ZA201607740B - Treatment of the complications of chronic liver disease with caspase inhibitors - Google Patents

Treatment of the complications of chronic liver disease with caspase inhibitors

Info

Publication number
ZA201607740B
ZA201607740B ZA2016/07740A ZA201607740A ZA201607740B ZA 201607740 B ZA201607740 B ZA 201607740B ZA 2016/07740 A ZA2016/07740 A ZA 2016/07740A ZA 201607740 A ZA201607740 A ZA 201607740A ZA 201607740 B ZA201607740 B ZA 201607740B
Authority
ZA
South Africa
Prior art keywords
complications
treatment
liver disease
chronic liver
caspase inhibitors
Prior art date
Application number
ZA2016/07740A
Other languages
English (en)
Inventor
P Spada Alfred
Original Assignee
Conatus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conatus Pharmaceuticals Inc filed Critical Conatus Pharmaceuticals Inc
Publication of ZA201607740B publication Critical patent/ZA201607740B/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA2016/07740A 2014-05-12 2016-11-09 Treatment of the complications of chronic liver disease with caspase inhibitors ZA201607740B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461992169P 2014-05-12 2014-05-12
PCT/US2015/030101 WO2015175381A1 (en) 2014-05-12 2015-05-11 Treatment of the complications of chronic liver disease with caspase inhibitors

Publications (1)

Publication Number Publication Date
ZA201607740B true ZA201607740B (en) 2020-02-26

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ID=53276268

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2016/07740A ZA201607740B (en) 2014-05-12 2016-11-09 Treatment of the complications of chronic liver disease with caspase inhibitors

Country Status (15)

Country Link
US (2) US20170100448A1 (enExample)
EP (2) EP3142649B1 (enExample)
JP (1) JP2017515854A (enExample)
KR (1) KR20170015312A (enExample)
CN (1) CN106470679A (enExample)
AU (1) AU2015259471A1 (enExample)
BR (1) BR112016026560A2 (enExample)
CA (1) CA2948540A1 (enExample)
ES (1) ES2751652T3 (enExample)
IL (1) IL248882A0 (enExample)
MX (1) MX2016014731A (enExample)
RU (1) RU2016148364A (enExample)
SG (1) SG11201609256SA (enExample)
WO (1) WO2015175381A1 (enExample)
ZA (1) ZA201607740B (enExample)

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CN111315412A (zh) * 2017-09-13 2020-06-19 诺华股份有限公司 Il-1b结合抗体用于治疗酒精性肝炎的用途
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WO2020181165A1 (en) * 2019-03-07 2020-09-10 Conatus Pharmaceuticals Inc. Caspase inhibitors and methods of use thereof
CN113767097B (zh) * 2019-04-30 2025-03-14 株式会社Lg化学 半胱天冬酶抑制剂的前药
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US20170100448A1 (en) 2017-04-13
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BR112016026560A2 (pt) 2017-08-15
WO2015175381A1 (en) 2015-11-19
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