JP2017508523A5 - - Google Patents
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- Publication number
- JP2017508523A5 JP2017508523A5 JP2016553431A JP2016553431A JP2017508523A5 JP 2017508523 A5 JP2017508523 A5 JP 2017508523A5 JP 2016553431 A JP2016553431 A JP 2016553431A JP 2016553431 A JP2016553431 A JP 2016553431A JP 2017508523 A5 JP2017508523 A5 JP 2017508523A5
- Authority
- JP
- Japan
- Prior art keywords
- culture
- fgf
- weeks
- compound
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- 102000003977 fibroblast growth factor 18 Human genes 0.000 claims 8
- 108090000370 fibroblast growth factor 18 Proteins 0.000 claims 8
- 210000000845 cartilage Anatomy 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000001963 growth medium Substances 0.000 claims 6
- 239000000463 material Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 230000002648 chondrogenic effect Effects 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000015100 cartilage disease Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 206010061762 Chondropathy Diseases 0.000 claims 1
- 201000009859 Osteochondrosis Diseases 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14000599.2 | 2014-02-20 | ||
| EP14000599 | 2014-02-20 | ||
| PCT/EP2015/053639 WO2015124735A1 (en) | 2014-02-20 | 2015-02-20 | Fgf-18 in graft transplantation and tissue engineering procedures |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508523A JP2017508523A (ja) | 2017-03-30 |
| JP2017508523A5 true JP2017508523A5 (enExample) | 2018-02-22 |
| JP6495934B2 JP6495934B2 (ja) | 2019-04-03 |
Family
ID=50151087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553431A Active JP6495934B2 (ja) | 2014-02-20 | 2015-02-20 | グラフト移植および組織工学的手順におけるｆｇｆ−１８ |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20170056554A1 (enExample) |
| EP (1) | EP3107591B1 (enExample) |
| JP (1) | JP6495934B2 (enExample) |
| KR (1) | KR102437057B1 (enExample) |
| CN (1) | CN106232153B (enExample) |
| AR (1) | AR099557A1 (enExample) |
| AU (1) | AU2015220781B2 (enExample) |
| BR (1) | BR112016018704B1 (enExample) |
| ES (1) | ES2676318T3 (enExample) |
| IL (1) | IL247105B (enExample) |
| MX (1) | MX2016010873A (enExample) |
| RU (1) | RU2682159C2 (enExample) |
| SG (1) | SG11201606696UA (enExample) |
| WO (1) | WO2015124735A1 (enExample) |
| ZA (1) | ZA201605549B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016018681B1 (pt) | 2014-02-20 | 2021-01-05 | Merck Patent Gmbh | sistema de distribuição de substâncias que compreende pelo menos um material polimérico formador de uma matriz e um fármaco anabólico, processo de produção do mesmo e artigo de manufatura |
| EP3119417B1 (en) | 2014-02-20 | 2018-07-11 | Merck Patent GmbH | Fgf-18 compound dosing regimen |
| WO2016120387A1 (en) | 2015-01-29 | 2016-08-04 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| CN107058217A (zh) * | 2017-01-22 | 2017-08-18 | 广州赛莱拉干细胞科技股份有限公司 | 一种软骨细胞的增殖培养基及增殖培养方法 |
| AU2017404163A1 (en) * | 2017-03-17 | 2019-10-31 | The Trustees Of The University Of Pennsylvania | Cartilage preservation media |
| RS63292B1 (sr) | 2017-09-29 | 2022-06-30 | Merck Patent Gmbh | Inflamatorni biomarkeri za predviđanje responsivnosti na jedinjenje fgf-18 |
| SI3687558T1 (sl) | 2017-09-29 | 2022-08-31 | Merck Patent Gmbh | Presnovni biooznačevalci za napovedovanje odzivnosti na spojino FGF-18 |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| CN113244413B (zh) * | 2021-06-28 | 2021-10-26 | 深圳市瑞吉生物科技有限公司 | 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用 |
| IT202300012807A1 (it) * | 2023-06-26 | 2024-12-26 | Umberto Parri | Protesi d'anca in biomateriali e procedimento di fabbricazione |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| US20140193468A1 (en) | 2001-03-23 | 2014-07-10 | Histogenics Corporation | Methods for preparation of neo-cartilage constructs |
| AU2003279835B2 (en) | 2002-10-07 | 2009-09-10 | Zymogenetics, Inc. | Methods of administering FGF18 |
| ES2392883T3 (es) * | 2006-08-25 | 2012-12-14 | Ares Trading S.A. | Tratamiento de trastornos de cartílagos con FGF-18 |
| HRP20120643T1 (hr) * | 2006-08-25 | 2012-08-31 | Ares Trading S.A. | Liječenje poremećaja hrskavice sa fgf-18 |
| JP5388233B2 (ja) * | 2011-01-19 | 2014-01-15 | 富士ソフト株式会社 | 再生軟骨の軟骨特性を評価する方法 |
-
2015
- 2015-02-20 ES ES15705823.1T patent/ES2676318T3/es active Active
- 2015-02-20 CN CN201580020522.0A patent/CN106232153B/zh active Active
- 2015-02-20 BR BR112016018704-0A patent/BR112016018704B1/pt active IP Right Grant
- 2015-02-20 AR ARP150100506A patent/AR099557A1/es active IP Right Grant
- 2015-02-20 JP JP2016553431A patent/JP6495934B2/ja active Active
- 2015-02-20 RU RU2016137290A patent/RU2682159C2/ru active
- 2015-02-20 WO PCT/EP2015/053639 patent/WO2015124735A1/en not_active Ceased
- 2015-02-20 AU AU2015220781A patent/AU2015220781B2/en active Active
- 2015-02-20 KR KR1020167025249A patent/KR102437057B1/ko active Active
- 2015-02-20 US US15/120,136 patent/US20170056554A1/en not_active Abandoned
- 2015-02-20 MX MX2016010873A patent/MX2016010873A/es active IP Right Grant
- 2015-02-20 SG SG11201606696UA patent/SG11201606696UA/en unknown
- 2015-02-20 EP EP15705823.1A patent/EP3107591B1/en active Active
-
2016
- 2016-08-04 IL IL247105A patent/IL247105B/en active IP Right Grant
- 2016-08-10 ZA ZA2016/05549A patent/ZA201605549B/en unknown
-
2022
- 2022-06-16 US US17/842,762 patent/US20220378981A1/en active Pending
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