JP2017518075A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017518075A5 JP2017518075A5 JP2017515025A JP2017515025A JP2017518075A5 JP 2017518075 A5 JP2017518075 A5 JP 2017518075A5 JP 2017515025 A JP2017515025 A JP 2017515025A JP 2017515025 A JP2017515025 A JP 2017515025A JP 2017518075 A5 JP2017518075 A5 JP 2017518075A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- composition
- virus
- hbv
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005395P | 2014-05-30 | 2014-05-30 | |
| US62/005,395 | 2014-05-30 | ||
| US201462029072P | 2014-07-25 | 2014-07-25 | |
| US62/029,072 | 2014-07-25 | ||
| PCT/US2015/033180 WO2015184259A1 (en) | 2014-05-30 | 2015-05-29 | Compositions and methods to treat latent viral infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019205922A Division JP2020043862A (ja) | 2014-05-30 | 2019-11-14 | 潜伏性ウイルス感染を処置するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017518075A JP2017518075A (ja) | 2017-07-06 |
| JP2017518075A5 true JP2017518075A5 (enExample) | 2018-07-05 |
Family
ID=53366336
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515025A Pending JP2017518075A (ja) | 2014-05-30 | 2015-05-29 | 潜伏性ウイルス感染を処置するための組成物および方法 |
| JP2017515026A Pending JP2017518372A (ja) | 2014-05-30 | 2015-05-29 | 潜伏性ウイルス感染用の処置剤を送達するための組成物および方法 |
| JP2019205922A Pending JP2020043862A (ja) | 2014-05-30 | 2019-11-14 | 潜伏性ウイルス感染を処置するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515026A Pending JP2017518372A (ja) | 2014-05-30 | 2015-05-29 | 潜伏性ウイルス感染用の処置剤を送達するための組成物および方法 |
| JP2019205922A Pending JP2020043862A (ja) | 2014-05-30 | 2019-11-14 | 潜伏性ウイルス感染を処置するための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US20160060655A1 (enExample) |
| EP (3) | EP3149169A1 (enExample) |
| JP (3) | JP2017518075A (enExample) |
| KR (1) | KR20170005494A (enExample) |
| CN (2) | CN107002094A (enExample) |
| AU (3) | AU2015266767A1 (enExample) |
| BR (1) | BR112016028023A2 (enExample) |
| CA (2) | CA2949713A1 (enExample) |
| SG (1) | SG11201610028TA (enExample) |
| WO (3) | WO2015184262A1 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| EP3919505B1 (en) | 2013-01-16 | 2023-08-30 | Emory University | Uses of cas9-nucleic acid complexes |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| CA2922428A1 (en) | 2013-08-29 | 2015-03-05 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for rna-guided treatment of hiv infection |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| KR20170005494A (ko) | 2014-05-30 | 2017-01-13 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 잠복 바이러스 감염에 대한 치료제를 전달하는 조성물 및 방법 |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CA2968440A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| WO2016089433A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| US10059940B2 (en) * | 2015-01-27 | 2018-08-28 | Minghong Zhong | Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| CA3000155A1 (en) * | 2015-05-29 | 2016-12-08 | Agenovir Corporation | Compositions and methods for cell targeted hpv treatment |
| US10117911B2 (en) | 2015-05-29 | 2018-11-06 | Agenovir Corporation | Compositions and methods to treat herpes simplex virus infections |
| EP3331582A4 (en) * | 2015-05-29 | 2019-08-07 | Agenovir Corporation | METHODS AND COMPOSITIONS FOR THE TREATMENT OF TRANSPLANTATION CELLS |
| US20160346362A1 (en) * | 2015-05-29 | 2016-12-01 | Agenovir Corporation | Methods and compositions for treating cytomegalovirus infections |
| HK1258900A1 (zh) * | 2015-09-29 | 2019-11-22 | 埃吉诺维亚公司 | 递送方法和组合物 |
| WO2017068077A1 (en) | 2015-10-20 | 2017-04-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and products for genetic engineering |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| WO2017100431A2 (en) * | 2015-12-09 | 2017-06-15 | Excision Biotherapeutics, Inc. | Gene editing methods and compositions for eliminating risk of jc virus activation and pml (progressive multifocal leukoencephalopathy) during immunosuppresive therapy |
