JP2017516756A5 - - Google Patents
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- JP2017516756A5 JP2017516756A5 JP2016562005A JP2016562005A JP2017516756A5 JP 2017516756 A5 JP2017516756 A5 JP 2017516756A5 JP 2016562005 A JP2016562005 A JP 2016562005A JP 2016562005 A JP2016562005 A JP 2016562005A JP 2017516756 A5 JP2017516756 A5 JP 2017516756A5
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- JP
- Japan
- Prior art keywords
- composition
- amino acid
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- seq
- acid sequence
- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020005711A JP7315487B2 (ja) | 2014-04-18 | 2020-01-17 | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461981519P | 2014-04-18 | 2014-04-18 | |
| US61/981,519 | 2014-04-18 | ||
| US201461984393P | 2014-04-25 | 2014-04-25 | |
| US61/984,393 | 2014-04-25 | ||
| US201462011482P | 2014-06-12 | 2014-06-12 | |
| US62/011,482 | 2014-06-12 | ||
| US201462036066P | 2014-08-11 | 2014-08-11 | |
| US62/036,066 | 2014-08-11 | ||
| US201462088374P | 2014-12-05 | 2014-12-05 | |
| US62/088,374 | 2014-12-05 | ||
| PCT/US2015/026415 WO2015161220A1 (en) | 2014-04-18 | 2015-04-17 | Methods for increasing red blood cell levels and treating sickle-cell disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020005711A Division JP7315487B2 (ja) | 2014-04-18 | 2020-01-17 | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516756A JP2017516756A (ja) | 2017-06-22 |
| JP2017516756A5 true JP2017516756A5 (enExample) | 2018-05-31 |
| JP6649895B2 JP6649895B2 (ja) | 2020-02-19 |
Family
ID=54324622
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562005A Active JP6649895B2 (ja) | 2014-04-18 | 2015-04-17 | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
| JP2020005711A Active JP7315487B2 (ja) | 2014-04-18 | 2020-01-17 | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
| JP2021130588A Pending JP2021175755A (ja) | 2014-04-18 | 2021-08-10 | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020005711A Active JP7315487B2 (ja) | 2014-04-18 | 2020-01-17 | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
| JP2021130588A Pending JP2021175755A (ja) | 2014-04-18 | 2021-08-10 | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20150361163A1 (enExample) |
| EP (2) | EP3131931B1 (enExample) |
| JP (3) | JP6649895B2 (enExample) |
| AP (1) | AP2016009549A0 (enExample) |
| AU (2) | AU2015247459A1 (enExample) |
| BR (1) | BR112016024319B1 (enExample) |
| CA (1) | CA2962197C (enExample) |
| ES (1) | ES2845650T3 (enExample) |
| MA (1) | MA52909A (enExample) |
| MX (2) | MX388380B (enExample) |
| WO (1) | WO2015161220A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME00380B (me) | 2005-11-23 | 2011-10-10 | Acceleron Pharma Inc | Amtagonisti aktivin-actriia i primjene za stimulaciju rasta kosti |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| KR101672156B1 (ko) | 2007-02-09 | 2016-11-02 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| LT3750552T (lt) | 2008-08-14 | 2023-06-26 | Acceleron Pharma Inc. | Gdf gaudyklės |
| MX385318B (es) | 2009-06-08 | 2025-03-18 | Acceleron Pharma Inc | Metodos para aumentar adipocitos termogenicos. |
| JP2012529294A (ja) | 2009-06-12 | 2012-11-22 | アクセルロン ファーマ， インコーポレイテッド | 切断型ＡｃｔＲＩＩＢ−Ｆｃ融合タンパク質 |
| EP2501400B1 (en) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| RU2018145985A (ru) | 2012-11-02 | 2019-02-18 | Селджин Корпорейшн | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
| TN2016000553A1 (en) | 2014-06-13 | 2018-04-04 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| DK3227675T3 (da) | 2014-12-03 | 2023-05-30 | Celgene Corp | Activin-actrii-antagonister og anvendelser til behandling af myelodysplastisk syndrom |
| MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
| DK3286206T3 (da) | 2015-04-22 | 2021-05-03 | Biogen Ma Inc | Hidtil ukendte hybride actriib-ligand-trap-proteiner til behandling af muskelsvindsygdomme |
| CN108350057A (zh) | 2015-05-20 | 2018-07-31 | 细胞基因公司 | 使用II型活化素受体配体阱的用于β-地中海贫血的体外细胞培养方法 |
