JP2017512058A5 - - Google Patents
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- Publication number
- JP2017512058A5 JP2017512058A5 JP2016553562A JP2016553562A JP2017512058A5 JP 2017512058 A5 JP2017512058 A5 JP 2017512058A5 JP 2016553562 A JP2016553562 A JP 2016553562A JP 2016553562 A JP2016553562 A JP 2016553562A JP 2017512058 A5 JP2017512058 A5 JP 2017512058A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- acute
- pancreatitis
- lung
- uti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000037865 fusion proteins Human genes 0.000 claims 10
- 108020001507 fusion proteins Proteins 0.000 claims 10
- 208000019206 urinary tract infection Diseases 0.000 claims 8
- 206010033645 Pancreatitis Diseases 0.000 claims 6
- 206010035664 Pneumonia Diseases 0.000 claims 6
- 230000001154 acute effect Effects 0.000 claims 4
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 206010003011 Appendicitis Diseases 0.000 claims 2
- 208000002251 Dissecting Aneurysm Diseases 0.000 claims 2
- 206010059284 Epidermal necrosis Diseases 0.000 claims 2
- 208000004852 Lung Injury Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 206010053159 Organ failure Diseases 0.000 claims 2
- 208000016222 Pancreatic disease Diseases 0.000 claims 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 2
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 claims 2
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 claims 2
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 2
- 206010069363 Traumatic lung injury Diseases 0.000 claims 2
- 208000009470 Ventilator-Associated Pneumonia Diseases 0.000 claims 2
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 201000003229 acute pancreatitis Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 206010002895 aortic dissection Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 206010009887 colitis Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 208000037906 ischaemic injury Diseases 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 231100000515 lung injury Toxicity 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 208000024691 pancreas disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 239000013636 protein dimer Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019109054A JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943617P | 2014-02-24 | 2014-02-24 | |
| US61/943,617 | 2014-02-24 | ||
| PCT/US2015/017152 WO2015127391A1 (en) | 2014-02-24 | 2015-02-23 | Uti fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019109054A Division JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512058A JP2017512058A (ja) | 2017-05-18 |
| JP2017512058A5 true JP2017512058A5 (enExample) | 2018-04-05 |
| JP6574431B2 JP6574431B2 (ja) | 2019-09-11 |
Family
ID=52629709
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553562A Active JP6574431B2 (ja) | 2014-02-24 | 2015-02-23 | Ｕｔｉ融合タンパク質 |
| JP2019109054A Active JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
| JP2021142544A Pending JP2022002513A (ja) | 2014-02-24 | 2021-09-01 | Ｕｔｉ融合タンパク質 |
| JP2023108024A Pending JP2023123763A (ja) | 2014-02-24 | 2023-06-30 | Ｕｔｉ融合タンパク質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019109054A Active JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
| JP2021142544A Pending JP2022002513A (ja) | 2014-02-24 | 2021-09-01 | Ｕｔｉ融合タンパク質 |
| JP2023108024A Pending JP2023123763A (ja) | 2014-02-24 | 2023-06-30 | Ｕｔｉ融合タンパク質 |
Country Status (38)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3178241A1 (en) * | 2014-02-24 | 2015-08-27 | Takeda Gmbh | Uti fusion proteins |