| CA3011874A1 (en) * | 2016-01-25 | 2017-08-03 | Excision Biotherapeutics, Inc. | Methods and compositions for rna-guided treatment of hiv infection |
| RU2018130641A (ru) * | 2016-01-25 | 2020-02-26 | Эксижн Биотерапьютикс | Направляемое рнк, удаление вируса jc человека и других полиомавирусов |
| US20170246260A1 (en) * | 2016-02-25 | 2017-08-31 | Agenovir Corporation | Modified antiviral nuclease |
| WO2017147446A1 (en) * | 2016-02-25 | 2017-08-31 | Agenovir Corporation | Viral and oncoviral nuclease treatment |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| US20190093092A1 (en) * | 2016-05-05 | 2019-03-28 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided eradication of varicella zoster virus |
| WO2017197038A1 (en) * | 2016-05-10 | 2017-11-16 | United States Government As Represented By The Department Of Veterans Affairs | Lentiviral delivery of crispr/cas constructs that cleave genes essential for hiv-1 infection and replication |
| US20170332610A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| WO2017210380A1 (en) * | 2016-06-01 | 2017-12-07 | Excision Biotherapeutics, Inc. | Compositions and methods of treatment for lytic and lysogenic viruses |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| US20190335726A1 (en) * | 2016-06-14 | 2019-11-07 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018045284A1 (en) * | 2016-09-02 | 2018-03-08 | The General Hospital Corporation | Methods and systems for non-contact construction of an internal structure |
| FI3526323T3 (fi) | 2016-10-14 | 2023-06-06 | Prec Biosciences Inc | Hepatiitti B -viruksen genomissa oleville tunnistussekvensseille spesifisiä muokattuja meganukleaaseja |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| US11584931B2 (en) | 2016-12-14 | 2023-02-21 | The J. David Gladstone Institutes | Methods and compositions for generating a deletion library and for identifying a defective interfering particle (DIP) |
| CN106729753A (zh) * | 2016-12-16 | 2017-05-31 | 谭旭 | 抗乙型肝炎病毒的递送系统和生物制剂 |
| WO2018118587A1 (en) * | 2016-12-22 | 2018-06-28 | Agenovir Corporation | Modified polynucleotides for antiviral therapy |
| WO2018118586A1 (en) * | 2016-12-22 | 2018-06-28 | Agenovir Corporation | Antiviral/endogenous combination therapy |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| WO2018136396A2 (en) * | 2017-01-18 | 2018-07-26 | Excision Biotherapeutics, Inc. | Crisprs |
| US20190071673A1 (en) * | 2017-01-18 | 2019-03-07 | Thomas Malcolm | CRISPRs WITH IMPROVED SPECIFICITY |
| CA3047350A1 (en) * | 2017-01-26 | 2018-08-02 | Excision Biotherapeutics, Inc. | Lentivirus and non-integrating lentivirus as viral vector to deliver crispr therapeutic |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN118581154A (zh) * | 2017-06-02 | 2024-09-03 | 国家健康与医学研究院 | 用于遗传障碍的基因疗法的基因组编辑手段和结合病毒载体的基因疗法 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| CA3073937A1 (en) * | 2017-08-25 | 2019-02-28 | Ovid Therapeutics Inc. | Recombinant adeno-associated vectors |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| TW201945388A (zh) | 2018-04-12 | 2019-12-01 | 美商精密生物科學公司 | 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶 |
| JP7399876B2 (ja) * | 2018-04-16 | 2023-12-18 | ジョージア テック リサーチ コーポレーション | 病態治療のためのRNAエディターのmRNA駆動型発現 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN109943563A (zh) * | 2019-03-08 | 2019-06-28 | 内蒙古大学 | CRISPR-Cas9系统介导的狂犬病病毒基因组敲除的方法 |
| EP3942043A2 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12614611B2 (en) * | 2019-06-06 | 2026-04-28 | Tata Consultancy Services Limited | Method and system for identification of candidate target sites for combating pathogens |
| CN112168808B (zh) * | 2019-07-02 | 2023-01-24 | 深圳市第二人民医院 | 一种基于crispr的细胞核靶向药物递送系统 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| ES3022990T3 (en) | 2019-12-06 | 2025-05-29 | Prec Biosciences Inc | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| CN112795696A (zh) * | 2020-12-31 | 2021-05-14 | 北京思尔成生物技术有限公司 | 乙型肝炎病毒pgRNA芯片数字PCR绝对定量检测试剂盒及方法 |
