JP2017514585A - 表示器付き自己注射器 - Google Patents
表示器付き自己注射器 Download PDFInfo
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- JP2017514585A JP2017514585A JP2016564573A JP2016564573A JP2017514585A JP 2017514585 A JP2017514585 A JP 2017514585A JP 2016564573 A JP2016564573 A JP 2016564573A JP 2016564573 A JP2016564573 A JP 2016564573A JP 2017514585 A JP2017514585 A JP 2017514585A
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Abstract
Description
17−アルファ・カプロン酸ヒドロキシプロゲステロン、副腎皮質刺激ホルモン(ACTH)、ラロニダーゼ、第VIII因子、フォン・ヴィレブランド因子複合体、アルファセプト、塩酸アポモルヒネ、ダルベポエチン・アルファ、ネララビン、ベバシズマブ、インターフェロン・ベータ−1a,11mcg、インターフェロン・ベータ−1a,33mcg、第IX因子複合体、インターフェロン・ベータ−1b、イバンドロン酸ナトリウム、ボツリヌス毒素、プロテインC濃縮物、アルグルセラーゼ、イミグルセラーゼ、注射液、セクレチン、合成物質、人間、1マイクログラム、グラチラマー酢酸塩、デシタビン、酢酸デスモプレシン、イデュルスルファーゼ、エタネルセプト、エポエチン・アルファ、Anadalufungin、セツキシマブ、オレイン酸エタノールアミン、ヒアルロン酸誘導体、アガルシダーゼ・ベータ、第IX因子非組み換え体、第IX因子組み換え体、第VIII因子(人間)、第VIII因子(豚)、第VIII因子組み換え体、ファイバVH、免疫グロブリン(静脈注射)(IVIG)、エンフュヴィルタイド、免疫グロブリン(静脈注射)(IVIG)、ソマトロピン、B型肝炎免疫グロブリン(静脈注射)(IVIG)、トラスツズマブ、フォン・ヴィレブランド因子複合体、アダリムマブ、DMEによるインスリン投与(すなわちインスリンポンプ)、ヒアルロン酸誘導体、メカセルミン、ゲフィチニブ、レボロイコボリンカルシウム、ラニビズマブ注射、ペガプタニブ、ウロフォリトロピン、ミカファンギン、ボツリヌス毒素B型、アグルコシダーゼ・アルファ、ガルスルファーゼ、ソマトロピン、第VIIa因子、Atacept、ヒアルロン酸誘導体、ヒアルロナン誘導体、免疫グロブリン(静脈注射)(IVIG)、ヘミン、ペグインターフェロン・アルファ−2a、ペグインターフェロン・アルファ−2b、エポエチン・アルファ、ソマトレム、エファリズマブ、インターフェロン・ベータ−1a、皮下投与、ゾレドロン酸、インフリキシマブ、トレプロスチニル、フルオシノロンアセトニド、硝子体内移植、ジドブジン、エクリズマブ、ランレオチド、ヒストレリンインプラント、パリビズマブ、ヒアルロン酸誘導体、テモゾロミド、抗トロンビンIII(人間)、ナタリズマブ、パニツムマブ、免疫グロブリン(静脈注射)(IVIG)、アザシチジン、ベルテポルフィン、ヒアルロニダーゼ、牛、防腐剤が入っていない、ナルトレキソン・デポ、テニポシド、オマリズマブ、90Y−イブリツモマブ・チウキセタン、ADEPT、アルデスロイキン、アレムツズマブ、ベバシズマブ、ボルテゾミブ、セツキシマブ、ダサチニブ、エルロチニブ、ゲフィチニブ、ゲムツズマブ、イマチニブ、インターフェロン・アルファ、インターロイキン−2、ヨウ素131トシツモマブ、ラパチニブ、レナリドミド、パニツムマブ、リツキシマブ、ソラフェニブ、スニチニブ、サリドマイド、トラスツズマブ。
アルファ1−アドレナリン拮抗薬、鎮痛薬、麻酔薬、アンジオテンシン拮抗薬、炎症性物質、抗不整脈薬、抗コリン作用薬、抗凝血剤、抗けいれん剤、下痢止め薬、抗新生物薬および代謝拮抗物質、抗新生物薬および代謝拮抗物質、抗硬化剤、ベータ−アドレナリン拮抗薬、ビスフォスフォネート、気管支拡張剤、心臓循環作動薬、心・血管作動薬、中枢作用性アルファ2−興奮誘発剤、造影剤、変換酵素阻害薬、皮膚病薬、利尿薬、勃起不全薬、乱用に対する薬物、エンドセリン拮抗薬、ホルモン剤およびサイトカイン、血糖降下薬、低尿酸血剤および痛風に用いられる薬物、免疫抑制剤、脂質異常症治療薬、精神治療薬、レニン阻害剤、セロトニン拮抗剤ステロイド、交感神経様作用薬、甲状腺薬および抗甲状腺薬、血管拡張剤、バソペプチダーゼ阻害薬。
Claims (25)
- 液体薬剤を送達する自己注射器であって、
硬質な外側容器と、
前記硬質な外側容器内に配され、近位端と遠位端とを有する、前記液体薬剤を収容する折り畳み式容器と、
前記折り畳み式容器の前記遠位端に連結され、前記折り畳み式容器内に前記液体薬剤を保持する開放可能な閉止部と、
