BR112016018704B1 - processo para produção de um material de cartilagem transplantável para engenharia de tecido - Google Patents
processo para produção de um material de cartilagem transplantável para engenharia de tecido Download PDFInfo
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- BR112016018704B1 BR112016018704B1 BR112016018704-0A BR112016018704A BR112016018704B1 BR 112016018704 B1 BR112016018704 B1 BR 112016018704B1 BR 112016018704 A BR112016018704 A BR 112016018704A BR 112016018704 B1 BR112016018704 B1 BR 112016018704B1
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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| EP14000599.2 | 2014-02-20 | ||
| EP14000599 | 2014-02-20 | ||
| PCT/EP2015/053639 WO2015124735A1 (en) | 2014-02-20 | 2015-02-20 | Fgf-18 in graft transplantation and tissue engineering procedures |
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| BR112016018704A2 BR112016018704A2 (pt) | 2017-10-17 |
| BR112016018704B1 true BR112016018704B1 (pt) | 2021-01-05 |
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| LT3107592T (lt) | 2014-02-20 | 2018-12-10 | Merck Patent Gmbh | Implantas, apimantis fgf-18 |
| MX2016010872A (es) | 2014-02-20 | 2016-11-17 | Merck Patent Gmbh | Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18. |
| CN107209177A (zh) | 2015-01-29 | 2017-09-26 | 阿雷斯贸易股份有限公司 | 用于高正电荷蛋白的免疫测定法 |
| CN107058217A (zh) * | 2017-01-22 | 2017-08-18 | 广州赛莱拉干细胞科技股份有限公司 | 一种软骨细胞的增殖培养基及增殖培养方法 |
| WO2018166632A1 (en) * | 2017-03-17 | 2018-09-20 | Merck Patent Gmbh | Cartilage preservation media |
| CN111164429B (zh) | 2017-09-29 | 2024-08-09 | 默克专利有限公司 | 预测对fgf-18化合物反应性的炎性生物标志物 |
| CN111163791A (zh) | 2017-09-29 | 2020-05-15 | 默克专利有限公司 | 预测对fgf-18化合物反应性的代谢生物标志物 |
| HRP20240665T1 (hr) | 2018-09-10 | 2024-08-16 | Merck Patent Gmbh | Markeri korisni u strategijama obogaćivanja za liječenje osteoartritisa |
| CN113244413B (zh) * | 2021-06-28 | 2021-10-26 | 深圳市瑞吉生物科技有限公司 | 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用 |
| IT202300012807A1 (it) * | 2023-06-26 | 2024-12-26 | Umberto Parri | Protesi d'anca in biomateriali e procedimento di fabbricazione |
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| US20140193468A1 (en) * | 2001-03-23 | 2014-07-10 | Histogenics Corporation | Methods for preparation of neo-cartilage constructs |
| JP4754823B2 (ja) * | 2002-10-07 | 2011-08-24 | ザイモジェネティクス， インコーポレイテッド | Ｆｇｆ１８の投与方法 |
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| JP5388233B2 (ja) * | 2011-01-19 | 2014-01-15 | 富士ソフト株式会社 | 再生軟骨の軟骨特性を評価する方法 |
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| US20220378981A1 (en) | 2022-12-01 |
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| CN106232153A (zh) | 2016-12-14 |
| US20170056554A1 (en) | 2017-03-02 |
| RU2682159C2 (ru) | 2019-03-15 |
| WO2015124735A1 (en) | 2015-08-27 |
| EP3107591A1 (en) | 2016-12-28 |
| RU2016137290A (ru) | 2018-03-23 |
| JP2017508523A (ja) | 2017-03-30 |
| KR20160124149A (ko) | 2016-10-26 |
| BR112016018704A2 (pt) | 2017-10-17 |
| IL247105A0 (en) | 2016-09-29 |
| ES2676318T3 (es) | 2018-07-18 |
| CA2938795A1 (en) | 2015-08-27 |
| SG11201606696UA (en) | 2016-09-29 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/02/2015, OBSERVADAS AS CONDICOES LEGAIS. |