| SG11201911603SA (en) * | 2017-06-07 | 2020-01-30 | Spark Therapeutics Inc | ENHANCING AGENTS FOR IMPROVED CELL TRANSFECTION AND/OR rAAV VECTOR PRODUCTION |
| WO2020106881A1 (en) * | 2018-11-20 | 2020-05-28 | Diamedica Inc. | Modified ulinastatin polypeptides |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| JP2021080177A (ja) | 2019-11-14 | 2021-05-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2021178843A1 (en) * | 2020-03-05 | 2021-09-10 | DiaMedica USA Inc. | Ulinastatin polypeptides |
| CA3206854A1 (en) * | 2021-01-29 | 2022-08-04 | Rick PAULS | Ulinastatin polypeptides for treating diseases |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| EP0401508B1 (de) * | 1989-05-13 | 1994-11-23 | Bayer Ag | Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| JPH0584083A (ja) | 1990-11-13 | 1993-04-06 | Mochida Pharmaceut Co Ltd | 新規ポリペプチド、それをコードする新規ｄｎａ、新規ポリペプチドの製造方法、新規医薬組成物、および新規酵素阻害方法 |
| JP2769083B2 (ja) | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
| BR9708021A (pt) | 1996-03-11 | 1999-07-27 | Bayer Ag | Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína |
| DE19725014A1 (de) | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
| SI1730191T1 (sl) * | 2004-03-30 | 2011-11-30 | Glaxo Group Ltd | Imunoglobulin-vezavni hOSM |
| US20080181892A1 (en) * | 2004-08-11 | 2008-07-31 | Trubion Pharmaceuticals | Binding Domain Fusion Protein |
| JP4067557B2 (ja) * | 2005-06-03 | 2008-03-26 | 持田製薬株式会社 | 抗ｃｄ１４抗体融合蛋白質 |
| CA2635589C (en) | 2005-12-29 | 2017-01-17 | Dyax Corp. | Protease inhibition |
| JP6063122B2 (ja) * | 2008-09-26 | 2017-01-18 | ユセベ ファルマ ソシエテ アノニム | 生物学的産物 |
| CN101721699B (zh) * | 2008-10-13 | 2012-11-07 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗伴随vegf升高的炎症反应的药物中的应用 |
| CN102580085B (zh) * | 2008-10-13 | 2013-09-18 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗脓毒症药物中的应用 |
| MX2011011815A (es) * | 2009-05-05 | 2012-01-27 | Amgen Inc | Mutantes fgf21 y usos de los mismos. |
| LT2536745T (lt) * | 2010-02-19 | 2016-09-26 | Xencor, Inc. | Nauji ctla4-ig imunoadhezinai |
| IL313299A (en) * | 2011-04-29 | 2024-08-01 | Univ Washington | Therapeutic nuclease compositions and methods |
| US8619331B2 (en) | 2011-07-19 | 2013-12-31 | Xerox Corporation | Simulated paper texture using clear toner and glossmark on texture-less stock |
| CN110078831A (zh) * | 2011-12-01 | 2019-08-02 | 圆祥生命科技股份有限公司 | 补体和vegf途径的蛋白质抑制剂及其使用方法 |
| ES2671631T3 (es) * | 2012-04-23 | 2018-06-07 | Nrl Pharma, Inc. | Proteína de fusión de lactoferrina y método para la preparación de la misma |
| CN103044554B (zh) * | 2012-05-14 | 2014-08-27 | 旭华（上海）生物研发中心有限公司 | 重组二聚化人尿胰蛋白酶抑制剂、其制备方法及其应用 |
| JP2013253079A (ja) * | 2012-05-14 | 2013-12-19 | Xuhua (Shanghai) Biological Research & Development Center Co Ltd | 生物学的に活性なヒト尿中トリプシンインヒビターのＦｃ融合タンパク質並びにその調製および使用 |
| CA3178241A1 (en) * | 2014-02-24 | 2015-08-27 | Takeda Gmbh | Uti fusion proteins |
-
2015
- 2015-02-23 CA CA3178241A patent/CA3178241A1/en active Pending
- 2015-02-23 SI SI201530516T patent/SI3110434T1/sl unknown
- 2015-02-23 CN CN201910282497.3A patent/CN110092837B/zh active Active
- 2015-02-23 EA EA202091567A patent/EA202091567A1/ru unknown
- 2015-02-23 GE GEAP201514277A patent/GEP20196970B/en unknown
- 2015-02-23 RS RS20181514A patent/RS58285B1/sr unknown
- 2015-02-23 BR BR112016019390-3A patent/BR112016019390B1/pt active IP Right Grant
- 2015-02-23 NZ NZ760008A patent/NZ760008A/en unknown
- 2015-02-23 AU AU2015218704A patent/AU2015218704B2/en active Active
- 2015-02-23 MX MX2020000537A patent/MX384070B/es unknown
