (cg-RX-API-DMAC7.html) |
| CN (2) | CN106574256A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2015266770A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016028023A2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2949710A1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201610028TA (cg-RX-API-DMAC7.html) |
| WO (3) | WO2015184262A1 (cg-RX-API-DMAC7.html) |
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| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
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| HUE040575T2 (hu) | 2013-04-16 | 2019-03-28 | Regeneron Pharma | A patkány genom célzott módosítása |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| KR20160060659A (ko) * | 2013-08-29 | 2016-05-30 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Hiv 감염증의 rna-유도 치료를 위한 방법 및 조성물 |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
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-
2015
- 2015-05-29 US US14/725,888 patent/US20160060655A1/en not_active Abandoned
- 2015-05-29 EP EP15729008.1A patent/EP3149171A1/en not_active Withdrawn
- 2015-05-29 CN CN201580029041.6A patent/CN106574256A/zh active Pending
- 2015-05-29 BR BR112016028023A patent/BR112016028023A2/pt not_active Application Discontinuation
- 2015-05-29 JP JP2017515025A patent/JP2017518075A/ja active Pending
- 2015-05-29 AU AU2015266770A patent/AU2015266770A1/en not_active Abandoned
- 2015-05-29 CA CA2949710A patent/CA2949710A1/en not_active Abandoned
- 2015-05-29 US US14/725,943 patent/US10066241B2/en not_active Expired - Fee Related
- 2015-05-29 WO PCT/US2015/033186 patent/WO2015184262A1/en not_active Ceased
- 2015-05-29 KR KR1020167036734A patent/KR20170005494A/ko not_active Withdrawn
- 2015-05-29 CN CN201580028992.1A patent/CN107002094A/zh active Pending
- 2015-05-29 JP JP2017515026A patent/JP2017518372A/ja active Pending
- 2015-05-29 AU AU2015266767A patent/AU2015266767A1/en not_active Abandoned
- 2015-05-29 CA CA2949713A patent/CA2949713A1/en not_active Abandoned
- 2015-05-29 EP EP15727838.3A patent/EP3149169A1/en not_active Withdrawn
- 2015-05-29 WO PCT/US2015/033180 patent/WO2015184259A1/en not_active Ceased
- 2015-05-29 SG SG11201610028TA patent/SG11201610028TA/en unknown
- 2015-05-29 AU AU2015266776A patent/AU2015266776A1/en not_active Abandoned
- 2015-05-29 EP EP15729007.3A patent/EP3149170A1/en not_active Withdrawn
- 2015-05-29 WO PCT/US2015/033199 patent/WO2015184268A1/en not_active Ceased
- 2015-07-02 US US14/790,748 patent/US9487802B2/en not_active Expired - Fee Related
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2016
- 2016-11-28 US US15/362,519 patent/US20170182190A1/en not_active Abandoned
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2018
- 2018-01-23 US US15/877,996 patent/US20190010518A1/en not_active Abandoned
- 2018-03-20 US US15/926,688 patent/US20190032090A1/en not_active Abandoned
- 2018-07-26 US US16/046,083 patent/US20190185882A1/en not_active Abandoned
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2019
- 2019-11-14 JP JP2019205922A patent/JP2020043862A/ja active Pending
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