JP2017513928A5 - - Google Patents
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- JP2017513928A5 JP2017513928A5 JP2016575316A JP2016575316A JP2017513928A5 JP 2017513928 A5 JP2017513928 A5 JP 2017513928A5 JP 2016575316 A JP2016575316 A JP 2016575316A JP 2016575316 A JP2016575316 A JP 2016575316A JP 2017513928 A5 JP2017513928 A5 JP 2017513928A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- item
- self
- ion
- assembling peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000243 solution Substances 0.000 claims description 137
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 121
- 238000000034 method Methods 0.000 claims description 106
- 210000004072 lung Anatomy 0.000 claims description 53
- 235000002639 sodium chloride Nutrition 0.000 claims description 41
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 36
- 239000000872 buffer Substances 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 28
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 26
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 22
- 239000001110 calcium chloride Substances 0.000 claims description 22
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 22
- 230000004888 barrier function Effects 0.000 claims description 20
- 239000000017 hydrogel Substances 0.000 claims description 20
- -1 ammonium ions Chemical class 0.000 claims description 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 15
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 15
- 239000001103 potassium chloride Substances 0.000 claims description 13
- 235000011164 potassium chloride Nutrition 0.000 claims description 13
- 239000011780 sodium chloride Substances 0.000 claims description 13
- 239000012266 salt solution Substances 0.000 claims description 12
- 230000004962 physiological condition Effects 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 10
- 239000002872 contrast media Substances 0.000 claims description 10
- 229910001414 potassium ion Inorganic materials 0.000 claims description 10
- 229910001415 sodium ion Inorganic materials 0.000 claims description 10
- 210000003456 pulmonary alveoli Anatomy 0.000 claims description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 8
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 5
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 5
- 150000001450 anions Chemical class 0.000 claims description 5
- 229910001424 calcium ion Inorganic materials 0.000 claims description 5
- 150000001768 cations Chemical class 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 210000000621 bronchi Anatomy 0.000 claims description 4
- 235000011148 calcium chloride Nutrition 0.000 claims description 4
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 4
- 230000002685 pulmonary effect Effects 0.000 claims description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 3
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 3
- 229940005654 nitrite ion Drugs 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 206010014561 Emphysema Diseases 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 210000003123 bronchiole Anatomy 0.000 claims description 2
- 230000009172 bursting Effects 0.000 claims description 2
- 229940006477 nitrate ion Drugs 0.000 claims description 2
- 229940085991 phosphate ion Drugs 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 46
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 229910002651 NO3 Inorganic materials 0.000 description 2
- 239000002121 nanofiber Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461950529P | 2014-03-10 | 2014-03-10 | |
| US61/950,529 | 2014-03-10 | ||
| US201461953049P | 2014-03-14 | 2014-03-14 | |
| US61/953,049 | 2014-03-14 | ||
| PCT/US2015/019743 WO2015138478A1 (en) | 2014-03-10 | 2015-03-10 | Autoassembling peptides for the treatment of pulmonary bulla |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513928A JP2017513928A (ja) | 2017-06-01 |
