|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
KR102874079B1
(ko)
|
2013-03-15 |
2025-10-22 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
WO2015066119A1
(en)
|
2013-10-30 |
2015-05-07 |
North Carolina State University |
Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
|
|
KR20230054509A
(ko)
|
2013-11-07 |
2023-04-24 |
에디타스 메디신, 인코포레이티드 |
지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
|
|
US11053481B2
(en)
|
2013-12-12 |
2021-07-06 |
President And Fellows Of Harvard College |
Fusions of Cas9 domains and nucleic acid-editing domains
|
|
CA2935032C
(en)
*
|
2013-12-26 |
2024-01-23 |
The General Hospital Corporation |
Multiplex guide rnas
|
|
EP3094729A1
(en)
*
|
2014-01-14 |
2016-11-23 |
Lam Therapeutics, Inc. |
Mutagenesis methods
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
CN106460003A
(zh)
|
2014-04-08 |
2017-02-22 |
北卡罗来纳州立大学 |
用于使用crispr相关基因rna引导阻遏转录的方法和组合物
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
WO2016033298A1
(en)
|
2014-08-28 |
2016-03-03 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
JP6788584B2
(ja)
*
|
2014-10-31 |
2020-11-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
Crisprについての超並列コンビナトリアル遺伝学
|
|
US10883111B2
(en)
*
|
2014-11-27 |
2021-01-05 |
Danziger Innovations Ltd. |
Nucleic acid constructs for genome editing
|
|
JP6529110B2
(ja)
*
|
2014-12-01 |
2019-06-12 |
国立大学法人 東京大学 |
複数のユニットが多重に連結したdnaカセットおよび該カセットを含むベクターの製造方法
|
|
DE112016002056T5
(de)
|
2015-05-06 |
2018-02-08 |
Snipr Technologies Limited |
Verändern mikrobieller Populationen und Modifizieren von Mikrobiomen
|
|
EP3303607A4
(en)
|
2015-05-29 |
2018-10-10 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
|
CN107922918B
(zh)
|
2015-06-15 |
2022-10-21 |
北卡罗来纳州立大学 |
用于有效递送核酸和基于rna的抗微生物剂的方法和组合物
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
US12043852B2
(en)
|
2015-10-23 |
2024-07-23 |
President And Fellows Of Harvard College |
Evolved Cas9 proteins for gene editing
|
|
FI3390632T3
(fi)
*
|
2015-12-18 |
2025-11-25 |
Danisco Us Inc |
Menetelmät ja koostumukset polymeraasi ii (pol-ii) -pohjaisen opas-rna:n ilmentämiseen
|
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
|
CN105543223A
(zh)
*
|
2015-12-25 |
2016-05-04 |
华侨大学 |
一种基于miRNA/shRNA转录加工机制转录sgRNA的方法
|
|
EP3199632A1
(en)
|
2016-01-26 |
2017-08-02 |
ACIB GmbH |
Temperature-inducible crispr/cas system
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US10752904B2
(en)
|
2016-04-26 |
2020-08-25 |
Massachusetts Institute Of Technology |
Extensible recombinase cascades
|
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
|
US11293021B1
(en)
|
2016-06-23 |
2022-04-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
IL290679B2
(en)
|
2016-07-05 |
2023-10-01 |
California Inst Of Techn |
Hybridization chain reaction based on a minimal initiator
|
|
KR20250103795A
(ko)
|
2016-08-03 |
2025-07-07 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
CN109804066A
(zh)
|
2016-08-09 |
2019-05-24 |
哈佛大学的校长及成员们 |
可编程cas9-重组酶融合蛋白及其用途
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
WO2018044939A1
(en)
|
2016-08-30 |
2018-03-08 |
California Institute Of Technology |
Immunohistochemistry via hybridization chain reaction
|
|
WO2018049168A1
(en)
*
|
2016-09-09 |
2018-03-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
High-throughput precision genome editing
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
EP3568476A1
(en)
*
|
2017-01-11 |
2019-11-20 |
Oxford University Innovation Limited |
Crispr rna
