JP2017513927A5 - - Google Patents

Info

Publication number

JP2017513927A5

JP2017513927A5 JP2016575314A JP2016575314A JP2017513927A5 JP 2017513927 A5 JP2017513927 A5 JP 2017513927A5 JP 2016575314 A JP2016575314 A JP 2016575314A JP 2016575314 A JP2016575314 A JP 2016575314A JP 2017513927 A5 JP2017513927 A5 JP 2017513927A5

Authority

JP

Japan

Prior art keywords

solution

item

self

target area

assembling peptide

Prior art date

2015-03-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000243 solution Substances 0.000 claims description 126
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 98
• 238000000034 method Methods 0.000 claims description 95
• 235000002639 sodium chloride Nutrition 0.000 claims description 38
• 210000004072 lung Anatomy 0.000 claims description 33
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 31
• 239000000872 buffer Substances 0.000 claims description 28
• 150000003839 salts Chemical class 0.000 claims description 27
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 22
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 20
• 239000001110 calcium chloride Substances 0.000 claims description 20
• 229910001628 calcium chloride Inorganic materials 0.000 claims description 20
• 150000001413 amino acids Chemical class 0.000 claims description 18
• 230000004888 barrier function Effects 0.000 claims description 17
• 239000000017 hydrogel Substances 0.000 claims description 17
• -1 ammonium ions Chemical class 0.000 claims description 16
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
• 230000002685 pulmonary effect Effects 0.000 claims description 14
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 12
• 239000001103 potassium chloride Substances 0.000 claims description 11
• 235000011164 potassium chloride Nutrition 0.000 claims description 11
• 239000011780 sodium chloride Substances 0.000 claims description 11
• 230000004962 physiological condition Effects 0.000 claims description 10
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 8
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 8
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
• 230000003872 anastomosis Effects 0.000 claims description 8
• 239000002872 contrast media Substances 0.000 claims description 8
• 229910001414 potassium ion Inorganic materials 0.000 claims description 8
• 229910001415 sodium ion Inorganic materials 0.000 claims description 8
• 239000012266 salt solution Substances 0.000 claims description 7
• 238000001356 surgical procedure Methods 0.000 claims description 6
• 239000000843 powder Substances 0.000 claims description 5
• 230000002265 prevention Effects 0.000 claims description 5
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
• BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 4
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 4
• XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 4
• JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 4
• 239000013543 active substance Substances 0.000 claims description 4
• 150000001450 anions Chemical class 0.000 claims description 4
• 235000011148 calcium chloride Nutrition 0.000 claims description 4
• 229910001424 calcium ion Inorganic materials 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• 229940079593 drug Drugs 0.000 claims description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
• 229910052742 iron Inorganic materials 0.000 claims description 4
• 229910001629 magnesium chloride Inorganic materials 0.000 claims description 4
• 229910001425 magnesium ion Inorganic materials 0.000 claims description 4
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
• 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
• 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
• 229910002651 NO3 Inorganic materials 0.000 claims description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
• KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
• 206010050456 Anastomotic leak Diseases 0.000 claims 2
• 239000007864 aqueous solution Substances 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 description 46
• NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 6
• FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 5
• 239000007853 buffer solution Substances 0.000 description 4
• 102000004196 processed proteins & peptides Human genes 0.000 description 4
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• 150000001768 cations Chemical class 0.000 description 3
• 230000002209 hydrophobic effect Effects 0.000 description 3
• 238000012544 monitoring process Methods 0.000 description 3
• JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 3
• 125000001453 quaternary ammonium group Chemical group 0.000 description 3
• 230000007547 defect Effects 0.000 description 2
• IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• 239000002121 nanofiber Substances 0.000 description 1
• 229940006477 nitrate ion Drugs 0.000 description 1
• 229940005654 nitrite ion Drugs 0.000 description 1
• 229940085991 phosphate ion Drugs 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1