| EP3370754A4 (en) * | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | METHOD FOR INCREASING ERYTHROCYTE CONCENTRATION AND TREATMENT OF INEFFICIENT ERYTHROPOIESE |
| WO2017083281A1 (en) * | 2015-11-09 | 2017-05-18 | Albert Einstein College Of Medicine, Inc. | Method of ameliorating side effects of sickle cell disease treatments |
| CA3005975A1 (en) | 2015-11-23 | 2017-06-01 | Acceleron Pharma Inc. | Methods for treating eye disorders |
| GB2550114A (en) * | 2016-05-03 | 2017-11-15 | Kymab Ltd | Methods, regimens, combinations & antagonists |
| RU2748278C2 (ru) | 2016-07-15 | 2021-05-21 | Акселерон Фарма Инк. | Композиции и способы лечения легочной гипертензии |
| EA201990226A1 (ru) | 2016-07-27 | 2019-08-30 | Акселерон Фарма Инк. | Способы и композиции для лечения миелофиброза |
| JP7280182B2 (ja) | 2016-10-05 | 2023-05-23 | アクセルロン ファーマ インコーポレイテッド | バリアントＡｃｔＲＩＩＢタンパク質およびその使用 |
| US11976111B2 (en) | 2016-10-05 | 2024-05-07 | Acceleron Pharma Inc. | ActRIIa and ALK4 polypeptides for treating kidney fibrosis, inflammation and injury |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| WO2018089715A1 (en) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| AU2018214629A1 (en) * | 2017-02-06 | 2019-08-22 | Acceleron Pharma Inc. | Compositions and methods for treating heart failure |
| KR20250059538A (ko) | 2017-11-09 | 2025-05-02 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| JP7510875B2 (ja) | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンｉｉｂ型受容体変異体および同変異体を含む医薬組成物 |
| KR20250133994A (ko) | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| US20220372135A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| KR20230004515A (ko) | 2020-03-20 | 2023-01-06 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 ii 키메라 및 이의 사용 방법 |
| EP4121088A4 (en) | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| CA3177830A1 (en) | 2020-05-13 | 2021-11-18 | Maria BECONI | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| US12186370B1 (en) | 2020-11-05 | 2025-01-07 | Celgene Corporation | ACTRIIB ligand trap compositions and uses thereof |
| KR20250024837A (ko) * | 2022-06-15 | 2025-02-19 | 페프티드림 아이엔씨. | 펩타이드 및 펩타이드를 포함하는 제제 |
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| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| KR101672156B1 (ko) | 2007-02-09 | 2016-11-02 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
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| CN107252486B (zh) * | 2008-06-26 | 2021-10-22 | 阿塞勒隆制药公司 | 激活素-actrii的拮抗剂及在提高红细胞水平中的用途 |
| LT3750552T (lt) | 2008-08-14 | 2023-06-26 | Acceleron Pharma Inc. | Gdf gaudyklės |
| EP3520805B1 (en) * | 2011-10-17 | 2021-03-10 | Acceleron Pharma Inc. | Compositions for treating myelofibrosis |
| CN104379159A (zh) * | 2011-12-19 | 2015-02-25 | 安姆根公司 | 变体激活素受体多肽,单独或与化疗结合,及其用途 |
| CA2889209C (en) * | 2012-10-24 | 2023-08-22 | Celgene Corporation | Biomarker for use in treating anemia |
-
2015
- 2015-04-17 MX MX2016013635A patent/MX388380B/es unknown
- 2015-04-17 CA CA2962197A patent/CA2962197C/en active Active
- 2015-04-17 MA MA052909A patent/MA52909A/fr unknown
- 2015-04-17 JP JP2016562005A patent/JP6649895B2/ja active Active
- 2015-04-17 US US14/689,477 patent/US20150361163A1/en not_active Abandoned
- 2015-04-17 EP EP15779814.1A patent/EP3131931B1/en active Active
- 2015-04-17 WO PCT/US2015/026415 patent/WO2015161220A1/en not_active Ceased
- 2015-04-17 ES ES15779814T patent/ES2845650T3/es active Active
- 2015-04-17 EP EP20197941.6A patent/EP3808778A1/en not_active Withdrawn
- 2015-04-17 AP AP2016009549A patent/AP2016009549A0/en unknown
- 2015-04-17 BR BR112016024319-6A patent/BR112016024319B1/pt active IP Right Grant
- 2015-04-17 AU AU2015247459A patent/AU2015247459A1/en not_active Abandoned
-
2016
- 2016-10-17 MX MX2021014709A patent/MX2021014709A/es unknown
-
2020
- 2020-01-17 JP JP2020005711A patent/JP7315487B2/ja active Active
- 2020-08-10 US US16/989,505 patent/US20210188955A1/en not_active Abandoned
-
2021
- 2021-04-20 AU AU2021202382A patent/AU2021202382B2/en active Active
- 2021-08-10 JP JP2021130588A patent/JP2021175755A/ja active Pending
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