| EP4351660A2 (en) | 2021-06-09 | 2024-04-17 | Scribe Therapeutics Inc. | Particle delivery systems |
| WO2023039586A1 (en) | 2021-09-10 | 2023-03-16 | Agilent Technologies, Inc. | Guide rnas with chemical modification for prime editing |
| CN114196556B (zh) * | 2021-12-31 | 2023-08-01 | 重庆大学 | 一种高毒力蝗绿僵菌菌株及其构建方法 |
| CN117065052A (zh) * | 2022-05-16 | 2023-11-17 | 上海行深生物科技有限公司 | 递送自复制rna分子的方法 |
| IL324634A (en) | 2023-05-15 | 2026-01-01 | Nchroma Bio Inc | Compositions and methods for epigenetic regulation of hbv gene expression |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1003131A (en) * | 1910-08-17 | 1911-09-12 | Leonard F Bellingrath | Valve operating and indicating mechanism. |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5208036A (en) | 1985-01-07 | 1993-05-04 | Syntex (U.S.A.) Inc. | N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| AU7979491A (en) | 1990-05-03 | 1991-11-27 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5580571A (en) | 1991-10-15 | 1996-12-03 | Hostetler; Karl Y. | Nucleoside analogues |
| SE9200951D0 (sv) | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical composition containing a defined lipid system |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| WO1993023569A1 (en) * | 1992-05-11 | 1993-11-25 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
| EP0702516A4 (en) | 1993-06-01 | 1998-04-22 | Life Technologies Inc | GENETIC IMMUNIZATION WITH CATIONIC LIPIDS |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| CA2196419C (en) | 1994-08-20 | 2007-08-21 | Yen Choo | Improvements in or relating to binding proteins for recognition of dna |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| US6383481B1 (en) | 1998-03-30 | 2002-05-07 | Japan Immunoresearch Laboratories Co., Ltd. | Method for transplantation of hemopoietic stem cells |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| WO2001037868A1 (en) * | 1999-11-24 | 2001-05-31 | Oklahoma Medical Research Foundation | Assays and therapies for latent viral infection |
| WO2004027036A2 (en) * | 2002-09-19 | 2004-04-01 | Johns Hopkins University School Of Medicine | Cancer immunotherapy with a viral antigen-defined, immunomodulator-secreting cell vaccine |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| CN101144817B (zh) * | 2003-08-20 | 2011-10-05 | 香港神农有限公司 | 一种eb病毒蛋白酶联免疫吸附诊断试剂盒及其制备方法 |
| WO2005028634A2 (en) | 2003-09-18 | 2005-03-31 | Emory University | Improved mva vaccines |
| EP2410043A3 (en) | 2004-12-29 | 2013-01-23 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
| EP2650366B1 (en) * | 2005-10-18 | 2017-03-22 | Precision Biosciences | Rationally designed meganucleases with altered sequence specificity and DNA-binding affinity |
| CA2630218A1 (en) | 2005-11-18 | 2007-08-30 | The Ohio State University Research Foundation | Viral gene products and methods for vaccination to prevent viral associated diseases |
| GB0526211D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| JP5266210B2 (ja) | 2006-05-25 | 2013-08-21 | サンガモ バイオサイエンシズ インコーポレイテッド | 改変開裂ハーフドメイン |
| WO2009024834A2 (en) * | 2006-12-05 | 2009-02-26 | Rosetta Genomics Ltd | Nucleic acids involved in viral infection |
| US20100076057A1 (en) | 2008-09-23 | 2010-03-25 | Northwestern University | TARGET DNA INTERFERENCE WITH crRNA |
| US20110023144A1 (en) | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Genomic editing of genes involved in amyotrophyic lateral sclerosis disease |
| CN101880649B (zh) | 2009-05-05 | 2012-09-05 | 中国福利会国际和平妇幼保健院 | 一种干细胞培养方法 |
| US10238734B2 (en) * | 2010-03-23 | 2019-03-26 | The Regents Of The University Of California | Compositions and methods for self-adjuvanting vaccines against microbes and tumors |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| CN103361328B (zh) * | 2012-03-30 | 2017-08-18 | 复旦大学 | 介导整合的hiv‑1前病毒基因敲除的锌指核酸内切酶及其制法和应用 |
