MX2016010873A - Factor de crecimiento de fibroblastos 18 en los procedimientos para el trasplante de injertos y para ingenieria de tejidos. - Google Patents
Factor de crecimiento de fibroblastos 18 en los procedimientos para el trasplante de injertos y para ingenieria de tejidos.Info
- Publication number
- MX2016010873A MX2016010873A MX2016010873A MX2016010873A MX2016010873A MX 2016010873 A MX2016010873 A MX 2016010873A MX 2016010873 A MX2016010873 A MX 2016010873A MX 2016010873 A MX2016010873 A MX 2016010873A MX 2016010873 A MX2016010873 A MX 2016010873A
- Authority
- MX
- Mexico
- Prior art keywords
- fgf
- tissue engineering
- graft transplantation
- engineering procedures
- cartilage
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102000003977 fibroblast growth factor 18 Human genes 0.000 title abstract 2
- 108090000370 fibroblast growth factor 18 Proteins 0.000 title abstract 2
- 238000002054 transplantation Methods 0.000 title abstract 2
- 206010007710 Cartilage injury Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 208000015100 cartilage disease Diseases 0.000 abstract 1
- 210000001612 chondrocyte Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3612—Cartilage, synovial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
Abstract
La presente invención proporciona un nuevo método relacionado con la medicina regenerativa para el tratamiento de los trastornos del cartílago, la osteoartritis y la lesión del cartílago en particular; más particularmente, se refiere a un compuesto de FGF-18 para usarse en los procedimientos de ingeniería del tejido y en los procedimientos de injertos, tal como el trasplante osteocondral, o el trasplante del cartílago, o el implante de condrocito autólogo (ACI).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14000599 | 2014-02-20 | ||
PCT/EP2015/053639 WO2015124735A1 (en) | 2014-02-20 | 2015-02-20 | Fgf-18 in graft transplantation and tissue engineering procedures |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016010873A true MX2016010873A (es) | 2016-11-17 |
Family
ID=50151087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016010873A MX2016010873A (es) | 2014-02-20 | 2015-02-20 | Factor de crecimiento de fibroblastos 18 en los procedimientos para el trasplante de injertos y para ingenieria de tejidos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US20170056554A1 (es) |
EP (1) | EP3107591B1 (es) |
JP (1) | JP6495934B2 (es) |
KR (1) | KR102437057B1 (es) |
CN (1) | CN106232153B (es) |
AR (1) | AR099557A1 (es) |
AU (1) | AU2015220781B2 (es) |
BR (1) | BR112016018704B1 (es) |
CA (1) | CA2938795A1 (es) |
ES (1) | ES2676318T3 (es) |
IL (1) | IL247105B (es) |
MX (1) | MX2016010873A (es) |
NZ (1) | NZ723169A (es) |
RU (1) | RU2682159C2 (es) |
SG (1) | SG11201606696UA (es) |
WO (1) | WO2015124735A1 (es) |
ZA (1) | ZA201605549B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9889179B2 (en) | 2014-02-20 | 2018-02-13 | Merck Patent Gmbh | FGF-18 compound dosing regimen |
CA2938796C (en) | 2014-02-20 | 2022-08-02 | Merck Patent Gmbh | Implant comprising fgf-18 |
CN107058217A (zh) * | 2017-01-22 | 2017-08-18 | 广州赛莱拉干细胞科技股份有限公司 | 一种软骨细胞的增殖培养基及增殖培养方法 |
WO2018166632A1 (en) * | 2017-03-17 | 2018-09-20 | Merck Patent Gmbh | Cartilage preservation media |
CN113244413B (zh) * | 2021-06-28 | 2021-10-26 | 深圳市瑞吉生物科技有限公司 | 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
US20140193468A1 (en) * | 2001-03-23 | 2014-07-10 | Histogenics Corporation | Methods for preparation of neo-cartilage constructs |
AU2003279835B2 (en) * | 2002-10-07 | 2009-09-10 | Zymogenetics, Inc. | Methods of administering FGF18 |
SI2054050T1 (sl) * | 2006-08-25 | 2012-12-31 | Ares Trading S.A. | Zdravljenje hrustanäśnih obolenj z fgf-18 |
WO2008023063A2 (en) * | 2006-08-25 | 2008-02-28 | Ares Trading S.A. | Treatment of cartilage disorders with fgf-18 |
JP5388233B2 (ja) * | 2011-01-19 | 2014-01-15 | 富士ソフト株式会社 | 再生軟骨の軟骨特性を評価する方法 |
-
2015
- 2015-02-20 MX MX2016010873A patent/MX2016010873A/es active IP Right Grant
- 2015-02-20 ES ES15705823.1T patent/ES2676318T3/es active Active
- 2015-02-20 KR KR1020167025249A patent/KR102437057B1/ko active IP Right Grant
- 2015-02-20 AU AU2015220781A patent/AU2015220781B2/en active Active
- 2015-02-20 BR BR112016018704-0A patent/BR112016018704B1/pt active IP Right Grant
- 2015-02-20 NZ NZ723169A patent/NZ723169A/en unknown
- 2015-02-20 CA CA2938795A patent/CA2938795A1/en active Pending
- 2015-02-20 RU RU2016137290A patent/RU2682159C2/ru active
- 2015-02-20 JP JP2016553431A patent/JP6495934B2/ja active Active
- 2015-02-20 US US15/120,136 patent/US20170056554A1/en not_active Abandoned
- 2015-02-20 WO PCT/EP2015/053639 patent/WO2015124735A1/en active Application Filing
- 2015-02-20 EP EP15705823.1A patent/EP3107591B1/en active Active
- 2015-02-20 CN CN201580020522.0A patent/CN106232153B/zh active Active
- 2015-02-20 SG SG11201606696UA patent/SG11201606696UA/en unknown
- 2015-02-20 AR ARP150100506A patent/AR099557A1/es unknown
-
2016
- 2016-08-04 IL IL247105A patent/IL247105B/en active IP Right Grant
- 2016-08-10 ZA ZA2016/05549A patent/ZA201605549B/en unknown
-
2022
- 2022-06-16 US US17/842,762 patent/US20220378981A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP6495934B2 (ja) | 2019-04-03 |
BR112016018704B1 (pt) | 2021-01-05 |
RU2016137290A (ru) | 2018-03-23 |
RU2682159C2 (ru) | 2019-03-15 |
AU2015220781B2 (en) | 2018-05-24 |
SG11201606696UA (en) | 2016-09-29 |
CN106232153A (zh) | 2016-12-14 |
EP3107591B1 (en) | 2018-04-18 |
ES2676318T3 (es) | 2018-07-18 |
AU2015220781A1 (en) | 2016-09-01 |
KR102437057B1 (ko) | 2022-08-26 |
AR099557A1 (es) | 2016-08-03 |
CN106232153B (zh) | 2020-01-17 |
US20220378981A1 (en) | 2022-12-01 |
CA2938795A1 (en) | 2015-08-27 |
IL247105B (en) | 2020-02-27 |
NZ723169A (en) | 2023-05-26 |
EP3107591A1 (en) | 2016-12-28 |
JP2017508523A (ja) | 2017-03-30 |
KR20160124149A (ko) | 2016-10-26 |
ZA201605549B (en) | 2018-12-19 |
BR112016018704A2 (pt) | 2017-10-17 |
US20170056554A1 (en) | 2017-03-02 |
WO2015124735A1 (en) | 2015-08-27 |
RU2016137290A3 (es) | 2018-09-07 |
IL247105A0 (en) | 2016-09-29 |
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