JP2014196354A5 - - Google Patents
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- Publication number
- JP2014196354A5 JP2014196354A5 JP2014145146A JP2014145146A JP2014196354A5 JP 2014196354 A5 JP2014196354 A5 JP 2014196354A5 JP 2014145146 A JP2014145146 A JP 2014145146A JP 2014145146 A JP2014145146 A JP 2014145146A JP 2014196354 A5 JP2014196354 A5 JP 2014196354A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- mesenchymal stem
- stem cells
- defect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 11
- 210000001258 synovial membrane Anatomy 0.000 claims 9
- 230000007547 defect Effects 0.000 claims 8
- 206010061762 Chondropathy Diseases 0.000 claims 5
- 230000005499 meniscus Effects 0.000 claims 5
- 210000000845 cartilage Anatomy 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 208000003947 Knee Osteoarthritis Diseases 0.000 claims 1
- 201000009859 Osteochondrosis Diseases 0.000 claims 1
- 206010031264 Osteonecrosis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 210000002449 bone cell Anatomy 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000000968 fibrocartilage Anatomy 0.000 claims 1
- 210000003035 hyaline cartilage Anatomy 0.000 claims 1
- 210000003559 hypertrophic chondrocyte Anatomy 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82313806P | 2006-08-22 | 2006-08-22 | |
| US60/823,138 | 2006-08-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525260A Division JP5656183B2 (ja) | 2006-08-22 | 2007-08-22 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014196354A JP2014196354A (ja) | 2014-10-16 |
| JP2014196354A5 true JP2014196354A5 (enExample) | 2015-03-05 |
| JP5928961B2 JP5928961B2 (ja) | 2016-06-01 |
Family
ID=39106908
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525260A Active JP5656183B2 (ja) | 2006-08-22 | 2007-08-22 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
| JP2014145146A Active JP5928961B2 (ja) | 2006-08-22 | 2014-07-15 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525260A Active JP5656183B2 (ja) | 2006-08-22 | 2007-08-22 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20100178274A1 (enExample) |
| JP (2) | JP5656183B2 (enExample) |
| WO (1) | WO2008023829A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| JP5843189B2 (ja) * | 2011-03-15 | 2016-01-13 | 国立大学法人名古屋大学 | Ｓｄｆ−１阻害剤を含有した軟骨組織再生用組成物 |
| WO2014110590A1 (en) * | 2013-01-14 | 2014-07-17 | Scripps Health | Tissue array printing |
| AU2014297188B2 (en) * | 2013-08-01 | 2017-05-11 | Two Cells Co., Ltd. | Cartilage-damage treatment agent and method for producing same |
| EP3116557B1 (en) | 2014-03-14 | 2020-03-11 | Scripps Health | Electrospinning of cartilage and meniscus matrix polymers |
| KR101641770B1 (ko) * | 2014-06-23 | 2016-07-22 | 씨제이제일제당 (주) | O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법 |
| CN104357385A (zh) * | 2014-11-17 | 2015-02-18 | 四川大学华西医院 | 一种半月板组织来源的间充质干细胞及其制备方法和鉴定 |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US11497831B2 (en) | 2016-05-26 | 2022-11-15 | Scripps Health | Systems and methods to repair tissue defects |
| WO2018131673A1 (ja) * | 2017-01-13 | 2018-07-19 | 公立大学法人首都大学東京 | 新規組織再生材料およびその製造方法 |
| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| KR102223043B1 (ko) * | 2018-09-28 | 2021-03-08 | 주식회사 히에라바이오 | 활액막 유래 중간엽 줄기세포 및 그의 용도 |
| EP3920946A4 (en) | 2019-02-07 | 2022-11-09 | Direct Biologics LLC | METHOD FOR TREATING OSTEOARTHRITIS USING A COMBINATION OF EXOSOMES OF MESENCHYMATE STEM CELLS, SYNOVIAL MESENCHYMATE STEM CELLS AND SCAFFOLDS |
| WO2020196233A1 (ja) * | 2019-03-26 | 2020-10-01 | 国立大学法人東京医科歯科大学 | 軟骨組織の再生を促進するための組成物 |
| CA3146433A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| KR20230004709A (ko) | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| JP6864302B1 (ja) | 2020-07-03 | 2021-04-28 | 富士フイルム株式会社 | 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法 |
| JP6864303B1 (ja) | 2020-07-03 | 2021-04-28 | 富士フイルム株式会社 | 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法 |
| KR20230058721A (ko) | 2020-10-07 | 2023-05-03 | 후지필름 가부시키가이샤 | 관절 치료용 세포 제제의 제조 방법, 관절 치료용 세포 제제 및 간엽계 줄기세포의 배양 방법 |
| JP7681279B2 (ja) * | 2021-03-12 | 2025-05-22 | 富士フイルム株式会社 | 関節症治療剤の製造方法及び関節症治療剤 |
| KR20240019341A (ko) | 2021-07-15 | 2024-02-14 | 후지필름 가부시키가이샤 | 세포의 품질 관리 방법 및 세포를 제조하는 방법 |
| TW202307203A (zh) | 2021-07-15 | 2023-02-16 | 日商富士軟片股份有限公司 | 特定細胞的品質管理方法及製造特定細胞之方法 |
| JPWO2023032945A1 (enExample) * | 2021-08-31 | 2023-03-09 | ||
| TW202407315A (zh) | 2022-06-24 | 2024-02-16 | 日商富士軟片股份有限公司 | 用以提供細胞產品的系統 |
| TW202603160A (zh) * | 2024-03-29 | 2026-01-16 | 日商富士軟片股份有限公司 | 滑膜來源間質幹細胞、其製造方法、及其利用 |
| WO2025226276A1 (en) | 2024-04-25 | 2025-10-30 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| CN119235920B (zh) * | 2024-12-06 | 2025-06-24 | 浙江大学 | 一种用于关节软骨损伤修复的mfap5阳性滑膜衬里层干细胞及其鉴定方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4246994B2 (ja) * | 2001-01-30 | 2009-04-02 | オーソジーン， インコーポレイテッド | 滑膜由来の組織または細胞を使用する関節軟骨における欠陥または病変の処置および修復のための組成物および方法 |
| JP2003199816A (ja) * | 2002-01-10 | 2003-07-15 | Takehisa Matsuda | 軟骨組織再生用補助材、軟骨組織再生用キット及び軟骨組織再生方法 |
| ES2564044T3 (es) * | 2003-06-27 | 2016-03-17 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas |
-
2007
- 2007-08-22 JP JP2009525260A patent/JP5656183B2/ja active Active
- 2007-08-22 US US12/438,298 patent/US20100178274A1/en not_active Abandoned
- 2007-08-22 WO PCT/JP2007/066708 patent/WO2008023829A1/en not_active Ceased
-
2014
- 2014-07-15 JP JP2014145146A patent/JP5928961B2/ja active Active
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