JP2017511816A5 - - Google Patents

Download PDF

Info

Publication number
JP2017511816A5
JP2017511816A5 JP2016573672A JP2016573672A JP2017511816A5 JP 2017511816 A5 JP2017511816 A5 JP 2017511816A5 JP 2016573672 A JP2016573672 A JP 2016573672A JP 2016573672 A JP2016573672 A JP 2016573672A JP 2017511816 A5 JP2017511816 A5 JP 2017511816A5
Authority
JP
Japan
Prior art keywords
compartment
aqueous
pharmaceutical composition
composition according
lipoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016573672A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017511816A (ja
JP6526066B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/018505 external-priority patent/WO2015134510A1/en
Publication of JP2017511816A publication Critical patent/JP2017511816A/ja
Publication of JP2017511816A5 publication Critical patent/JP2017511816A5/ja
Application granted granted Critical
Publication of JP6526066B2 publication Critical patent/JP6526066B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016573672A 2014-03-03 2015-03-03 リポ酸コリンエステル組成物及び使用方法 Expired - Fee Related JP6526066B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461947378P 2014-03-03 2014-03-03
US61/947,378 2014-03-03
PCT/US2015/018505 WO2015134510A1 (en) 2014-03-03 2015-03-03 Lipoic acid choline ester compositions and methods of use

Publications (3)

Publication Number Publication Date
JP2017511816A JP2017511816A (ja) 2017-04-27
JP2017511816A5 true JP2017511816A5 (enExample) 2018-04-12
JP6526066B2 JP6526066B2 (ja) 2019-06-05

Family

ID=54055796

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016573672A Expired - Fee Related JP6526066B2 (ja) 2014-03-03 2015-03-03 リポ酸コリンエステル組成物及び使用方法

Country Status (12)

Country Link
US (2) US20160354340A1 (enExample)
EP (1) EP3113613A4 (enExample)
JP (1) JP6526066B2 (enExample)
KR (1) KR20160145558A (enExample)
CN (2) CN112641720A (enExample)
AU (2) AU2015227307A1 (enExample)
BR (1) BR112016020181A8 (enExample)
CA (1) CA2941518A1 (enExample)
IL (1) IL247529B (enExample)
MX (1) MX384877B (enExample)
RU (1) RU2735790C2 (enExample)
WO (1) WO2015134510A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016326572B9 (en) * 2015-09-24 2019-08-08 Novartis Ag Lipoic acid choline ester compositions and methods to generate biocompatible ophthalmic formulations
JOP20190057A1 (ar) * 2016-09-23 2019-03-24 Encore Vision Inc تركيبات استر كولين حمض الليبويك وطرق تثبيتها إلى منتجات عقار ذات صلة دوائية
US10052343B1 (en) 2017-02-03 2018-08-21 Gene Signal International Sa Sterile formulation comprising a stable phosphorothioate oligonucleotide
CN107089967A (zh) * 2017-05-12 2017-08-25 苏州富士莱医药股份有限公司 一种r‑硫辛酸胆碱酯卤化物的制备方法
CN106967044B (zh) * 2017-05-12 2019-02-22 苏州富士莱医药股份有限公司 制备r-硫辛酸胆碱酯卤化物的方法
CN109394745A (zh) * 2017-08-17 2019-03-01 博瑞生物医药(苏州)股份有限公司 一种包含左旋肉碱和β-羟基丁酸化合物的组合物
EP3957365A4 (en) * 2019-04-17 2023-01-11 Santen Pharmaceutical Co., Ltd. Lipoic acid prodrug
WO2020227578A1 (en) * 2019-05-07 2020-11-12 Aciont Inc. Lipoic acid formulations
CN113387923A (zh) * 2020-03-13 2021-09-14 诺华股份有限公司 硫辛酸胆碱酯盐的药物组合物及使用其的治疗方法
CN113717770B (zh) * 2020-05-25 2022-06-03 中国石油天然气股份有限公司 一种金属加工油
GB202305212D0 (en) 2023-04-06 2023-05-24 Elixa Mediscience Ltd Compounds

