JP2018516983A5 - - Google Patents
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- Publication number
- JP2018516983A5 JP2018516983A5 JP2018513744A JP2018513744A JP2018516983A5 JP 2018516983 A5 JP2018516983 A5 JP 2018516983A5 JP 2018513744 A JP2018513744 A JP 2018513744A JP 2018513744 A JP2018513744 A JP 2018513744A JP 2018516983 A5 JP2018516983 A5 JP 2018516983A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- nucleic acid
- item
- hsv
- guide rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims description 40
- 102000039446 nucleic acids Human genes 0.000 claims description 40
- 150000007523 nucleic acids Chemical class 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 35
- 241000700584 Simplexvirus Species 0.000 claims description 32
- 108091033409 CRISPR Proteins 0.000 claims description 21
- 108020005004 Guide RNA Proteins 0.000 claims description 19
- 239000013598 vector Substances 0.000 claims description 14
- 230000000295 complement effect Effects 0.000 claims description 12
- 239000002105 nanoparticle Substances 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 102000004389 Ribonucleoproteins Human genes 0.000 claims description 6
- 108010081734 Ribonucleoproteins Proteins 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 6
- 229920006317 cationic polymer Polymers 0.000 claims description 6
- 239000002502 liposome Substances 0.000 claims description 6
- 239000002082 metal nanoparticle Substances 0.000 claims description 6
- 239000002073 nanorod Substances 0.000 claims description 6
- 229940037201 oris Drugs 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 241000710929 Alphavirus Species 0.000 claims description 5
- 241000702421 Dependoparvovirus Species 0.000 claims description 5
- 241000713666 Lentivirus Species 0.000 claims description 5
- 241000700618 Vaccinia virus Species 0.000 claims description 5
- 239000013612 plasmid Substances 0.000 claims description 5
- 241000701161 unidentified adenovirus Species 0.000 claims description 5
- 241001529453 unidentified herpesvirus Species 0.000 claims description 5
- 241001430294 unidentified retrovirus Species 0.000 claims description 5
- -1 cationic lipid Chemical class 0.000 claims description 4
- 229940100613 topical solution Drugs 0.000 claims description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 3
- 230000010076 replication Effects 0.000 claims description 3
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 208000009889 Herpes Simplex Diseases 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 description 45
- 241000701022 Cytomegalovirus Species 0.000 description 31
- 230000008685 targeting Effects 0.000 description 15
- 208000015181 infectious disease Diseases 0.000 description 6
- 238000010459 TALEN Methods 0.000 description 5
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 description 5
- 108010017070 Zinc Finger Nucleases Proteins 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 4
- 239000013603 viral vector Substances 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 238000010354 CRISPR gene editing Methods 0.000 description 3
- 230000005782 double-strand break Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 238000001216 nucleic acid method Methods 0.000 description 3
- 230000009870 specific binding Effects 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- 108020005091 Replication Origin Proteins 0.000 description 1
- 230000005889 cellular cytotoxicity Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000009295 sperm incapacitation Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168259P | 2015-05-29 | 2015-05-29 | |
| US201562168262P | 2015-05-29 | 2015-05-29 | |
| US62/168,262 | 2015-05-29 | ||
| US62/168,259 | 2015-05-29 | ||
| PCT/US2016/034606 WO2016196273A1 (en) | 2015-05-29 | 2016-05-27 | Compositions and methods to treat viral infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018516983A JP2018516983A (ja) | 2018-06-28 |
| JP2018516983A5 true JP2018516983A5 (enExample) | 2019-06-27 |
Family
ID=57441664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513744A Pending JP2018516983A (ja) | 2015-05-29 | 2016-05-27 | ウイルス感染を処置するための組成物および方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3331571A4 (enExample) |
| JP (1) | JP2018516983A (enExample) |
| CA (1) | CA3000189A1 (enExample) |
| WO (1) | WO2016196273A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| EP4079847A1 (en) | 2014-07-30 | 2022-10-26 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| GB2543873A (en) * | 2015-05-29 | 2017-05-03 | Agenovir Corp | Compositions and methods for cell targeted HPV treatment |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3794130A4 (en) | 2018-05-16 | 2022-07-27 | Synthego Corporation | METHODS AND SYSTEMS FOR DESIGNING AND USING GUIDE RNA |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| GB2614813B (en) | 2020-05-08 | 2025-05-07 | Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| EP4179085A1 (en) * | 2020-07-07 | 2023-05-17 | Oriengene Biotechnology Ltd | Guide rna for hsv-1 gene editing and method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150098954A1 (en) * | 2013-10-08 | 2015-04-09 | Elwha Llc | Compositions and Methods Related to CRISPR Targeting |
-
2016
- 2016-05-27 CA CA3000189A patent/CA3000189A1/en not_active Abandoned
- 2016-05-27 EP EP16804107.7A patent/EP3331571A4/en not_active Withdrawn
- 2016-05-27 WO PCT/US2016/034606 patent/WO2016196273A1/en not_active Ceased
- 2016-05-27 JP JP2018513744A patent/JP2018516983A/ja active Pending
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