CN106661004A - 丙型肝炎病毒的有效和选择性抑制剂 - Google Patents

丙型肝炎病毒的有效和选择性抑制剂 Download PDF

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Publication number
CN106661004A
CN106661004A CN201580032237.0A CN201580032237A CN106661004A CN 106661004 A CN106661004 A CN 106661004A CN 201580032237 A CN201580032237 A CN 201580032237A CN 106661004 A CN106661004 A CN 106661004A
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CN
China
Prior art keywords
alkyl
compound
aryl
hcv
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580032237.0A
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English (en)
Chinese (zh)
Inventor
斯蒂文·J·科阿斯
理查德·安东尼·惠特克
塔玛拉·罗萨里奥·麦克布瑞尔
石俊兴
弗兰克·安布拉尔
张宏旺
周龙胡
雷蒙德·F·斯基那兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Cocrystal Pharma Inc
Original Assignee
Emory University
Cocrystal Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University, Cocrystal Pharma Inc filed Critical Emory University
Publication of CN106661004A publication Critical patent/CN106661004A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201580032237.0A 2014-04-15 2015-04-15 丙型肝炎病毒的有效和选择性抑制剂 Pending CN106661004A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461980016P 2014-04-15 2014-04-15
US61/980,016 2014-04-15
PCT/US2015/025903 WO2015160907A2 (en) 2014-04-15 2015-04-15 Potent and selective inhibitors of hepatitis c virus

Publications (1)

Publication Number Publication Date
CN106661004A true CN106661004A (zh) 2017-05-10

Family

ID=54324704

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580032237.0A Pending CN106661004A (zh) 2014-04-15 2015-04-15 丙型肝炎病毒的有效和选择性抑制剂

Country Status (14)

Country Link
US (1) US9926295B2 (enExample)
EP (1) EP3131892A4 (enExample)
JP (1) JP2017513852A (enExample)
KR (1) KR20170002407A (enExample)
CN (1) CN106661004A (enExample)
AU (1) AU2015247706A1 (enExample)
BR (1) BR112016023833A2 (enExample)
CA (1) CA2945514A1 (enExample)
IL (1) IL248318A0 (enExample)
MX (1) MX2016013434A (enExample)
PH (1) PH12016502039A1 (enExample)
RU (1) RU2016144076A (enExample)
SG (1) SG11201608587QA (enExample)
WO (1) WO2015160907A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109456375A (zh) * 2018-12-11 2019-03-12 枣庄学院 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
US9775831B2 (en) 2013-07-17 2017-10-03 Bristol-Myers Squibb Company Combinations comprising biphenyl derivatives for use in the treatment of HCV
WO2015184644A1 (zh) * 2014-06-06 2015-12-10 爱博新药研发(上海)有限公司 抑制丙肝病毒的化合物、药物组合物及其应用
US10617675B2 (en) 2015-08-06 2020-04-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US11752166B2 (en) 2018-05-09 2023-09-12 Cocrystal Pharma, Inc. Combination therapy for treatment of HCV

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102007122A (zh) * 2008-02-13 2011-04-06 百时美施贵宝公司 作为丙型肝炎病毒抑制剂的咪唑基联苯基咪唑
CN102395590A (zh) * 2009-02-06 2012-03-28 Rfs制药公司 用于治疗癌症和病毒感染的嘌呤核苷单磷酸酯前药
WO2012048421A1 (en) * 2010-10-14 2012-04-19 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
CN102741242A (zh) * 2009-12-16 2012-10-17 百时美施贵宝公司 丙型肝炎病毒抑制剂
US20130210774A1 (en) * 2010-08-26 2013-08-15 Emory University Potent and selective inhibitors of hepatitis c virus
CN103328466A (zh) * 2010-11-01 2013-09-25 Rfs制药公司 Hcv ns3蛋白酶抑制剂

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102007122A (zh) * 2008-02-13 2011-04-06 百时美施贵宝公司 作为丙型肝炎病毒抑制剂的咪唑基联苯基咪唑
CN102395590A (zh) * 2009-02-06 2012-03-28 Rfs制药公司 用于治疗癌症和病毒感染的嘌呤核苷单磷酸酯前药
CN102741242A (zh) * 2009-12-16 2012-10-17 百时美施贵宝公司 丙型肝炎病毒抑制剂
US20130210774A1 (en) * 2010-08-26 2013-08-15 Emory University Potent and selective inhibitors of hepatitis c virus
WO2012048421A1 (en) * 2010-10-14 2012-04-19 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
CN103328466A (zh) * 2010-11-01 2013-09-25 Rfs制药公司 Hcv ns3蛋白酶抑制剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109456375A (zh) * 2018-12-11 2019-03-12 枣庄学院 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法
CN109456375B (zh) * 2018-12-11 2019-10-22 枣庄学院 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法

Also Published As

Publication number Publication date
SG11201608587QA (en) 2016-11-29
BR112016023833A2 (pt) 2017-10-10
JP2017513852A (ja) 2017-06-01
IL248318A0 (en) 2016-11-30
WO2015160907A2 (en) 2015-10-22
AU2015247706A1 (en) 2016-10-27
WO2015160907A3 (en) 2016-12-01
MX2016013434A (es) 2017-03-03
US20170029407A1 (en) 2017-02-02
EP3131892A2 (en) 2017-02-22
KR20170002407A (ko) 2017-01-06
PH12016502039A1 (en) 2017-01-09
CA2945514A1 (en) 2015-10-22
US9926295B2 (en) 2018-03-27
EP3131892A4 (en) 2017-09-20
RU2016144076A (ru) 2018-05-16

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Application publication date: 20170510