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB935962A (en) 1960-06-17 1963-09-04 Fujisawa Pharmaceutical Co Improvements in or relating to the production of 6.8-dithiooctanamides
US3855240A (en) 1969-04-28 1974-12-17 Exxon Research Engineering Co Sulfur containing heterocycles
US4210667A (en) 1979-04-19 1980-07-01 Pfizer Inc. Pharmaceutical preparations containing coumarin carboxylic acid derivatives
US4755528A (en) 1984-12-06 1988-07-05 Alcon Laboratories, Inc. High energy ionizing protective 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and N-acyl and N-alkyl derivatives thereof, compositions and method of use therefor
US6030950A (en) 1987-07-09 2000-02-29 Ohlenschlaeger; Gerhard Pharmaceutical therapeutic use of glutathione derivative
US5599903A (en) 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
FR2638970A1 (fr) 1988-11-16 1990-05-18 Corbiere Jerome Nouvelles compositions pharmaceutiques agissant sur la presbytie et leur procede d'obtention
WO1993002639A1 (en) 1991-08-06 1993-02-18 Autogenesis Technologies, Inc. Injectable collagen-based compositions for making intraocular lens
US5466680A (en) 1992-03-26 1995-11-14 Cytologics, Inc. Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
US5459133A (en) 1992-06-05 1995-10-17 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
AU4633793A (en) 1992-06-10 1994-01-04 Summit Technology, Inc. Correction of presbyopia by photorefractive keratectomy
WO1994001096A1 (en) 1992-07-02 1994-01-20 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
JPH08505119A (ja) 1992-07-06 1996-06-04 バイオミラ、インコーポレーテッド 接合目的のためのタンパク質の光活性化
US5354331A (en) 1992-07-15 1994-10-11 Schachar Ronald A Treatment of presbyopia and other eye disorders
US5465737A (en) 1992-07-15 1995-11-14 Schachar; Ronald A. Treatment of presbyopia and other eye disorders
DK0653926T3 (da) 1992-08-07 1999-11-01 Keravision Inc Intrastromal cornealring
DE4345199C2 (de) 1993-05-22 1995-10-12 Asta Medica Ag Verwendung von Dihydroliponsäure zur Unterdrückung von Unverträglichkeitsreaktionen im Grenzbereich von Implantaten mit lebendem Körpergewebe
US5395356A (en) 1993-06-04 1995-03-07 Summit Technology, Inc. Correction of presbyopia by photorefractive keratectomy
US5527774A (en) 1993-07-12 1996-06-18 Girard; Louis J. Dislocation of cataractous lens by enzymatic zonulolysis
US5665770A (en) 1993-11-05 1997-09-09 Gakko Hojin Kinki Daigaku Method for treatment of cataract with radical scavenger
EP0754046A1 (en) 1994-04-04 1997-01-22 FREEMAN, William R. Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US6063116A (en) 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5624955A (en) 1995-05-03 1997-04-29 Regents Of The University Of Minnesota Compounds that enhance the concentration of glutathione in tissues
US5686450A (en) 1995-06-07 1997-11-11 Alcon Laboratories, Inc. Use of N,N'-bis(mercaptoacetyl) hydrazine derivatives as anticataract agents
US6007510A (en) 1996-10-25 1999-12-28 Anamed, Inc. Implantable devices and methods for controlling the flow of fluids within the body
US5817630A (en) 1997-03-18 1998-10-06 Austin Nutriceutical Corporation Glutathione antioxidant eye drops
AU728488B2 (en) 1997-04-02 2001-01-11 Sankyo Company Limited Dithiolan derivatives, their preparation and their therapeutic effect
US5843184A (en) 1998-01-26 1998-12-01 Cionni; Robert J. Endocapsular tension ring and method of implanting same
US6153647A (en) 1998-11-12 2000-11-28 My-Tech, Inc. Method for augmenting the inotropic effects of β-adrenergic agonists using pyruvate therapy
US6472541B2 (en) 1998-11-20 2002-10-29 The Regents Of The University Of California Protecting groups with increased photosensitivities
AU758903B2 (en) 1998-11-26 2003-04-03 Pentapharm Ag Transport system conjugate
US6288106B1 (en) 1999-05-25 2001-09-11 Chronorx, Llc Processes for the synthesis and use of various α-lipoic acid complexes
US6339102B1 (en) 1999-06-09 2002-01-15 The United States Of America As Represented By The Secretary Of The Army Method and composition for treating and preventing retinal damage
JP4476435B2 (ja) * 1999-07-22 2010-06-09 株式会社細川洋行 仕切部材、複室輸液容器および薬剤入り複室輸液容器の製造方法
US6890896B1 (en) 1999-11-18 2005-05-10 Ceremedix, Inc. Compositions and methods for counteracting effects of reactive oxygen species and free radicals
US6387945B2 (en) 2000-04-11 2002-05-14 The Regents Of The University Of California Lipoic acid analogs
JP2004502484A (ja) 2000-07-10 2004-01-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 撮像医用装置に対する幾何学適合
US6906210B2 (en) 2000-08-02 2005-06-14 Basf Aktiengesellschaft Method for producing lipoic acid and dihydrolipoic acid
US20050112113A1 (en) 2000-08-16 2005-05-26 Till Jonathan S. Presbyopia treatment by lens alteration
US8697109B2 (en) 2000-08-16 2014-04-15 Encore Health, Llc Caged mercaptan and seleno-mercaptan compounds and methods of using them
US8147816B2 (en) 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
US7935332B2 (en) 2000-08-16 2011-05-03 Encore Health, Llc Presbyopia treatment by lens alteration
US6923955B2 (en) 2000-08-16 2005-08-02 Newlens, Llc Presbyopia treatment by lens alteration
AU2001283386A1 (en) 2000-08-16 2002-02-25 Refocus, Llc. Presbyopia treatment by lens alteration
