|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
|
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
ES8702440A1
(es)
|
1984-10-04 |
1986-12-16 |
Monsanto Co |
Un procedimiento para la preparacion de una composicion de polipeptido inyectable sustancialmente no acuosa.
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
PH30995A
(en)
|
1989-07-07 |
1997-12-23 |
Novartis Inc |
Sustained release formulations of water soluble peptides.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
TW333456B
(en)
|
1992-12-07 |
1998-06-11 |
Takeda Pharm Ind Co Ltd |
A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
|
US6087324A
(en)
|
1993-06-24 |
2000-07-11 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
|
EP0835101B1
(en)
|
1995-06-27 |
2004-06-09 |
Takeda Chemical Industries, Ltd. |
Method of producing sustained-release preparation
|
|
TW448055B
(en)
|
1995-09-04 |
2001-08-01 |
Takeda Chemical Industries Ltd |
Method of production of sustained-release preparation
|
|
JP2909418B2
(ja)
|
1995-09-18 |
1999-06-23 |
株式会社資生堂 |
薬物の遅延放出型マイクロスフイア
|
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
|
US5980945A
(en)
|
1996-01-16 |
1999-11-09 |
Societe De Conseils De Recherches Et D'applications Scientifique S.A. |
Sustained release drug formulations
|
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
|
US6264970B1
(en)
|
1996-06-26 |
2001-07-24 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6419961B1
(en)
|
1996-08-29 |
2002-07-16 |
Takeda Chemical Industries, Ltd. |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer
|
|
KR100353304B1
(ko)
|
1996-10-01 |
2002-09-30 |
에스알아이 인터내셔널 |
맛이 차폐된 마이크로캡슐 조성물 및 이것의 제조 방법
|
|
CA2217134A1
(en)
|
1996-10-09 |
1998-04-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Sustained release formulation
|
|
DK0839525T3
(da)
|
1996-10-31 |
2004-11-29 |
Takeda Pharmaceutical |
Præparat med forlænget frigivelse
|
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
|
ZA9711385B
(en)
|
1996-12-20 |
1999-06-18 |
Takeda Chemical Industries Ltd |
Method of producing a sustained-release preparation
|
|
US5891474A
(en)
|
1997-01-29 |
1999-04-06 |
Poli Industria Chimica, S.P.A. |
Time-specific controlled release dosage formulations and method of preparing same
|
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
|
US6613358B2
(en)
|
1998-03-18 |
2003-09-02 |
Theodore W. Randolph |
Sustained-release composition including amorphous polymer
|
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
|
KR19990085365A
(ko)
|
1998-05-16 |
1999-12-06 |
허영섭 |
지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
|
|
US6544951B2
(en)
|
1998-07-02 |
2003-04-08 |
Idun Pharmaceuticals, Inc. |
C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
|
|
US7053056B2
(en)
|
1998-07-02 |
2006-05-30 |
Idun Pharmaceuticals, Inc. |
C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
|
|
US6197750B1
(en)
|
1998-07-02 |
2001-03-06 |
Idun Pharmaceuticals, Inc. |
C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
|
|
US6559304B1
(en)
|
1998-08-19 |
2003-05-06 |
Vertex Pharmaceuticals Incorporated |
Method for synthesizing caspase inhibitors
|
|
US6201118B1
(en)
|
1998-08-19 |
2001-03-13 |
Vertex Pharmaceuticals Inc. |
Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
|
ATE266623T1
(de)
|
1999-08-06 |
2004-05-15 |
Vertex Pharma |
Caspase inhibitoren und deren verwendung
|
|
US6790989B2
(en)
|
2000-01-13 |
2004-09-14 |
Idun Pharmaceuticals, Inc. |
Inhibitors of the ICE/ced-3 family of cysteine proteases
|
|
WO2001072707A2
(en)
|
2000-03-29 |
2001-10-04 |
Vertex Pharmaceuticals Incorporated |
Carbamate caspase inhibitors and uses thereof
|
|
TR200200767T1
(tr)
|
2000-05-23 |
2002-09-23 |
Vertex Pharmaceuticals Incorporated |
Kaspaz engelleyiciler ve kullanımları
|
|
KR20030025235A
(ko)
|
2000-06-07 |
2003-03-28 |
버텍스 파마슈티칼스 인코포레이티드 |
카스파제 억제제 및 이의 용도
|
|
EP1317454B1
(en)
|
2000-09-13 |
2011-05-25 |
Vertex Pharmaceuticals Incorporated |
Caspase inhibitors and uses thereof
|
|
US6665495B1
(en)
|
2000-10-27 |
2003-12-16 |
Yotta Networks, Inc. |
Non-blocking, scalable optical router architecture and method for routing optical traffic
|
|
MXPA03009647A
(es)
|
2001-04-19 |
2004-01-29 |
Vertex Pharma |
Heterociclildicarbamidas como inhibidores de caspasa.