| LT3401400T (lt) | 2012-05-25 | 2019-06-10 | The Regents Of The University Of California | Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui |
| US9102936B2 (en) | 2012-06-11 | 2015-08-11 | Agilent Technologies, Inc. | Method of adaptor-dimer subtraction using a CRISPR CAS6 protein |
| WO2014071235A1 (en) * | 2012-11-01 | 2014-05-08 | Massachusetts Institute Of Technology | Genetic device for the controlled destruction of dna |
| WO2014093479A1 (en) | 2012-12-11 | 2014-06-19 | Montana State University | Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation |
| IL239317B (en) * | 2012-12-12 | 2022-07-01 | Broad Inst Inc | Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications |
| ES2576126T3 (es) | 2012-12-12 | 2016-07-05 | The Broad Institute, Inc. | Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias |
| JP2016504026A (ja) | 2012-12-12 | 2016-02-12 | ザ・ブロード・インスティテュート・インコーポレイテッド | 配列操作のための系、方法および最適化ガイド組成物のエンジニアリング |
| EP2896697B1 (en) | 2012-12-12 | 2015-09-02 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| SG10201912991WA (en) | 2012-12-17 | 2020-03-30 | Harvard College | Rna-guided human genome engineering |
| EP3919505B1 (en) | 2013-01-16 | 2023-08-30 | Emory University | Uses of cas9-nucleic acid complexes |
| US10660943B2 (en) | 2013-02-07 | 2020-05-26 | The Rockefeller University | Sequence specific antimicrobials |
| US10612043B2 (en) | 2013-03-09 | 2020-04-07 | Agilent Technologies, Inc. | Methods of in vivo engineering of large sequences using multiple CRISPR/cas selections of recombineering events |
| SG11201507378UA (en) | 2013-03-14 | 2015-10-29 | Caribou Biosciences Inc | Compositions and methods of nucleic acid-targeting nucleic acids |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| US20140349400A1 (en) | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| US10378027B2 (en) | 2013-03-15 | 2019-08-13 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| JP6576904B2 (ja) | 2013-04-04 | 2019-09-18 | トラスティーズ・オブ・ダートマス・カレッジ | HIV−1プロウイルスDNAのinvivo切除のための組成物及び方法 |
| WO2014172470A2 (en) | 2013-04-16 | 2014-10-23 | Whitehead Institute For Biomedical Research | Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal |
| EP3730615A3 (en) | 2013-05-15 | 2020-12-09 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a genetic condition |
| US11414695B2 (en) | 2013-05-29 | 2022-08-16 | Agilent Technologies, Inc. | Nucleic acid enrichment using Cas9 |
| KR20260047646A (ko) | 2013-07-09 | 2026-04-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 멀티플렉스 rna-가이드된 게놈 조작 |
| JP6482546B2 (ja) | 2013-07-19 | 2019-03-13 | ラリクス・バイオサイエンス・リミテッド・ライアビリティ・カンパニーLarix Bioscience, Llc | 二重対立遺伝子ノックアウトを生成するための方法および組成物 |
| CA2922428A1 (en) | 2013-08-29 | 2015-03-05 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for rna-guided treatment of hiv infection |
| US10760065B2 (en) | 2013-09-05 | 2020-09-01 | Massachusetts Institute Of Technology | Tuning microbial populations with programmable nucleases |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| RU2016128077A (ru) * | 2013-12-12 | 2018-12-06 | Те Брод Инститьют Инк. | Доставка, применение и применения в терапии систем и композиций crispr-cas для лечения обусловленных hbv и вирусных заболеваний и нарушений |
| BR112016013213A2 (pt) | 2013-12-12 | 2017-12-05 | Massachusetts Inst Technology | administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas |
| AU2014368982B2 (en) | 2013-12-19 | 2021-03-25 | Amyris, Inc. | Methods for genomic integration |
| EP3107999A4 (en) | 2014-02-18 | 2017-10-04 | Duke University | Compositions for the inactivation of virus replication and methods of making and using the same |
| WO2015153889A2 (en) | 2014-04-02 | 2015-10-08 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| CN103911376B (zh) | 2014-04-03 | 2017-02-15 | 黄行许 | CRISPR‑Cas9靶向敲除乙肝病毒cccDNA及其特异性sgRNA |
