KR20170002407A - C형 간염 바이러스의 강력하고 선택적인 저해제 - Google Patents
C형 간염 바이러스의 강력하고 선택적인 저해제 Download PDFInfo
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- KR20170002407A KR20170002407A KR1020167030815A KR20167030815A KR20170002407A KR 20170002407 A KR20170002407 A KR 20170002407A KR 1020167030815 A KR1020167030815 A KR 1020167030815A KR 20167030815 A KR20167030815 A KR 20167030815A KR 20170002407 A KR20170002407 A KR 20170002407A
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- Prior art keywords
- alkyl
- hcv
- compound
- aryl
- substituents
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims description 54
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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| PCT/US2015/025903 WO2015160907A2 (en) | 2014-04-15 | 2015-04-15 | Potent and selective inhibitors of hepatitis c virus |
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| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| JP2016527232A (ja) | 2013-07-17 | 2016-09-08 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｈｃｖの治療に使用するためのビフェニル誘導体を含む組み合わせ |
| WO2015184644A1 (zh) * | 2014-06-06 | 2015-12-10 | 爱博新药研发(上海)有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TWI833753B (zh) * | 2018-05-09 | 2024-03-01 | 美商共結晶製藥公司 | 用於治療hcv之組合療法 |
| CN109456375B (zh) * | 2018-12-11 | 2019-10-22 | 枣庄学院 | 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法 |
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| DK2242752T3 (da) * | 2008-02-13 | 2012-11-19 | Bristol Myers Squibb Co | Imidazolyl-biphenylimidazoler som hepatitis C-virus-inhibitorer |
| CA2751458C (en) * | 2009-02-06 | 2018-06-05 | Rfs Pharma, Llc | Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections |
| US8377980B2 (en) * | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2012027712A2 (en) * | 2010-08-26 | 2012-03-01 | Rfs Pharma, Llc | Potent and selective inhibitors of hepatitis c virus |
| WO2012048421A1 (en) * | 2010-10-14 | 2012-04-19 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
| BR112013010836A2 (pt) * | 2010-11-01 | 2019-09-24 | Genoscience Pharma | inibidores específicos de ns3 protease de hcv |
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- 2015-04-15 CN CN201580032237.0A patent/CN106661004A/zh active Pending
- 2015-04-15 SG SG11201608587QA patent/SG11201608587QA/en unknown
- 2015-04-15 RU RU2016144076A patent/RU2016144076A/ru unknown
- 2015-04-15 WO PCT/US2015/025903 patent/WO2015160907A2/en not_active Ceased
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| CA2945514A1 (en) | 2015-10-22 |
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| BR112016023833A2 (pt) | 2017-10-10 |
| US9926295B2 (en) | 2018-03-27 |
| EP3131892A2 (en) | 2017-02-22 |
| AU2015247706A1 (en) | 2016-10-27 |
| JP2017513852A (ja) | 2017-06-01 |
| PH12016502039A1 (en) | 2017-01-09 |
| WO2015160907A3 (en) | 2016-12-01 |
| MX2016013434A (es) | 2017-03-03 |
| RU2016144076A (ru) | 2018-05-16 |
| CN106661004A (zh) | 2017-05-10 |
| SG11201608587QA (en) | 2016-11-29 |
| US20170029407A1 (en) | 2017-02-02 |
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