RU2682159C2 - Fgf-18 в процедурах пересадки трансплантата и тканевой инженерии - Google Patents

Fgf-18 в процедурах пересадки трансплантата и тканевой инженерии Download PDF

Info

Publication number
RU2682159C2
RU2682159C2 RU2016137290A RU2016137290A RU2682159C2 RU 2682159 C2 RU2682159 C2 RU 2682159C2 RU 2016137290 A RU2016137290 A RU 2016137290A RU 2016137290 A RU2016137290 A RU 2016137290A RU 2682159 C2 RU2682159 C2 RU 2682159C2
Authority
RU
Russia
Prior art keywords
cartilage
fgf
culture
compound
day
Prior art date
Application number
RU2016137290A
Other languages
English (en)
Russian (ru)
Other versions
RU2016137290A (ru
RU2016137290A3 (enExample
Inventor
Кристоф Х. ЛАДЕЛ
Ханс ГЮРИНГ
Анна ЖИГУ
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of RU2016137290A publication Critical patent/RU2016137290A/ru
Publication of RU2016137290A3 publication Critical patent/RU2016137290A3/ru
Application granted granted Critical
Publication of RU2682159C2 publication Critical patent/RU2682159C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3612—Cartilage, synovial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
RU2016137290A 2014-02-20 2015-02-20 Fgf-18 в процедурах пересадки трансплантата и тканевой инженерии RU2682159C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14000599 2014-02-20
EP14000599.2 2014-02-20
PCT/EP2015/053639 WO2015124735A1 (en) 2014-02-20 2015-02-20 Fgf-18 in graft transplantation and tissue engineering procedures

Publications (3)

Publication Number Publication Date
RU2016137290A RU2016137290A (ru) 2018-03-23
RU2016137290A3 RU2016137290A3 (enExample) 2018-09-07
RU2682159C2 true RU2682159C2 (ru) 2019-03-15

Family

ID=50151087

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016137290A RU2682159C2 (ru) 2014-02-20 2015-02-20 Fgf-18 в процедурах пересадки трансплантата и тканевой инженерии

Country Status (15)

Country Link
US (2) US20170056554A1 (enExample)
EP (1) EP3107591B1 (enExample)
JP (1) JP6495934B2 (enExample)
KR (1) KR102437057B1 (enExample)
CN (1) CN106232153B (enExample)
AR (1) AR099557A1 (enExample)
AU (1) AU2015220781B2 (enExample)
BR (1) BR112016018704B1 (enExample)
ES (1) ES2676318T3 (enExample)
IL (1) IL247105B (enExample)
MX (1) MX2016010873A (enExample)
RU (1) RU2682159C2 (enExample)
SG (1) SG11201606696UA (enExample)
WO (1) WO2015124735A1 (enExample)
ZA (1) ZA201605549B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20181570T1 (hr) 2014-02-20 2018-11-30 Merck Patent Gmbh Režim doziranja spoja fgf-18
ES2698117T3 (es) 2014-02-20 2019-01-31 Merck Patent Gmbh Implante que comprende FGF-18
CA2971315C (en) 2015-01-29 2023-02-14 Ares Trading S.A. Immunoassays for high positively charged proteins
CN107058217A (zh) * 2017-01-22 2017-08-18 广州赛莱拉干细胞科技股份有限公司 一种软骨细胞的增殖培养基及增殖培养方法
US20200128812A1 (en) * 2017-03-17 2020-04-30 Merck Patent Gmbh Cartilage preservation media
LT3687558T (lt) 2017-09-29 2022-06-27 Merck Patent Gmbh Metaboliniai biožymenys, skirti atsako į fgf-18 junginį numatymui
RS63292B1 (sr) 2017-09-29 2022-06-30 Merck Patent Gmbh Inflamatorni biomarkeri za predviđanje responsivnosti na jedinjenje fgf-18
IL281333B2 (en) 2018-09-10 2025-11-01 Merck Patent Gmbh A method for reducing risk in a clinical trial
CN113244413B (zh) * 2021-06-28 2021-10-26 深圳市瑞吉生物科技有限公司 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用
CN117230002A (zh) * 2022-06-06 2023-12-15 友康生物科技(北京)股份有限公司 一种软骨细胞培养基
IT202300012807A1 (it) * 2023-06-26 2024-12-26 Umberto Parri Protesi d'anca in biomateriali e procedimento di fabbricazione