| KR20170005494A (ko) | 2014-05-30 | 2017-01-13 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 잠복 바이러스 감염에 대한 치료제를 전달하는 조성물 및 방법 |
-
2015
- 2015-05-29 KR KR1020167036734A patent/KR20170005494A/ko not_active Withdrawn
- 2015-05-29 WO PCT/US2015/033186 patent/WO2015184262A1/en not_active Ceased
- 2015-05-29 AU AU2015266767A patent/AU2015266767A1/en not_active Abandoned
- 2015-05-29 EP EP15727838.3A patent/EP3149169A1/en not_active Withdrawn
- 2015-05-29 EP EP15729007.3A patent/EP3149170A1/en not_active Withdrawn
- 2015-05-29 WO PCT/US2015/033180 patent/WO2015184259A1/en not_active Ceased
- 2015-05-29 AU AU2015266776A patent/AU2015266776A1/en not_active Abandoned
- 2015-05-29 EP EP15729008.1A patent/EP3149171A1/en not_active Withdrawn
- 2015-05-29 JP JP2017515025A patent/JP2017518075A/ja active Pending
- 2015-05-29 CN CN201580028992.1A patent/CN107002094A/zh active Pending
- 2015-05-29 AU AU2015266770A patent/AU2015266770A1/en not_active Abandoned
- 2015-05-29 WO PCT/US2015/033199 patent/WO2015184268A1/en not_active Ceased
- 2015-05-29 US US14/725,888 patent/US20160060655A1/en not_active Abandoned
- 2015-05-29 BR BR112016028023A patent/BR112016028023A2/pt not_active Application Discontinuation
- 2015-05-29 US US14/725,943 patent/US10066241B2/en not_active Expired - Fee Related
- 2015-05-29 SG SG11201610028TA patent/SG11201610028TA/en unknown
- 2015-05-29 CA CA2949713A patent/CA2949713A1/en not_active Abandoned
- 2015-05-29 CN CN201580029041.6A patent/CN106574256A/zh active Pending
- 2015-05-29 CA CA2949710A patent/CA2949710A1/en not_active Abandoned
- 2015-05-29 JP JP2017515026A patent/JP2017518372A/ja active Pending
- 2015-07-02 US US14/790,748 patent/US9487802B2/en not_active Expired - Fee Related
-
2016
- 2016-11-28 US US15/362,519 patent/US20170182190A1/en not_active Abandoned
-
2018
- 2018-01-23 US US15/877,996 patent/US20190010518A1/en not_active Abandoned
- 2018-03-20 US US15/926,688 patent/US20190032090A1/en not_active Abandoned
- 2018-07-26 US US16/046,083 patent/US20190185882A1/en not_active Abandoned
-
2019
- 2019-11-14 JP JP2019205922A patent/JP2020043862A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017518372A5 (enExample) | ||
| JP2018516984A5 (enExample) | ||
| JP2020043862A (ja) | 潜伏性ウイルス感染を処置するための組成物および方法 | |
| AU2017219605B2 (en) | Excision of retroviral nucleic acid sequences | |
| AU2016270702B2 (en) | Methods and compositions for RNA-guided treatment of HIV infection | |
| Vannucci et al. | Viral vectors: a look back and ahead on gene transfer technology | |
| RU2018124657A (ru) | Способы редактирования генов и композиции для устранения риска активации вируса jc и пмл (прогрессирующая мультифокальная лейкоэнцефалопатия) во время иммуносупрессивной терапии | |
| JP2018532403A5 (enExample) | ||
| Sun et al. | Advances in therapeutic application of CRISPR-Cas9 | |
| JP2020511931A5 (enExample) | ||
| Herskovitz et al. | Pathways toward a functional HIV-1 cure: Balancing promise and perils of CRISPR therapy | |
| Small et al. | The effect of adenovirus-specific antibodies on adenoviral vector–induced, transgene product–specific T cell responses | |
| CN108103094B (zh) | 用于靶向抑制hiv-1前病毒表达的表达载体及其制备方法和应用 | |
| MX354571B (es) | Genomas lentivirales quimericos no integrativos como vacunas innovadoras contra el virus de la inmunodeficiencia humana tipo 1 (vih-1). | |
| Solanki et al. | CRISPR-Cas based genome editing for eradication of human viruses | |
| Shoji et al. | Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa | |
| De Clercq | Status presens of antiviral drugs and strategies: Part II: RNA VIRUSES (EXCEPT RETROVIRUSES) | |
| Khudhur | Utilizing CRISPR Technology to Develop Vaccinations and Treatments Against Viruses | |
| Mayes | CRISPR Technology as an Antiviral in dsDNA and ssRNA Viruses | |
| Kundu et al. | Developing New Molecular-Targeted Therapeutics,‘from Gene to Drug' | |
| Pattacini | The perils of cutting what you cannot see | |
| Dev et al. | Letters in Animal Biology |