前記開放可能な閉止部に連結された、前記折り畳み式容器から前記液体薬剤を送達する注射手段と、
前記硬質な外側容器内に配される加圧手段であって、前記折り畳み式容器の前記近位端に作用して前記折り畳み式容器の前記近位端を前記折り畳み式容器の前記遠位端に向って付勢する力を与え、これにより、前記液体薬剤が前記開放可能な閉止部が開放されると前記注射手段を経由して送達されるように、前記折り畳み式容器に収容された前記液体薬剤を加圧する加圧手段とを備え、
前記硬質な外側容器内に少なくとも部分的に配され、前記開放可能な閉止部が開放されると前記折り畳み式容器の前記遠位端に向って長手方向に運動するよう構成された細長い表示部材であって、前記細長い表示部材の長手方向の運動により、前記自己注射器の使用者に対して、注射の進行度合に関する視覚および/または音声および/または触覚フィードバックを生成する表示部材をさらに備える、自己注射器。 - 請求項1に記載の自己注射器であって、
前記折り畳み式容器は、部分的には硬質な内壁によって、また部分的には前記硬質な内壁内に摺動可能に構成されたピストンによって、前記折り畳み式容器の容積が前記ピストンの位置に依存して変化するように規定される、自己注射器。 - 請求項2に記載の自己注射器であって、
前記折り畳み式容器の前記硬質な内壁は、前記硬質な外側容器の内壁によって規定される、自己注射器。 - 請求項2に記載の自己注射器であって、
前記折り畳み式容器が医薬品用のガラス製またはプラスチック製のカートリッジまたはプレフィルドシリンジである、自己注射器。 - 請求項1に記載の自己注射器であって、
前記折り畳み式容器が前記開放可能な閉止部に連結された蛇腹である、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記細長い表示部材の遠位端が前記折り畳み式容器の近位端に接続されている、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記開放可能な閉止部がエアロゾル弁などのノーマルクローズ弁である、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記開放可能な閉止部が穿孔可能な隔壁と穿孔手段とを備える、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記細長い表示部材の一部が前記硬質な外側容器の外へ延在し、これにより前記自己注射器の使用者に対して、注射の進行度合に関する触覚および/または視覚指示を与える、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記硬質な外側容器は、前記細長い表示部材の運動を監視することができる窓部を備え、これにより前記自己注射器の使用者に対して、注射の進行度合に関する指示を与える、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記音声フィードバックは連続するクリック音形式である、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記細長い表示部材は表示部に接続されており、前記細長い表示部材の長手方向の運動が前記表示部の前記自己注射器ケーシングに対する回転運動に変換され、前記表示部の回転運動により前記注射の進行度合に関する前記視覚および/または音声および/または触覚フィードバックを与える、自己注射器。 - 請求項12に記載の自己注射器であって、
前記細長い表示部材は前記細長い表示部材の部分の長さに沿ってねじれた断面形状を有し、前記表示部は、前記細長い表示部材の長手方向の運動が前記表示部の前記自己注射器ケーシングに対する回転運動に変換されるよう、前記細長い表示部材に係合するよう形成されたスロットを有する、自己注射器。 - 請求項12に記載の自己注射器であって、
前記細長い表示部材は、溝状のネジがついた円筒形状であり、前記表示部は、前記細長い表示部材の長手方向の運動が前記表示部の前記自己注射器ケーシングに対する回転運動に変換されるよう、記溝状のネジと係合するよう構成されたピンである、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記細長い表示部材は、電子的手段によって視覚、音声および/または触覚フィードバックを与える、自己注射器。 - 請求項15に記載の自己注射器であって、
前記細長い表示部材は、
(a)前記細長い表示部材が運動すると音声フィードバックを与える音声発生器および/または
(b)前記細長い表示部材が運動すると視覚フィードバックを与える光源を備える、自己注射器。 - 請求項15または16に記載の自己注射器であって、
前記細長い表示部材は、前記折り畳み式容器の前記遠位端に向って長手方向に移動すると電気接点を閉鎖するよう構成され、前記電気接点の閉止部は、前記自己注射器の使用者に対して、注射の開始および進行度合に関するフィードバックを与える、自己注射器。 - 請求項15から17のいずれか1項に記載の自己注射器であって、