- 2015-02-23 UA UAA201609101A patent/UA118866C2/uk unknown
- 2015-02-23 PE PE2016001522A patent/PE20170257A1/es unknown
- 2015-02-23 MX MX2016010950A patent/MX2016010950A/es active IP Right Grant
- 2015-02-23 MA MA39347A patent/MA39347B2/fr unknown
- 2015-02-23 SG SG11201606691QA patent/SG11201606691QA/en unknown
- 2015-02-23 SM SM20180674T patent/SMT201800674T1/it unknown
- 2015-02-23 DK DK15708411.2T patent/DK3110434T3/en active
- 2015-02-23 LT LTEP15708411.2T patent/LT3110434T/lt unknown
- 2015-02-23 EP EP15708411.2A patent/EP3110434B1/en active Active
- 2015-02-23 EP EP18192690.8A patent/EP3443978A1/en not_active Withdrawn
- 2015-02-23 CN CN201580014645.3A patent/CN106232135B/zh active Active
- 2015-02-23 PT PT15708411T patent/PT3110434T/pt unknown
- 2015-02-23 HR HRP20182029TT patent/HRP20182029T1/hr unknown
- 2015-02-23 NZ NZ760789A patent/NZ760789A/en unknown
- 2015-02-23 SG SG10201708400QA patent/SG10201708400QA/en unknown
- 2015-02-23 PH PH1/2016/501629A patent/PH12016501629B1/en unknown
- 2015-02-23 NZ NZ724196A patent/NZ724196A/en unknown
- 2015-02-23 US US15/120,956 patent/US9856310B2/en active Active
- 2015-02-23 ES ES15708411T patent/ES2700149T3/es active Active
- 2015-02-23 JP JP2016553562A patent/JP6574431B2/ja active Active
- 2015-02-23 KR KR1020167026429A patent/KR102461210B1/ko active Active
- 2015-02-23 KR KR1020227037377A patent/KR102722304B1/ko active Active
- 2015-02-23 CA CA2939639A patent/CA2939639C/en active Active
- 2015-02-23 EA EA201691702A patent/EA037256B1/ru unknown
- 2015-02-23 CR CR20160444A patent/CR20160444A/es unknown
- 2015-02-23 MY MYPI2016703046A patent/MY178774A/en unknown
- 2015-02-23 PL PL15708411T patent/PL3110434T3/pl unknown
- 2015-02-23 GE GEAP201814277A patent/GEAP201814277A/en unknown
- 2015-02-23 KR KR1020247035230A patent/KR20240155987A/ko active Pending
- 2015-02-23 WO PCT/US2015/017152 patent/WO2015127391A1/en not_active Ceased
- 2015-08-20 JO JOP/2015/0200A patent/JO3729B1/ar active
- 2015-08-20 AR ARP150102677A patent/AR101597A1/es unknown
- 2015-08-21 TW TW104127393A patent/TWI694084B/zh active
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2016
- 2016-08-10 DO DO2016000202A patent/DOP2016000202A/es unknown
- 2016-08-17 IL IL247321A patent/IL247321B/en active IP Right Grant
- 2016-08-23 MX MX2024000004A patent/MX2024000004A/es unknown
- 2016-08-23 MX MX2019013124A patent/MX2019013124A/es unknown
- 2016-08-24 CL CL2016002136A patent/CL2016002136A1/es unknown
- 2016-09-13 ZA ZA2016/06327A patent/ZA201606327B/en unknown
- 2016-09-23 EC ECIEPI201676535A patent/ECSP16076535A/es unknown
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2017
- 2017-11-27 US US15/823,398 patent/US10351618B2/en active Active
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2018
- 2018-12-18 CY CY181101355T patent/CY1120997T1/el unknown
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2019
- 2019-02-15 US US16/277,606 patent/US20200040062A1/en not_active Abandoned
- 2019-06-11 JP JP2019109054A patent/JP6938565B2/ja active Active
- 2019-06-25 AU AU2019204448A patent/AU2019204448B2/en active Active
-
2021
- 2021-06-03 US US17/337,922 patent/US20220127334A1/en not_active Abandoned
- 2021-08-31 AU AU2021225156A patent/AU2021225156B2/en active Active
- 2021-09-01 JP JP2021142544A patent/JP2022002513A/ja active Pending
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2023
- 2023-02-16 AU AU2023200875A patent/AU2023200875A1/en not_active Abandoned
- 2023-06-30 JP JP2023108024A patent/JP2023123763A/ja active Pending
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