| JP2017513928A5 true JP2017513928A5 (enExample) | 2018-07-26 |
| JP6545727B2 JP6545727B2 (ja) | 2019-07-17 |
Family
ID=52737415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575316A Expired - Fee Related JP6545727B2 (ja) | 2014-03-10 | 2015-03-10 | 肺大気胞を治療するための自発組織化ペプチド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10245299B2 (enExample) |
| EP (1) | EP3116524B1 (enExample) |
| JP (1) | JP6545727B2 (enExample) |
| ES (1) | ES2712608T3 (enExample) |
| WO (1) | WO2015138478A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2345433B1 (en) | 2008-10-06 | 2017-03-01 | 3-D Matrix, Ltd. | Tissue plug |
| JP6389170B2 (ja) | 2012-07-06 | 2018-09-12 | スリーディー マトリックス， エルティーディー３−Ｄ Ｍａｔｒｉｘ， Ｌｔｄ． | ペプチド溶液のためのフィル−フィニッシュ過程 |
| JP6554121B2 (ja) * | 2014-03-10 | 2019-07-31 | 株式会社スリー・ディー・マトリックス | 気管支閉鎖剤としての自己組織化ペプチド |
| CA2939696C (en) | 2014-03-10 | 2023-01-10 | 3-D Matrix, Ltd. | Self-assembling peptide compositions |
| JP6684719B2 (ja) | 2014-03-10 | 2020-04-22 | 株式会社スリー・ディー・マトリックス | ペプチド組成物の滅菌および濾過 |
| ES2712608T3 (es) | 2014-03-10 | 2019-05-14 | 3 D Matrix Ltd | Péptidos autoensamblantes para el tratamiento de las bullas pulmonares |
| WO2017120092A1 (en) * | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Combination compositions |
| CN106539561B (zh) * | 2016-12-09 | 2023-08-11 | 中国科学院西安光学精密机械研究所 | 一种肺大泡破裂部位定位装置 |
| EP3723726A1 (en) | 2017-12-15 | 2020-10-21 | 3-D Matrix, Ltd. | Surfactant peptide nanostructures and uses in drug delivery |
| WO2020008377A2 (en) | 2018-07-03 | 2020-01-09 | 3-D Matrix, Ltd. | Ionic self-assembling peptides |
| WO2021202577A1 (en) | 2020-03-31 | 2021-10-07 | 3-D Matrix, Ltd. | Sterilization of self-assembling peptides by irradiation |
| WO2022035783A2 (en) * | 2020-08-10 | 2022-02-17 | Gel4Med, Inc. | Topical and parenteral use and administration of self-assembling amphiphilic peptide hydrogels |
| US20240366717A1 (en) * | 2020-08-10 | 2024-11-07 | Gel4Med, Inc. | Antimicrobial matrix formed from peptide hydrogels |
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| CN103251690B (zh) * | 2013-02-26 | 2015-10-28 | 中国人民解放军新疆军区联勤部药品仪器检验所 | 维药瘤果黑种草子挥发油在制备治疗慢性阻塞性肺病药物的应用 |
| KR20190102101A (ko) | 2013-03-06 | 2019-09-02 | 가부시끼가이샤 쓰리디 매트릭스 | 정제된 양친매성 펩타이드 조성물을 이용하는 수술 방법 |
| JP2016513523A (ja) | 2013-03-14 | 2016-05-16 | 株式会社スリー・ディー・マトリックス | 胆汁漏の処置 |
| KR20160003651A (ko) | 2013-03-14 | 2016-01-11 | 가부시끼가이샤 쓰리디 매트릭스 | 위장 폐색 예방용 물질 |
| CN105658252A (zh) | 2013-08-22 | 2016-06-08 | 阿奇生物外科有限公司 | 用于控制流体移动的可植入网状物 |
| CN105611963B (zh) | 2013-09-02 | 2020-04-24 | 大成化工株式会社 | 注射器以及注射器组件 |
| JP6684719B2 (ja) | 2014-03-10 | 2020-04-22 | 株式会社スリー・ディー・マトリックス | ペプチド組成物の滅菌および濾過 |
| CA2939696C (en) | 2014-03-10 | 2023-01-10 | 3-D Matrix, Ltd. | Self-assembling peptide compositions |
| JP6554121B2 (ja) | 2014-03-10 | 2019-07-31 | 株式会社スリー・ディー・マトリックス | 気管支閉鎖剤としての自己組織化ペプチド |
| US20170173105A1 (en) | 2014-03-10 | 2017-06-22 | 3-D Matrix, Ltd. | Autoassembling peptides for the treatment of pulmonary leakage |
| ES2712608T3 (es) | 2014-03-10 | 2019-05-14 | 3 D Matrix Ltd | Péptidos autoensamblantes para el tratamiento de las bullas pulmonares |
| WO2015194194A1 (en) | 2014-06-20 | 2015-12-23 | 3-D Matrix, Ltd. | Materials and methods for filling bone voids |
| WO2017120092A1 (en) | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Combination compositions |
-
2015
- 2015-03-10 ES ES15712233T patent/ES2712608T3/es active Active
- 2015-03-10 US US15/124,636 patent/US10245299B2/en not_active Expired - Fee Related
- 2015-03-10 WO PCT/US2015/019743 patent/WO2015138478A1/en not_active Ceased
- 2015-03-10 JP JP2016575316A patent/JP6545727B2/ja not_active Expired - Fee Related
- 2015-03-10 EP EP15712233.4A patent/EP3116524B1/en not_active Not-in-force
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