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511958B1 (en) * 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
WO2004032849A2 (en) * 2002-10-07 2004-04-22 Zymogenetics, Inc. Methods of administering fgf18
WO2008023063A2 (en) * 2006-08-25 2008-02-28 Ares Trading S.A. Treatment of cartilage disorders with fgf-18

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140193468A1 (en) * 2001-03-23 2014-07-10 Histogenics Corporation Methods for preparation of neo-cartilage constructs
NZ574216A (en) * 2006-08-25 2011-11-25 Ares Trading Sa Treatment of cartilage disorders with fgf-18
JP5388233B2 (ja) * 2011-01-19 2014-01-15 富士ソフト株式会社 再生軟骨の軟骨特性を評価する方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511958B1 (en) * 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
WO2004032849A2 (en) * 2002-10-07 2004-04-22 Zymogenetics, Inc. Methods of administering fgf18
WO2008023063A2 (en) * 2006-08-25 2008-02-28 Ares Trading S.A. Treatment of cartilage disorders with fgf-18

Also Published As

Publication number Publication date
NZ723169A (en) 2023-05-26
JP6495934B2 (ja) 2019-04-03
KR20160124149A (ko) 2016-10-26
IL247105A0 (en) 2016-09-29
CN106232153B (zh) 2020-01-17
RU2016137290A (ru) 2018-03-23
US20220378981A1 (en) 2022-12-01
CN106232153A (zh) 2016-12-14
ES2676318T3 (es) 2018-07-18
KR102437057B1 (ko) 2022-08-26
RU2016137290A3 (enExample) 2018-09-07
IL247105B (en) 2020-02-27
CA2938795A1 (en) 2015-08-27
WO2015124735A1 (en) 2015-08-27
AU2015220781A1 (en) 2016-09-01
JP2017508523A (ja) 2017-03-30
BR112016018704B1 (pt) 2021-01-05
AR099557A1 (es) 2016-08-03
BR112016018704A2 (pt) 2017-10-17
MX2016010873A (es) 2016-11-17
ZA201605549B (en) 2018-12-19
EP3107591B1 (en) 2018-04-18
SG11201606696UA (en) 2016-09-29
EP3107591A1 (en) 2016-12-28
US20170056554A1 (en) 2017-03-02
AU2015220781B2 (en) 2018-05-24

Similar Documents

Publication Publication Date Title
US20220378981A1 (en) Fgf-18 in graft transplantation and tissue engineering procedures
US9700583B2 (en) Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
US11801331B2 (en) Composition for cartilage regeneration and preparing thereof
Lindahl et al. Cartilage repair with chondrocytes: clinical and cellular aspects
JP2001502905A (ja) ホウォートンゼリーから分離した細胞を用いた軟骨組織の形成
JP2004524839A (ja) オートロガスな細胞の内植／移植方法のための哺乳動物の細胞のインビトロでの改良した培養方法
US20180236005A1 (en) Fibroblasts for treatment of degenerative disc disease
RU2691946C2 (ru) Схема применения соединения fgf-18
JP2020000891A (ja) 線維芽細胞からのエクスビボ軟骨生成
KR20200087748A (ko) 지방 유래 줄기세포를 포함하는 생체재료 및 이를 생산하는 방법
KR101901568B1 (ko) 연골 무세포 파쇄물 및 줄기세포를 포함하는 연골분화 촉진용 복합체 및 그의 용도
CA2938795C (en) Fgf-18 in graft transplantation and tissue engineering procedures
Trzeciak et al. Evaluation of cartilage reconstruction by means of autologous chondrocyte versus periosteal graft transplantation: an animal study
Milano et al. The effect of autologous conditioned plasma on the treatment of focal chondral defects of the knee. An experimental study
KR20180035911A (ko) Fgf-18 화합물을 포함하는 조합 조성물
HK1231785B (en) Fgf-18 in graft transplantation and tissue engineering procedures
Frisbie et al. Stem cells as a treatment for osteoarthritis
HK1231785A1 (en) Fgf-18 in graft transplantation and tissue engineering procedures
US20200128812A1 (en) Cartilage preservation media
KR20130007184A (ko) 반월상 연골 이식을 위한 연골세포의 증식방법
Clinton et al. Osteoarthritis: Treatment Exploration Using Stem Cells
Caviglia Tissue engineering in musculoskeletal problems related to haemophilia