RU2016148364A - Лечение осложнений хронического заболевания печени - Google Patents
Лечение осложнений хронического заболевания печени Download PDFInfo
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- RU2016148364A RU2016148364A RU2016148364A RU2016148364A RU2016148364A RU 2016148364 A RU2016148364 A RU 2016148364A RU 2016148364 A RU2016148364 A RU 2016148364A RU 2016148364 A RU2016148364 A RU 2016148364A RU 2016148364 A RU2016148364 A RU 2016148364A
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- Prior art keywords
- caspase inhibitor
- pharmaceutically acceptable
- acceptable derivative
- active substance
- individual
- Prior art date
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- 208000019423 liver disease Diseases 0.000 title claims 14
- 230000001684 chronic effect Effects 0.000 title 1
- 229940123169 Caspase inhibitor Drugs 0.000 claims 57
- 238000000034 method Methods 0.000 claims 55
- 239000013543 active substance Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 16
- 208000007232 portal hypertension Diseases 0.000 claims 15
- 210000004185 liver Anatomy 0.000 claims 14
- 230000007882 cirrhosis Effects 0.000 claims 11
- 206010016654 Fibrosis Diseases 0.000 claims 8
- 208000019425 cirrhosis of liver Diseases 0.000 claims 8
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 6
- DTLOVISJEFBXLX-REAFJZEQSA-N relexan 2 Chemical compound C([C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(N1)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(O)=O)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DTLOVISJEFBXLX-REAFJZEQSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 206010046996 Varicose vein Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 230000019491 signal transduction Effects 0.000 claims 4
- 229960004605 timolol Drugs 0.000 claims 4
- 208000027185 varicose disease Diseases 0.000 claims 4
- POMVPJBWDDJCMP-RUKDTIIFSA-M (4r,5r)-5-[4-[[4-(1-aza-4-azoniabicyclo[2.2.2]octan-4-ylmethyl)phenyl]methoxy]phenyl]-3,3-dibutyl-7-(dimethylamino)-1,1-dioxo-4,5-dihydro-2h-1$l^{6}-benzothiepin-4-ol;chloride Chemical compound [Cl-].O[C@H]1C(CCCC)(CCCC)CS(=O)(=O)C2=CC=C(N(C)C)C=C2[C@H]1C(C=C1)=CC=C1OCC(C=C1)=CC=C1C[N+]1(CC2)CCN2CC1 POMVPJBWDDJCMP-RUKDTIIFSA-M 0.000 claims 3
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims 3
- 108010082126 Alanine transaminase Proteins 0.000 claims 3
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 3
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 3
- 108010010056 Terlipressin Proteins 0.000 claims 3
- WTAVOESJEWSDJC-OBOLPPCUSA-N [2-methoxy-4-[(E)-3-(4-nitrooxybutoxy)-3-oxoprop-1-enyl]phenyl] (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound COc1cc(\C=C\C(=O)OCCCCO[N+]([O-])=O)ccc1OC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C WTAVOESJEWSDJC-OBOLPPCUSA-N 0.000 claims 3
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 claims 3
- 108700013806 aldafermin Proteins 0.000 claims 3
- 230000036772 blood pressure Effects 0.000 claims 3
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 claims 3
- 229960004195 carvedilol Drugs 0.000 claims 3
- 230000000116 mitigating effect Effects 0.000 claims 3
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 claims 3
- 229960004255 nadolol Drugs 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 229960003712 propranolol Drugs 0.000 claims 3
- 229960002792 serelaxin Drugs 0.000 claims 3
- 229950009513 simtuzumab Drugs 0.000 claims 3
- 229960003787 sorafenib Drugs 0.000 claims 3
- BENFXAYNYRLAIU-QSVFAHTRSA-N terlipressin Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC1 BENFXAYNYRLAIU-QSVFAHTRSA-N 0.000 claims 3
- 229960003813 terlipressin Drugs 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical group OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 230000000740 bleeding effect Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 206010003445 Ascites Diseases 0.000 claims 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 208000034158 bleeding Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461992169P | 2014-05-12 | 2014-05-12 | |
| US61/992,169 | 2014-05-12 | ||
| PCT/US2015/030101 WO2015175381A1 (en) | 2014-05-12 | 2015-05-11 | Treatment of the complications of chronic liver disease with caspase inhibitors |
Publications (2)
| Publication Number | Publication Date |
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| RU2016148364A true RU2016148364A (ru) | 2018-06-13 |
| RU2016148364A3 RU2016148364A3 (enExample) | 2019-07-24 |
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| RU2016148364A RU2016148364A (ru) | 2014-05-12 | 2015-05-11 | Лечение осложнений хронического заболевания печени |
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| EP (2) | EP3142649B1 (enExample) |
| JP (1) | JP2017515854A (enExample) |
| KR (1) | KR20170015312A (enExample) |
