JP2017513852A5 - - Google Patents
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- Publication number
- JP2017513852A5 JP2017513852A5 JP2016562874A JP2016562874A JP2017513852A5 JP 2017513852 A5 JP2017513852 A5 JP 2017513852A5 JP 2016562874 A JP2016562874 A JP 2016562874A JP 2016562874 A JP2016562874 A JP 2016562874A JP 2017513852 A5 JP2017513852 A5 JP 2017513852A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- independently
- compound
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000001424 substituent group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- -1 hydroxy, hydroxy Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 2
- 150000001356 alkyl thiols Chemical class 0.000 claims 2
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980016P | 2014-04-15 | 2014-04-15 | |
| US61/980,016 | 2014-04-15 | ||
| PCT/US2015/025903 WO2015160907A2 (en) | 2014-04-15 | 2015-04-15 | Potent and selective inhibitors of hepatitis c virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017513852A JP2017513852A (ja) | 2017-06-01 |
| JP2017513852A5 true JP2017513852A5 (enExample) | 2018-05-31 |
Family
ID=54324704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562874A Pending JP2017513852A (ja) | 2014-04-15 | 2015-04-15 | Ｃ型肝炎ウイルスの強力及び選択的な阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9926295B2 (enExample) |
| EP (1) | EP3131892A4 (enExample) |
| JP (1) | JP2017513852A (enExample) |
| KR (1) | KR20170002407A (enExample) |
| CN (1) | CN106661004A (enExample) |
| AU (1) | AU2015247706A1 (enExample) |
| BR (1) | BR112016023833A2 (enExample) |
| CA (1) | CA2945514A1 (enExample) |
| IL (1) | IL248318A0 (enExample) |
| MX (1) | MX2016013434A (enExample) |
| PH (1) | PH12016502039A1 (enExample) |
| RU (1) | RU2016144076A (enExample) |
| SG (1) | SG11201608587QA (enExample) |
| WO (1) | WO2015160907A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| JP2016527232A (ja) | 2013-07-17 | 2016-09-08 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｈｃｖの治療に使用するためのビフェニル誘導体を含む組み合わせ |
| WO2015184644A1 (zh) * | 2014-06-06 | 2015-12-10 | 爱博新药研发(上海)有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN112203652A (zh) * | 2018-05-09 | 2021-01-08 | 共晶制药公司 | 用于治疗hcv的组合疗法 |
| CN109456375B (zh) * | 2018-12-11 | 2019-10-22 | 枣庄学院 | 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101492672B1 (ko) * | 2008-02-13 | 2015-02-16 | 브리스톨-마이어스 스큅 컴퍼니 | Ｃ형 간염 바이러스 억제제로서의 이미다졸릴 바이페닐 이미다졸 |
| CA2751458C (en) * | 2009-02-06 | 2018-06-05 | Rfs Pharma, Llc | Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections |
| US8377980B2 (en) * | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| BR112013004520A2 (pt) * | 2010-08-26 | 2016-06-07 | Univ Emory | inibidores potentes e seletivos do virus da hepatite c |
| WO2012048421A1 (en) * | 2010-10-14 | 2012-04-19 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
| MX2013004906A (es) * | 2010-11-01 | 2013-12-06 | Genoscience Pharma | Nuevos inhibidores especificos de la proteasa ns3 de hcv. |
-
2015
- 2015-04-15 CN CN201580032237.0A patent/CN106661004A/zh active Pending
- 2015-04-15 SG SG11201608587QA patent/SG11201608587QA/en unknown
- 2015-04-15 EP EP15779578.2A patent/EP3131892A4/en not_active Withdrawn
- 2015-04-15 WO PCT/US2015/025903 patent/WO2015160907A2/en not_active Ceased
- 2015-04-15 BR BR112016023833A patent/BR112016023833A2/pt active Search and Examination
- 2015-04-15 CA CA2945514A patent/CA2945514A1/en not_active Abandoned
- 2015-04-15 RU RU2016144076A patent/RU2016144076A/ru unknown
- 2015-04-15 US US15/303,277 patent/US9926295B2/en active Active
- 2015-04-15 AU AU2015247706A patent/AU2015247706A1/en not_active Abandoned
- 2015-04-15 JP JP2016562874A patent/JP2017513852A/ja active Pending
- 2015-04-15 MX MX2016013434A patent/MX2016013434A/es unknown
- 2015-04-15 KR KR1020167030815A patent/KR20170002407A/ko not_active Withdrawn
-
2016
- 2016-10-12 PH PH12016502039A patent/PH12016502039A1/en unknown
- 2016-10-13 IL IL248318A patent/IL248318A0/en unknown
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