前記細長い表示部材は、バッテリーとプリント基板(PCB)とを備える、自己注射器。 - 請求項18に記載の自己注射器であって、
前記細長い表示部材は音声発生器を備え、前記音声発生器およびバッテリーはプレス金属バネ接点によって前記PCBに接続されている、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記加圧手段はバネなどの付勢手段である、自己注射器。 - 先行する請求項のいずれか1項に記載の自己注射器であって、
前記加圧手段は、前記液体薬剤の保管中、第1の力を前記折り畳み式容器に加えて、そこに収容される液体薬剤を連続的に加圧するよう構成され、
前記加圧手段は、第2の力を前記折り畳み式容器に加えるよう作動可能であり、前記第2の力は前記第1の力よりも大きい、自己注射器。 - 請求項21に記載の自己注射器であって、
前記加圧手段は、ボタンの押下またはキャップもしくはラッチの取り外しにより、第2の力を前記折り畳み式容器に加えるよう作動される、自己注射器。 - 請求項22に記載の自己注射器であって、
前記細長い表示部材は前記ラッチを備える、自己注射器。 - 請求項21に記載の自己注射器であって、
前記細長い表示部材はネジ山を備え、前記自己注射器は前記ネジ山と係合可能なナットを備え、
前記加圧手段は、前記ナットが前記ネジ山から外れるまで前記ナットを回すことにより、前記第2の力を前記折り畳み式容器に加えるよう作動される、自己注射器。 - 自己注射器の使用方法であって、先行する請求項のいずれか1項に記載の自己注射器を使用する方法であり、
(a)前記開放可能な閉止部を開放して、前記注射手段を経由した前記液体薬剤の送達と、前記折り畳み式容器の前記遠位端へ向う前記細長い表示部材の長手方向の運動とを可能とするステップと、
(b)前記細長い表示部材の前記長手方向の運動により生成される視覚および/または音声および/または触覚フィードバックにより、前記注射の進行度合を監視するステップとを含む、自己注射器の使用方法。
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GB1407680.6 | 2014-05-01 | ||
GBGB1407680.6A GB201407680D0 (en) | 2014-05-01 | 2014-05-01 | Indicator |
PCT/GB2015/050393 WO2015121655A1 (en) | 2014-02-12 | 2015-02-12 | Injector assembly |
GBPCT/GB2015/050393 | 2015-02-12 | ||
PCT/GB2015/051304 WO2015166286A2 (en) | 2014-05-01 | 2015-05-01 | Indicator |
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US (1) | US20170049969A1 (ja) |
EP (1) | EP3137132A2 (ja) |
JP (1) | JP6270232B2 (ja) |
KR (1) | KR101825868B1 (ja) |
CN (1) | CN106659849A (ja) |
AU (1) | AU2015255027B2 (ja) |
BR (1) | BR112016024892A2 (ja) |
CA (1) | CA2946683A1 (ja) |
GB (1) | GB201407680D0 (ja) |
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WO2015166286A3 (en) | 2015-12-23 |
EP3137132A2 (en) | 2017-03-08 |
WO2015166286A2 (en) | 2015-11-05 |
JP6270232B2 (ja) | 2018-01-31 |
RU2653686C1 (ru) | 2018-05-11 |
AU2015255027B2 (en) | 2016-12-22 |
KR101825868B1 (ko) | 2018-02-05 |
SG11201608972WA (en) | 2016-11-29 |
GB201407680D0 (en) | 2014-06-18 |
KR20170020757A (ko) | 2017-02-24 |
CA2946683A1 (en) | 2015-11-05 |
US20170049969A1 (en) | 2017-02-23 |
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CN106659849A (zh) | 2017-05-10 |
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