JP2019501190A5 - - Google Patents
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- JP2019501190A5 JP2019501190A5 JP2018535278A JP2018535278A JP2019501190A5 JP 2019501190 A5 JP2019501190 A5 JP 2019501190A5 JP 2018535278 A JP2018535278 A JP 2018535278A JP 2018535278 A JP2018535278 A JP 2018535278A JP 2019501190 A5 JP2019501190 A5 JP 2019501190A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- subject
- dgla
- derivative
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims description 19
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims description 19
- 210000003979 eosinophil Anatomy 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 5
- 239000007788 liquid Substances 0.000 claims 4
- 206010047302 ventricular tachycardia Diseases 0.000 claims 4
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 3
- 208000003251 Pruritus Diseases 0.000 claims 3
- 208000003734 Supraventricular Tachycardia Diseases 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 206010061592 cardiac fibrillation Diseases 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000002600 fibrillogenic effect Effects 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 208000030673 Homozygous familial hypercholesterolemia Diseases 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- 206010063985 Phytosterolaemia Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 2
- 208000002227 Sitosterolemia Diseases 0.000 claims 2
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000000306 recurrent effect Effects 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 208000003663 ventricular fibrillation Diseases 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 206010003267 Arthritis reactive Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 claims 1
- 206010003662 Atrial flutter Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010011803 Cystocele Diseases 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 1
- 206010013786 Dry skin Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010014522 Embolism venous Diseases 0.000 claims 1
- 208000007530 Essential hypertension Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021639 Incontinence Diseases 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 1
- 206010029279 Neurogenic bladder Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000004362 Penile Induration Diseases 0.000 claims 1
- 208000020758 Peyronie disease Diseases 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 208000011191 Pulmonary vascular disease Diseases 0.000 claims 1
- 206010067171 Regurgitation Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000033626 Renal failure acute Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 208000004717 Ruptured Aneurysm Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000001871 Tachycardia Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 210000003484 anatomy Anatomy 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 230000037336 dry skin Effects 0.000 claims 1
- 208000010706 fatty liver disease Diseases 0.000 claims 1
- 230000036074 healthy skin Effects 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000006750 hematuria Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000019267 mild heart failure Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000003711 photoprotective effect Effects 0.000 claims 1
- 210000003281 pleural cavity Anatomy 0.000 claims 1
- 208000030761 polycystic kidney disease Diseases 0.000 claims 1
- 208000017497 prostate disease Diseases 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 230000001950 radioprotection Effects 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 208000037851 severe atopic dermatitis Diseases 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
- 230000006794 tachycardia Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 208000004043 venous thromboembolism Diseases 0.000 claims 1
- 230000000007 visual effect Effects 0.000 claims 1
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276019P | 2016-01-07 | 2016-01-07 | |
| US62/276,019 | 2016-01-07 | ||
| US201662357000P | 2016-06-30 | 2016-06-30 | |
| US62/357,000 | 2016-06-30 | ||
| PCT/IB2017/000066 WO2017118911A1 (en) | 2016-01-07 | 2017-01-06 | Pharmaceutical compositions comprising dgla and use of same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019501190A JP2019501190A (ja) | 2019-01-17 |
| JP2019501190A5 true JP2019501190A5 (https=) | 2020-02-13 |
Family
ID=58213263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535278A Pending JP2019501190A (ja) | 2016-01-07 | 2017-01-06 | Ｄｇｌａを含む薬学的組成物及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20170196825A1 (https=) |
| EP (1) | EP3399971A1 (https=) |
| JP (1) | JP2019501190A (https=) |
| CN (1) | CN108778266A (https=) |
| CA (1) | CA3027867A1 (https=) |
| WO (1) | WO2017118911A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| EP3068757B1 (en) | 2013-11-15 | 2019-02-27 | DS Biopharma Limited | Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid |
| ES2784240T3 (es) | 2014-06-04 | 2020-09-23 | Ds Biopharma Ltd | Composiciones farmacéuticas que comprenden DGLA y uso de las mismas |
| CN117402059A (zh) | 2015-05-13 | 2024-01-16 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
| EP3624787A1 (en) * | 2017-05-19 | 2020-03-25 | DS Biopharma Limited | Pharmaceutical compositions comprising dgla and use of same |
| US10639313B2 (en) | 2017-09-01 | 2020-05-05 | Ndsu Research Foundation | Compound for inhibition of delta-5-desaturase (D5D) and treatment of cancer and inflammation |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8302708D0 (en) * | 1983-02-01 | 1983-03-02 | Efamol Ltd | Pharmaceutical and dietary composition |
| WO2006085687A1 (ja) * | 2005-02-14 | 2006-08-17 | Suntory Limited | ジホモ−γ−リノレン酸（ＤＧＬＡ）を有効成分として含んで成る組成物 |
| JP5546087B2 (ja) * | 2005-02-14 | 2014-07-09 | サントリーホールディングス株式会社 | 皮膚疾患経口治療または予防剤 |
| US7485323B2 (en) | 2005-05-31 | 2009-02-03 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions |
| ES2784240T3 (es) * | 2014-06-04 | 2020-09-23 | Ds Biopharma Ltd | Composiciones farmacéuticas que comprenden DGLA y uso de las mismas |
-
2017
- 2017-01-06 EP EP17708574.3A patent/EP3399971A1/en not_active Withdrawn
- 2017-01-06 US US15/400,132 patent/US20170196825A1/en not_active Abandoned
- 2017-01-06 CA CA3027867A patent/CA3027867A1/en not_active Abandoned
- 2017-01-06 JP JP2018535278A patent/JP2019501190A/ja active Pending
- 2017-01-06 WO PCT/IB2017/000066 patent/WO2017118911A1/en not_active Ceased
- 2017-01-06 CN CN201780015787.0A patent/CN108778266A/zh active Pending
-
2018
- 2018-10-11 US US16/158,085 patent/US20190175534A1/en not_active Abandoned
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