US7914815B2 (en) 2000-08-16 2011-03-29 Encore Health, Llc Method for delivery of pharmaceuticals for treating or preventing presbyopia
US8647612B2 (en) 2008-03-05 2014-02-11 Encore Health, Llc Dithiol compounds, derivatives, and treatment of presbyopia
DE10045059A1 (de) 2000-09-12 2002-03-21 Basf Ag Therapeutische Kombination von Liponsäure und Konjuensäuren zur Behandlung diabetischer Störungen
US6273092B1 (en) 2000-09-22 2001-08-14 Gerard M. Nolan Methods for treating various eye disorders
US6703039B2 (en) 2000-12-06 2004-03-09 Bausch & Lomb Incorporated Reversible gelling system for ocular drug delivery
EP1808158A3 (en) 2001-01-19 2008-06-18 Newlens, LLC Presbyopia treatment by lens alteration
JP4072062B2 (ja) 2001-03-19 2008-04-02 千寿製薬株式会社 新規α−リポ酸誘導体およびその用途
JP2005515156A (ja) 2001-05-25 2005-05-26 セレメディックス,インク. 反応性酸素種およびフリーラジカルの効力を中和するための単一アミノ酸に基づく化合物
FR2832637B1 (fr) 2001-06-07 2004-07-30 Lefaix Marie Therese Droy Utilisation d'un antioxydant pour la fabrication d'un medicament destine au traitement des affections oculaires de surface
ITMI20011232A1 (it) 2001-06-12 2002-12-12 St Microelectronics Srl Metodo di riprogrammazione successiva ad una operazione di cancellazione di una matrice di celle di memoria non volatile, in particolare di
WO2003084532A1 (en) 2002-04-03 2003-10-16 Avery Mitchell A Lipoic acid analogs useful as provitamins and antioxidants
US20050137124A1 (en) 2002-08-09 2005-06-23 Vitreo-Retinal Technologies, Inc. A California Corporation Agents for intravitreal administration to treat or prevent disorders of the eye
WO2004024139A1 (ja) 2002-09-13 2004-03-25 Oga Research, Incorporated メラニン消去剤
US7795203B2 (en) * 2002-09-30 2010-09-14 Babizhayev Mark A Method for topical treatment of eye disease and composition and device for said treatment
US20060177430A1 (en) 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
US7941211B2 (en) 2003-11-17 2011-05-10 Zeavision, Llc. Preloading with macular pigment to improve photodynamic treatment of retinal vascular disorders
WO2005051978A2 (en) 2003-11-25 2005-06-09 University Of Rochester Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
US7718697B2 (en) 2003-12-17 2010-05-18 Alcon, Inc. Method for treating glaucoma comprising administering α-lipoic acid
GB0404693D0 (en) 2004-03-02 2004-04-07 Univ London Pharmaceutical preparations for the treatment of ocular surface and other disorders
FR2869531B1 (fr) 2004-04-30 2006-07-14 Optis France Sa Sa Dispositif de iontophorese oculaire diminuant les irritations
US7264279B2 (en) 2004-07-08 2007-09-04 Fab-Tech, Inc. Segmented conduit having a monolithic lining
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US20060188492A1 (en) 2005-01-13 2006-08-24 Chronorx Llc, An Alaska Limited Liability Company Topical management of ocular and periocular conditions
US20060275278A1 (en) * 2005-06-02 2006-12-07 Choy Camus K M Method and ophthalmic formulation for eye protection or treatment
CA2615360A1 (en) 2005-07-15 2007-01-25 Chakshu Research Inc. Formulation and method for administration of ophthalmologically active agents
US20070055070A1 (en) 2005-09-07 2007-03-08 Lawrence Lowell J Novel esters of lipoic acid
US20070207116A1 (en) * 2006-03-01 2007-09-06 Brown David C Antioxidant compositions for the eye
CN101522658A (zh) 2006-06-16 2009-09-02 因迪基恩药物公司 作为抗糖尿病药用于控制糖尿病高血糖症和糖尿病并发症的二甲双胍r-(+)硫辛酸盐
BRPI0720000A2 (pt) * 2006-12-08 2013-12-17 Sachtleben Chemie Gmbh Corpo moldado contendo titâno
DE102006062599B4 (de) 2006-12-29 2018-03-08 Endress + Hauser Gmbh + Co. Kg Opto-elektronische Vorrichtung zur Übertragung eines elektrischen Signals und deren Verwendung
EP2131679B1 (en) 2007-02-22 2019-03-27 Children's Hospital & Research Center at Oakland Fatty acid formulations and methods of use thereof
JP2010520333A (ja) 2007-03-01 2010-06-10 セダーズ−シナイ メディカル センター 〔1,2〕−ジチオラン部分を含有する抗酸化剤重合体およびその使用
UA86441C2 (ru) 2007-03-30 2009-04-27 Акционерное Общество Открытого Типа "Галичфарм" (2-гидроксиэтил)триметиламмония тиоктат (холина тиоктат), имеющий гепатопротекторное, гипоаммониемическое и детоксицирующее действие, способ его получения, фармацевтическая композиция на его основе
KR20100045503A (ko) * 2007-08-09 2010-05-03 센주 세이야꾸 가부시키가이샤 피레녹신 함유 2 액성 점안제
US9044439B2 (en) * 2008-03-05 2015-06-02 Encore Health, Llc Low dose lipoic and pharmaceutical compositions and methods
WO2009111635A2 (en) 2008-03-05 2009-09-11 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
WO2010147962A1 (en) * 2009-06-15 2010-12-23 Encore Health, Llc Choline esters
EP2442647B1 (en) 2009-06-15 2016-03-16 Encore Health LLC Dithiol compounds, derivatives, and uses therefor
DE102010009475B4 (de) * 2010-02-26 2011-11-24 F. Holzer Gmbh Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates
ES2564502T3 (es) 2010-03-17 2016-03-23 Novaliq Gmbh Composición farmacéutica para el tratamiento de la presión intraocular aumentada
AU2012204932B2 (en) * 2011-01-04 2017-02-23 Novaliq Gmbh O/w-emulsions comprising semifluorinated alkanes
CN104066442B (zh) * 2012-01-23 2018-05-18 诺瓦利克有限责任公司 基于半氟化烷烃的稳定蛋白质组合物
EP3479839A1 (en) * 2012-02-22 2019-05-08 Stealth Peptides International, Inc. Methods and compositions for preventing or treating opthalmic conditions