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
EP3592381A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Cancer vaccine
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
KR20190127797A
(ko)
|
2017-03-10 |
2019-11-13 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
시토신에서 구아닌으로의 염기 편집제
|
|
WO2018162702A1
(en)
|
2017-03-10 |
2018-09-13 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Nuclease fusions for enhancing genome editing by homology-directed transgene integration
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
US20180362944A1
(en)
*
|
2017-06-12 |
2018-12-20 |
California Institute Of Technology |
CONDITIONAL GUIDE RNAs
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
KR102424850B1
(ko)
|
2017-06-30 |
2022-07-22 |
인스크립타 인코포레이티드 |
자동 세포 처리 방법, 모듈, 기기 및 시스템
|
|
US11041154B2
(en)
|
2017-07-21 |
2021-06-22 |
Arizona Board Of Regents On Behalf Of Arizona State University |
CRISPR fluorescent guide RNA (fgRNA) to understanding gRNAs expressed from pol II promotors
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
CN111373041B
(zh)
|
2017-09-26 |
2024-10-11 |
伊利诺伊大学理事会 |
用于基因组编辑和调节转录的crispr/cas系统和方法
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
|
|
CN111788307A
(zh)
*
|
2018-03-12 |
2020-10-16 |
南京北恒生物科技有限公司 |
工程化的嵌合向导rna及其用途
|
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
|
CN108330138B
(zh)
*
|
2018-03-29 |
2018-09-25 |
上海欣百诺生物科技有限公司 |
一种sgRNA的体外合成方法及其试剂盒
|
|
CN108728441B
(zh)
*
|
2018-04-18 |
2022-07-22 |
深圳市第二人民医院 |
特异性识别p53突变的基因系统
|
|
US10526598B2
(en)
|
2018-04-24 |
2020-01-07 |
Inscripta, Inc. |
Methods for identifying T-cell receptor antigens
|
|
WO2019209926A1
(en)
|
2018-04-24 |
2019-10-31 |
Inscripta, Inc. |
Automated instrumentation for production of peptide libraries
|
|
US10858761B2
(en)
|
2018-04-24 |
2020-12-08 |
Inscripta, Inc. |
Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
|
|
AU2019263055A1
(en)
*
|
2018-04-30 |
2020-11-19 |
Oregon Health & Science University |
Methods of gene therapy
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
AU2019292919A1
(en)
|
2018-06-30 |
2021-03-11 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
US11142740B2
(en)
|
2018-08-14 |
2021-10-12 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
|
EP3861120A4
(en)
|
2018-10-01 |
2023-08-16 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
US12264313B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression
|
|
US12203123B2
(en)
|
2018-10-01 |
2025-01-21 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
|
GB201817010D0
(en)
*
|
2018-10-18 |
2018-12-05 |
Imperial Innovations Ltd |
Methods
|
|
WO2020086475A1
(en)
|
2018-10-22 |
2020-04-30 |
Inscripta, Inc. |
Engineered enzymes
|
|
US11214781B2
(en)
|
2018-10-22 |
2022-01-04 |
Inscripta, Inc. |
Engineered enzyme
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
EP3891281A1
(en)
*
|
2018-12-05 |
2021-10-13 |
DSM IP Assets B.V. |
Crispr guide-rna expression strategies for multiplex genome engineering
|
|
WO2020131986A1
(en)
*
|
2018-12-21 |
2020-06-25 |
Pioneer Hi-Bred International, Inc. |
Multiplex genome targeting
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
DE112020001306T5
(de)
|
2019-03-19 |
2022-01-27 |
Massachusetts Institute Of Technology |
Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen
|
|
US11001831B2
(en)
|
2019-03-25 |
2021-05-11 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
|
EP3947691A4
(en)
|
2019-03-25 |
2022-12-14 |
Inscripta, Inc. |
