JP2017516823A5 - - Google Patents
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- JP2017516823A5 JP2017516823A5 JP2016570986A JP2016570986A JP2017516823A5 JP 2017516823 A5 JP2017516823 A5 JP 2017516823A5 JP 2016570986 A JP2016570986 A JP 2016570986A JP 2016570986 A JP2016570986 A JP 2016570986A JP 2017516823 A5 JP2017516823 A5 JP 2017516823A5
- Authority
- JP
- Japan
- Prior art keywords
- dgla
- disease
- pharmaceutical composition
- skin
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims description 68
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims description 68
- 239000000126 substance Substances 0.000 claims description 2
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims 67
- 239000008194 pharmaceutical composition Substances 0.000 claims 26
- 235000014113 dietary fatty acids Nutrition 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 229930195729 fatty acid Natural products 0.000 claims 13
- 239000000194 fatty acid Substances 0.000 claims 13
- 150000004665 fatty acids Chemical class 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 239000002775 capsule Substances 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 8
- 208000017520 skin disease Diseases 0.000 claims 8
- 206010047302 ventricular tachycardia Diseases 0.000 claims 8
- 206010061592 cardiac fibrillation Diseases 0.000 claims 7
- 230000002600 fibrillogenic effect Effects 0.000 claims 7
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims 6
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 6
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 6
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 6
- 235000021297 Eicosadienoic acid Nutrition 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 206010019280 Heart failures Diseases 0.000 claims 6
- 239000005642 Oleic acid Substances 0.000 claims 6
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 6
- 208000003734 Supraventricular Tachycardia Diseases 0.000 claims 6
- 206010012601 diabetes mellitus Diseases 0.000 claims 6
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 6
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 5
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims 5
- 235000021313 oleic acid Nutrition 0.000 claims 5
- 208000002874 Acne Vulgaris Diseases 0.000 claims 4
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 4
- 108010010803 Gelatin Proteins 0.000 claims 4
- 208000030673 Homozygous familial hypercholesterolemia Diseases 0.000 claims 4
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 4
- 206010030113 Oedema Diseases 0.000 claims 4
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims 4
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 4
- 206010000496 acne Diseases 0.000 claims 4
- 208000029078 coronary artery disease Diseases 0.000 claims 4
- 239000008273 gelatin Substances 0.000 claims 4
- 229920000159 gelatin Polymers 0.000 claims 4
- 235000019322 gelatine Nutrition 0.000 claims 4
- 235000011852 gelatine desserts Nutrition 0.000 claims 4
- 208000017169 kidney disease Diseases 0.000 claims 4
- 201000006370 kidney failure Diseases 0.000 claims 4
- 230000000306 recurrent effect Effects 0.000 claims 4
- 208000003663 ventricular fibrillation Diseases 0.000 claims 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 3
- 206010063985 Phytosterolaemia Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 3
- 208000025747 Rheumatic disease Diseases 0.000 claims 3
- 208000002227 Sitosterolemia Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 206010003267 Arthritis reactive Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010003662 Atrial flutter Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010011803 Cystocele Diseases 0.000 claims 2
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 2
- 206010013786 Dry skin Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 206010014522 Embolism venous Diseases 0.000 claims 2
- 208000007530 Essential hypertension Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010021639 Incontinence Diseases 0.000 claims 2
- 208000004575 Infectious Arthritis Diseases 0.000 claims 2
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 2
- 206010029279 Neurogenic bladder Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 241000736199 Paeonia Species 0.000 claims 2
- 235000006484 Paeonia officinalis Nutrition 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 208000004717 Ruptured Aneurysm Diseases 0.000 claims 2
- 208000007718 Stable Angina Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000001871 Tachycardia Diseases 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000012931 Urologic disease Diseases 0.000 claims 2
- 206010047249 Venous thrombosis Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 206010000891 acute myocardial infarction Diseases 0.000 claims 2
- 230000003712 anti-aging effect Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 230000037336 dry skin Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 230000036074 healthy skin Effects 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 208000006750 hematuria Diseases 0.000 claims 2