Similar Documents

Publication Publication Date Title
JP2017511816A5 (enExample)
AR092470A1 (es) Formulaciones acuosas estables de adalimumab
JP2019529457A5 (enExample)
RU2016137784A (ru) Композиции и способы применения холинового эфира липоевой кислоты
RU2016143341A (ru) Водный офтальмологический раствор и способ лечения синдрома сухих глаз
AR088381A1 (es) Formulaciones de etanercept estabilizadas con meglumina
AU2016204371A1 (en) Lyophilised and aqueous anti-CD40 antibody formulations
PH12017500844B1 (en) Stable protein solution formulation containing high concentration of an anti-vegf antibody
NZ602392A (en) Stable bortezomib formulations
JP2016503058A5 (enExample)
RU2012153786A (ru) Стабильные многодозовые композиции, содержащие антитело и консервант
WO2012071389A3 (en) Stable cannabinoid compositions and methods for making and storing them
FI3528787T3 (fi) Farmaseuttisia formulaatioita ja menetelmiä niiden valmistamiseksi
BR112016001544A2 (pt) composições farmacêuticas para injeção intraocular compreendendo agentes anti-bacteriano e anti-inflamatório, seu método de preparação, kit farmacêutico e uso dos referidos agentes no preparo das referidas composições farmacêuticas
JP2017514924A5 (enExample)
EA202092926A2 (ru) Лиофилизированные составы, содержащие фактор ix
RU2019139886A (ru) Терапевтическое средство против дисфункции мейбомиевых желез
EA202192322A1 (ru) Фармацевтические составы
RU2019119405A (ru) Лиофилизированные фармацевтические композиции далбаванцина
JP2018532806A5 (enExample)
EA201991023A1 (ru) Фармацевтическая композиция для парентерального введения, содержащая карглумовую кислоту
PH12013502476B1 (en) Ophthalmic solution containing hyaluronic acid or salt thereof and propylene glycol
WO2015183984A3 (en) Therapeutic compositions including tocopherol and uses thereof
JP2016522257A5 (enExample)
RU2012130852A (ru) Фармацевтическая композиция для местного применения при лечении воспалительных заболеваний глаз и способ ее использования