SIMULTANEOUS MULTIPLEX GENOME EDITING IN A YEAST
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN113939593A
(zh)
|
2019-06-06 |
2022-01-14 |
因思科瑞普特公司 |
用于递归的核酸指导的细胞编辑的处治
|
|
CN114008070A
(zh)
|
2019-06-21 |
2022-02-01 |
因思科瑞普特公司 |
导致大肠杆菌赖氨酸产量增加的全基因组合理设计的突变
|
|
US10927385B2
(en)
|
2019-06-25 |
2021-02-23 |
Inscripta, Inc. |
Increased nucleic-acid guided cell editing in yeast
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021102059A1
(en)
|
2019-11-19 |
2021-05-27 |
Inscripta, Inc. |
Methods for increasing observed editing in bacteria
|
|
US10883095B1
(en)
|
2019-12-10 |
2021-01-05 |
Inscripta, Inc. |
Mad nucleases
|
|
CN114829607A
(zh)
|
2019-12-18 |
2022-07-29 |
因思科瑞普特公司 |
用于体内检测核酸引导的核酸酶编辑的细胞的Cascade/dCas3互补测定
|
|
WO2021154706A1
(en)
|
2020-01-27 |
2021-08-05 |
Inscripta, Inc. |
Electroporation modules and instrumentation
|
|
EP3889259A1
(en)
|
2020-03-30 |
2021-10-06 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Internal standard for crispr guide rna
|
|
US20210332388A1
(en)
|
2020-04-24 |
2021-10-28 |
Inscripta, Inc. |
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
|
|
JP2023525304A
(ja)
|
2020-05-08 |
2023-06-15 |
ザ ブロード インスティテュート,インコーポレーテッド |
標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物
|
|
US11787841B2
(en)
|
2020-05-19 |
2023-10-17 |
Inscripta, Inc. |
Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
|
|
GB202007943D0
(en)
|
2020-05-27 |
2020-07-08 |
Snipr Biome Aps |
Products & methods
|
|
CN111850011B
(zh)
*
|
2020-06-24 |
2022-08-26 |
湖南文理学院 |
改良的Csy4序列、改良方法及应用
|
|
EP4172330A1
(en)
*
|
2020-06-30 |
2023-05-03 |
The University Court Of The University of Edinburgh |
Transgene expression system
|
|
EP4214314A4
(en)
|
2020-09-15 |
2024-10-16 |
Inscripta, Inc. |
Crispr editing to embed nucleic acid landing pads into genomes of live cells
|
|
US11512297B2
(en)
|
2020-11-09 |
2022-11-29 |
Inscripta, Inc. |
Affinity tag for recombination protein recruitment
|
|
US11306298B1
(en)
|
2021-01-04 |
2022-04-19 |
Inscripta, Inc. |
Mad nucleases
|
|
US11332742B1
(en)
|
2021-01-07 |
2022-05-17 |
Inscripta, Inc. |
Mad nucleases
|
|
EP4284925A4
(en)
|
2021-01-26 |
2025-08-13 |
California Inst Of Techn |
ALLOSTERIC CONDITIONAL GUIDE RNAS FOR SELECTIVE REGULATION OF CRISPR/CAS CELLS
|
|
US11884924B2
(en)
|
2021-02-16 |
2024-01-30 |
Inscripta, Inc. |
Dual strand nucleic acid-guided nickase editing
|
|
US20220298509A1
(en)
*
|
2021-03-22 |
2022-09-22 |
Massachusetts Institute Of Technology |
Multi-input mirna sensing with constitutive erns to regulate multi-output gene expression in mammalian cells
|
|
WO2022226107A1
(en)
*
|
2021-04-20 |
2022-10-27 |
Texas Tech University System |
Tissue-culture independent gene editing of cells by a long-distance rna transport system
|
|
CN115704040A
(zh)
*
|
2021-08-06 |
2023-02-17 |
华东理工大学 |
基于CRISPRi和CRISPRa的转录调控系统、其建立方法及应用
|
|
WO2023018938A1
(en)
*
|
2021-08-12 |
2023-02-16 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Methods for generation of precise rna transcripts
|
|
CN113604472B
(zh)
*
|
2021-09-17 |
2024-01-09 |
中国科学院植物研究所 |
一种应用于里氏木霉的CRISPR/Cas基因编辑系统
|
|
GB202209518D0
(en)
|
2022-06-29 |
2022-08-10 |
Snipr Biome Aps |
Treating & preventing E coli infections
|
|
WO2025165779A1
(en)
*
|
2024-02-01 |
2025-08-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Simultaneous gene knockin and knockout in engineered cell therapies with mrna expressed guide rnas
|
|
CN119220682B
(zh)
*
|
2024-10-25 |
2025-04-22 |
首都医科大学附属北京儿童医院 |
Saal1作为神经母细胞瘤预后评估标志物和药物靶点的应用
|