JP2018532403A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018532403A5 JP2018532403A5 JP2018516030A JP2018516030A JP2018532403A5 JP 2018532403 A5 JP2018532403 A5 JP 2018532403A5 JP 2018516030 A JP2018516030 A JP 2018516030A JP 2018516030 A JP2018516030 A JP 2018516030A JP 2018532403 A5 JP2018532403 A5 JP 2018532403A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- item
- tissue
- guide rna
- genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562234340P | 2015-09-29 | 2015-09-29 | |
| US62/234,340 | 2015-09-29 | ||
| PCT/US2016/053960 WO2017058793A1 (en) | 2015-09-29 | 2016-09-27 | Delivery methods and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532403A JP2018532403A (ja) | 2018-11-08 |
| JP2018532403A5 true JP2018532403A5 (enExample) | 2019-10-31 |
Family
ID=58408949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516030A Pending JP2018532403A (ja) | 2015-09-29 | 2016-09-27 | 送達方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20170087224A1 (enExample) |
| EP (1) | EP3355954A4 (enExample) |
| JP (1) | JP2018532403A (enExample) |
| CN (1) | CN108601883A (enExample) |
| AU (1) | AU2016332704A1 (enExample) |
| CA (1) | CA2999922A1 (enExample) |
| HK (1) | HK1258900A1 (enExample) |
| WO (1) | WO2017058793A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| EP4079847A1 (en) | 2014-07-30 | 2022-10-26 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| AU2017289267B2 (en) | 2016-06-27 | 2021-08-12 | Galvanize Therapeutics, Inc. | Generator and a catheter with an electrode and a method for treating a lung passageway |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| JP2021508533A (ja) | 2017-12-26 | 2021-03-11 | ギャラリー，インコーポレイテッド | 様々な用途のためのエネルギー送達の最適化 |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020015279A1 (zh) * | 2018-07-17 | 2020-01-23 | 杭州观梓健康科技有限公司 | 一种在干细胞中进行基因定向敲入的方法 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US20220001027A1 (en) * | 2018-11-15 | 2022-01-06 | President And Fellows Of Harvard College | Genetically Engineered Skin Cells for the Systemic In Vivo Treatment of Deficient Enzymes, Factors or Proteins |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
| TWI874374B (zh) * | 2019-03-25 | 2025-03-01 | 香港中文大學 | 確定循環核酸之線性及環狀形式 |
| IL285920B2 (en) * | 2019-04-08 | 2025-03-01 | Velanidi Tech Llc | System, apparatus and method for sensing, detecting and effecting in a micro-to-nano environment |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| GB2614813B (en) | 2020-05-08 | 2025-05-07 | Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| EP4157226B1 (en) * | 2020-05-29 | 2025-11-12 | Georgia Tech Research Corporation | Devices and systems for facilitating tissue delivery of drug |
| CN116829691A (zh) * | 2020-08-04 | 2023-09-29 | 盖能适治疗股份有限公司 | 分子到体内细胞的脉冲电场转移 |
| CN112807273B (zh) * | 2021-02-23 | 2022-06-17 | 浙江大学 | 一种治疗炎症性皮肤病的基因编辑微针及其应用 |
| JP2023094496A (ja) * | 2021-12-23 | 2023-07-05 | 委子 陌間 | 抗菌・ウイルス治療薬の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
| CA2452653A1 (en) * | 2001-07-17 | 2003-01-30 | Anne Josephine Milner | Silencing of gene expression by sirna |
| CA2788560A1 (en) * | 2010-02-08 | 2011-08-11 | Sangamo Biosciences, Inc. | Engineered cleavage half-domains |
| WO2011109735A2 (en) * | 2010-03-05 | 2011-09-09 | Cornell University | Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly |
| EP3080261B1 (en) * | 2013-12-12 | 2019-05-22 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders |
| CA2940084A1 (en) * | 2014-02-18 | 2015-08-27 | Duke University | Compositions for the inactivation of virus replication and methods of making and using the same |
| JP2017518372A (ja) * | 2014-05-30 | 2017-07-06 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 潜伏性ウイルス感染用の処置剤を送達するための組成物および方法 |
| GB2543873A (en) * | 2015-05-29 | 2017-05-03 | Agenovir Corp | Compositions and methods for cell targeted HPV treatment |
| CA3015353A1 (en) * | 2016-02-25 | 2017-08-31 | Agenovir Corporation | Viral and oncoviral nuclease treatment |
-
2016
- 2016-09-27 EP EP16852411.4A patent/EP3355954A4/en not_active Withdrawn
- 2016-09-27 WO PCT/US2016/053960 patent/WO2017058793A1/en not_active Ceased
- 2016-09-27 JP JP2018516030A patent/JP2018532403A/ja active Pending
- 2016-09-27 AU AU2016332704A patent/AU2016332704A1/en not_active Abandoned
- 2016-09-27 CA CA2999922A patent/CA2999922A1/en not_active Abandoned
- 2016-09-27 CN CN201680068693.5A patent/CN108601883A/zh active Pending
- 2016-09-27 HK HK19101376.1A patent/HK1258900A1/zh unknown
- 2016-09-27 US US15/277,595 patent/US20170087224A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018532403A5 (enExample) | ||
| Liu et al. | Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications | |
| JP2018532403A (ja) | 送達方法および組成物 | |
| Yadav et al. | Biomedical applications of nanomaterials in the advancement of nucleic acid therapy: mechanistic challenges, delivery strategies, and therapeutic applications | |
| JP2020043862A (ja) | 潜伏性ウイルス感染を処置するための組成物および方法 | |
| JP2018516983A5 (enExample) | ||
| Walsh et al. | Ultrasonic particles: An approach for targeted gene delivery | |
| EP4180526A3 (en) | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof | |
| JP2019508051A5 (enExample) | ||
| JP2018516984A5 (enExample) | ||
| Lin et al. | The use of CRISPR/Cas9 as a tool to study human infectious viruses | |
| Feng et al. | Strategies for high-efficiency mutation using the CRISPR/Cas system | |
| CN104805078A (zh) | 用于高效基因组编辑的rna分子的设计、合成及其应用 | |
| WO2018183808A9 (en) | Antiviral therapeutic | |
| Dai et al. | Innovative Precision Gene‐Editing Tools in Personalized Cancer Medicine | |
| Soriano | Gene Therapy with CRISPR/Cas9 Coming to Age for HIV Cure. | |
| AU2019382824A8 (en) | Method and means to deliver miRNA to target cells | |
| Marie et al. | Antibiotic-free gene vectors: A 25-year journey to clinical trials | |
| Bhattacharjee et al. | CRISPR/Cas9 genome editing system in the diagnosis and treatment of cancer. | |
| CN102206680B (zh) | 基于短链核酸片段的基因电转染缓冲液及其制备和应用方法 | |
| Bloom et al. | Recent advances in use of gene therapy to treat hepatitis B virus infection | |
| Hussain et al. | Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy | |
| Sharaf-Eldin | Technologies of gene editing and related clinical trials for the treatment of genetic and acquired diseases: a systematic review | |
| CN104404076A (zh) | 利用锌指核酸酶敲除人乳头瘤病毒e6e7基因的方法 | |
| Kharwade et al. | CRISPR-Cas9 in Drug Discovery: Potential Applications and Ethical consideration |