AU2015259471A1 - Treatment of the complications of chronic liver disease with caspase inhibitors - Google Patents

Treatment of the complications of chronic liver disease with caspase inhibitors Download PDF

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Publication number
AU2015259471A1
AU2015259471A1 AU2015259471A AU2015259471A AU2015259471A1 AU 2015259471 A1 AU2015259471 A1 AU 2015259471A1 AU 2015259471 A AU2015259471 A AU 2015259471A AU 2015259471 A AU2015259471 A AU 2015259471A AU 2015259471 A1 AU2015259471 A1 AU 2015259471A1
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AU
Australia
Prior art keywords
caspase inhibitor
pharmaceutically acceptable
acceptable derivative
subject
portal hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2015259471A
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English (en)
Inventor
Alfred P. Spada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Histogen Inc
Original Assignee
Conatus Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Conatus Pharmaceuticals Inc filed Critical Conatus Pharmaceuticals Inc
Publication of AU2015259471A1 publication Critical patent/AU2015259471A1/en
Abandoned legal-status Critical Current

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015259471A 2014-05-12 2015-05-11 Treatment of the complications of chronic liver disease with caspase inhibitors Abandoned AU2015259471A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461992169P 2014-05-12 2014-05-12
US61/992,169 2014-05-12
PCT/US2015/030101 WO2015175381A1 (en) 2014-05-12 2015-05-11 Treatment of the complications of chronic liver disease with caspase inhibitors

Publications (1)

Publication Number Publication Date
AU2015259471A1 true AU2015259471A1 (en) 2016-11-24

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AU2015259471A Abandoned AU2015259471A1 (en) 2014-05-12 2015-05-11 Treatment of the complications of chronic liver disease with caspase inhibitors

Country Status (15)

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US (2) US20170100448A1 (enExample)
EP (2) EP3142649B1 (enExample)
JP (1) JP2017515854A (enExample)
KR (1) KR20170015312A (enExample)
CN (1) CN106470679A (enExample)
AU (1) AU2015259471A1 (enExample)
BR (1) BR112016026560A2 (enExample)
CA (1) CA2948540A1 (enExample)
ES (1) ES2751652T3 (enExample)
IL (1) IL248882A0 (enExample)
MX (1) MX2016014731A (enExample)
RU (1) RU2016148364A (enExample)
SG (1) SG11201609256SA (enExample)
WO (1) WO2015175381A1 (enExample)
ZA (1) ZA201607740B (enExample)

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WO2017193951A1 (zh) * 2016-05-11 2017-11-16 正大天晴药业集团股份有限公司 Caspase抑制剂及其药物组合物、用途和治疗方法
WO2018148250A1 (en) * 2017-02-07 2018-08-16 The Regents Of The University Of California Methods for inhibiting nonalcoholic steatohepatitis, nonalcoholic fatty liver disease, and/or de novo lipogenesis
MX2020002813A (es) * 2017-09-13 2020-07-21 Novartis Ag Uso de anticuerpos de union a il-1b para el tratamiento de la hepatitis alcoholica.
CN109748843B (zh) * 2017-11-06 2022-11-11 正大天晴药业集团股份有限公司 Caspase抑制剂及其药物组合物、用途和治疗方法
CA3102755A1 (en) * 2018-06-29 2020-01-02 The Doshisha Formulation containing emricasan
WO2020006341A1 (en) 2018-06-29 2020-01-02 Conatus Pharmaceuticals, Inc. (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
WO2020181165A1 (en) * 2019-03-07 2020-09-10 Conatus Pharmaceuticals Inc. Caspase inhibitors and methods of use thereof
WO2020222541A1 (ko) * 2019-04-30 2020-11-05 주식회사 엘지화학 캐스파제 저해제의 프로드럭
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EP4143204A4 (en) 2020-05-01 2024-10-02 Medstar Health, Inc. METHODS OF TREATMENT OF COVID-19
US20230042509A1 (en) * 2021-06-22 2023-02-09 Amerimmune Llc Treatment for diseases caused by rna viruses

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