|
|
WO2002094263A2
(en)
|
2001-05-23 |
2002-11-28 |
Vertex Pharmaceuticals Incorporated |
Caspase inhibitors and uses thereof
|
|
WO2003068242A1
(en)
|
2002-02-11 |
2003-08-21 |
Vertex Pharmaceuticals Incorporated |
Phospholipids as caspase inhibitor prodrugs
|
|
WO2004002961A1
(en)
|
2002-06-28 |
2004-01-08 |
Vertex Pharmaceuticals Incorporated |
Caspase inhibitors and uses thereof
|
|
WO2004058718A1
(en)
|
2002-12-20 |
2004-07-15 |
Vertex Pharmaceuticals Incorporated |
4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors
|
|
PE20050159A1
(es)
|
2003-05-27 |
2005-04-19 |
Vertex Pharma |
Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
|
|
KR100594544B1
(ko)
|
2003-08-27 |
2006-06-30 |
주식회사 엘지생명과학 |
이소옥사졸린 구조를 갖는 캐스파제 저해제
|
|
WO2005085236A2
(en)
|
2004-02-27 |
2005-09-15 |
Vertex Pharmaceuticals Incorporated |
Caspase inhibitors and uses thereof
|
|
JP2005319019A
(ja)
|
2004-05-07 |
2005-11-17 |
Bridgestone Sports Co Ltd |
ゴルフクラブヘッド
|
|
CA2573644A1
(en)
|
2004-07-12 |
2006-02-16 |
Idun Pharmaceuticals, Inc. |
Tetrapeptide analogs
|
|
CA2669849C
(en)
|
2006-12-06 |
2012-01-31 |
Pfizer Inc. |
Crystalline forms of (3s)-3-[n-(n'-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-oxopentanoic acid
|
|
WO2008106167A1
(en)
*
|
2007-02-28 |
2008-09-04 |
Conatus Pharmaceuticals, Inc. |
Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
|
|
AU2009255994B2
(en)
*
|
2008-06-05 |
2014-07-17 |
Bristol-Myers Squibb Company |
Use of pegylated Type III Interferons for the treatment of hepatitis C
|
|
US20140050728A1
(en)
*
|
2011-01-28 |
2014-02-20 |
Board Of Regents Of The University Of Nebraska |
Methods and compositions for inhibiting cyclophilin d for the treatment and prevention of obesity and kidney indications
|
|
CA2842707A1
(en)
|
2011-08-04 |
2013-02-07 |
Lumena Pharmaceuticals, Inc. |
Bile acid recycling inhibitors for treatment of pancreatitis
|
|
AU2012328453B2
(en)
|
2011-10-28 |
2017-05-04 |
Shire Human Genetic Therapies, Inc. |
Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
|
|
ES2633766T3
(es)
|
2011-10-28 |
2017-09-25 |
Lumena Pharmaceuticals Llc |
Inhibidores de reciclaje de ácido biliar para el tratamiento de enfermedades de hígado colestático pediátrico
|