| CN (1) | CN106470679A (enExample) |
| AU (1) | AU2015259471A1 (enExample) |
| BR (1) | BR112016026560A2 (enExample) |
| CA (1) | CA2948540A1 (enExample) |
| ES (1) | ES2751652T3 (enExample) |
| IL (1) | IL248882A0 (enExample) |
| MX (1) | MX2016014731A (enExample) |
| RU (1) | RU2016148364A (enExample) |
| SG (1) | SG11201609256SA (enExample) |
| WO (1) | WO2015175381A1 (enExample) |
| ZA (1) | ZA201607740B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017079566A1 (en) * | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| BR112018013558A2 (pt) * | 2015-12-31 | 2018-12-04 | Conatus Pharmaceuticals Inc | método de tratamento de uma doença hepática em um indivíduo, método de uso de um inibidor de caspase, método para diminuir ou sustentar uma classificação meld ou seus componentes, método para tratar, diminuir ou sustentar uma classificação meld ou seus componentes, método para tratar, diminuir ou sustentar uma classificação de child-pugh ou seus componentes, composição farmacêutica que compreende um inibidor de caspase, kit, método de tratamento, método de tratamento de cirrose hepática e prevenção de uma classificação meld elevada, método de tratamento de cirrose hepática e prevenção de uma classificação de child-pugh elevada |
| FR3050112B1 (fr) | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
| WO2017193951A1 (zh) * | 2016-05-11 | 2017-11-16 | 正大天晴药业集团股份有限公司 | Caspase抑制剂及其药物组合物、用途和治疗方法 |
| WO2018148250A1 (en) * | 2017-02-07 | 2018-08-16 | The Regents Of The University Of California | Methods for inhibiting nonalcoholic steatohepatitis, nonalcoholic fatty liver disease, and/or de novo lipogenesis |
| MX2020002813A (es) * | 2017-09-13 | 2020-07-21 | Novartis Ag | Uso de anticuerpos de union a il-1b para el tratamiento de la hepatitis alcoholica. |
| CN109748843B (zh) * | 2017-11-06 | 2022-11-11 | 正大天晴药业集团股份有限公司 | Caspase抑制剂及其药物组合物、用途和治疗方法 |
| CA3102755A1 (en) * | 2018-06-29 | 2020-01-02 | The Doshisha | Formulation containing emricasan |
| WO2020006341A1 (en) | 2018-06-29 | 2020-01-02 | Conatus Pharmaceuticals, Inc. | (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
| WO2020181165A1 (en) * | 2019-03-07 | 2020-09-10 | Conatus Pharmaceuticals Inc. | Caspase inhibitors and methods of use thereof |
| WO2020222541A1 (ko) * | 2019-04-30 | 2020-11-05 | 주식회사 엘지화학 | 캐스파제 저해제의 프로드럭 |
| US20230338459A1 (en) | 2020-04-14 | 2023-10-26 | Amerimmune, Llc | Treatment for Diseases Caused by RNA Viruses |
| EP4143204A4 (en) | 2020-05-01 | 2024-10-02 | Medstar Health, Inc. | METHODS OF TREATMENT OF COVID-19 |
| US20230042509A1 (en) * | 2021-06-22 | 2023-02-09 | Amerimmune Llc | Treatment for diseases caused by rna viruses |
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-
2015
- 2015-05-11 JP JP2016567605A patent/JP2017515854A/ja active Pending
- 2015-05-11 SG SG11201609256SA patent/SG11201609256SA/en unknown
- 2015-05-11 KR KR1020167033885A patent/KR20170015312A/ko not_active Withdrawn
- 2015-05-11 EP EP15726430.0A patent/EP3142649B1/en active Active
- 2015-05-11 ES ES15726430T patent/ES2751652T3/es active Active
- 2015-05-11 WO PCT/US2015/030101 patent/WO2015175381A1/en not_active Ceased
- 2015-05-11 EP EP18178387.9A patent/EP3444011A1/en not_active Withdrawn
- 2015-05-11 US US15/310,610 patent/US20170100448A1/en not_active Abandoned
- 2015-05-11 AU AU2015259471A patent/AU2015259471A1/en not_active Abandoned
- 2015-05-11 CA CA2948540A patent/CA2948540A1/en not_active Abandoned
- 2015-05-11 CN CN201580037983.9A patent/CN106470679A/zh active Pending
- 2015-05-11 RU RU2016148364A patent/RU2016148364A/ru not_active Application Discontinuation
- 2015-05-11 BR BR112016026560A patent/BR112016026560A2/pt not_active Application Discontinuation
- 2015-05-11 MX MX2016014731A patent/MX2016014731A/es unknown
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2016
- 2016-04-07 US US15/093,616 patent/US20160213736A1/en not_active Abandoned
- 2016-11-09 IL IL248882A patent/IL248882A0/en unknown
- 2016-11-09 ZA ZA2016/07740A patent/ZA201607740B/en unknown
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| US20160213736A1 (en) | 2016-07-28 |
| BR112016026560A2 (pt) | 2017-08-15 |
| CA2948540A1 (en) | 2015-11-19 |
| JP2017515854A (ja) | 2017-06-15 |
| RU2016148364A3 (enExample) | 2019-07-24 |
| ES2751652T3 (es) | 2020-04-01 |
| WO2015175381A1 (en) | 2015-11-19 |
| MX2016014731A (es) | 2017-05-04 |
| IL248882A0 (en) | 2017-01-31 |
| EP3142649A1 (en) | 2017-03-22 |
| ZA201607740B (en) | 2020-02-26 |
| SG11201609256SA (en) | 2016-12-29 |
| KR20170015312A (ko) | 2017-02-08 |
| EP3444011A1 (en) | 2019-02-20 |
| AU2015259471A1 (en) | 2016-11-24 |
| US20170100448A1 (en) | 2017-04-13 |
| CN106470679A (zh) | 2017-03-01 |
| EP3142649B1 (en) | 2019-07-24 |
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