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 208000019267 mild heart failure Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 230000001314 paroxysmal effect Effects 0.000 claims 2
- 230000003711 photoprotective effect Effects 0.000 claims 2
- 230000036470 plasma concentration Effects 0.000 claims 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims 2
- 208000017497 prostate disease Diseases 0.000 claims 2
- 230000004224 protection Effects 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 208000002574 reactive arthritis Diseases 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 201000001223 septic arthritis Diseases 0.000 claims 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 2
- 230000006794 tachycardia Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 208000014001 urinary system disease Diseases 0.000 claims 2
- 208000019206 urinary tract infection Diseases 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 208000004043 venous thromboembolism Diseases 0.000 claims 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- 229940084778 1,4-sorbitan Drugs 0.000 claims 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010065929 Cardiovascular insufficiency Diseases 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 208000011191 Pulmonary vascular disease Diseases 0.000 claims 1
- 208000033626 Renal failure acute Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 208000026723 Urinary tract disease Diseases 0.000 claims 1
- 206010047370 Vesicoureteric reflux Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 230000001746 atrial effect Effects 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 210000002837 heart atrium Anatomy 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 229940057917 medium chain triglycerides Drugs 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 208000017443 reproductive system disease Diseases 0.000 claims 1
- 230000000552 rheumatic effect Effects 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 210000000115 thoracic cavity Anatomy 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
- 201000008618 vesicoureteral reflux Diseases 0.000 claims 1
- 208000031355 vesicoureteral reflux 1 Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 description 2
- 229960004195 carvedilol Drugs 0.000 description 2
- 238000013480 data collection Methods 0.000 description 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 2
- 229960001802 phenylephrine Drugs 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007752P | 2014-06-04 | 2014-06-04 | |
| US62/007,752 | 2014-06-04 | ||
| US201462058469P | 2014-10-01 | 2014-10-01 | |
| US62/058,469 | 2014-10-01 | ||
| PCT/EP2015/062518 WO2015185698A1 (en) | 2014-06-04 | 2015-06-04 | Pharmaceutical compositions comprising dgla and use of same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020003665A Division JP2020090508A (ja) | 2014-06-04 | 2020-01-14 | Ｄｇｌａを含む薬学的組成物及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017516823A JP2017516823A (ja) | 2017-06-22 |
| JP2017516823A5 true JP2017516823A5 (https=) | 2018-09-20 |
Family
ID=53298373
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570986A Pending JP2017516823A (ja) | 2014-06-04 | 2015-06-04 | Ｄｇｌａを含む薬学的組成物及びその使用 |
| JP2020003665A Withdrawn JP2020090508A (ja) | 2014-06-04 | 2020-01-14 | Ｄｇｌａを含む薬学的組成物及びその使用 |
| JP2022030554A Pending JP2022071061A (ja) | 2014-06-04 | 2022-03-01 | Ｄｇｌａを含む薬学的組成物及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020003665A Withdrawn JP2020090508A (ja) | 2014-06-04 | 2020-01-14 | Ｄｇｌａを含む薬学的組成物及びその使用 |
| JP2022030554A Pending JP2022071061A (ja) | 2014-06-04 | 2022-03-01 | Ｄｇｌａを含む薬学的組成物及びその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (9) | US9682055B2 (https=) |
| EP (2) | EP3692986A1 (https=) |
| JP (3) | JP2017516823A (https=) |
| KR (1) | KR102391827B1 (https=) |
| CN (1) | CN107072959A (https=) |
| AU (2) | AU2015270418B2 (https=) |
| BR (1) | BR112016028518A2 (https=) |
| CA (1) | CA2953633A1 (https=) |
| ES (1) | ES2784240T3 (https=) |
| IL (2) | IL249364B (https=) |
| MA (1) | MA52644A (https=) |
| MX (2) | MX375328B (https=) |
| PH (1) | PH12016502530A1 (https=) |
| RU (2) | RU2020101477A (https=) |
| SG (2) | SG11201610207WA (https=) |
| WO (1) | WO2015185698A1 (https=) |
| ZA (2) | ZA201708681B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| EP3068757B1 (en) | 2013-11-15 | 2019-02-27 | DS Biopharma Limited | Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid |
| ES2784240T3 (es) * | 2014-06-04 | 2020-09-23 | Ds Biopharma Ltd | Composiciones farmacéuticas que comprenden DGLA y uso de las mismas |
| CN117402059A (zh) | 2015-05-13 | 2024-01-16 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
| EP3399971A1 (en) * | 2016-01-07 | 2018-11-14 | DS Biopharma Limited | Pharmaceutical compositions comprising dgla and use of same |
| EP3624787A1 (en) * | 2017-05-19 | 2020-03-25 | DS Biopharma Limited | Pharmaceutical compositions comprising dgla and use of same |
| JP7500037B2 (ja) * | 2019-07-24 | 2024-06-17 | 国立大学法人 東京大学 | 血中尿酸値低下剤及び血中尿酸値低下用食品組成物 |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
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